A quantum mechanics/molecular mechanics study of the catalytic mechanism of the thymidylate synthase

Biochemistry

Volumn 46, Issue 12, 2007, Pages 3704-3713

  Kanaan, Natalia ^a   Martí, Sergio ^a   Moliner, Vicent ^a   Kohen, Amnon ^b  

^a UNIVERSITAT JAUME I   (Spain)

^b E11 SSH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; HAMILTONIANS; MOLECULAR MECHANICS; POTENTIAL ENERGY; QUANTUM THEORY;

ENZYME MECHANISM; EXOCYCLIC METHYLENE INTERMEDIATE;

ENZYME KINETICS;

CARBENE; CYSTEINE; DEUTERIUM; DIHYDROFOLIC ACID; ISOTOPE; SULFUR; TETRAHYDROFOLIC ACID; THYMIDYLATE SYNTHASE; TRITIUM;

ARTICLE; CALCULATION; CATALYSIS; ENERGY TRANSFER; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME MECHANISM; ESCHERICHIA COLI; HYBRID; MOLECULAR BIOLOGY; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; QUANTUM MECHANICS; REACTION ANALYSIS; REDUCTION;

CATALYSIS; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; MODELS, CHEMICAL; TETRAHYDROFOLATES; THYMIDINE MONOPHOSPHATE; THYMIDYLATE SYNTHASE;

ESCHERICHIA COLI;

EID: 33947669870     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi061953y     Document Type: Article

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