Drug-induced hypersensitivity syndrome associated with cytomegalovirus reactivation: Immunological characterization of pathogenic T cells

Acta Dermato-Venereologica

Volumn 85, Issue 1, 2005, Pages 47-50

  Hashizume, Hideo ^a   Takigawa, Masahiro ^a  

^a HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Cytomegalovirus; Drug induced hypersensitivity syndrome; T cell

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; HEMOZA; HLA A2 ANTIGEN; PARACETAMOL; TRIBENOSIDE;

ADULT; ARTICLE; CASE REPORT; CELL TYPE; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOMEGALOVIRUS; DRUG HYPERSENSITIVITY; HAPLOTYPE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOLOGY; IN VITRO STUDY; LYMPHOCYTE PROLIFERATION; LYMPHOCYTIC INFILTRATION; MALE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; VIRUS REACTIVATION;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIBODIES, VIRAL; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; DRUG HYPERSENSITIVITY; GENOME, VIRAL; GLYCOSIDES; HUMANS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INTERFERON TYPE II; INTERLEUKIN-4; MALE; MIDDLE AGED; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; SKIN; VIRUS ACTIVATION;

EID: 13844262708     PISSN: 00015555     EISSN: None     Source Type: Journal    
DOI: 10.1080/00015550410024094     Document Type: Article

References (14)

1. Sullivan JR, Shear NH. The drug hypersensitivity syndrome: what is the pathogenesis? Arch Dermatol 2001; 137: 357-364.
2. Suzuki Y, Inagi R, Aono T, Yamanishi K, Shiohara T. Human herpesvirus 6 infection as a risk factor for the development of severe drug-induced hypersensitivity syndrome. Arch Dermatol 1998; 134: 1108-1112.
3. Arakawa M, Kakuto Y, Ichikawa K, Chiba J, Tabata N, Sasaki Y. Allopurinol hypersensitivity syndrome associated with systemic cytomegalovirus infection and systemic bacteremia. Intern Med 2001; 40: 331-335.
4. Hashizume H, Takigawa M, Tokura Y. Characterization of drug-specific T cells in phenobarbital-induced eruption. J Immunol 2002; 168: 5359-5368.
5. Yagi J, Baron J, Buxser S, Janeway CA Jr. Bacterial proteins that mediate the association of a defined subset of T cell receptor:CD4 complexes with class II MHC. J Immunol 1990; 144: 892-901.
6. Roujeau JC, Stern RS. Severe adverse cutaneous reactions to drugs. N Engl J Med 1994; 10: 1272-1285.
7. Behrendt C, Gollnick H, Bonnekoh B. Up-regulated perform expression of CD8+ blood lymphocytes in generalized non-anaphylactic drug eruptions and exacerbated psoriasis. Eur J Dermatol 2000; 10: 365-369.
8. Schnyder B, Frutig K, Mauri-Hellweg D, Limat A, Yawalkar N, Pichler WJ. T-cell-mediated cytotoxicity against keratinocytes in sulfamethoxazol-induced skin reaction. Clin Exp Allergy 1998; 28: 1412-1417.
9. Le Cleach L, Delaire S, Boumsell L, Bagot M, Bourgault-Villada I, Bensussan A, et al. Blister fluid T lymphocytes during toxic epidermal necrolysis are functional cytotoxic cells which express human natural killer (NK) inhibitory receptors. Clin Exp Immunol 2000; 119: 225-230.
10. Retiere C, Prod'homme V, Imbert-Marcille BM, Bonneville M, Vie H, Hallet MM. Generation of cytomegalovirus-specific human T-lymphocyte clones by using autologous B-lymphoblastoid cells with stable expression of pp65 or IE1 proteins: a tool to study the fine specificity of the antiviral response. J Virol 2000; 74: 3948-3952.
11. Keever-Taylor CA, Margolis D, Konings S, Sandford GR, Nicolette CA, Lawendowski C, et al. Cytomegalovirus-specific cytolytic T-cell lines and clones generated against adenovirus-pp65-infected dendritic cells. Biol Blood Marrow Transplant 2001; 7: 247-256.
12. Bolovan-Fritts CA, Mocarski ES, Wiedeman JA. Peripheral blood CD14(+) cells from healthy subjects carry a circular conformation of latent cytomegalovirus genome. Blood 1999; 93: 394-398.
13. Maggi E, Manetti R, Annunziato F, Cosmi L, Giudizi MG, Biagiotti R, et al. Functional characterization and modulation of cytokine production by CD8+ T cells from human immunodeficiency virus-infected individuals. Blood 1997; 89: 3672-3681.
14. Hashimoto K, Yasukawa M, Tohyama M. Human herpesvirus 6 and drug allergy. Curr Opin Allergy Clin Immunol 2003; 3: 255-260.