Novel 5-substituted 1-pyrazolol analogues of ibotenic acid: Synthesis and pharmacology at glutamate receptors

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 10, 2007, Pages 3524-3538

  Jørgensen, Charlotte G ^a   Bräuner Osborne, Hans ^a   Nielsen, Birgitte ^a   Kehler, Jan ^b   Clausen, Rasmus P ^a   Krogsgaard Larsen, Povl ^a   Madsen, Ulf ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b H LUNDBECK A S   (Denmark)

Author keywords

1 Pyrazolol; Amino acids; Ibotenic acid; Ionotropic and metabotropic glutamate receptor ligands; Pyrazole; Synthesis

Indexed keywords

2 AMINO(1 BENZYLOXY 5 BUTYL 4 PYRAZOLYL)ACETIC ACID; 2 AMINO(1 HYDROXY 5 PENTYL 4 PYRAZOLYL)ACETIC ACID; 2 AMINO(1 HYDROXY 5 PHENYL 4 PYRAZOLYL)ACETIC ACID; 2 AMINO(1 HYDROXY 5 PHENYLETHYL 4 PYRAZOLYL)ACETIC ACID; 2 AMINO(1 HYDROXY 5 PROPYL 4 PYRAZOLYL)ACETIC ACID; 2 AMINO(5 BENZHYDRYL 1 HYDROXY 4 PYRAZOLYL)ACETIC ACID; 2 AMINO(5 BENZYL 1 HYDROXY 4 PYRAZOLYL)ACETIC ACID; 2 AMINO(5 BROMO 1 HYDROXY 4 PYRAZOLYL)ACETIC ACID; 2 AMINO(5 CYCLOHEXYLMETHYL 1 HYDROXY 4 PYRAZOLYL)ACETIC ACID; 2 AMINO(5 CYCLOPROPYLMETHYL 1 HYDROXY 4 PYRAZOLYL)ACETIC ACID; 2 AMINO(5 ETHYL 1 HYDROXY 4 PYRAZOLYL)ACETIC ACID; 2 AMINO[1 HYDROXY 5 (3 PHENYLPROPYL) 4 PYRAZOLYL]ACETIC ACID; ALKYL GROUP; BENZENE DERIVATIVE; BROMIDE; IBOTENIC ACID; IONOTROPIC RECEPTOR; METABOTROPIC RECEPTOR; METABOTROPIC RECEPTOR 2; METABOTROPIC RECEPTOR AGONIST; METABOTROPIC RECEPTOR ANTAGONIST; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PYRAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; DRUG SYNTHESIS; NONHUMAN; RAT;

ALKYLATION; ANIMALS; BRAIN; CHO CELLS; CRICETINAE; CRICETULUS; EXCITATORY AMINO ACID AGONISTS; IBOTENIC ACID; INDICATORS AND REAGENTS; MAGNETIC RESONANCE SPECTROSCOPY; PYRAZOLES; RATS; RECEPTORS, AMPA; RECEPTORS, GLUTAMATE; RECEPTORS, N-METHYL-D-ASPARTATE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34047239442     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.02.047     Document Type: Article

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