Ketopyrrolidines and ketoazetidines as potent dipeptidyl peptidase IV (DPP IV) inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 22, 2004, Pages 5579-5583

  Ferraris, Dana ^a   Ko, Yao Sen ^a   Calvin, David ^a   Chiou, Tiffany ^a   Lautar, Susan ^a   Thomas, Bert ^a   Wozniak, Krystyna ^a   Rojas, Camilo ^a   Kalish, Vincent ^a   Belyakov, Sergei ^a  

^a GUILFORD PHARMACEUTICALS INC   (United States)

Author keywords

Diabetes; DPP IV; Serine protease

Indexed keywords

2 BENZOTHIAZOLE; 2 THIAZOLE; AZETIDINE DERIVATIVE; BENZOTHIAZOLE DERIVATIVE; CARBOXYLIC ACID DERIVATIVE; CYCLOHEXYLGLYCINE; DIPEPTIDYL PEPTIDASE IV; GLYCINE DERIVATIVE; KETONE DERIVATIVE; OCTAHYDROINDOLE CARBOXYLATE; PYRROLIDINE DERIVATIVE; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY; NONHUMAN; PLASMA; RAT; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; TIME;

ANIMALS; ANTIGENS, CD26; AZETIDINES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRROLIDINES; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 5144231567     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.08.057     Document Type: Article

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