메뉴 건너뛰기




Volumn 25, Issue 16 SPEC. ISS., 2007, Pages 3041-3052

Site-specific UBITh® amyloid-β vaccine for immunotherapy of Alzheimer's disease

Author keywords

Alzheimer disease immunotherapy; APP transgenic mice; A vaccine; Non human primate toxicology

Indexed keywords

ALZHEIMER DISEASE VACCINE; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-42]; ANTIGEN; PLACEBO; UBITH; UNCLASSIFIED DRUG;

EID: 33947582998     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2007.01.031     Document Type: Article
Times cited : (82)

References (29)
  • 1
    • 0037135111 scopus 로고    scopus 로고
    • The Amyloid Hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics
    • Hardy J., and Selkoe D.J. The Amyloid Hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297 5580 (2002) 353-356
    • (2002) Science , vol.297 , Issue.5580 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 2
    • 0034700471 scopus 로고    scopus 로고
    • A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease
    • Janus C., Pearson J., McLaurin J., Mathews P.M., Jiang Y., Schmidt S.D., et al. A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease. Nature 408 6815 (2000) 979-982
    • (2000) Nature , vol.408 , Issue.6815 , pp. 979-982
    • Janus, C.1    Pearson, J.2    McLaurin, J.3    Mathews, P.M.4    Jiang, Y.5    Schmidt, S.D.6
  • 3
    • 84984755327 scopus 로고    scopus 로고
    • A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease
    • Morgan D., Diamond D.M., Gottschall P.E., Ugen K.E., Dickey C., Hardy J., et al. A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. Nature 408 6815 (2000) 982-985
    • (2000) Nature , vol.408 , Issue.6815 , pp. 982-985
    • Morgan, D.1    Diamond, D.M.2    Gottschall, P.E.3    Ugen, K.E.4    Dickey, C.5    Hardy, J.6
  • 4
    • 0033536163 scopus 로고    scopus 로고
    • Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse
    • Schenk D., Barbour R., Dunn W., Gordon G., Grajeda H., Guido T., et al. Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature 400 6740 (1999) 173-177
    • (1999) Nature , vol.400 , Issue.6740 , pp. 173-177
    • Schenk, D.1    Barbour, R.2    Dunn, W.3    Gordon, G.4    Grajeda, H.5    Guido, T.6
  • 5
    • 0037452779 scopus 로고    scopus 로고
    • Epitope and isotype specificities of antibodies to beta -amyloid peptide for protection against Alzheimer's disease-like neuropathology
    • Bard F., Barbour R., Cannon C., Carretto R., Fox M., Games D., et al. Epitope and isotype specificities of antibodies to beta -amyloid peptide for protection against Alzheimer's disease-like neuropathology. Proc Natl Acad Sci USA 100 4 (2003) 2023-2028
    • (2003) Proc Natl Acad Sci USA , vol.100 , Issue.4 , pp. 2023-2028
    • Bard, F.1    Barbour, R.2    Cannon, C.3    Carretto, R.4    Fox, M.5    Games, D.6
  • 6
    • 0033835996 scopus 로고    scopus 로고
    • Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease
    • Bard F., Cannon C., Barbour R., Burke R.L., Games D., Grajeda H., et al. Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nat Med 6 8 (2000) 916-919
    • (2000) Nat Med , vol.6 , Issue.8 , pp. 916-919
    • Bard, F.1    Cannon, C.2    Barbour, R.3    Burke, R.L.4    Games, D.5    Grajeda, H.6
  • 7
    • 0035902619 scopus 로고    scopus 로고
    • Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease
    • DeMattos R.B., Bales K.R., Cummins D.J., Dodart J.C., Paul S.M., and Holtzman D.M. Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease. Proc Natl Acad Sci USA 98 15 (2001) 8850-8855
    • (2001) Proc Natl Acad Sci USA , vol.98 , Issue.15 , pp. 8850-8855
    • DeMattos, R.B.1    Bales, K.R.2    Cummins, D.J.3    Dodart, J.C.4    Paul, S.M.5    Holtzman, D.M.6
  • 8
    • 2542462019 scopus 로고    scopus 로고
    • Evidence supporting a role for anti-Abeta antibodies in the treatment of Alzheimer's disease
    • Morgan D., and Gitter B.D. Evidence supporting a role for anti-Abeta antibodies in the treatment of Alzheimer's disease. Neurobiol Aging 25 5 (2004) 605-608
    • (2004) Neurobiol Aging , vol.25 , Issue.5 , pp. 605-608
    • Morgan, D.1    Gitter, B.D.2
  • 9
    • 20944448555 scopus 로고    scopus 로고
    • Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial
    • Gilman S., Koller M., Black R.S., Jenkins L., Griffith S.G., Fox N.C., et al. Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial. Neurology 64 9 (2005) 1553-1562
    • (2005) Neurology , vol.64 , Issue.9 , pp. 1553-1562
    • Gilman, S.1    Koller, M.2    Black, R.S.3    Jenkins, L.4    Griffith, S.G.5    Fox, N.C.6
  • 10
  • 11
    • 0037391853 scopus 로고    scopus 로고
    • Alzheimer disease's double-edged vaccine
    • Greenberg S.M., Bacskai B.J., and Hyman B.T. Alzheimer disease's double-edged vaccine. Nat Med 9 4 (2003) 389-390
    • (2003) Nat Med , vol.9 , Issue.4 , pp. 389-390
    • Greenberg, S.M.1    Bacskai, B.J.2    Hyman, B.T.3
  • 12
    • 10744230547 scopus 로고    scopus 로고
    • Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization
    • Orgogozo J.M., Gilman S., Dartigues J.F., Laurent B., Puel M., Kirby L.C., et al. Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization. Neurology 61 1 (2003) 46-54
    • (2003) Neurology , vol.61 , Issue.1 , pp. 46-54
    • Orgogozo, J.M.1    Gilman, S.2    Dartigues, J.F.3    Laurent, B.4    Puel, M.5    Kirby, L.C.6
  • 13
    • 1042265187 scopus 로고    scopus 로고
    • Neuropathology and pathogenesis of encephalitis following amyloid-beta immunization in Alzheimer's disease
    • Ferrer I., Boada Rovira M., Sanchez Guerra M.L., Rey M.J., and Costa-Jussa F. Neuropathology and pathogenesis of encephalitis following amyloid-beta immunization in Alzheimer's disease. Brain Pathol 14 1 (2004) 11-20
    • (2004) Brain Pathol , vol.14 , Issue.1 , pp. 11-20
    • Ferrer, I.1    Boada Rovira, M.2    Sanchez Guerra, M.L.3    Rey, M.J.4    Costa-Jussa, F.5
  • 14
    • 0037393454 scopus 로고    scopus 로고
    • Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report
    • Nicoll J.A., Wilkinson D., Holmes C., Steart P., Markham H., and Weller R.O. Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report. Nat Med 9 4 (2003) 448-452
    • (2003) Nat Med , vol.9 , Issue.4 , pp. 448-452
    • Nicoll, J.A.1    Wilkinson, D.2    Holmes, C.3    Steart, P.4    Markham, H.5    Weller, R.O.6
  • 15
    • 0036852750 scopus 로고    scopus 로고
    • Therapeutically effective antibodies against amyloid-beta peptide target amyloid-beta residues 4-10 and inhibit cytotoxicity and fibrillogenesis
    • McLaurin J., Cecal R., Kierstead M.E., Tian X., Phinney A.L., Manea M., et al. Therapeutically effective antibodies against amyloid-beta peptide target amyloid-beta residues 4-10 and inhibit cytotoxicity and fibrillogenesis. Nat Med 8 11 (2002) 1263-1269
    • (2002) Nat Med , vol.8 , Issue.11 , pp. 1263-1269
    • McLaurin, J.1    Cecal, R.2    Kierstead, M.E.3    Tian, X.4    Phinney, A.L.5    Manea, M.6
  • 16
    • 0041886776 scopus 로고    scopus 로고
    • Increased T cell reactivity to amyloid beta protein in older humans and patients with Alzheimer disease
    • Monsonego A., Zota V., Karni A., Krieger J.I., Bar-Or A., Bitan G., et al. Increased T cell reactivity to amyloid beta protein in older humans and patients with Alzheimer disease. J Clin Invest 112 3 (2003) 415-422
    • (2003) J Clin Invest , vol.112 , Issue.3 , pp. 415-422
    • Monsonego, A.1    Zota, V.2    Karni, A.3    Krieger, J.I.4    Bar-Or, A.5    Bitan, G.6
  • 17
    • 0035889404 scopus 로고    scopus 로고
    • Early formation of mature amyloid-beta protein deposits in a mutant APP transgenic model depends on levels of Abeta (1-42)
    • Rockenstein E., Mallory M., Mante M., Sisk A., and Masliaha E. Early formation of mature amyloid-beta protein deposits in a mutant APP transgenic model depends on levels of Abeta (1-42). J Neurosci Res 66 4 (2001) 573-582
    • (2001) J Neurosci Res , vol.66 , Issue.4 , pp. 573-582
    • Rockenstein, E.1    Mallory, M.2    Mante, M.3    Sisk, A.4    Masliaha, E.5
  • 18
    • 0028875687 scopus 로고
    • Levels and alternative splicing of amyloid beta protein precursor (APP) transcripts in brains of APP transgenic mice and humans with Alzheimer's disease
    • Rockenstein E.M., McConlogue L., Tan H., Power M., Masliah E., and Mucke L. Levels and alternative splicing of amyloid beta protein precursor (APP) transcripts in brains of APP transgenic mice and humans with Alzheimer's disease. J Biol Chem 270 47 (1995) 28257-28267
    • (1995) J Biol Chem , vol.270 , Issue.47 , pp. 28257-28267
    • Rockenstein, E.M.1    McConlogue, L.2    Tan, H.3    Power, M.4    Masliah, E.5    Mucke, L.6
  • 19
  • 20
    • 33947605772 scopus 로고    scopus 로고
    • Immunogenic peptide composition for the prevention and treatment of Alzheimer's disease
    • United Biomedical Inc., United States
    • Wang C.Y. Immunogenic peptide composition for the prevention and treatment of Alzheimer's disease. United States patent application publication no. US 2004/0247612 A1 (2004), United Biomedical Inc., United States
    • (2004) United States patent application publication no. US 2004/0247612 A1
    • Wang, C.Y.1
  • 22
    • 0037036196 scopus 로고    scopus 로고
    • Effective synthetic peptide vaccine for foot-and-mouth disease in swine
    • Wang C.Y., Chang T.Y., Walfield A.M., Ye J., Shen M., Chen S.P., et al. Effective synthetic peptide vaccine for foot-and-mouth disease in swine. Vaccine 20 19-20 (2002) 2603-2610
    • (2002) Vaccine , vol.20 , Issue.19-20 , pp. 2603-2610
    • Wang, C.Y.1    Chang, T.Y.2    Walfield, A.M.3    Ye, J.4    Shen, M.5    Chen, S.P.6
  • 23
    • 0037159614 scopus 로고    scopus 로고
    • Synthetic AIDS vaccine by targeting HIV receptor
    • Wang C.Y., Shen M., Tam G., Fang X.D., Ye J., Shen F., et al. Synthetic AIDS vaccine by targeting HIV receptor. Vaccine 21 1-2 (2002) 89-97
    • (2002) Vaccine , vol.21 , Issue.1-2 , pp. 89-97
    • Wang, C.Y.1    Shen, M.2    Tam, G.3    Fang, X.D.4    Ye, J.5    Shen, F.6
  • 24
    • 14844318008 scopus 로고    scopus 로고
    • Site-specific peptide vaccines for immunotherapy and immunization against chronic diseases, cancer, infectious diseases, and for veterinary applications
    • Wang C.Y., and Walfield A.M. Site-specific peptide vaccines for immunotherapy and immunization against chronic diseases, cancer, infectious diseases, and for veterinary applications. Vaccine 23 17-18 (2005) 2049-2056
    • (2005) Vaccine , vol.23 , Issue.17-18 , pp. 2049-2056
    • Wang, C.Y.1    Walfield, A.M.2
  • 25
    • 0037413960 scopus 로고    scopus 로고
    • Synthetic IgE peptide vaccine for immunotherapy of allergy
    • Wang C.Y., Walfield A.M., Fang X., Hammerberg B., Ye J., Li M.L., et al. Synthetic IgE peptide vaccine for immunotherapy of allergy. Vaccine 21 15 (2003) 1580-1590
    • (2003) Vaccine , vol.21 , Issue.15 , pp. 1580-1590
    • Wang, C.Y.1    Walfield, A.M.2    Fang, X.3    Hammerberg, B.4    Ye, J.5    Li, M.L.6
  • 27
    • 0032876565 scopus 로고    scopus 로고
    • CpG DNA as mucosal adjuvant
    • McCluskie M.J., and Davis H.L. CpG DNA as mucosal adjuvant. Vaccine 18 3-4 (1999) 231-237
    • (1999) Vaccine , vol.18 , Issue.3-4 , pp. 231-237
    • McCluskie, M.J.1    Davis, H.L.2
  • 29
    • 12344251551 scopus 로고    scopus 로고
    • Aluminium assay and evaluation of the local reaction at several time points after intramuscular administration of aluminium containing vaccines in the Cynomolgus monkey
    • Verdier F., Burnett R., Michelet-Habchi C., Moretto P., Fievet-Groyne F., and Sauzeat E. Aluminium assay and evaluation of the local reaction at several time points after intramuscular administration of aluminium containing vaccines in the Cynomolgus monkey. Vaccine 23 11 (2005) 1359-1367
    • (2005) Vaccine , vol.23 , Issue.11 , pp. 1359-1367
    • Verdier, F.1    Burnett, R.2    Michelet-Habchi, C.3    Moretto, P.4    Fievet-Groyne, F.5    Sauzeat, E.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.