Associations of serotonin transporter genotypes to components of the tripartite model of depression and anxiety

Personality and Individual Differences

Volumn 43, Issue 1, 2007, Pages 107-118

  Perez, Marisol ^a   Burns, Andrea B ^b   Brown, Jessica S ^b   Sachs Ericsson, Natalie ^b   Plant, Ashby ^b   Joiner Jr , Thomas E ^b  

^a TEXAS A AND M UNIVERSITY   (United States)

^b FLORIDA STATE UNIVERSITY   (United States)

Author keywords

5HTLLPR; Anxiety; Depression; Negative affect; Serotonin transporter gene

Indexed keywords

EID: 33947576415     PISSN: 01918869     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.paid.2006.11.014     Document Type: Article

References (31)

1. Barr C.S., Newman T.K., Schwandt M., Shannon C., et al. Sexual dichotomy of an interaction between early adversity and the serotonin transporter gene promoter variant in rhesus macaques. Proceedings of the National Academy of Sciences 101 (2004) 12358-12363
2. Beck A.T., and Steer R.A. Manual for the Beck anxiety inventory (1993), Psychological Corporation, San Antonio, TX
3. Beck A.T., Steer R.A., and Brown G.K. Beck depression inventory - second edition manual (1996), Psychological Corporation, San Antonio, TX
4. Beck A.T., Steer R.A., and Garbin M.G. Psychometric properties of the Beck depression inventory: twenty-five years of evaluation. Clinical Psychology Review 8 (1988) 77-100
5. Camarena B., Rinetti G., Cruz C., Hernandez S., et al. Association study of the serotonin-transporter gene polymorphism in obsessive-compulsive disorder. International Journal of Neuropsychopharmacology 4 (2001) 269-272
6. Caspi A., Sugden K., Moffit T.E., Taylor A., et al. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 301 (2003) 386-389
7. Cavillini M.C., Di Bella D., Siliprandi F., Malachiodi F., et al. Exploratory factor analysis of obsessive-compulsive patients and association with 5-HTTLPR polymorphism. American Journal of Medical Genetics 114 (2002) 347-353
8. Costa Jr. P.T., and McCrae R.R. NEO PI-R: professional manual (1992), Psychological Assessment Resources, Inc., Lutz, FL
9. Greenberg B.D., Li Q., Lucas F.R., Hu S., et al. Association between the serotonin transporter promoter polymorphism and personality traits in a primarily female population sample. American Journal of Medical Genetics (Neuropsychiatric Genetics) 96 (2000) 202-216
10. Herman A.I., Philbeck J.W., Vasilopoulos N.L., and Depetrillo P.B. Serotonin transporter promoter polymorphism and differences in alcohol consumption behavior in a college student population. Alcohol and Alcoholism 38 (2003) 446-449
11. Hu X., Lipsky R.H., Zhu G., Akhtar L.A., et al. Serotonin transporter promoter gain of function genotypes are linked to obsessive-compulsive disorder. The American Journal of Human Genetics 78 (2006) 815-826
12. Joiner Jr. T.E., Johnson F., Soderstrom K., and Brown J.S. Is there an association between serotonin transporter gene polymorphism and family history of depression?. Journal of Affective Disorders 77 (2003) 273-275
13. Joiner Jr. T.E., Steer R.A., Beck A.T., Schmidt N.B., et al. Physiological hyperarousal: construct validity of a central aspect of the tripartite model of depression and anxiety. Journal of Abnormal Psychology 108 (1999) 290-298
14. Judd L.L. The clinical course of unipolar major depressive disorders. Archives of General Psychiatry 54 (1997) 989-991
15. Katsuragi S., Kunugi H., Sano A., Tsutsumi T., et al. Association between serotonin transporter gene polymorphism and anxiety-related traits. Biological Psychiatry 45 (1999) 368-370
16. Lesch K.P., Bengel D., Heils A., Sabol S.Z., et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274 (1996) 1527-1531
17. Mineka S., Watson D., and Clark L.A. Comorbidity of anxiety and unipolar mood disorders. Annual Review of Psychology 49 (1998) 377-412
18. Munafo M.R., Clark T., and Flint J. Does measurement instrument moderate the association between the serotonin transporter gene and anxiety-related personality traits? A meta-analysis. Molecular Psychiatry 10 (2005) 415-419
19. Ohara K., Nagai M., Suzuki Y., Ochiai M., et al. Association between anxiety disorders and a functional polymorphism in the serotonin transporter gene. Psychiatry Research 81 (1998) 277-279
20. Pritchard J.K., Stephens M., and Donnelly P. Inference of population structure using multilocus genotype data. Genetics 155 (2000) 945-959
21. Rose R. Genetic and environmental variance in content dimensions of the MMPI. Journal of Personality & Social Psychology 55 (1988) 302-311
22. Rotondo A., Mazzanti C., Dell'Osso L., Rucci P., et al. Catechol o-methyltransferase, serotonin transporter, and tryptophan hydroxylase gene polymorphisms in bipolar disorder patients with and without comorbid panic disorder. American Journal of Psychiatry 159 (2002) 23-29
23. Schinka J.A., Busch R.M., and Robichaus-Keene N. A meta-analysis of the association between the serotonin transporter gene polymorphism (5-HTTLPR) and trait anxiety. Molecular Psychiatry 9 (2004) 197-202
24. Schmidt N.B., Storey J., Greenberg B.D., Santiago H.T., et al. Evaluating gene × psychological risk factor effects in the pathogenesis of anxiety: a new model approach. Journal of Abnormal Psychology 109 (2000) 308-320
25. Sen S., Burmeister M., and Ghosh D. Meta-analysis of the association between a serotonin transporter promoter polymorphism (5-HTTLPR) and anxiety-related personality traits. American Journal of Medical Genetics Part B 127B (2004) 85-89
26. Steer R.A., Kumar G., Ranieri W.F., and Beck A.T. Use of the Beck anxiety inventory with adolescent psychiatric outpatients. Psychological Reports 76 (1995) 459-465
27. Surtees P.G., Wainwright N.W.J., Willis-Owen S.A.G., Luben R., et al. Social adversity, the serotonin transporter (5-HTTLPR) polymorphism, and major depressive disorder. Biological Psychiatry 59 (2006) 224-229
28. Tabachnick B.G., and Fidell L.S. Using mulivariate statistics. 4th ed. (2001), Allyn & Bacon, Boston, MA
29. Watson D., Clark L.A., and Tellegen A. Development and validation of brief measures of positive and negative affect: The PANAS scales. Journal of Personality and Social Psychology 54 (1988) 1063-1070
30. Willis-Owen S.A.G., Turri M.G., Munafo M.R., Surtees P.G., et al. The serotonin transporter length polymorphism, neuroticism, and depression: a comprehensive assessment of association. Biological Psychiatry 58 (2005) 451-456
31. Yonan A.L., Palmer A.A., and Gilliam T.C. Hardy-Weinberg disequilibrium identified genotyping error of the serotonin transporter (SLC6A4) promoter polymorphism. Psychiatric Genetics 16 (2006) 31-34