A genetically engineered live-attenuated simian-human immunodeficiency virus that co-expresses the RANTES gene improves the magnitude of cellular immunity in rhesus macaques

Virology

Volumn 361, Issue 1, 2007, Pages 68-79

  Shimizu, Yuya ^a   Inaba, Katsuhisa ^b   Kaneyasu, Kentaro ^b   Ibuki, Kentaro ^b   Himeno, Ai ^b   Okoba, Masashi ^a   Goto, Yoshitaka ^a   Hayami, Masanori ^b   Miura, Tomoyuki ^b   Haga, Takeshi ^a  

^a UNIVERSITY OF MIYAZAKI   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

Adjuvant; Chemokine; HIV 1; RANTES; SHIV; SIV; Vaccine

Indexed keywords

CHEMOKINE; LIVE ATTENUATED SIMIAN IMMUNODEFICIENCY VIRUS VACCINE; LIVE VACCINE; RANTES; UNCLASSIFIED DRUG;

ANTIBODY TITER; ANTIGEN SPECIFICITY; ARTICLE; CD4+ T LYMPHOCYTE; CELLULAR IMMUNITY; ENZYME LINKED IMMUNOSPOT ASSAY; GENE EXPRESSION; IMMUNE RESPONSE; IN VIVO STUDY; MACACA; NONHUMAN; PRIORITY JOURNAL; RHESUS MONKEY; SIMIAN IMMUNODEFICIENCY VIRUS; VIRUS LOAD;

ACQUIRED IMMUNODEFICIENCY SYNDROME; ADJUVANTS, IMMUNOLOGIC; ANIMALS; CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; HIV ANTIGENS; HIV-1; INTERFERON TYPE II; MACACA MULATTA; MALE; RANTES; REASSORTANT VIRUSES; SIMIAN IMMUNODEFICIENCY VIRUS; T-CELL ANTIGEN RECEPTOR SPECIFICITY; VACCINATION; VIRAL LOAD;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA MULATTA; SIMIAN IMMUNODEFICIENCY VIRUS; SIMIAN-HUMAN IMMUNODEFICIENCY VIRUS;

EID: 34047266631     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2006.10.050     Document Type: Article

References (46)

1. Abel K., Alegria-Hartman M.J., Zanotto K., McChesney M.B., Marthas M.L., and Miller C.J. Anatomic site and immune function correlate with relative cytokine mRNA expression levels in lymphoid tissues of normal rhesus macaques. Cytokine 16 (2001) 191-204
2. Ahmed R.K., Nilsson C., Wang Y., Lehner T., Biberfeld G., and Thorstensson R. Beta-chemokine production in macaques vaccinated with live attenuated virus correlates with protection against simian immunodeficiency virus (SIVsm) challenge. J. Gen. Virol. 80 Pt. 7 (1999) 1569-1574
3. Alkhatib G., Combadiere C., Broder C.C., Feng Y., Kennedy P.E., Murphy P.M., and Berger E.A. CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1. Science 272 (1996) 1955-1958
4. Baba T.W., Liska V., Khimani A.H., Ray N.B., Dailey P.J., Penninck D., Bronson R., Greene M.F., McClure H.M., Martin L.N., and Ruprecht R.M. Live attenuated, multiply deleted simian immunodeficiency virus causes AIDS in infant and adult macaques. Nat. Med. 5 (1999) 194-203
5. Bonecchi R., Bianchi G., Bordignon P.P., D'Ambrosio D., Lang R., Borsatti A., Sozzani S., Allavena P., Gray P.A., Mantovani A., and Sinigaglia F. Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s. J. Exp. Med. 187 (1998) 129-134
6. Cocchi F., DeVico A.L., Garzino-Demo A., Arya S.K., Gallo R.C., and Lusso P. Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells. Science 270 (1995) 1811-1815
7. Enose Y., Ui M., Miyake A., Suzuki H., Uesaka H., Kuwata T., Kunisawa J., Kiyono H., Takahashi H., Miura T., and Hayami M. Protection by intranasal immunization of a nef-deleted, nonpathogenic SHIV against intravaginal challenge with a heterologous pathogenic SHIV. Virology 298 (2002) 306-316
8. Enose Y., Kita M., Yamamoto T., Suzuki H., Miyake A., Horiuchi R., Ibuki K., Kaneyasu K., Kuwata T., Takahashi E., Sakai K., Shinohara K., Miura T., and Hayami M. Protective effects of nef-deleted SHIV or that having IFN-gamma against disease induced with a pathogenic virus early after vaccination. Arch. Virol. 149 (2004) 1705-1720
9. Frauenschuh A., DeVico A.L., Lim S.P., Gallo R.C., and Garzino-Demo A. Differential polarization of immune responses by co-administration of antigens with chemokines. Vaccine 23 (2004) 546-554
10. Gauduin M.C., Glickman R.L., Ahmad S., Yilma T., and Johnson R.P. Immunization with live attenuated simian immunodeficiency virus induces strong type 1 T helper responses and beta-chemokine production. Proc. Natl. Acad. Sci. U.S.A. 96 (1999) 14031-14036
11. Giavedoni L., Ahmad S., Jones L., and Yilma T. Expression of gamma interferon by simian immunodeficiency virus increases attenuation and reduces postchallenge virus load in vaccinated rhesus macaques. J. Virol. 71 (1997) 866-872
12. Gundlach B.R., Lewis M.G., Sopper S., Schnell T., Sodroski J., Stahl-Hennig C., and Uberla K. Evidence for recombination of live, attenuated immunodeficiency virus vaccine with challenge virus to a more virulent strain. J. Virol. 74 (2000) 3537-3542
13. Haga T., Kuwata T., Ui M., Igarashi T., Miyazaki Y., and Hayami M. A new approach to AIDS research and prevention: the use of gene-mutated HIV-1/SIV chimeric viruses for anti-HIV-1 live-attenuated vaccines. Microbiol. Immunol. 42 (1998) 245-251
14. Heeney J.L., Teeuwsen V.J., van Gils M., Bogers W.M., De Giuli Morghen C., Radaelli A., Barnett S., Morein B., Akerblom L., Wang Y., Lehner T., and Davis D. beta-chemokines and neutralizing antibody titers correlate with sterilizing immunity generated in HIV-1 vaccinated macaques. Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 10803-10808
15. Hofmann-Lehmann R., Williams A.L., Swenerton R.K., Li P.L., Rasmussen R.A., Chenine A.L., McClure H.M., and Ruprecht R.M. Quantitation of simian cytokine and beta-chemokine mRNAs, using real-time reverse transcriptase-polymerase chain reaction: variations in expression during chronic primate lentivirus infection. AIDS Res. Hum. Retroviruses 18 (2002) 627-639
16. Igarashi T., Kuwata T., Yamamoto H., Moriyama H., Ui M., Miyazaki Y., and Hayami M. Infectivity and immunogenicity of SIVmac/HIV-1 chimeric viruses (SHIVs) with deletions in two or three genes (vpr, nef and vpx). Microbiol. Immunol. 42 (1998) 71-74
17. Imami N., Pires A., Hardy G., Wilson J., Gazzard B., and Gotch F. A balanced type 1/type 2 response is associated with long-term nonprogressive human immunodeficiency virus type 1 infection. J. Virol. 76 (2002) 9011-9023
18. Johnson R.P., and Desrosiers R.C. Protective immunity induced by live attenuated simian immunodeficiency virus. Curr. Opin. Immunol. 10 (1998) 436-443
19. Kalams S.A., and Walker B.D. The critical need for CD4 help in maintaining effective cytotoxic T lymphocyte responses. J. Exp. Med. 188 (1998) 2199-2204
20. Kim J.J., Nottingham L.K., Sin J.I., Tsai A., Morrison L., Oh J., Dang K., Hu Y., Kazahaya K., Bennett M., Dentchev T., Wilson D.M., Chalian A.A., Boyer J.D., Agadjanyan M.G., and Weiner D.B. CD8 positive T cells influence antigen-specific immune responses through the expression of chemokines. J. Clin. Invest. 102 (1998) 1112-1124
21. Kinter A., Catanzaro A., Monaco J., Ruiz M., Justement J., Moir S., Arthos J., Oliva A., Ehler L., Mizell S., Jackson R., Ostrowski M., Hoxie J., Offord R., and Fauci A.S. CC-chemokines enhance the replication of T-tropic strains of HIV-1 in CD4(+) T cells: role of signal transduction. Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 11880-11885
22. Koff W.C., Johnson P.R., Watkins D.I., Burton D.R., Lifson J.D., Hasenkrug K.J., McDermott A.B., Schultz A., Zamb T.J., Boyle R., and Desrosiers R.C. HIV vaccine design: insights from live attenuated SIV vaccines. Nat. Immunol. 7 (2006) 19-23
23. Kuwata T., Miura T., Haga T., Kozyrev I., and Hayami M. Construction of chimeric simian and human immunodeficiency viruses that produce interleukin 12. AIDS Res. Hum. Retroviruses 16 (2000) 465-470
24. Kuwata T., Miura T., and Hayami M. Using SHIVs to develop an anti-HIV-1 live-attenuated vaccine. Trends Microbiol. 9 (2001) 475-480
25. Kwofie T.B., Haga T., Iida T., Hayami M., and Miura T. Plasma levels of the chemokine RANTES in macaque monkeys infected with pathogenic and non-pathogenic SIV/HIV-1 chimeric viruses at an early stage of infection. J. Vet. Med. Sci. 62 (2000) 1311-1312
26. Lillard Jr. J.W., Boyaka P.N., Taub D.D., and McGhee J.R. RANTES potentiates antigen-specific mucosal immune responses. J. Immunol. 166 (2001) 162-169
27. Loetscher P., Uguccioni M., Bordoli L., Baggiolini M., Moser B., Chizzolini C., and Dayer J.M. CCR5 is characteristic of Th1 lymphocytes. Nature 391 (1998) 344-345
28. Luster A.D. Chemokines-chemotactic cytokines that mediate inflammation. N. Engl. J. Med. 338 (1998) 436-445
29. Matloubian M., Concepcion R.J., and Ahmed R. CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection. J. Virol. 68 (1994) 8056-8063
30. Miller C.J., and Abel K. Immune mechanisms associated with protection from vaginal SIV challenge in rhesus monkeys infected with virulence-attenuated SHIV 89.6. J. Med. Primatol. 34 (2005) 271-281
31. Pfaffl M.W. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 29 (2001) e45
32. Proudfoot A.E., Wells T.N., and Clapham P.R. Chemokine receptors-future therapeutic targets for HIV?. Biochem. Pharmacol. 57 (1999) 451-463
33. Rosenberg E.S., Billingsley J.M., Caliendo A.M., Boswell S.L., Sax P.E., Kalams S.A., and Walker B.D. Vigorous HIV-1-specific CD4+ T cell responses associated with control of viremia. Science 278 (1997) 1447-1450
34. Rosenberg E.S., Altfeld M., Poon S.H., Phillips M.N., Wilkes B.M., Eldridge R.L., Robbins G.K., D'Aquila R.T., Goulder P.J., and Walker B.D. Immune control of HIV-1 after early treatment of acute infection. Nature 407 (2000) 523-526
35. Sallusto F., Lanzavecchia A., and Mackay C.R. Chemokines and chemokine receptors in T-cell priming and Th1/Th2-mediated responses. Immunol. Today 19 (1998) 568-574
36. Schmittel A., Keilholz U., and Scheibenbogen C. Evaluation of the interferon-gamma ELISPOT-assay for quantification of peptide specific T lymphocytes from peripheral blood. J. Immunol. Methods 210 (1997) 167-174
37. Shimizu Y., Miyazaki Y., Ibuki K., Suzuki H., Kaneyasu K., Goto Y., Hayami M., Miura T., and Haga T. Induction of immune response in macaque monkeys infected with simian-human immunodeficiency virus having the TNF-alpha gene at an early stage of infection. Virology 343 (2005) 151-161
38. Shimizu Y., Okoba M., Yamazaki N., Goto Y., Miura T., Hayami M., Hoshino H., and Haga T. Construction and in vitro characterization of a chimeric simian and human immunodeficiency virus with the RANTES gene. Microbes Infect. 8 (2006) 105-113
39. Shinohara K., Sakai K., Ando S., Ami Y., Yoshino N., Takahashi E., Someya K., Suzaki Y., Nakasone T., Sasaki Y., Kaizu M., Lu Y., and Honda M. A highly pathogenic simian/human immunodeficiency virus with genetic changes in cynomolgus monkey. J. Gen. Virol. 80 (1999) 1231-1240
40. Stahl-Hennig C., Gundlach B.R., Dittmer U., ten Haaft P., Heeney J., Zou W., Emilie D., Sopper S., and Uberla K. Replication, immunogenicity, and protective properties of live-attenuated simian immunodeficiency viruses expressing interleukin-4 or interferon-gamma. Virology 305 (2003) 473-485
41. Suryanarayana K., Wiltrout T.A., Vasquez G.M., Hirsch V.M., and Lifson J.D. Plasma SIV RNA viral load determination by real-time quantification of product generation in reverse transcriptase-polymerase chain reaction. AIDS Res. Hum. Retroviruses 14 (1998) 183-189
42. Tanner M.A., Berk L.S., Felten D.L., Blidy A.D., Bit S.L., and Ruff D.W. Substantial changes in gene expression level due to the storage temperature and storage duration of human whole blood. Clin. Lab. Haematol. 24 (2002) 337-341
43. Taub D.D., Ortaldo J.R., Turcovski-Corrales S.M., Key M.L., Longo D.L., and Murphy W.J. Beta chemokines costimulate lymphocyte cytolysis, proliferation, and lymphokine production. J. Leukocyte Biol. 59 (1996) 81-89
44. Ui M., Kuwata T., Igarashi T., Ibuki K., Miyazaki Y., Kozyrev I.L., Enose Y., Shimada T., Uesaka H., Yamamoto H., Miura T., and Hayami M. Protection of macaques against a SHIV with a homologous HIV-1 Env and a pathogenic SHIV-89.6P with a heterologous Env by vaccination with multiple gene-deleted SHIVs. Virology 265 (1999) 252-263
45. Waterman P.M., Kitabwalla M., Hatfield G.S., Evans P.S., Lu Y., Tikhonov I., Bryant J.L., and Pauza C.D. Effects of virus burden and chemokine expression on immunity to SHIV in nonhuman primates. Viral Immunol. 17 (2004) 545-557
46. Xin K.Q., Lu Y., Hamajima K., Fukushima J., Yang J., Inamura K., and Okuda K. Immunization of RANTES expression plasmid with a DNA vaccine enhances HIV-1-specific immunity. Clin. Immunol. 92 (1999) 90-96