Cytotoxicity of chloroacetanilide herbicide alachlor in HepG2 cells independent of CYP3A4 and CYP3A7

Food and Chemical Toxicology

Volumn 45, Issue 5, 2007, Pages 871-877

  Miranda, Sonia R ^a   Meyer, Sharon A ^a  

^a UNIVERSITY OF LOUISIANA AT MONROE   (United States)

Author keywords

2 chloro 2 ,6 diethyl N (methoxymethyl) acetanilide; Chloroacetanilide herbicides; DPX 2 cells; Hepatotoxicity; N dealkylation

Indexed keywords

2,6 DIETHYLBENZOQUINONIMINE; ACETANILIDE; ALACHLOR; BENZYL DERIVATIVE; CYTOCHROME P450 3A4; CYTOCHROME P450 3A7; DEXAMETHASONE; ETHER DERIVATIVE; HERBICIDE; LACTATE DEHYDROGENASE; LUCIFERIN; PREGNANE X RECEPTOR; RIFAMPICIN; TROLEANDOMYCIN; UNCLASSIFIED DRUG;

2 CHLORO N (2,6 DIETHYLPHENYL)ACETAMIDE; ARTICLE; BENZYLATION; CARCINOGENICITY; CATALYSIS; CELL STRAIN HEPG2; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; DEALKYLATION; ENZYME ACTIVITY; GENE OVEREXPRESSION; HEPATOBLASTOMA; HUMAN; HUMAN CELL; LIVER TOXICITY; NOSE CARCINOMA; PROTEIN EXPRESSION;

ACETAMIDES; ARYL HYDROCARBON HYDROXYLASES; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CYTOCHROME P-450 ENZYME SYSTEM; DEXAMETHASONE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; ENZYME INDUCTION; HERBICIDES; HUMANS; L-LACTATE DEHYDROGENASE; LIVER NEOPLASMS; RECEPTORS, STEROID; TIME FACTORS;

RATTUS;

EID: 33947423329     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2006.11.011     Document Type: Article

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