Azetidine-based inhibitors of dipeptidyl peptidase IV (DPP IV)

Current Topics in Medicinal Chemistry

Volumn 7, Issue 6, 2007, Pages 597-608

  Ferraris, Dana ^a   Belyakov, Sergei ^a   Li, Weixing ^a   Oliver, Eddie ^a   Ko, Yao Sen ^a   Calvin, David ^a   Lautar, Susan ^a   Thomas, Bert ^a   Rojas, Camilo ^a  

^a MGI Pharma   (United States)

Author keywords

Cyanopyrrolidine; Fluoroazetidines; Ketone based DPP IV inhibitors; Ketopyrrolidines; Pyrrolidine Based DPP IV Inhibitors

Indexed keywords

2 CYANOAZETIDINE DERIVATIVE; 2 KETOAZETIDINE DERIVATIVE; 3 FLUORO 2 CYANOAZETIDINE; 3 FLUOROAZETIDINE DERIVATIVE; 3,3 DIFLUOROAZETIDINE DERIVATIVE; ALPHA BUTYL FLUOROAZETIDINE; ALPHA CYCLOHEXYL CYANOPYRROLIDINE; AZETIDINE DERIVATIVE; CYANOPYRROLIDINE; CYANOPYRROLIDINE DERIVATIVE; DESCYANOPYRROLIDINE; DIPEPTIDYL PEPTIDASE IV; DIPEPTIDYL PEPTIDASE IV INHIBITOR; N CYCLOHEXYL KETOAZETIDINE DERIVATIVE; PEPTIDE HYDROLASE INHIBITOR; PYRROLIDINE DERIVATIVE; SAXAGLIPTIN; UNCLASSIFIED DRUG; VILDAGLIPTIN;

AQUEOUS SOLUTION; CHEMICAL MODIFICATION; CLINICAL TRIAL; CONCENTRATION RESPONSE; COVALENT BOND; CYCLIZATION; DRUG POTENCY; DRUG SENSITIVITY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; HUMAN; IC 50; MOLECULAR MODEL; NON INSULIN DEPENDENT DIABETES MELLITUS; REACTION ANALYSIS; REVIEW; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ANTIGENS, CD26; AZETIDINES; MOLECULAR STRUCTURE; SERINE PROTEINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33947611932     PISSN: 15680266     EISSN: None     Source Type: Journal    
DOI: 10.2174/156802607780090993     Document Type: Review

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