Pharmacological Characterization of a Serotonin Receptor (5-HT 7) Stimulating cAMP Production in Human Corneal Epithelial Cells

Investigative Ophthalmology and Visual Science

Volumn 44, Issue 11, 2003, Pages 4837-4844

  Crider, Julie Y ^a   Williams, Gary W ^a   Drace, Colene D ^a   Katoli, Parvaneh ^a   Senchyna, Michelle ^b   Sharif, Najam A ^a  

^a ALCON RESEARCH LTD   (United States)

^b UNIVERSITY OF WATERLOO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 3,N DIMETHYL N [1 METHYL 3 (4 METHYL 1 PIPERIDINYL)PROPYL]BENZENESULFONAMIDE; 5 CARBAMOYLTRYPTAMINE; 5 METHOXY N,N DIMETHYLTRYPTAMINE; 5 METHOXYTRYPTAMINE; ALPHA METHYLSEROTONIN; CLOZAPINE; CYCLIC AMP; KETANSERIN; MESULERGINE; METERGOLINE; METITEPINE; MIANSERIN; SEROTONIN 1 RECEPTOR; SEROTONIN 7 RECEPTOR; SPIPERONE;

ADULT; ARTICLE; CONCENTRATION RESPONSE; CORNEA EPITHELIUM; DRUG RECEPTOR BINDING; ENZYME IMMUNOASSAY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; RECEPTOR AFFINITY; RECEPTOR BLOCKING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADENYLATE CYCLASE; ADULT; CELL LINE; CELL MEMBRANE; CYCLIC AMP; EPITHELIUM, CORNEAL; HUMANS; KIDNEY; LYSERGIC ACID DIETHYLAMIDE; MIDDLE AGED; RECEPTORS, SEROTONIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS;

EID: 0142200833     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.02-1292     Document Type: Article

References (39)

1. Hoyer D, Clarke DE, Fozard JR, et al. VII. International union of pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharm Rev. 1994;46:157-203.
2. Barnes NM, Sharp T. A review of central 5-HT receptors and their function. Neuropharmacology, 1999;38:1083-1152.
3. 7 receptors: Current knowledge and future prospects. Trends in Pharmacol Sci. 2000;21:70-77.
4. Gerhardt CC, van Heerikuizen, H. Functional characteristic of heterologously expressed 5-HT receptors. Eur J Pharmacol. 1997;334:1-23.
5. 7(a) receptor isoform coupled to adenylate cyclase stimulation. J Pharm Exp Ther. 1998;287:508-514.
6. 7) positively linked to adenylate cyclase. J Biol Chem. 1993;268:23422-23246.
7. Roth BL, Craigo SC, Choudhary, MS, et al. Binding of typical and atypical antipsychotic agents to 5-hydroxytrptamine-6 and 5-hydroxytryptamine-7 receptors. J Pharmacol Exp Ther. 1994;268:1403-1410.
8. 7) activating cAMP formation. Proc Natl Acad Sci USA. 1993;90:8547-8551.
9. Shen Y, Monsma FJ, Metcalf MA, Jose PA, Hamblin MW, Sibley DR. Molecular cloning and expression of a 5-hydroxytryptamine-7 serotonin receptor subtype. J Biol Chem. 1993;268:18200-18204.
10. 7 receptor splice variants: a comparative characterization of their pharmacology function and distribution. Nau nyn-Schmiedebergs Arch Pharm. 2001;363:620-632.
11. 7) receptor isoforms in human and rat produced by alternative splicing: species differences due to altered intron-exon organization. J Neurochem. 1997;68:1372-1378.
12. 7A receptor. J Biol Chem. 1998;273:17469-17476.
13. 7) receptor isoforms produced by alternative splicing. Neuropharmacology. 1998;37:1621-1632.
14. 7) implicated in the regulation of mammalian circadian rhythms. Neuron. 1993;11:449-458.
15. 7 receptors mediate serotonergic effects on light-sensitive suprachiasmatic nucleus neurons. Brain Res. 1997;755:246-254.
16. 7 receptors in human vascular smooth muscle cells. Br J Pharmacol. 1996;117:993-994.
17. 7 receptor binding sites in rat hypothalamus. Mol Pharmacol. 1995;47:99-103.
18. Fozard JR. the 5-hydroxytryptamine-nitric oxide connection: the key in the initiation of migraine? Arch Int Pharmacdyn 1995;329:111-119.
19. Tobin AB, Unger W, Osborne NN. Evidence for presence of serotonergic nerves and receptors in the iris-ciliary body complex of the rabbit. J Neurosci. 1988;8:3713-3721.
20. Martin XD, Brennan MC, Lichter, PR. Serotonin in human aqueous humor. Ophthalmology. 1988;95:1221-1226.
21. 3H]-5-hydroxytryptamine binding to iris-ciliary body tissue of the rabbit. Invest Ophthalmol Vis Sci. 1995;36:2238-2245.
22. 7) autoreceptors. Exp Eye Res. 2001;73:59-67.
23. Neufeld AH, Ledgard SE, Jumblatt MM, Klyce SD. Serotonin-stimulated cyclic AMP synthesis in the rabbit corneal epithelium. Invest Ophthalmol Vis Sci. 1982;23:193-198.
24. Sharif NA, Wiernas TK, Howe WE, Griffin BW, Offord EA, Pfeifer AMA. Human corneal epithelial cell functional responses to inflammatory agents and their antagonists. Invest Ophthalmol Vis Sci. 1998;39:2562-2571.
25. Offord E, Sharif NA, Mace K, et al. Immortalized human corneal epithelial cells for ocular toxicity and inflammation studies. Invest Ophthalmol Vis Sci. 1999;40:1091-1101.
26. 2-bradykinin receptors in human corneal epithelial cells and their pharmacological characterization with agonists and antagonists. Br J Pharmacol. 1997;121:649-656.
27. Crider JY, Griffin BW, Sharif NA. Prostaglandin DP receptors positively coupled to adenylyl cyclase in embryonic bovine tracheal (EBTr) cells: pharmacological characterization using agonists and antagonists. Br J Pharmacol. 1999;127:204-210.
28. 2 receptor in human nonpigmented ciliary epithelial cells. J Ocular Pharmacol. 1998;14:293-304.
29. Sharif NA, Senchyna, M, Xu SX. Pharmacological and molecular biological (RT-PCR) characterization of functional TP prostanoid receptors in immortalized human non-pigmented ciliary epithelial cells. J Ocul Pharmacol Ther. 2002;18:141-162.
30. 7 receptor (long form): antagonist profile of SB-258719. Br J Pharmacol. 1998;124:1300-1306.
31. Hirst WD, Price GW, Rattray M, Wilkin GP. Identification of 5-hydroxytryptamine receptors positively coupled to adenylyl cyclase in rat cultured astrocytes. Br J Pharmacol. 1997;120:509-515.
32. 7 receptor mediating smooth muscle relaxation in canine cerebral arteries. Br J Pharmacol. 1999;127:609-616.
33. 7(b)). Br J Pharmacol. 1997;122:126-132.
34. Ullmer C, Schmuck K, Kalkman, HO, Lubbert, H. Expression of serotonin receptor mRNA in blood vessels. FEBS Lett. 1995;370:215-221.
35. Kyveris A, Maruscak E, Senchyna M. Optimization of RNA isolation from human ocular tissues and analysis of prostanoid receptor mRNA expression using RT-PCR. Mol Vis. 2002;8:51-58.
36. Klyce SD, Palkama KA, Harkonen M, et al. Neural serotonin stimulates chloride transport in the rabbit corneal epithelium. Invest Ophthahnol Vis Sci. 1982;23:181-192.
37. Martin XD, Brennan MC. Serotonin in human tears. Eur J Ophthalmol. 1994;4:159-165.
38. 6 receptor antagonist, Ro-04-6790, in rats. Br J Pharmacol. 1999;126:1537-1542.
39. 7 receptor antagonist. J Med Chem. 1998;41:655-657.