Short-term intermittent exposure to diazoxide improves functional performance of β-cells in a high-glucose environment

American Journal of Physiology - Endocrinology and Metabolism

Volumn 287, Issue 6 50-6, 2004, Pages

  Yoshikawa, Hiroyasu ^a   Ma, Zuheng ^b   Björklund, Anneli ^b   Grill, Valdemar ^a,b  

^a NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Adenosine triphosphate dependent potassium channels; Insulin release; Islets of Langerhans; Type 2 diabetes

Indexed keywords

ADENOSINE TRIPHOSPHATE; CYCLOHEXIMIDE; DIAZOXIDE; GLUCOSE; INSULIN; MESSENGER RNA; OLEIC ACID; POTASSIUM CHLORIDE; SNARE PROTEIN; SULFONYLUREA RECEPTOR; SYNAPTOSOMAL ASSOCIATED PROTEIN 25; TOLBUTAMIDE; UNCOUPLING PROTEIN 2; VOLTAGE GATED CALCIUM CHANNEL;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG EXPOSURE; GENE EXPRESSION; GLUCOSE OXIDATION; INSULIN RELEASE; INSULIN RESPONSE; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT;

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ANIMALS; APOPTOSIS; CYCLOHEXIMIDE; DIAZOXIDE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; GLUCOSE; INSULIN; ISLETS OF LANGERHANS; MALE; OLEIC ACID; OXIDATION-REDUCTION; POTASSIUM CHLORIDE; RATS; RATS, SPRAGUE-DAWLEY; SNARE PROTEINS; TISSUE CULTURE TECHNIQUES; VESICULAR TRANSPORT PROTEINS;

EID: 8544253979     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.00255.2004     Document Type: Article

References (25)

1. Atlas D. Functional and physical coupling of voltage-sensitive calcium channels with exocytotic proteins: ramifications for the secretion mechanism. J Neurochem 77: 972-985, 2001.
2. Björklund A and Grill V. B-cell insensitivity in vitro: reversal by diazoxide entails more than one event in stimulus-secretion coupling. Endocrinology 132: 1319-1328, 1993.
3. Carlsson C, Borg LA, and Welsh N. Sodium palmitate induces partial mitochondrial uncoupling and reactive oxygen species in rat pancreatic islets in vitro. Endocrinology 140: 3422-3428, 1999.
4. Gerber SH and Sudhof TC. Molecular determinants of regulated exocytosis. Diabetes 51, Suppl 1: S3-S11, 2002.
5. Grill V and Björklund A. Overstimulation and β-cell function. Diabetes 50: S122-S124, 2001.
6. Herbert V, Lau KS, Gottlieb CW, and Bleicher SJ. Coated charcoal immunoassay of insulin. J Clin Endocrinol Metab 25: 1375-1384, 1965.
7. Ji J, Yang SN, Huang X, Li X, Sheu L, Diamant N, Berggren PO, and Gaisano HY. Modulation of L-type Ca(2+) channels by distinct domains within SNAP-25. Diabetes 51: 1425-1436, 2002.
8. Jonas JC, Sharma A, Hasenkamp W, Ilkova H, Patane G, Laybutta R, Bonner-Weir S, and Weir GC. Chronic hyperglycemia triggers loss of pancreatic β-cell differentiation in an animal model of diabetes. J Biol Chem 274: 14112-14121, 1999.
9. Keen H, Field JB, and Pastan IH. A simple method for in vitro metabolic studies using small volume of tissue and medium. Metab Clin Exp 12: 143-147, 1963.
10. Lacy PE and Kostianovsky M. Method for the isolation of intact islets of Langerhans from the pancreas. Diabetes 16: 35-39, 1967.
11. Laybutt DR, Sharma A, Sgroi DC, Gaudet J, Bonner-Weir S, and Weir GC. Genetic regulation of metabolic pathway in beta-cells disrupted by hyperglycemia. J Biol Chem 29: 10912-10921, 2002.
12. Lee K, Dixon AK, Richardson PJ, and Pinnock RD. Glucose-receptive neurons in the rat ventromedial hypothalamus express K ATP channels composed of Kir 6.1 and SUR1 subunits. J Physiol 515: 439-453, 1999.
13. Li LiXin Skorpen F, Egeberg K, Jörgensen I, and Grill V. Induction of UCP-2 mRNA in beta cells is stimulated by oxidation of fatty acids but not by nutrient oversupply. Endocrinology 143: 1371-1377, 2002.
14. Qvigstad E, Kollind M, and Grill V. Nine weeks of bedtime diazoxide is well tolerated and beta-cell beneficial in subjects with type 2 diabetes. Diabet Med 21: 73-76, 2004.
15. Saleh M, Wheeler M, and Chan C. Uncoupling protein-2: evidence for its function as a metabolic regulator. Diabetologia 45: 174-187, 2002.
16. Sato Y and Henquin JC. The K+-ATP channel-independent pathway of regulation of insulin secretion by glucose. Diabetes 47: 1713-1721, 1998.
17. Skulachev VP. Anion carriers in fatty acid-mediated physiological uncoupling. J Bioenerg Biomembr 31: 431-445, 1999.
18. Straub SG and Sharp GW. Glucose-stimulated signaling pathways in biphasic insulin secretion. Diabetes Metab Res Rev 18: 451-463, 2002.
19. Tokuyama V, Sturis J, Depaoli AM, Takeda J, Stoffel M, Tang J, Sun X, Polonsky KS, and Bell GI. Evolution of β-cell dysfunction in the male Zucker diabetic fatty rat. Diabetes 44: 1447-1457, 1995.
20. + channel in the mouse pancreatic β-cells. Pflügers Arch 407: 493-499, 1986.
21. UK Prospective Diabetes Study Group. UK Prospective Diabetes Study 16. Overview of 16 years therapy of type 2 diabetes: a progressive disease. Diabetes 44: 1249-1258, 1995.
22. Umbreit WW, Burris RH, and Staffer JF. Manometric Techniques. Minneapolis, MN: Burgess, 1957, p. 149-150.
23. Unger R and Grundy S. Hyperglycemia as an inducer as well as a consequence of impaired islet cell function and insulin resistance: implications for the management of diabetes. Diabetologia 28: 119-121, 1985.
24. Wang W, Hino N, Yamasaki H, Aoki T, and Ochi Kv 2 R.1. K+ channels underlie major voltage-gated K+ outward current in H9c2 myoblasts. Jpn J Physiol 52: 507-514, 2002.
25. Yki-Järvinen H. Glucose toxicity. Endocr Rev 13: 415-431, 1992.