Enzyme redesign and interactions of substrate analogues with sterol methyltransferase to understand phytosterol diversity, reaction mechanism and the nature of the active site

Biochemical Society Transactions

Volumn 33, Issue 5, 2005, Pages 1189-1196

  Nes, W D ^a  

^a TEXAS TECH UNIVERSITY   (United States)

Author keywords

Enzyme redesign; Ergosterol; Phytosterol diversity; Site directed mutagenesis; Sterol biosynthesis inhibitor; Sterol methyltransferase

Indexed keywords

ENZYME; METHYLTRANSFERASE; PHYTOSTEROL; STEROL;

CATALYSIS; CONFERENCE PAPER; ENZYME KINETICS; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; GENE EXPRESSION; GENE SEQUENCE; HYDROPHOBICITY; MOLECULAR CLONING; NONHUMAN; PHYLOGENY; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; STEROL ANALYSIS;

AMINO ACID SEQUENCE; ARABIDOPSIS PROTEINS; BACTERIA; BACTERIAL PROTEINS; BINDING SITES; ENZYMES; METHYLTRANSFERASES; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; STEROLS; SUBSTRATE SPECIFICITY;

EID: 27844444116     PISSN: 03005127     EISSN: None     Source Type: Journal    
DOI: 10.1042/BST20051189     Document Type: Conference Paper

References (43)

1. Nes, W.D. (1990) Rec. Adv. Phytochem. 24, 283-327
2. Nes, W.R. and McKean, M.L. (1977) Biochemistry of Steroids and Other Isopentenoids, University Park Press, Baltimore
3. Benveniste, P. (2004) Annu. Rev. Plant Biol. 55, 429-457
4. Nes, W.D. (2003) Phytochemistry 64, 75-95
5. Nes, W.D., Janssen, G.G. and Bergenstrahle, A. (1991) J. Biol. Chem. 266, 15202-15212
6. Nes, W.D., Wong, R.Y., Benson, M., Landrey, J.R. and Nes, W.R. (1984) Proc. Natl. Acad. Sci. U.S.A. 81, 5896-5900
7. Nes, W.O., Koike, K., Jia, Z., Sakamoto, Y., Satou, T., Nakaido, T. and Griffin, J.F. (1998) J. Am. Chem. Soc. 120, 5970-5980
8. Bloch, K.E. (1983) CRC Crit. Rev. Biochem. 14, 47-82
9. Schuler, I., Milon, A., Nakatani, Y., Ourisson, G., Albrecht, A.-M., Benveniste, P. and Hartmann, M.-A. (1991) Proc. Natl. Acad. Sci. U.S.A. 88, 6926-6930
10. Nes, W.R., Sekula, B.C., Nes, W.D. and Adler, J.H. (1978) J. Biol. Chem. 253, 6218-6225
11. Nes, W.D. and Heupel, R.C. (1986) Arch. Biochem. Biophys. 244, 211-217
12. Nes, W.D., Hanners, P.K. and Parish, E.J. (1986) Biochem. Biophys. Res. Commun. 139, 410-415
13. Goad, L.J. (1989) Biochem. Soc. Trans. 18, 63-65
14. Pierce, A.M., Unrau, A.M., Oehlschlager, A.C. and Woods, R.A. (1979) Can. J. Biochem. 57, 201-208
15. Roberts, C.W., McLeod, R., Rice, D.W., Ginger, M., Chance, M.L. and Goad, L.J. (2003) Mol. Biochem. Paristol. 126, 129-142
16. Nes, W.D., Xu, S. and Haddon, W.F. (1989) Steroids 53, 533-558
17. Guo, D., Venkatramesh, M. and Nes, W.D. (1995) Lipids 30, 203-219
18. Nes, W.D. (2000) Biochim. Biophys. Acta 1529, 63-88
19. Henneberry, A.L. and Sturley, S.L. (2005) Semin. Cell Dev. Biol. 16, 155-161
20. Rodriguez, R.J., Low, C., Bottema, C.D. and Parks, L.W. (1985) Biochim. Biophys. Acta 837, 336-343
21. Pinto, W.J. and Nes, W.R. (1983) J. Biol. Chem. 258, 4472-4476
22. Ramgopal, M. and Bloch, K. (1983) Proc. Natl. Acad. Sci. U.S.A. 80, 712-715
23. Kanagasabai, R., Zhou, W., Liu, J., Nguyen, T.T.M., Veeramacheneni, P. and Nes, W.D. (2005) Lipids 39, 737-746
24. Nes, W.D., Janssen, G.G., Crumley, F.G., Kalinowska, M. and Akihisa, T. (1993) Arch. Biochem. Biophys. 300, 724-733
25. Rohmer, M., Bouvier, P. and Ourisson, G. (1979) Proc. Natl. Acad. Sci. U.S.A. 76, 847-851
26. Arigoni, D. (1978) Ciba Found. Symp. 60, 243-256
27. Venkatramesh, M., Guo, D., Jia, Z. and Nes, W.D. (1996) Biochim. Biophys. Acta 1299, 313-324
28. Venkatramesh, M., Guo, D., Harman, J.G. and Nes, W.O. (1996) Lipids 31, 373-377
29. Mangla, A.T. and Nes, W.D. (2000) Bioorg. Med. Chem. 8, 925-936
30. Janssen, G.G. and Nes, W.D. (1992) J. Biol. Chem. 267, 25856-25863
31. Zhou, W. and Nes, W.D. (2003) Arch. Biochem. Biophys. 420, 18-34
32. Nes, W.D., Song, Z., Dennis, A.L., Zhou, W., Nam, J. and Miller, M.B. (2003) J. Biol. Chem. 278, 34505-34515
33. Acuna-Johnson, A.P., Oehlschlager, A.C., Pierce, A.M., Pierce, Jr, H.D. and Czyzewska, E.K. (1997) Bioorg. Med. Chem. 5, 821-832
34. Bouvier-Nave, P., Husselstein, T., Desprez, T. and Benveniste, P. (1998) Eur. J. Biochem. 256, 88-96
35. Zhou, W., Nguyen, H.T. and Nes, W.D. (2005) in Advances in Plant Biochemistry and Molecular Biology, vol. 1 (Lewis, N.G., ed.), Elsevier Science, Oxford, in the press
36. Nes, W.D., Marshall, J.A., Jia, Z., Jaradat, T.T., Song, Z. and Jayasimha, P. (2003) J. Biol. Chem. 277, 42549-42556
37. Marshall, J.A. (2001) Ph.D. dissertation, Texas Tech University, Lubbock
38. Nes, W.D., Jayasimha, P., Zhou, W., Kanagasabai, R., Jin, C., Jaradat, T.T., Shaw, R.W. and Bujnicki, J.M. (2004) Biochemistry 43, 569-576
39. Kaneshiro, E.S., Rosenfeld, J.A., Basselin-eiweida, M., Stringer, J.R., Keeley, S.P., Smulian, A.G. and Giner, J.-L. (2002) Mol. Microbiol. 44, 989-999
40. Goad, L.J. and Goodwm, T.W. (1973) Prog. Phytochem. 1, 113-198
41. Rahier, A., Genot, J.-C., Schuber, F., Benveniste, P. and Narula, A.S. (1984) J. Biol. Chem. 259, 15215-15223
42. Guo, D., Jia, Z. and Nes, W.D. (1996) Tetrahedron Lett. 37, 6823-6826
43. Nes, W.D., McCourt, B.S., Marshall, J.A., Ma, J., Dennis, A.L., Lopez, M., Li, H. and He, L. (1999) J. Org. Chem. 64, 1535-1542