메뉴 건너뛰기




Volumn 59, Issue 2, 2007, Pages 197-203

Influence of the Plasmodium falciparum P-glycoprotein homologue 1 (pfmdr1 gene product) on the antimalarial action of cyclosporin

Author keywords

Cyclosporin A; Malaria; Pgh1

Indexed keywords

ARTEMISININ; CHLOROQUINE; CYCLOSPORIN A; HALOFANTRINE; MEFLOQUINE; MULTIDRUG RESISTANCE PROTEIN 1; QUININE; ANTIMALARIAL AGENT; CYCLOSPORIN; MDR1 PROTEIN, PLASMODIUM FALCIPARUM; MULTIDRUG RESISTANCE PROTEIN; UNCLASSIFIED DRUG;

EID: 33947492184     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkl461     Document Type: Article
Times cited : (14)

References (38)
  • 1
    • 0029683050 scopus 로고    scopus 로고
    • In vivo pharmacological effects of cyclosporin and some analogues
    • Borel JF, Baumann G, Chapman I et al. In vivo pharmacological effects of cyclosporin and some analogues. Adv Pharmacol 1996; 35: 115-246.
    • (1996) Adv Pharmacol , vol.35 , pp. 115-246
    • Borel, J.F.1    Baumann, G.2    Chapman, I.3
  • 2
    • 0030250811 scopus 로고    scopus 로고
    • The antiparasite effects of cyclosporin A: Possible drug targets and clinical applications
    • Bell A, Roberts HC, Chappell LH. The antiparasite effects of cyclosporin A: Possible drug targets and clinical applications. Gen Pharmacol 1996; 27: 963-71.
    • (1996) Gen Pharmacol , vol.27 , pp. 963-971
    • Bell, A.1    Roberts, H.C.2    Chappell, L.H.3
  • 3
    • 0034045947 scopus 로고    scopus 로고
    • Mechanisms of action of cyclosporine
    • Matsuda S, Koyasu S. Mechanisms of action of cyclosporine. Immunopharmacology 2000; 47: 119-25.
    • (2000) Immunopharmacology , vol.47 , pp. 119-125
    • Matsuda, S.1    Koyasu, S.2
  • 4
    • 33644857804 scopus 로고    scopus 로고
    • Crystal structures of cyclophilin and its partners
    • Ke H, Huai Q. Crystal structures of cyclophilin and its partners. Front Biosci 2004; 9: 2285-96.
    • (2004) Front Biosci , vol.9 , pp. 2285-2296
    • Ke, H.1    Huai, Q.2
  • 5
    • 33644852955 scopus 로고    scopus 로고
    • Peptidyl-prolyl cis-trans isomerases (immunophilins) and their roles in parasite biochemistry, host-parasite interaction and antiparasitic drug action
    • Bell A, Monaghan P, Page AP. Peptidyl-prolyl cis-trans isomerases (immunophilins) and their roles in parasite biochemistry, host-parasite interaction and antiparasitic drug action. Int J Parasitol 2006; 36: 261-76.
    • (2006) Int J Parasitol , vol.36 , pp. 261-276
    • Bell, A.1    Monaghan, P.2    Page, A.P.3
  • 6
    • 0029118878 scopus 로고
    • Molecular and biochemical characterization of a Plasmodium falciparum cyclophilin containing a cleavable signal sequence
    • Hirtzlin J, Färber PM, Franklin RM et al. Molecular and biochemical characterization of a Plasmodium falciparum cyclophilin containing a cleavable signal sequence. Eur J Biochem 1995; 232: 765-72.
    • (1995) Eur J Biochem , vol.232 , pp. 765-772
    • Hirtzlin, J.1    Färber, P.M.2    Franklin, R.M.3
  • 7
    • 0032168604 scopus 로고    scopus 로고
    • Detailed characterization of a cyclophilin from the human malaria parasite Plasmodium falciparum
    • Berriman M, Fairlamb AH. Detailed characterization of a cyclophilin from the human malaria parasite Plasmodium falciparum. Biochem J 1998; 334: 437-45.
    • (1998) Biochem J , vol.334 , pp. 437-445
    • Berriman, M.1    Fairlamb, A.H.2
  • 8
    • 0142124382 scopus 로고    scopus 로고
    • Cyclosporin-binding proteins of Plasmodium falciparum
    • Gavigan CS, Kiely SP, Hirtzlin J et al. Cyclosporin-binding proteins of Plasmodium falciparum. Int J Parasitol 2003; 33: 987-96.
    • (2003) Int J Parasitol , vol.33 , pp. 987-996
    • Gavigan, C.S.1    Kiely, S.P.2    Hirtzlin, J.3
  • 9
    • 16244382411 scopus 로고    scopus 로고
    • Plasmodium falciparum calcineurin and its association with heat shock protein 90: Mechanisms for the antimalarial activity of cyclosporin A and synergism with geldanamycin
    • Kumar R, Musiyenko A, Barik S. Plasmodium falciparum calcineurin and its association with heat shock protein 90: Mechanisms for the antimalarial activity of cyclosporin A and synergism with geldanamycin. Mol Biochem Parasitol 2005; 141: 29-37.
    • (2005) Mol Biochem Parasitol , vol.141 , pp. 29-37
    • Kumar, R.1    Musiyenko, A.2    Barik, S.3
  • 10
    • 0028060031 scopus 로고
    • Roles of peptidyl-prolyl cis-trans isomerase and calcineurin in the mechanisms of antimalarial action of cyclosporin A, FK506, and rapamycin
    • Bell A, Wernli B, Franklin RM. Roles of peptidyl-prolyl cis-trans isomerase and calcineurin in the mechanisms of antimalarial action of cyclosporin A, FK506, and rapamycin. Biochem Pharmacol 1994; 48 495-503.
    • (1994) Biochem Pharmacol , vol.48 , pp. 495-503
    • Bell, A.1    Wernli, B.2    Franklin, R.M.3
  • 11
    • 0032900953 scopus 로고    scopus 로고
    • Biochemical, cellular, and pharmacological aspects of the multidrug transporter
    • Ambudkar SV, Dey S, Hrycyna CA et al. Biochemical, cellular, and pharmacological aspects of the multidrug transporter. Annu Rev Pharmacol Toxicol 1999; 39: 361-98.
    • (1999) Annu Rev Pharmacol Toxicol , vol.39 , pp. 361-398
    • Ambudkar, S.V.1    Dey, S.2    Hrycyna, C.A.3
  • 12
    • 13244292479 scopus 로고    scopus 로고
    • Three-dimensional structure of P-glycoprotein: The transmembrane regions adopt an asymmetric configuration in the nucleotide-bound state
    • Rosenberg MF, Callaghan R, Modok S et al. Three-dimensional structure of P-glycoprotein: The transmembrane regions adopt an asymmetric configuration in the nucleotide-bound state. J Biol Chem 2005; 280: 2857-62.
    • (2005) J Biol Chem , vol.280 , pp. 2857-2862
    • Rosenberg, M.F.1    Callaghan, R.2    Modok, S.3
  • 13
    • 0037052062 scopus 로고    scopus 로고
    • The medicinal chemistry of multidrug resistance (MDR) reversing drugs
    • Teodori E, Dei S, Scapecchi S et al. The medicinal chemistry of multidrug resistance (MDR) reversing drugs. Farmaco 2002; 57 385-415.
    • (2002) Farmaco , vol.57 , pp. 385-415
    • Teodori, E.1    Dei, S.2    Scapecchi, S.3
  • 14
    • 0033055888 scopus 로고    scopus 로고
    • Valspodar: Current status and perspectives
    • Loor F. Valspodar: Current status and perspectives. Expert Opin Investig Drugs 1999; 8: 807-35.
    • (1999) Expert Opin Investig Drugs , vol.8 , pp. 807-835
    • Loor, F.1
  • 15
    • 4644374002 scopus 로고    scopus 로고
    • Molecular and cellular biology of chloroquine resistance in Plasmodium falciparum
    • Waters AP, Janse CJ, eds, Wymondham, UK: Caister Academic Press
    • Waller KL, Lee S, Fidock DA. Molecular and cellular biology of chloroquine resistance in Plasmodium falciparum. In: Waters AP, Janse CJ, eds. Malaria Parasites: Genomes and Molecular Biolgy. Wymondham, UK: Caister Academic Press, 2004; 501-40.
    • (2004) Malaria Parasites: Genomes and Molecular Biolgy , pp. 501-540
    • Waller, K.L.1    Lee, S.2    Fidock, D.A.3
  • 16
    • 19344377032 scopus 로고    scopus 로고
    • Contribution of the pfmdr1 gene to antimalarial drug-resistance
    • Duraisingh MT, Cowman AF. Contribution of the pfmdr1 gene to antimalarial drug-resistance. Acta Trop 2005; 94: 181-90.
    • (2005) Acta Trop , vol.94 , pp. 181-190
    • Duraisingh, M.T.1    Cowman, A.F.2
  • 17
    • 0030007435 scopus 로고    scopus 로고
    • The ATP-binding cassette (ABC) gene family of Plasmodium falciparum
    • Rubio JP, Cowman AF. The ATP-binding cassette (ABC) gene family of Plasmodium falciparum. Parasitol Today 1996; 12: 135-40.
    • (1996) Parasitol Today , vol.12 , pp. 135-140
    • Rubio, J.P.1    Cowman, A.F.2
  • 18
    • 0025786518 scopus 로고
    • A P-glycoprotein homologue of Plasmodium falciparum is localized on the digestive vacuole
    • Cowman AF, Karcz S, Galatis D et al. A P-glycoprotein homologue of Plasmodium falciparum is localized on the digestive vacuole. J Cell Biol 1991; 113: 1033-42.
    • (1991) J Cell Biol , vol.113 , pp. 1033-1042
    • Cowman, A.F.1    Karcz, S.2    Galatis, D.3
  • 19
    • 10744231302 scopus 로고    scopus 로고
    • Multiple transporters associated with malaria parasite responses to chloroquine and quinine
    • Mu J, Ferdig MT, Feng X et al. Multiple transporters associated with malaria parasite responses to chloroquine and quinine. Mol Microbiol 2003; 49: 977-89.
    • (2003) Mol Microbiol , vol.49 , pp. 977-989
    • Mu, J.1    Ferdig, M.T.2    Feng, X.3
  • 20
    • 0029041725 scopus 로고
    • Mefloquine resistance in Plasmodium falciparum
    • Mockenhaupt FP. Mefloquine resistance in Plasmodium falciparum. Parasitol Today 1995; 11: 248-53.
    • (1995) Parasitol Today , vol.11 , pp. 248-253
    • Mockenhaupt, F.P.1
  • 21
    • 0034708162 scopus 로고    scopus 로고
    • Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum
    • Reed MB, Saliba KJ, Caruana SR et al. Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum. Nature 2000; 403: 906-9.
    • (2000) Nature , vol.403 , pp. 906-909
    • Reed, M.B.1    Saliba, K.J.2    Caruana, S.R.3
  • 22
    • 23744435838 scopus 로고    scopus 로고
    • pfmdr1 mutations contribute to quinine resistance and enhance mefloquine and artemisinin sensitivity in Plasmodium falciparum
    • Sidhu AB, Valderramos SG, Fidock DA. pfmdr1 mutations contribute to quinine resistance and enhance mefloquine and artemisinin sensitivity in Plasmodium falciparum. Mol Microbiol 2005; 57: 913-26.
    • (2005) Mol Microbiol , vol.57 , pp. 913-926
    • Sidhu, A.B.1    Valderramos, S.G.2    Fidock, D.A.3
  • 23
    • 12944300985 scopus 로고    scopus 로고
    • Mutations in pfmdr1 modulate the sensitivity of Plasmodium falciparum to the intrinsic antiplasmodial activity of verapamil
    • Hayward R, Saliba KJ, Kirk K. Mutations in pfmdr1 modulate the sensitivity of Plasmodium falciparum to the intrinsic antiplasmodial activity of verapamil. Antimicrob Agents Chemother 2005; 49: 840-2.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 840-842
    • Hayward, R.1    Saliba, K.J.2    Kirk, K.3
  • 24
    • 27944483714 scopus 로고    scopus 로고
    • Antimalarial drug synergism and antagonism: Mechanistic and clinical significance
    • Bell A. Antimalarial drug synergism and antagonism: Mechanistic and clinical significance. FEMS Microbiol Lett 2005; 253: 171-84.
    • (2005) FEMS Microbiol Lett , vol.253 , pp. 171-184
    • Bell, A.1
  • 25
    • 30544439248 scopus 로고    scopus 로고
    • Cellular and molecular actions of dinitroaniline and phosphorothioamidate herbicides on Plasmodium falciparum: Tubulin as a specific antimalarial target
    • Fennell BJ, Naughton JA, Dempsey E et al. Cellular and molecular actions of dinitroaniline and phosphorothioamidate herbicides on Plasmodium falciparum: Tubulin as a specific antimalarial target. Mol Biochem Parasitol 2006; 145: 226-38.
    • (2006) Mol Biochem Parasitol , vol.145 , pp. 226-238
    • Fennell, B.J.1    Naughton, J.A.2    Dempsey, E.3
  • 26
    • 0027419597 scopus 로고
    • Effects of microtubule inhibitors on protein synthesis in Plasmodium falciparum
    • Bell A, Wernli B, Franklin RM. Effects of microtubule inhibitors on protein synthesis in Plasmodium falciparum. Parasitol Res 1993; 79: 146-52.
    • (1993) Parasitol Res , vol.79 , pp. 146-152
    • Bell, A.1    Wernli, B.2    Franklin, R.M.3
  • 27
    • 0027281689 scopus 로고
    • Parasite lactate dehydrogenase as an assay for Plasmodium falciparum drug sensitivity
    • Makler MT, Ries JM, Williams JA et al. Parasite lactate dehydrogenase as an assay for Plasmodium falciparum drug sensitivity. Am J Trop Med Hyg 1993; 48: 739-41.
    • (1993) Am J Trop Med Hyg , vol.48 , pp. 739-741
    • Makler, M.T.1    Ries, J.M.2    Williams, J.A.3
  • 28
    • 0031878901 scopus 로고    scopus 로고
    • Plasmodium chabaudi chabaudi and P. falciparum: Inhibition of aminopeptidase and parasite growth by bestatin and nitrobestatin
    • Nankya-Kitaka MF, Curley GP, Gavigan CS et al. Plasmodium chabaudi chabaudi and P. falciparum: Inhibition of aminopeptidase and parasite growth by bestatin and nitrobestatin. Parasitol Res 1998; 84: 552-8.
    • (1998) Parasitol Res , vol.84 , pp. 552-558
    • Nankya-Kitaka, M.F.1    Curley, G.P.2    Gavigan, C.S.3
  • 29
    • 0034775098 scopus 로고    scopus 로고
    • Analysis of antimalarial synergy between bestatin and endoprotease inhibitors using statistical response-surface modelling
    • Gavigan CS, Machado SG, Dalton JP et al. Analysis of antimalarial synergy between bestatin and endoprotease inhibitors using statistical response-surface modelling. Antimicrob Agents Chemother 2001; 45: 3175-81.
    • (2001) Antimicrob Agents Chemother , vol.45 , pp. 3175-3181
    • Gavigan, C.S.1    Machado, S.G.2    Dalton, J.P.3
  • 30
    • 0027939470 scopus 로고
    • A direct, general approach based on isobolograms for assessing the joint action of drugs in pre-clinical experiments
    • Machado SG, Robinson GA. A direct, general approach based on isobolograms for assessing the joint action of drugs in pre-clinical experiments. Stat Med 1994; 13: 2289-309.
    • (1994) Stat Med , vol.13 , pp. 2289-2309
    • Machado, S.G.1    Robinson, G.A.2
  • 31
    • 0031713287 scopus 로고    scopus 로고
    • Role for the Plasmodium falciparum digestive vacuole in chloroquine resistance
    • Saliba KJ, Folb PI, Smith PJ. Role for the Plasmodium falciparum digestive vacuole in chloroquine resistance. Biochem Pharmacol 1998; 56: 313-20.
    • (1998) Biochem Pharmacol , vol.56 , pp. 313-320
    • Saliba, K.J.1    Folb, P.I.2    Smith, P.J.3
  • 32
    • 0028014644 scopus 로고
    • Selection for mefloquine resistance in Plasmodium falciparum is linked to amplification of the pfmdr1 gene and cross-resistance to halofantrine and quinine
    • Cowman AF, Galatis D, Thompson JK. Selection for mefloquine resistance in Plasmodium falciparum is linked to amplification of the pfmdr1 gene and cross-resistance to halofantrine and quinine. Proc Natl Acad Sci USA 1994; 91: 1143-7.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 1143-1147
    • Cowman, A.F.1    Galatis, D.2    Thompson, J.K.3
  • 33
    • 0023432272 scopus 로고
    • Calcium and calmodulin antagonists inhibit human malaria parasites (Plasmodium falciparum): Implications for drug design
    • Scheibel LW, Colombani PM, Hess AD et al. Calcium and calmodulin antagonists inhibit human malaria parasites (Plasmodium falciparum): Implications for drug design. Proc Natl Acad Sci USA 1987; 84: 7310-4.
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 7310-7314
    • Scheibel, L.W.1    Colombani, P.M.2    Hess, A.D.3
  • 34
    • 0024432823 scopus 로고
    • Identification of the multidrug resistance-related P-glycoprotein as a cyclosporine binding protein
    • Foxwell BM, Mackie A, Ling V et al. Identification of the multidrug resistance-related P-glycoprotein as a cyclosporine binding protein. Mol Pharmacol 1989; 36: 543-6.
    • (1989) Mol Pharmacol , vol.36 , pp. 543-546
    • Foxwell, B.M.1    Mackie, A.2    Ling, V.3
  • 35
    • 0030889916 scopus 로고    scopus 로고
    • Molecular interactions of cyclosporin A with P-glycoprotein. Photolabeling with cyclosporin derivatives
    • Demeule M, Wenger RM, Beliveau R. Molecular interactions of cyclosporin A with P-glycoprotein. Photolabeling with cyclosporin derivatives. J Biol Chem 1997; 272: 6647-52.
    • (1997) J Biol Chem , vol.272 , pp. 6647-6652
    • Demeule, M.1    Wenger, R.M.2    Beliveau, R.3
  • 36
    • 33746289507 scopus 로고    scopus 로고
    • Genetic linkage of pfmdr1 with food vacuolar solute import in Plasmodium falciparum
    • Rohrbach P, Sanchez CP, Hayton K et al. Genetic linkage of pfmdr1 with food vacuolar solute import in Plasmodium falciparum. EMBO J 2006; 25: 3000-11.
    • (2006) EMBO J , vol.25 , pp. 3000-3011
    • Rohrbach, P.1    Sanchez, C.P.2    Hayton, K.3
  • 37
    • 0027406890 scopus 로고
    • Nucleotide binding properties of a P-glycoprotein homologue from Plasmodium falciparum
    • Karcz SR, Galatis D, Cowman AF. Nucleotide binding properties of a P-glycoprotein homologue from Plasmodium falciparum. Mol Biochem Parasitol 1993; 58: 269-76.
    • (1993) Mol Biochem Parasitol , vol.58 , pp. 269-276
    • Karcz, S.R.1    Galatis, D.2    Cowman, A.F.3
  • 38
    • 0031847073 scopus 로고    scopus 로고
    • Quinoline antimalarials: Mechanisms of action and resistance and prospects for new agents
    • Foley M, Tilley L. Quinoline antimalarials: Mechanisms of action and resistance and prospects for new agents. Pharmacol Ther 1998; 79: 55-87.
    • (1998) Pharmacol Ther , vol.79 , pp. 55-87
    • Foley, M.1    Tilley, L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.