Modulation of Bone Morphogenetic Protein (BMP) 2 gene expression by Sp1 transcription factors

Gene

Volumn 392, Issue 1-2, 2007, Pages 221-229

  Xu, Junwang ^a   Rogers, Melissa B ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

Embryonal carcinoma cells; Evolution; Retinoids; Transcription

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; TRANSCRIPTION FACTOR SP1; TRANSCRIPTION FACTOR SP4;

ANIMAL CELL; ARTICLE; CELL CULTURE; CONTROLLED STUDY; EMBRYO; GENE EXPRESSION; MAMMAL; MODULATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; STOICHIOMETRY;

ANIMALS; BASE SEQUENCE; BINDING SITES; BONE MORPHOGENETIC PROTEINS; GC RICH SEQUENCE; GENE EXPRESSION REGULATION; GENES, REPORTER; MICE; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS (GENETICS); SEQUENCE HOMOLOGY, NUCLEIC ACID; SP1 TRANSCRIPTION FACTOR; SP3 TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA; TUMOR CELLS, CULTURED;

MAMMALIA;

EID: 33947621669     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.gene.2006.12.032     Document Type: Article

References (72)

1. Abrams K.L., Xu J., Nativelle-Serpentini C., Dabirshahsahebi S., and Rogers M.B. An evolutionary and molecular analysis of Bmp2 expression. J. Biol. Chem. 279 (2004) 15916-15928
2. Bostrom M.P., et al. Immunolocalization and expression of bone morphogenetic proteins 2 and 4 in fracture healing. J. Orthop. Res. 13 (1995) 357-367
3. Bouletreau P.J., et al. Hypoxia and VEGF up-regulate BMP-2 mRNA and protein expression in microvascular endothelial cells: implications for fracture healing. Plast. Reconstr. Surg. 109 (2002) 2384-2397
4. Bouwman P., and Philipsen S. Regulation of the activity of Sp1-related transcription factors. Mol. Cell. Endocrinol. 195 (2002) 27-38
5. Canalis E., Economides A.N., and Gazzerro E. Bone morphogenetic proteins, their antagonists, and the skeleton. Endocr. Rev. 24 (2003) 218-235
6. Celeste A.J., et al. Identification of transforming growth factor β family members present in bone-inductive protein purified from bovine bone. Proc. Natl. Acad. Sci. U. S. A. 87 (1990) 9843-9847
7. Chen D., Zhao M., and Mundy G.R. Bone morphogenetic proteins. Growth Factors 22 (2004) 233-241
8. Cho T.J., Gerstenfeld L.C., and Einhorn T.A. Differential temporal expression of members of the transforming growth factor beta superfamily during murine fracture healing. J. Bone Miner. Res. 17 (2002) 513-520
9. Chu S., and Ferro T.J. Sp1: regulation of gene expression by phosphorylation. Gene 348 (2005) 1-11
10. Coucouvanis E., and Martin G.R. BMP signaling plays a role in visceral endoderm differentiation and cavitation in the early mouse embryo. Development 126 (1999) 535-546
11. Devlin R.D., et al. Skeletal overexpression of noggin results in osteopenia and reduced bone formation. Endocrinology 144 (2003) 1972-1978
12. Fritz D.T., Liu D., Xu J., Jiang S., and Rogers M.B. Conservation of Bmp2 post-transcriptional regulatory mechanisms. J. Biol. Chem. 279 (2004) 48950-48958
13. Fritz D.T., Jiang S., Xu J., and Rogers M.B. A polymorphism in a conserved posttranscriptional regulatory motif alters bone morphogenetic protein 2 (BMP2) RNA:protein interactions. Mol. Endocrinol. 20 (2006) 1574-1586
14. Gerstenfeld L.C., Cullinane D.M., Barnes G.L., Graves D.T., and Einhorn T.A. Fracture healing as a post-natal developmental process: molecular, spatial, and temporal aspects of its regulation. J. Cell. Biochem. 88 (2003) 873-884
15. Gidoni D., Dynan W.S., and Tjian R. Multiple specific contacts between a mammalian transcription factor and its cognate promoters. Nature 312 (1984) 409-413
16. Glozak M.A., and Rogers M.B. Specific induction of apoptosis in P19 embryonal carcinoma cells by retinoic acid and BMP2 or BMP4. Dev. Biol. 179 (1996) 458-470
17. Glozak M.A., Li Y., Reuille R., Kim K.H., Vo M.N., and Rogers M.B. Trapping and characterization of novel retinoid response elements. Mol. Endocrinol. 17 (2003) 27-41
18. Gong Y., et al. Heterozygous mutations in the gene encoding noggin affect human joint morphogenesis. Nat. Genet. 21 (1999) 302-304
19. Graham A., Francis-West P., Brickell P., and Lumsden A. The signalling molecule BMP4 mediates apoptosis in the rhombencephalic neural crest. Nature 372 (1994) 684-686
20. Hagen G., Muller S., Beato M., and Suske G. Sp1-mediated transcriptional activation is repressed by Sp3. EMBO J. 13 (1994) 3843-3851
21. Hallahan A.R., et al. BMP-2 mediates retinoid-induced apoptosis in medulloblastoma cells through a paracrine effect. Nat. Med. 9 (2003) 1033-1038
22. Hao H., Qi H., and Ratnam M. Modulation of the folate receptor type beta gene by coordinate actions of retinoic acid receptors at activator Sp1/ets and repressor AP-1 sites. Blood 101 (2003) 4551-4560
23. Hardwick J.C., et al. Bone morphogenetic protein 2 is expressed by, and acts upon, mature epithelial cells in the colon. Gastroenterology 126 (2004) 111-121
24. Harris S.E., Harris M.A., Mahy P., Wozney J., Feng J.Q., and Mundy G.R. Expression of bone morphogenetic protein messenger RNAs by normal rat and human prostate and prostate cancer cells. Prostate 24 (1994) 204-211
25. Hill C.S. Turning off Smads: identification of a Smad phosphatase. Dev. Cell 10 (2006) 412-413
26. Hogan B. Bone morphogenetic proteins: multifunctional regulators of vertebrate development. Genes Dev. 10 (1996) 1580-1594
27. Horvath L.G., et al. Loss of BMP2, Smad8, and Smad4 expression in prostate cancer progression. Prostate 59 (2004) 234-242
28. Husmann M., Dragneva Y., Romahn E., and Jehnichen P. Nuclear receptors modulate the interaction of Sp1 and GC-rich DNA via ternary complex formation. Biochem. J. 352 Pt 3 (2000) 763-772
29. Jackson S.P., and Tjian R. Purification and analysis of RNA polymerase II transcription factors by using wheat germ agglutinin affinity chromatography. Proc. Natl. Acad. Sci. U. S. A. 86 (1989) 1781-1785
30. James R.G., and Schultheiss T.M. Bmp signaling promotes intermediate mesoderm gene expression in a dose-dependent, cell-autonomous and translation-dependent manner. Dev. Biol. 288 (2005) 113-125
31. Kawamura C., et al. Bone morphogenetic protein-2 induces apoptosis in human myeloma cells with modulation of STAT3. Blood 96 (2000) 2005-2011
32. Kleeff J., et al. Bone morphogenetic protein 2 exerts diverse effects on cell growth in vitro and is expressed in human pancreatic cancer in vivo. Gastroenterology 116 (1999) 1202-1216
33. Langenfeld E.M., Calvano S.E., Abou-Nukta F., Lowry S.F., Amenta P., and Langenfeld J. The mature bone morphogenetic protein-2 is aberrantly expressed in non-small cell lung carcinomas and stimulates tumor growth of A549 cells. Carcinogenesis 24 (2003) 1445-1454
34. Li L., He S., Sun J.M., and Davie J.R. Gene regulation by Sp1 and Sp3. Biochem. Cell. Biol. 82 (2004) 460-471
35. Lyons K., Pelton R., and Hogan B. Patterns of expression of murine Vgr-1 and BMP-2a RNA suggest that transforming growth factor-β-like genes coordinately regulate aspects of embryonic development. Genes Dev. 3 (1989) 1657-1668
36. Lyons K.M., Pelton R.W., and Hogan B.L.M. Organogenesis and pattern formation in the mouse: RNA distribution patterns suggest a role for bone morphogenetic protein-2A (BMP-2A). Development 109 (1990) 833-844
37. Mann V., and Ralston S.H. Meta-analysis of COL1A1 Sp1 polymorphism in relation to bone mineral density and osteoporotic fracture. Bone 32 (2003) 711-717
38. Mann V., et al. A COL1A1 Sp1 binding site polymorphism predisposes to osteoporotic fracture by affecting bone density and quality. J. Clin. Invest. 107 (2001) 899-907
39. Marcelino J., et al. Human disease-causing NOG missense mutations: effects on noggin secretion, dimer formation, and bone morphogenetic protein binding. Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 11353-11358
40. Martinez-Barbera J.P., Toresson H., Da Rocha S., and Krauss S. Cloning and expression of three members of the zebrafish Bmp family: Bmp2a, Bmp2b and Bmp4. Gene 198 (1997) 53-59
41. Massague J., Seoane J., and Wotton D. Smad transcription factors. Genes Dev. 19 (2005) 2783-2810
42. Masson N., Hurst H.C., and Lee K.A. Identification of proteins that interact with CREB during differentiation of F9 embryonal carcinoma cells. Nucleic Acids Res. 21 (1993) 1163-1169
43. Mishina Y., et al. Bone morphogenetic protein type IA receptor signaling regulates postnatal osteoblast function and bone remodeling. J. Biol. Chem. 279 (2004) 27560-27566
44. Raftery L.A., and Sutherland D.J. Gradients and thresholds: BMP response gradients unveiled in Drosophila embryos. Trends Genet. 19 (2003) 701-708
45. Ralston S.H. Genetic determinants of osteoporosis. Curr. Opin. Rheumatol. 17 (2005) 475-479
46. Reinholz M.M., Iturria S.J., Ingle J.N., and Roche P.C. Differential gene expression of TGF-beta family members and osteopontin in breast tumor tissue: analysis by real-time quantitative PCR. Breast Cancer Res. Treat. 74 (2002) 255-269
47. Reneland R.H., et al. Association between a variation in the phosphodiesterase 4D gene and bone mineral density. BMC Med. Genet. 6 (2005) 9
48. Rodriguez-Leon J., Merino R., Macias D., Ganan Y., Santesteban E., and Hurle J.M. Retinoic acid regulates programmed cell death through BMP signalling. Nat. Cell Biol. 1 (1999) 125-126
49. Rogers M. Receptor-selective retinoids implicate RAR alpha and gamma in the regulation of bmp-2 and bmp-4 in F9 embryonal carcinoma cells. Cell Growth Differ. 7 (1996) 115-122
50. Rogers M.B., Rosen V., Wozney J.M., and Gudas L.J. Bone morphogenetic proteins-2 and 4 are involved in the retinoic acid-induced differentiation of embryonal carcinoma cells. Mol. Biol. Cell 3 (1992) 189-196
51. Safe S., and Abdelrahim M. Sp transcription factor family and its role in cancer. Eur. J. Cancer 41 (2005) 2438-2448
52. Schlueter J., Manner J., and Brand T. BMP is an important regulator of proepicardial identity in the chick embryo. Dev. Biol. 295 (2006) 546-558
53. Shafritz A., et al. Overexpression of an osteogenic morphogen in fibrodysplasia ossificans progressiva. New Engl. J. Med. 335 (1996) 555-561
54. Shimada J., Suzuki Y., Kim S.J., Wang P.C., Matsumura M., and Kojima S. Transactivation via RAR/RXR-Sp1 interaction: characterization of binding between Sp1 and GC box motif. Mol. Endocrinol. 15 (2001) 1677-1692
55. Spector J.A., Luchs J.S., Mehrara B.J., Greenwald J.A., Smith L.P., and Longaker M.T. Expression of bone morphogenetic proteins during membranous bone healing. Plast. Reconstr. Surg. 107 (2001) 124-134
56. Styrkarsdottir U., et al. Linkage of osteoporosis to chromosome 20p12 and association to BMP2. PLoS Biol. 1 (2003) E69
57. Suzuki Y., Shimada J., Shudo K., Matsumura M., Crippa M.P., and Kojima S. Physical interaction between retinoic acid receptor and Sp1: mechanism for induction of urokinase by retinoic acid. Blood 93 (1999) 4264-4276
58. Tsuji K., et al. BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing. Nat. Genet. 38 (2006) 1424-1429
59. Ureta-Vidal A., Ettwiller L., and Birney E. Comparative genomics: genome-wide analysis in metazoan eukaryotes. Nat. Rev., Genet. 4 (2003) 251-262
60. Urist M. Bone: formation by autoinduction. Science 150 (1965) 893-899
61. Usui M., et al. Tob deficiency superenhances osteoblastic activity after ovariectomy to block estrogen deficiency-induced osteoporosis. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 6653-6658
62. Vaahtokari A., Aberg T., Jernvall J., Keranen S., and Thesleff I. The enamel knot as a signaling center in the developing mouse tooth. Mech. Dev. 54 (1996) 39-43
63. Valdes A.M., et al. Association study of candidate genes for the prevalence and progression of knee osteoarthritis. Arthritis Rheum. 50 (2004) 2497-2507
64. Valdes A.M., et al. Reproducible genetic associations between candidate genes and clinical knee osteoarthritis in men and women. Arthritis Rheum. 54 (2006) 533-539
65. Vasios G.W., Gold J.D., Petkovich M., Chambon P., and Gudas L.J. A retinoic acid-responsive element is present in the 5′ flanking region of the laminin B1 gene. Proc. Natl. Acad. Sci. U. S. A. 86 (1989) 9099-9103
66. Vincent J.P., and Briscoe J. Morphogens. Curr. Biol. 11 (2001) R851-R854
67. Wozney J.M., et al. Novel regulators of bone formation: molecular clones and activities. Science 242 (1988) 1528-1534
68. Wu X.B., et al. Impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis in noggin-overexpressing mice. J. Clin. Invest. 112 (2003) 924-934
69. Xiong D.H., et al. Robust and comprehensive analysis of 20 osteoporosis candidate genes by very high-density single-nucleotide polymorphism screen among 405 white nuclear families identified significant association and gene-gene interaction. J. Bone. Miner. Res. 21 (2006) 1678-1695. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd= Retrieve&do% 20pt=AbstractPlus&list_uids=17002564&query_hl=5& itool=pubmed_docsum http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve &do%20pt=AbstractPlus&list_uids=17002564&query_hl=&itool =pubmed_docsum
70. Yatani A., et al. Down regulation of the L-type Ca2+ channel, GRK2, and phosphorylated phospholamban: protective mechanisms for the denervated failing heart. J. Mol. Cell. Cardiol. 40 (2006) 619-628
71. Zhang S., et al. Bone morphogenetic proteins induce apoptosis in human pulmonary vascular smooth muscle cells. Am. J. Physiol., Lung Cell. Mol. Physiol. 285 (2003) L740-L754
72. Zhao M., et al. Bone morphogenetic protein receptor signaling is necessary for normal murine postnatal bone formation. J. Cell Biol. 157 (2002) 1049-1060