Evaluation of synthetic polymeric micelles as a stabilization medium for the handling of membrane proteins in pharmaceutical drug discovery

Journal of Pharmacy and Pharmaceutical Sciences

Volumn 9, Issue 3, 2006, Pages 271-280

  Trubetskoy, Olga V ^a   Finel, Moshe ^b   Burke, Thomas J ^a   Trubetskoy, Vladimir S ^a  

^a Quintessence Biosciences Inc   (United States)

^b UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 2; GLUCURONOSYLTRANSFERASE 1A1; MEMBRANE PROTEIN; POLYMER; SCOPOLETIN;

ARTICLE; BIOLOGICAL ACTIVITY; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG STABILITY; DRUG TARGETING; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME SUBSTRATE; FLUORESCENCE ANALYSIS; FLUORESCENCE RESONANCE ENERGY TRANSFER; FREEZE THAWING; INCUBATION TIME; LIGHT SCATTERING; MICELLE; PARTICLE SIZE; PHOTON CORRELATION SPECTROSCOPY; ROOM TEMPERATURE; SPECTRAL SENSITIVITY; STRUCTURE ANALYSIS; ULTRASOUND; ZETA POTENTIAL;

DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; HUMANS; MEMBRANE PROTEINS; MEMBRANES, ARTIFICIAL; MICELLES; POLYMERS; PROTEIN BINDING; TECHNOLOGY, PHARMACEUTICAL;

EID: 33947524042     PISSN: None     EISSN: 14821826     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. Trubetskoy, V.S., Polymeric micelles as carriers of diagnostic agents. Adv Drug Deliv Rev, 37(1-3): 81-88, 1999.
2. le Maire, M.; Champeil, P. and Moller, J.V., Interaction of membrane proteins and lipids with solubilizing detergents. Biochim Biophys Acta, 1508(1-2): 86-111, 2000.
3. Torchilin, V.P., Structure and design of polymeric surfactant-based drug delivery systems. J Control Release, 73(2-3): 137-172, 2001.
4. Johansson, E.; Engvall, C.; Arfvidsson, M.; Lundahl, P. and Edwards, K., Development and initial evaluation of PEG-stabilized bilayer disks as novel model membranes. Biophys Chem, 113(2): 183-192, 2005.
5. Tribet, C.; Audebert, R. and Popot, J.L., Amphipols: polymers that keep membrane proteins soluble in aqueous solutions. Proc Natl Acad Sci U S A, 93(26): 15047-15050, 1996.
6. Duval-Terrie, C.; Cosette, P.; Molle, G.; Muller, G. and De, E., Amphiphilic biopolymers (amphibiopols) as new surfactants for membrane protein solubilization. Protein Sci, 12(4): 681-689, 2003.
7. Schafmeister, C.E.; Miercke, L.J. and Stroud, R.M., Structure at 2.5 A of a designed peptide that maintains solubility of membrane proteins. Science, 262(5134): 734-738, 1993.
8. McGregor, C.L.; Chen, L.; Pomroy, N.C.; Hwang, P.; Go, S.; Chakrabartty, A. and Prive, G.G., Lipopeptide detergents designed for the structural study of membrane proteins. Nat Biotechnol, 21(2): 171-176, 2003.
9. Johnsson, M. and Edwards, K., Liposomes, disks, and spherical micelles: aggregate structure in mixtures of gel phase phosphatidylcholines and poly(ethylene glycol)- phospholipids. Biophys J, 85(6): 3839-3847, 2003.
10. Breyton, C.; Chabaud, E.; Chaudier, Y.; Pucci, B. and Popot, J.L., Hemifluorinated surfactants: a nondissociating environment for handling membrane proteins in aqueous solutions? FEBS Lett, 564(3): 312-318, 2004.
11. Bergmann, C.; Senderek, J.; Kupper, F.; Schneider, F.; Dornia, C.; Windelen, E.; Eggermann, T.; Rudnik-Schoneborn,S.; Kirfel, J.; Furu, L.; Onuchic, L.F.; Rossetti, S.; Harris, P.C.; Somlo, S.; Guay-Woodford, L.; Germino, G.G.; Moser, M.; Buttner, R. and Zerres, K., PKHD1 mutations in autosomal recessive polycystic kidney disease (ARPKD). Hum Mutat, 23(5): 453-463, 2004.
12. Blann, A.D.; Nadar, S.K. and Lip, G.Y., The adhesion molecule P-selectin and cardiovascular disease. Eur Heart J, 24(24): 2166-2179, 2003.
13. Powell, K. and Zeitlin, P.L., Therapeutic approaches to repair defects in deltaF508 CFTR folding and cellular targeting. Adv Drug Deliv Rev, 54(11): 1395-1408, 2002.
14. Adam, P.J.; Boyd, R.; Tyson, K.L.; Fletcher, G.C.; Stamps, A.; Hudson, L.; Poyser, H.R.; Redpath, N.; Griffiths, M.; Steers, G.; Harris, A.L.; Patel, S.; Berry, J.; Loader, J.A.; Townsend, R.R.; Daviet, L.; Legrain, P.; Parekh, R. and Terrett, J.A., Comprehensive proteomic analysis of breast cancer cell membranes reveals unique proteins with potential roles in clinical cancer. J Biol Chem, 278(8): 6482-6489, 2003.
15. Hori, H.; Yano, S.; Koufuji, K.; Takeda, J. and Shirouzu, K., CD9 expression in gastric cancer and its significance. J Surg Res, 117(2): 208-215, 2004.
16. Zhao, Y.; Zhang, W.; Kho, Y. and Zhao, Y., Proteomic analysis of integral plasma membrane proteins. Anal Chem, 76(7): 1817-1823, 2004.
17. Shao, J.; Catalano, P.M.; Yamashita, H.; Ruyter, I.; Smith, S.; Youngren, J. and Friedman, J.E., Decreased insulin receptor tyrosine kinase activity and plasma cell membrane glycoprotein-1 overexpression in skeletal muscle from obese women with gestational diabetes mellitus (GDM): evidence for increased serine/threonine phosphorylation in pregnancy and GDM. Diabetes, 49(4): 603-610, 2000.
18. Grziwa, B.; Grimm, M.O.; Masters, C.L.; Beyreuther, K.; Hartmann, T. and Lichtenthaler, S.F., The transmembrane domain of the amyloid precursor protein in microsomal membranes is on both sides shorter than predicted. J Biol Chem, 278(9): 6803-6808, 2003.
19. Vassar, R., BACE1: the beta-secretase enzyme in Alzheimer's disease. J Mol Neurosci, 23(1-2): 105-114, 2004.
20. Loll, P.J., Membrane protein structural biology: the high throughput challenge. J Struct Biol, 142(1): 144-153, 2003.
21. Stevens, T.J. and Arkin, I.T., Do more complex organisms have a greater proportion of membrane proteins in their genomes? Proteins, 39(4): 417-420, 2000.
22. Kragh-Hansen, U.; le Maire, M. and Moller, J.V., The mechanism of detergent solubilization of liposomes and protein-containing membranes. Biophys J, 75(6): 2932-2946, 1998.
23. Hong, H. and Tamm, L.K., Elastic coupling of integral membrane protein stability to lipid bilayer forces. Proc Natl Acad Sci U S A, 101(12): 4065-4070, 2004.
24. Popot, J.L.; Berry, E.A.; Charvolin, D.; Creuzenet, C.; Ebel, C.; Engelman, D.M.; Flotenmeyer, M.; Giusti, F.; Gohon, Y.; Hong, Q.; Lakey, J.H.; Leonard, K.; Shuman, H.A.; Timmins, P.; Warschawski, D.E.; Zito, F.; Zoonens, M.; Pucci, B. and Tribet, C., Amphipols: polymeric surfactants for membrane biology research. Cell Mol Life Sci, 60(8): 1559-1574, 2003.
25. White, S.H., The progress of membrane protein structure determination. Protein Sci, 13(7): 1948-1949, 2004.
26. Murray, M., Mechanisms and significance of inhibitory drug interactions involving cytochrome P450 enzymes (review). Int J Mol Med, 3(3): 227-238, 1999.
27. Avdeev, A., Absorption and drug development: Solubility, permeability, and charge state, John Wiley & Sons, 2003.
28. Desai, A.A.; Innocenti, F. and Ratain, M.J., UGT pharmacogenomics: implications for cancer risk and cancer therapeutics. Pharmacogenetics, 13(8): 517-523, 2003.
29. Dehal, S.S.; Gagne, P.V.; Crespi, C.L. and Patten, C.J., Differential effect of common organic solvents on human UGT enzyme activities. Drug Metabolism Reviews, 35(S1): 60-60, 2003.
30. Fitzpatrick, F.A., Cyclooxygenase enzymes: regulation and function. Curr Pharm Des, 10(6): 577-588, 2004.
31. Urlacher, V.B.; Lutz-Wahl, S. and Schmid, R.D., Microbial P450 enzymes in biotechnology. Appl Microbiol Biotechnol, 64(3): 317-325, 2004.
32. Yamazaki, H.; Inoue, K.; Turvy, C.G.; Guengerich, F.P. and Shimada, T., Effects of freezing, thawing, and storage of human liver samples on the microsomal contents and activities of cytochrome P450 enzymes. Drug Metab Dispos, 25(2): 168-174, 1997.
33. Illing, H.P. and House, E.S., Effects of detergents and organic solvents on rat liver microsomal UDP-glucuronosyltransferase activity towards phenolic substrates. Xenobiotica, 11(10): 709-718, 1981.
34. Pache, T. and Reichmann, H., On the stability of key enzymes of energy metabolism in muscle biopsies. Enzyme, 43(4): 183-187, 1990.
35. Kurkela, M.; Garcia-Horsman, J.A.; Luukkanen, L.; Morsky, S.; Taskinen, J.; Baumann, M.; Kostiainen, R.; Hirvonen, J. and Finel, M., Expression and characterization of recombinant human UDP-glucuronosyltransferases (UGTs). UGT1A9 is more resistant to detergent inhibition than other UGTs and was purified as an active dimeric enzyme. J Biol Chem, 278(6): 3536-3544, 2003.
36. Sen, S.; Jaakola, V.P.; Pirila, P.; Finel, M. and Goldman, A., Functional studies with membrane-bound and detergent-solubilized alpha2-adrenergic receptors expressed in Sf9 cells. Biochim Biophys Acta, 1712(1): 62-70, 2005.
37. http://www.bdbioscience.com/discovery_labware/gentest/products/pdf/ S01T044R2.pdf.
38. Nasir, M.S. and Jolley, M.E., Fluorescence polarization: an analytical tool for immunoassay and drug discovery. Comb Chem High Throughput Screen, 2(4): 177-190, 1999.
39. New, R.R.C., Liposomes: a Practical Approach, IRL Press, 1997.
40. Casey, J.L.; Coley, A.M.; Tilley, L.M. and Foley, M., Green fluorescent antibodies: novel in vitro tools. Protein Eng, 13(6): 445-452, 2000.
41. http://www.qbilifesci.com/PDF/ AAPS%20Poster%20June2005%20legal%20size.pdf.
42. Fisher, M.B.; Campanale, K.; Ackermann, B.L.; VandenBranden, M. and Wrighton, S.A., In vitro glucuronidation using human liver microsomes and the pore-forming peptide alamethicin. Drug Metab Dispos, 28(5): 560-566, 2000.
43. Radominska-Pandya, A.; Bratton, S. and Little, J.M., A historical overview of the heterologous expression of mammalian UDP-glucuronosyltransferase isoforms over the past twenty years. Curr Drug Metab, 6(2): 141-160, 2005.
44. Matsuura, B.; Dong, M.; Coulie, B.; Pinon, D.I. and Miller, L.J., Demonstration of a specific site of covalent labeling of the human motilin receptor using a biologically active photolabile motilin analog. J Pharmacol Exp Ther, 313(3): 1101-1108, 2005.