2-Cyano-4-fluoro-1-thiovalylpyrrolidine analogues as potent inhibitors of DPP-IV

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 23, 2005, Pages 5257-5261

  Haffner, Curt D ^a   McDougald, Darryl L ^a   Reister, Steven M ^a   Thompson, Brian D ^a   Conlee, Christopher ^a   Fang, Jing ^a   Bass, Jonathan ^a   Lenhard, James M ^a,b   Croom, Dallas ^a   Secosky Chang, Melissa B ^a   Tomaszek, Thaddeus ^a   McConn, Donavon ^a   Wells Knecht, Kevin ^a,c   Johnson, Paul R ^a  

^a GLAXOSMITHKLINE   (United States)

^b JOHNSON JOHNSON   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Dipeptidyl peptidase IV; DPP IV; Glucagon like peptide 1; Glucose dependent inhibitory polypeptide

Indexed keywords

DIPEPTIDYL PEPTIDASE IV; DIPEPTIDYL PEPTIDASE IV INHIBITOR; PYRROLIDINE DERIVATIVE;

ARTICLE; BIOLOGICAL ACTIVITY; DRUG MECHANISM; DRUG SYNTHESIS; GASTROINTESTINAL TOXICITY; NONHUMAN; RAT;

ADMINISTRATION, ORAL; ANIMALS; ANTIGENS, CD26; DOGS; PROTEASE INHIBITORS; PYRROLIDINES; RATS; VALINE;

CANIS FAMILIARIS;

EID: 26844433886     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.08.050     Document Type: Article

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