Inhibition of activator protein-1 binding activity and phosphatidylinositol 3-kinase pathway by nobiletin, a polymethoxy flavonoid, results in augmentation of tissue inhibitor of metalloproteinases-1 production and suppression of production of matrix metalloproteinases-1 and -9 in human fibrosarcoma HT-1080 cells

Cancer Research

Volumn 62, Issue 4, 2002, Pages 1025-1029

  Sato, Takashi ^a   Koike, Leona ^a   Miyata, Yoshiki ^a   Hirata, Michiko ^a,b   Ito, Akira ^a   Mimaki, Yoshihiro ^a   Sashida, Yutaka ^a   Yano, Masamichi ^c  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^b NARO Bio oriented Technology Research Advancement Institution   (Japan)

^c NATIONAL INSTITUTE OF FRUIT TREE SCIENCE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; FLAVONOID; GELATINASE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERSTITIAL COLLAGENASE; MATRIGEL; NOBILETIN; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHATIDYLINOSITOL 3 KINASE; POLYMETHOXYFLAVONOID; PROCOLLAGENASE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG;

ARTICLE; CANCER INVASION; CITRUS DEPRESSA; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; ENZYME INHIBITION; FIBROSARCOMA; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; MEDICINAL PLANT; PRIORITY JOURNAL; ZYMOGRAPHY;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANTICARCINOGENIC AGENTS; CHROMONES; ENZYME INHIBITORS; FIBROSARCOMA; FLAVONES; FLAVONOIDS; HUMANS; MATRIX METALLOPROTEINASE 1; MATRIX METALLOPROTEINASE 9; MORPHOLINES; NEOPLASM INVASIVENESS; NF-KAPPA B; SIGNAL TRANSDUCTION; TISSUE INHIBITOR OF METALLOPROTEINASE-1; TRANSCRIPTION FACTOR AP-1; TUMOR CELLS, CULTURED;

EID: 0036173982     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Tumor cell interactions with the extracellular matrix during invasion and metastasis
2. Regulation of matrix metalloproteinase expression in tumor invasion
3. Matrix metalloproteinases
4. Interstitial collagenase gene expression in oral squamous cell carcinoma
5. A novel host/tumor cell interaction activates matrix metalloproteinase 1 and mediates invasion through type I collagen
6. The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis
7. The matrix metalloproteinase stromelysin-1 acts as a natural mammary tumor promoter
8. Membrane-type matrix metalloproteinases
9. Tissue inhibitors of metalloproteinases: Evolution, structure and function
10. Host TIMP-1 overexpression confers resistance to experimental brain metastasis of a fibrosarcoma cell line
11. Enhancement of membrane-type 1-matrix metalloproteinase (MT-MMP) production and sequential activation of progelatinase A on human squamous carcinoma cells co-cultured with human dermal fibroblasts
12. Suppression of metastasis by tissue inhibitor of metalloproteinase-1 in a newly established human oral squamous cell carcinoma cell line
13. Inhibition of tumor growth and metastasis of human breast cancer cells transfected with tissue inhibitor of metalloproteinase 4
14. Inhibition of invasion and induction of apoptotic cell death of cancer cell lines by overexpression of TIMP-3
15. Antiproliferative effects of citrus flavonoids on a human squamous cell carcinoma in vitro
16. Quercetin down-regulates signal transduction in human breast carcinoma cells
17. Synergistic action of quercetin and genistein in human ovarian carcinoma cells
18. Studies on the inhibitory effects of quercetin on the growth of HL-60 leukemia cells
19. Genistein exerts multiple suppressive effects on human breast carcinoma cells
20. Effects of luteolin and quercetin, inhibitors of tyrosine kinase, on cell growth and metastasis-associated properties in A431 cells overexpressing epidermal growth factor receptor
21. Inhibitory effect of citrus nobiletin on phorbol ester-induced skin inflammation, oxidative stress, and tumor promotion in mice
22. A citrus flavonoid, nobiletin, suppresses production and gene expression of matrix metalloproteinase 9/gelatinase B in rabbit synovial fibroblasts
23. Effect of catechins and citrus flavonoids on invasion in vitro
24. Heat shock suppresses membrane type 1-matrix metalloproteinase production and progelatinase A activation in human fibrosarcoma HT-1080 cells and thereby inhibits cellular invasion
25. Hormonal regulation of matrix metalloproteinase 9/gelatinase B gene expression in rabbit uterine cervical fibroblasts
26. Calmodulin differentially modulates the interleukin 1-induced biosynthesis of tissue inhibitor of metalloproteinases and matrix metalloproteinases in human uterine cervical fibroblasts
27. Cloning and characterization of human tumour cell interstitial collagenase
28. A matrix metalloproteinase expressed on the surface of invasive turnout cells
29. The citrus flavonoid, nobiletin inhibits peritoneal dissemination of human gastric carcinoma in SCID mice
30. Specific expression of matrix metalloproteinases 1, 3, 9 and 13 associated with invasiveness of breast cancer cells in vitro
31. Tyrosine phosphorylation mediates Con A-induced membrane type 1-matrix metalloproteinase expression and matrix metalloproteinase-2 activation in MDA-MB-231 human breast carcinoma cells
32. Stimulation of 92-kDa gelatinase B promoter activity by ras is mitogen-activated protein kinase kinase 1-independent and requires multiple transcription factor binding sites including closely spaced PEA3/ets and AP-1 sequences
33. Dual regulation of IL-1β-mediated matrix metalloproteinase-9 expression in mesangial cells by NF-ΚB and AP-1
34. The AP-1 site and MMP gene regulation: What is all the fuss about?
35. v-src activation of the collagenase-1 (matrix metalloproteinase-1) promoter through PEA3 and STAT: Requirement of extracellular signal-regulated kinases and inhibition by retinoic acid receptors
36. Role of transcription factor NF-ΚB/Rel in induction of nitric oxide synthase
37. In murine 3T3 fibroblasts, different second messenger pathways resulting in the induction of NO synthase II (iNOS) converge in the activation of transcription factor NF-ΚB
38. Transcriptional activity of the human tissue inhibitor of metalloproteinases 1 (TIMP-1) gene in fibroblasts involves elements in the promoter, exon 1 and intron 1
39. Structure and characterization of the human tissue inhibitor of metalloproteinases-2 gene
40. Characterization of the promoter of the gene encoding human tissue inhibitor of metalloproteinases-2 (TIMP-2)
41. Involvement of AP1 and PEA3 binding sites in the regulation of murine tissue inhibitor of metalloproteinases-1 (TIMP-1) transcription
42. Synergistic transcriptional activation of the tissue inhibitor of metalloproteinases-1 promoter via functional interaction of AP-1 and Ets-1 transcription factors
43. The mitogen-activated protein kinase and JAK-STAT signaling pathways are required for an oncostatin M-responsive element-mediated activation of matrix metalloproteinase 1 gene expression
44. Upstream tissue inhibitor of metalloproteinases-1 (TIMP-1) element-1, a novel and essential regulatory DNA motif in the human TIMP-1 gene promoter, directly interacts with a 30-kDa nuclear protein
45. Kinase pathways in chemoattractant-induced degranulation of neutrophils: The role of p38 mitogen-activated protein kinase activated by Src family kinases