New prolyl endopeptidase inhibitors: In vitro and in vivo activities of azabicyclo[2.2.2]octane, azabicyclo[2.2.1]heptane, and perhydroindole derivatives

Journal of Medicinal Chemistry

Volumn 39, Issue 12, 1996, Pages 2379-2391

  Portevin, Bernard ^a   Benoist, Alain ^a   Rémond, Georges ^a   Hervé, Yolande ^a   Vincent, Michel ^a   Lepagnol, Jean ^a   De Nanteuil, Guillaume ^a  

^a INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

1 (4 PHENYLBUTYRYL) 2 (1 PYRROLIDINYLCARBONYL)PERHYDROINDOLE; 1 (5,5 DICYCLOPROPYLPENTANOYL) 2 (1 PYRROLIDINYLCARBONYL)PERHYDROINDOLE; 1 [1 (4 PHENYLBUTANOYL)PROLYL]PYRROLIDINE; 1 [3 (4 CHLOROBENZYLCARBAMOYL)PROPIONYL]PROLINAL; 1 [N (4 CHLOROBENZYL)SUCCINAMOYL]PROLINAL; 2 (4 PHENYLBUTYRYL) 3 (1 PYRROLIDINYLCARBONYL) 2 AZABICYCLO[2.2.2]HEPTANE; 2 (5,5 DICYCLOPROPYLPENTANOYL) 3 (1 PYRROLIDINYLCARBONYL) 2 AZABICYCLO[2.2.2]OCTANE; ENZYME INHIBITOR; PROLYL ENDOPEPTIDASE; PROLYL ENDOPEPTIDASE INHIBITOR; SUAM 1221; UNCLASSIFIED DRUG;

AMNESIA; ARTICLE; AVOIDANCE BEHAVIOR; COGNITION; ENZYME ACTIVITY; ENZYME INHIBITION; STRUCTURE ACTIVITY RELATION;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMNESIA; ANIMALS; AVOIDANCE LEARNING; BICYCLO COMPOUNDS, HETEROCYCLIC; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; HUMANS; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; PYRROLES; RATS; SCOPOLAMINE; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0029977323     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm950858c     Document Type: Article

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