메뉴 건너뛰기




Volumn 23, Issue 1, 2007, Pages 1-13

AL-34662: A potent, selective, and efficacious ocular hypotensive serotonin-2 receptor agonist

Author keywords

[No Author keywords available]

Indexed keywords

1 (2 AMINOPROPYL) 1H INDAZOL 6 OL; 6 CHLORO 5 METHYL 1 [[2 [(2 METHYL 3 PYRIDYL)OXY] 5 PYRIDYL]CARBAMOYL]INDOLINE; 8 [4 (5 AMINO 2,4 DIMETHOXYBENZOYL)BUTYL] 1,3,8 TRIAZASPIRO[4.5]DECANE 2,4 DIONE; AL 34497; AL 34662; AL 34707; ALPHA (2,3 DIMETHOXYPHENYL) 1 [2 (4 FLUOROPHENYL)ETHYL] 4 PIPERIDINEMETHANOL; ANTIHYPERTENSIVE AGENT; CALCIUM; INDAZOLE DERIVATIVE; PHOSPHATIDYLINOSITIDE; RS 127445; SEROTONIN 2 RECEPTOR; SEROTONIN 2A ANTAGONIST; SEROTONIN 2A RECEPTOR; SEROTONIN 2B RECEPTOR; SEROTONIN 2C ANTAGONIST; SEROTONIN 2C RECEPTOR; UNCLASSIFIED DRUG;

EID: 33947403538     PISSN: 10807683     EISSN: None     Source Type: Journal    
DOI: 10.1089/jop.2006.0093     Document Type: Article
Times cited : (26)

References (49)
  • 1
    • 0028183017 scopus 로고
    • VII. International union of pharmacology classification of receptors for 5-hydroxytryptamine (serotonin)
    • Hoyer, D., Clarke, D.E., Fozard, J.R., et al. VII. International union of pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharm. Rev. 46:157-203, 1994.
    • (1994) Pharm. Rev , vol.46 , pp. 157-203
    • Hoyer, D.1    Clarke, D.E.2    Fozard, J.R.3
  • 2
    • 0036119338 scopus 로고    scopus 로고
    • Molecular, pharmacological, and functional diversity of 5-HT receptors
    • Hoyer, D., Hannon, J.P., and Martin, G.R. Molecular, pharmacological, and functional diversity of 5-HT receptors. Pharmacol. Biochem. Behav. 71:533-554, 2002.
    • (2002) Pharmacol. Biochem. Behav , vol.71 , pp. 533-554
    • Hoyer, D.1    Hannon, J.P.2    Martin, G.R.3
  • 3
    • 0030774639 scopus 로고    scopus 로고
    • Functional characteristics of heterogeneously expressed 5-HT receptors
    • Gerhardt, C.C., and van Heerikhuizen, H. Functional characteristics of heterogeneously expressed 5-HT receptors. Eur. J. Pharmacol. 334:1-23, 1997.
    • (1997) Eur. J. Pharmacol , vol.334 , pp. 1-23
    • Gerhardt, C.C.1    van Heerikhuizen, H.2
  • 5
    • 33947394237 scopus 로고    scopus 로고
    • Sharif, N.A., and Klimko, P. CNS: Ophthalmic agents. In: Taylor, J.B., and Triggle, D.J., eds. Comprehensive Medicinal Chemistry II (6). Oxford, UK: Elsevier, 2007.
    • Sharif, N.A., and Klimko, P. CNS: Ophthalmic agents. In: Taylor, J.B., and Triggle, D.J., eds. Comprehensive Medicinal Chemistry II (Vol. 6). Oxford, UK: Elsevier, 2007.
  • 7
    • 0031937675 scopus 로고    scopus 로고
    • Evaluation of serotonin levels in human aqueous humor
    • Veglio, F., De Sanctis, U., Schiavone, D., et al. Evaluation of serotonin levels in human aqueous humor. Ophthalmologica 212:160-163, 1998.
    • (1998) Ophthalmologica , vol.212 , pp. 160-163
    • Veglio, F.1    De Sanctis, U.2    Schiavone, D.3
  • 8
    • 0026847088 scopus 로고
    • The ciliary body-the third organ found to synthesize indoleamines in humans
    • Martin, X.D., Malina, H.Z., Brennan, M.C., et al. The ciliary body-the third organ found to synthesize indoleamines in humans. Eur. J. Ophthalmol. 2:67-72, 1992.
    • (1992) Eur. J. Ophthalmol , vol.2 , pp. 67-72
    • Martin, X.D.1    Malina, H.Z.2    Brennan, M.C.3
  • 9
    • 0023723116 scopus 로고
    • Evidence for presence of serotonergic nerves and receptors in the iris-ciliary body complex of the rabbit
    • Tobin, A.B., Unger, W., and Osborne N.N. Evidence for presence of serotonergic nerves and receptors in the iris-ciliary body complex of the rabbit. J. Neurosci. 8:3713-3721, 1988.
    • (1988) J. Neurosci , vol.8 , pp. 3713-3721
    • Tobin, A.B.1    Unger, W.2    Osborne, N.N.3
  • 10
    • 1842728388 scopus 로고    scopus 로고
    • Expression of serotonin receptor mRNAs in human ciliary body: A polymerase chain reaction study
    • Chidlow, G., Hiscott, P.S., and Osborne, N.N. Expression of serotonin receptor mRNAs in human ciliary body: A polymerase chain reaction study. Graefe's Arch. Clin. Exp. Ophthalmol. 242:259-264, 2004.
    • (2004) Graefe's Arch. Clin. Exp. Ophthalmol , vol.242 , pp. 259-264
    • Chidlow, G.1    Hiscott, P.S.2    Osborne, N.N.3
  • 13
    • 0036668787 scopus 로고    scopus 로고
    • 3H]norepinephrine release from isolated mammalian iris-ciliary bodies
    • 3H]norepinephrine release from isolated mammalian iris-ciliary bodies. J. Ocul. Pharmacol. Ther. 18:339-348, 2002.
    • (2002) J. Ocul. Pharmacol. Ther , vol.18 , pp. 339-348
    • Harris, L.C.1    Awe, S.O.2    Opere, C.A.3
  • 15
    • 0027330347 scopus 로고
    • 2, receptor-mediated phosphoinositide turnover and mobilization of calcium in cultured rat retinal pigment epithelium cells
    • 2, receptor-mediated phosphoinositide turnover and mobilization of calcium in cultured rat retinal pigment epithelium cells. Vis. Res. 33: 2171-2179, 1993.
    • (1993) Vis. Res , vol.33 , pp. 2171-2179
    • Osborne, N.N.1    Fitzgibbon, F.2    Nash, M.3
  • 18
    • 33748436596 scopus 로고    scopus 로고
    • 2) receptor-mediated signal transduction in human ciliary muscle cells: Role in ocular hypotension
    • 2) receptor-mediated signal transduction in human ciliary muscle cells: Role in ocular hypotension. J. Ocul. Pharmacol. Ther. 22:389-401, 2006.
    • (2006) J. Ocul. Pharmacol. Ther , vol.22 , pp. 389-401
    • Sharif, N.A.1    Kelly, C.R.2    Crider, J.Y.3
  • 19
    • 33748416317 scopus 로고    scopus 로고
    • Serotonin receptor subtype mRNA expression in human ocular tissues determined by RT-PCR
    • Sharif, N.A., and Senchyna, M. Serotonin receptor subtype mRNA expression in human ocular tissues determined by RT-PCR. Mol. Vis. 12:1040-1047, 2006.
    • (2006) Mol. Vis , vol.12 , pp. 1040-1047
    • Sharif, N.A.1    Senchyna, M.2
  • 20
    • 33644811977 scopus 로고    scopus 로고
    • Aqueous humor dynamics in monkeys after topical R-DOI
    • Gabelt, B.T., Okka, M., Dean, T.R., et al. Aqueous humor dynamics in monkeys after topical R-DOI. Invest. Ophthalmol. Vis. Sci. 46:4691-4696, 2005.
    • (2005) Invest. Ophthalmol. Vis. Sci , vol.46 , pp. 4691-4696
    • Gabelt, B.T.1    Okka, M.2    Dean, T.R.3
  • 21
    • 0034002380 scopus 로고    scopus 로고
    • The regulation of trabecular meshwork and ciliary muscle contractility
    • Wiederholt, M., Thieme, H., and Stumpff F. The regulation of trabecular meshwork and ciliary muscle contractility. Prog. Retinal Eye Res. 19:271-295, 2000.
    • (2000) Prog. Retinal Eye Res , vol.19 , pp. 271-295
    • Wiederholt, M.1    Thieme, H.2    Stumpff, F.3
  • 22
  • 23
    • 0026696862 scopus 로고
    • Ocular hypotensive actions of serotonin antagonist-ketanserin analogs
    • Chiou, G.C., and Li, B.H. Ocular hypotensive actions of serotonin antagonist-ketanserin analogs. J. Ocul. Pharmacol. Ther. 8:11-21, 1992.
    • (1992) J. Ocul. Pharmacol. Ther , vol.8 , pp. 11-21
    • Chiou, G.C.1    Li, B.H.2
  • 24
    • 0031283537 scopus 로고    scopus 로고
    • Ocular hypotensive effect of ketanserin in patients with primary open-angle glaucoma
    • Mastropasqua, L., Costagliola, C., Ciancaglini, M., et al. Ocular hypotensive effect of ketanserin in patients with primary open-angle glaucoma. Acta. Ophthalmol. Scand. Suppl. 224:24-25, 1997.
    • (1997) Acta. Ophthalmol. Scand. Suppl , vol.224 , pp. 24-25
    • Mastropasqua, L.1    Costagliola, C.2    Ciancaglini, M.3
  • 26
    • 0030743820 scopus 로고    scopus 로고
    • Effect of 5-methyl-urapidil, an alpha-1a adrenergic antagonist and 5-hydroxytrptamine 1A agonist, on aqueous humor dynamics in monkeys and rabbits
    • Wang, R.F., Lee, P.Y., Mittag, T.W., et al. Effect of 5-methyl-urapidil, an alpha-1a adrenergic antagonist and 5-hydroxytrptamine 1A agonist, on aqueous humor dynamics in monkeys and rabbits. Curr. Eye Res. 16:769-775, 1997.
    • (1997) Curr. Eye Res , vol.16 , pp. 769-775
    • Wang, R.F.1    Lee, P.Y.2    Mittag, T.W.3
  • 28
    • 0027318246 scopus 로고
    • The role of receptor binding in drug discovery
    • Sweetnam, P.M., Caldwell, L., Lancaster, J., et al. The role of receptor binding in drug discovery. J. Nat. Prod. 56:441-455, 1993.
    • (1993) J. Nat. Prod , vol.56 , pp. 441-455
    • Sweetnam, P.M.1    Caldwell, L.2    Lancaster, J.3
  • 29
    • 0031892718 scopus 로고    scopus 로고
    • Effect of prostaglandins on cyclic AMP production in cultured human ciliary smooth muscle cells
    • Zhan, G.L., Camras, C., Opere, C., et al. Effect of prostaglandins on cyclic AMP production in cultured human ciliary smooth muscle cells. J. Ocul. Pharmacol. Ther. 14:45-55, 1998.
    • (1998) J. Ocul. Pharmacol. Ther , vol.14 , pp. 45-55
    • Zhan, G.L.1    Camras, C.2    Opere, C.3
  • 30
    • 0036202309 scopus 로고    scopus 로고
    • Alterations in arachidonic acid release and phospholipase C-β expression in glaucoma tous human ciliary muscle cells
    • Husain, S., Kaddour-Djebbar, I., and Abdel-Latif, A.A. Alterations in arachidonic acid release and phospholipase C-β expression in glaucoma tous human ciliary muscle cells. Invest. Ophthalmol. Vis. Sci. 43: 1127-1134, 2002.
    • (2002) Invest. Ophthalmol. Vis. Sci , vol.43 , pp. 1127-1134
    • Husain, S.1    Kaddour-Djebbar, I.2    Abdel-Latif, A.A.3
  • 32
    • 0037309867 scopus 로고    scopus 로고
    • Human trabecular meshwork cell responses induced by bimatoprost, travoprost, unoprostone, and other FP prostaglandin receptor agonist analogues
    • Sharif, N.A., Kelly, C.R., and Crider, J.Y. Human trabecular meshwork cell responses induced by bimatoprost, travoprost, unoprostone, and other FP prostaglandin receptor agonist analogues. Invest. Ophthalmol. Vis. Res. 44:715-721, 2003.
    • (2003) Invest. Ophthalmol. Vis. Res , vol.44 , pp. 715-721
    • Sharif, N.A.1    Kelly, C.R.2    Crider, J.Y.3
  • 34
    • 0037214424 scopus 로고    scopus 로고
    • 2+ mobilization by travoprost acid, bimatoprost, unoprostone, and other analogs via endogenous mouse, rat, and cloned human FP prostaglandin receptors
    • 2+ mobilization by travoprost acid, bimatoprost, unoprostone, and other analogs via endogenous mouse, rat, and cloned human FP prostaglandin receptors. J. Pharmacol. Exp. Ther. 304: 238-245, 2003.
    • (2003) J. Pharmacol. Exp. Ther , vol.304 , pp. 238-245
    • Kelly, C.R.1    Williams, G.W.2    Sharif, N.A.3
  • 35
    • 0037982350 scopus 로고    scopus 로고
    • Ophthalmic Toxicology" and "Assessing Ocular Irritation
    • Marzulli, F.N, and Maibach, H.I, eds, 5th ed. Washington, DC: Hemisphere Publishing Corp
    • Hackett, R.B., and McDonald, T.O. "Ophthalmic Toxicology" and "Assessing Ocular Irritation" In: Marzulli, F.N., and Maibach, H.I., eds. Dermatoxicology, 5th ed. Washington, DC: Hemisphere Publishing Corp., 1996.
    • (1996) Dermatoxicology
    • Hackett, R.B.1    McDonald, T.O.2
  • 36
    • 0034741547 scopus 로고    scopus 로고
    • Levobetaxolol (Betaxon™) and other beta-adrenergic antagonists: Preclinical pharmacology, IOP-lowering activity and sites of action in human eyes
    • Sharif, N.A., Xu, S.X., Crider, J.Y., et al. Levobetaxolol (Betaxon™) and other beta-adrenergic antagonists: Preclinical pharmacology, IOP-lowering activity and sites of action in human eyes. J. Ocul. Pharmacol. Ther. 17:305-317, 2001.
    • (2001) J. Ocul. Pharmacol. Ther , vol.17 , pp. 305-317
    • Sharif, N.A.1    Xu, S.X.2    Crider, J.Y.3
  • 40
    • 0030087741 scopus 로고    scopus 로고
    • Pharmacologic characterization of the human 5-hydroxytryptamine2B receptor: Evidence for species differences
    • Wainscott D.B., Lucaites, V.L., Kursar, J.D., et al. Pharmacologic characterization of the human 5-hydroxytryptamine2B receptor: Evidence for species differences. J. Pharmacol. Exp. Ther. 276:720-726, 1996.
    • (1996) J. Pharmacol. Exp. Ther , vol.276 , pp. 720-726
    • Wainscott, D.B.1    Lucaites, V.L.2    Kursar, J.D.3
  • 44
    • 33645392026 scopus 로고    scopus 로고
    • Endothelin antagonism: Effect of FP receptor agonists prostaglandin F2 and fluprostenol on trabecular meshwork contractility
    • Thieme, H., Schimmat, C., Münzer, G., et al. Endothelin antagonism: Effect of FP receptor agonists prostaglandin F2 and fluprostenol on trabecular meshwork contractility. Invest. Ophthalmol. Vis. Sci. 47:938-945, 2006.
    • (2006) Invest. Ophthalmol. Vis. Sci , vol.47 , pp. 938-945
    • Thieme, H.1    Schimmat, C.2    Münzer, G.3
  • 45
    • 10044229247 scopus 로고    scopus 로고
    • Increase in outflow facility with unoprostone treatment in ocular hypertensive patients
    • Toris, C.B., Zhan, G., and Camras C. Increase in outflow facility with unoprostone treatment in ocular hypertensive patients. Arch. Ophthalmol. 122:1782-1787, 2004.
    • (2004) Arch. Ophthalmol , vol.122 , pp. 1782-1787
    • Toris, C.B.1    Zhan, G.2    Camras, C.3
  • 46
    • 0033044222 scopus 로고    scopus 로고
    • Acute versus chronic effects of brimonidine on aqueous humor dynamics in ocular hypertensive patients
    • Toris, C.B., Camras, C.B., and Yablonski, M., Acute versus chronic effects of brimonidine on aqueous humor dynamics in ocular hypertensive patients. Am. J. Ophthalmol. 128:8-14, 1999.
    • (1999) Am. J. Ophthalmol , vol.128 , pp. 8-14
    • Toris, C.B.1    Camras, C.B.2    Yablonski, M.3
  • 47
    • 0036669680 scopus 로고    scopus 로고
    • Hellberg, M.R., McLaughlin, M.A., Sharif, N.A., et al. Identification and characterization of the ocular hypotensive efficacy of travoprost, a potent and selective FP prostaglandin receptor agonist, and AL-6598, a DP prostaglandin receptor agonist. Surv. Ophthalmol. (Suppl. #1) 47:S13-S33, 2002.
    • Hellberg, M.R., McLaughlin, M.A., Sharif, N.A., et al. Identification and characterization of the ocular hypotensive efficacy of travoprost, a potent and selective FP prostaglandin receptor agonist, and AL-6598, a DP prostaglandin receptor agonist. Surv. Ophthalmol. (Suppl. #1) 47:S13-S33, 2002.
  • 48
    • 0035203853 scopus 로고    scopus 로고
    • Pre-clinical efficacy of travoprost, a potent and selective FP prostaglandin receptor agonist
    • Hellberg, M.R., Sallee, V., McLaughlin M., et al. Pre-clinical efficacy of travoprost, a potent and selective FP prostaglandin receptor agonist. J. Ocular Pharmacol. Ther. 17:421-432, 2001.
    • (2001) J. Ocular Pharmacol. Ther , vol.17 , pp. 421-432
    • Hellberg, M.R.1    Sallee, V.2    McLaughlin, M.3
  • 49
    • 1342343004 scopus 로고    scopus 로고
    • Serotonin increase glial cell-line-derived neurotrophic factor release in C6 glioblastoma cells
    • Hisaoka, K., Nishida, A., Takebayashi, M., et al. Serotonin increase glial cell-line-derived neurotrophic factor release in C6 glioblastoma cells. Brain Res. 1002:167-170, 2004.
    • (2004) Brain Res , vol.1002 , pp. 167-170
    • Hisaoka, K.1    Nishida, A.2    Takebayashi, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.