Bone morphogenetic protein-2 induces apoptosis in human myeloma cells with modulation of STAT3

Blood

Volumn 96, Issue 6, 2000, Pages 2005-2011

  Kawamura, C ^a   Kizaki, M ^a   Yamato, K ^a   Uchida, H ^a   Fukuchi, Y ^a   Hattori, Y ^a   Koseki, T ^a   Nishihara, T ^a   Ikeda, Y ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; CYCLIN DEPENDENT KINASE INHIBITOR; CYTOKINE; INTERLEUKIN 6; PROTEIN BAD; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL X; PROTEIN P21; PROTEIN P27; RETINOBLASTOMA PROTEIN; STAT3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

ADULT; AGED; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CARTILAGE; CELL CYCLE G1 PHASE; CLINICAL ARTICLE; DRUG MECHANISM; FEMALE; HUMAN; HUMAN CELL; MALE; MULTIPLE MYELOMA; MYELOMA; MYELOMA CELL; OSSIFICATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

EID: 0034665673     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v96.6.2005.h8002005a_2005_2011     Document Type: Article

References (44)

1. Multiple myeloma
2. Novel regulators of bone formation: Molecular clones and activities
3. Bone morphogenetic protein: Multifunctional regulators of vertebrate development
4. The BMP proteins in bone formation and repair
5. Bone and cartilage differentiation
6. BMP-2/-4 mediate programmed cell death in chicken limb buds
7. Specific activation of the p38 mitogen-activated protein kinase signaling pathway and induction of neurite outgrowth in PC12 cells by bone morphogenetic protein-2
8. Bone morphogenetic proteins regulate the developmental program of human hematopoietic stem cells
9. Differential inhibition of Smad6 and Smad7 on bone morphogenetic protein- and activin-mediated growth arrest and apoptosis in B cells
10. Cooperative effects of growth factors involved in the induction of hematopoietic mesoderm
11. TGF-β signal transduction
12. Signal transduction by bone morphogenetic proteins
13. TGF-β signaling from cell membrane to nucleus through SMAD proteins
14. Signaling via hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors
15. Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas
16. Inteleukin-6 in human multiple myeloma
17. Interleukin-6 inhibits apoptosis of malignant plasma cells
18. Interleukin-6 inhibits Fas-induced apoptosis and SAP kinase activation in multiple myeloma cells
19. IL-6 cytokine family and signal transduction: A model of the cytokine system
20. STATs: Signal transducers and activators of transcription
21. Two signals are necessary for cell proliferation induced by a cytokine receptor gp130: Involvement of STAT3 in anti-apoptosis
22. STAT3 as an oncogene
23. Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: Generation and characterization of T cell-specific Stat3-deficient mice
24. Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells
25. Two distinct human myeloma cell lines originating from one patient with myeloma
26. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
27. p15(INK4b) is a potential effector of TGF-β-induced cell cycle arrest
28. The caspase-RB connection in cell death
29. Paracrine but not autocrine regulation of myeloma-cell growth and differentiation by interleukin-6
30. Adhesion of human myetoma-derived cell lines to bone marrow stromal cells stimulates IL-6 secretion
31. Growth of human myeloid leukemias in the human marrow environment of SCID-hu mice
32. The proliferative potential of myeloma plasma cells manifest in the SCID-hu host
33. Activin A induction of cell-cycle arrest involves modulation of cyclin D2 and p21(CIP1/WAF1) in plasmacytic cells
34. Dexamethasone induces apoptosis of multiple myeloma cells in a JNK/SAP kinase independent mechanism
35. Cytochrome-c dependent and independent induction of apoptosis in multiple myeloma cells
36. Prevention of myeloma cell apoptosis by ectopic bcl-2 expression or interleukin 6-mediated up-regulation of bcl-X(L)
37. Role of bcl-XL in the control of apoptosis in murine myeloma cells
38. Bcl-X expression in multiple myeloma: Possible indicator of chemoresistance
39. A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3
40. Role of TAK1 and TAB1 in BMP signaling in early Xenopus development
41. XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway
42. Involvement of the p38 mitogen-activated protein kinase pathway in transforming growth factor-β-induced gene expression
43. Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300
44. Mechanisms of bone lesions in multiple myeloma