Infectivity and immunogenicity of SIVmac/HIV-1 chimeric viruses (SHIVs) with deletions in two or three genes (vpr, nef and vpx)

Microbiology and Immunology

Volumn 42, Issue 1, 1998, Pages 71-74

  Igarashi, Tatsuhiko ^a,b   Kuwata, Takeo ^a   Yamamoto, Hiroshi ^c   Moriyama, Hiroyuki ^a   Ui, Masahiro ^a   Miyazaki, Yasuyuki ^a   Hayami, Masanori ^a  

^a KYOTO UNIVERSITY   (Japan)

^b The Japan Foundation   (Japan)

^c UNIVERSITY OF TOYAMA   (Japan)

Author keywords

AIDS; Live attenuated vaccine; SHIV

Indexed keywords

SIMIAN IMMUNODEFICIENCY VIRUS VACCINE;

ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ARTICLE; DOSE RESPONSE; GENE DELETION; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOGENICITY; MACACA; MEMORY CELL; NATURAL KILLER CELL; NONHUMAN; SIMIAN IMMUNODEFICIENCY VIRUS; VACCINE PRODUCTION; VIREMIA; VIRUS INFECTIVITY; VIRUS MUTATION;

EID: 0031941029     PISSN: 03855600     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1348-0421.1998.tb01973.x     Document Type: Article

References (5)

1. Igarashi, T., Ami, Y., Yamamoto, H., Shibata, R., Kuwata, T., Mukai, R., Shinohara, K., Komatsu, T., Adachi, A., and Hayami, M. 1997. Protection of monkeys vaccinated with vpr-and/or nef-defective simian immunodeficiency virus strain mac/human immunodeficiency virus type 1 chimeric viruses: a potential candidate live-attenuated human AIDS vaccine. J. Gen. Virol. 78: 985-989.
2. Kestler, H.W., Ringler, D.J., Mori, K., Panicali, D.L., Sehgal, P.K., Daniel, M.D., and Desrosiers, R.C. 1991. Importance of the nef gene for maintenance of high virus loads and for development of AIDS. Cell 65: 651-662.
3. Kuwata, T., Igarashi, T., Ido, E., Jin, M., Mizuno, A., Chen, J., and Hayami, M. 1995. Construction of human immunodeficiency virus 1/simian immunodeficiency strain mac chimeric viruses having vpr and/or nef of different parental origins and their in vitro and in vivo replication. J. Gen. Virol. 76: 2181-2191.
4. Shibata, R., Kawamura, M., Sakai, H., Hayami, M., Ishimoto, A., and Adachi, A. 1991. Generation of a chimeric human and simian immunodeficiency virus infectious to monkey peripheral blood mononuclear cells. J. Virol. 65: 3514-3520.
5. Shibata, R., Sakai, H., Kawamura, M., Tokunaga, K., and Adachi, A. 1995. Early replication block of human immunodeficiency virus type 1 in monkey cells. J. Gen. Virol. 76: 2723-2730.