Evaluation of the ocular hypotensive response of serotonin 5-HT1A and 5-HT2 receptor ligands in conscious ocular hypertensive cynomolgus monkeys

Journal of Pharmacology and Experimental Therapeutics

Volumn 306, Issue 1, 2003, Pages 301-309

  May, Jesse A ^a   McLaughlin, Marsha A ^a   Sharif, Najam A ^a   Hellberg, Mark R ^a   Dean, Thomas R ^a  

^a ALCON RESEARCH LTD   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 DIBUTYLAMINO 8 HYDROXYTETRALIN; 4 IODO 2,5 DIMETHOXYAMPHETAMINE; 5 METHOXY N,N DIMETHYLTRYPTAMINE; 6 CHLORO 5 METHYL 1 [[2 [(2 METHYL 3 PYRIDYL)OXY] 5 PYRIDYL]CARBAMOYL]INDOLINE; ALPHA (2,3 DIMETHOXYPHENYL) 1 [2 (4 FLUOROPHENYL)ETHYL] 4 PIPERIDINEMETHANOL; BUFOTENINE; FLESINOXAN; SEROTONIN 1A AGONIST; SEROTONIN 1A RECEPTOR; SEROTONIN 2A ANTAGONIST; SEROTONIN 2A RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG RESPONSE; EVALUATION; INTRAOCULAR HYPERTENSION; INTRAOCULAR PRESSURE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR INTRINSIC ACTIVITY;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ANIMALS; CHO CELLS; CRICETINAE; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; FEMALE; HUMANS; LIGANDS; MACACA FASCICULARIS; MALE; OCULAR HYPERTENSION; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; TRANSFECTION;

EID: 0038340963     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.103.049528     Document Type: Article

References (40)

1. Aldous FAB, Barrass E, Brewster K, Buxton DA, Green DM, Pinder RM, Rich P, Skeels M, and Tutt KJ (1974) Structure-activity relationships in psychotomimetic phenylalkylamines. J Med Chem 17:1100-1111.
2. 2 receptor agonist, DOI. Eur J Pharmacol 213:41-46.
3. Boerrigter RMM, Siertsema JV, and Kema IP (1992) Serotonin (5-HT) and the rat's eye. Some pilot studies. Doc Ophthalomol 82:141-150.
4. Bowen WP and Jerman JC (1995) Nonlinear regression using spreadsheets. Trends Pharmacol Sci 16:413-417.
5. 2C receptor antagonist. J Med Chem 40:3494-3496.
6. Chang FW, Burke JA, and Potter DE (1985) Mechanism of the ocular hypotensive action of ketanserin. J Ocul Pharmacol 1:137-147.
7. Chiang TS (1974) Effects of intravenous infusions of histamine 5-hydroxytryptamine, bradykinin and prostaglandins on intraocular pressure. Arch Int Pharmacodyn Ther 207:131-138.
8. 1-adrenoceptor antagonist, lowers intraocular pressure in NZW rabbits. Curr Eye Res 23:144-153.
9. Chidlow G, Le Corre S, and Osborne NN (1998) Localization of 5-hydroxytryptamine1A and 5-hydroxytryptamine7 receptors in rabbit ocular and brain tissues. Neuroscience 87:675-689.
10. 1A receptor agonist 8-OH-DPAT lowers intraocular pressure in normotensive NZW rabbits. Exp Eye Res 69:587-593.
11. Chu TC, Ogidigben MJ, and Potter DE (1999) 8-OH-DPAT-induced ocular hypotension: sites and mechanisms of action. Exp Eye Res 69:227-238.
12. Colasanti BK and Trotter RR (1982) Effects of selective inhibition of type A and B monoamine oxidase on intraocular pressure in the cat and the rabbit. Curr Eye Res 1:501-506.
13. Glennon RA, Young R, Benington F, and Morin RD (1982) Behavioral and serotonin receptor properties of 4-substituted derivatives of the hallucinogen 1-(2,5-dimethoxyphenyl)-2-aminopropane. J Med Chem 25:1163-1168.
14. Gunaratna C and Kissinger PT (1998) Investigation of stereoselective metabolism of amphetamine in rat liver microsomes by microdialysis and liquid chromatography with precolumn chiral derivatization. J Chromatogr A 828:95-103.
15. Hellberg MR, Sallee VL, McLaughlin MA, Sharif NA, DeSantis L, Dean TR, and Zinke PW (2001) Preclinical efficacy of travoprost, a potent and selective FP prostaglandin receptor agonist. J Ocul Pharmacol Ther 17:421-432.
16. 125I-DOI. Neuropharmacology 26:1803-1806.
17. Kantor RE, Dudlettes SD, and Shulgin AT (1980) 5-Methoxy-α-methyltryptamine (α,O-dimethylserotonin), a hallucinogenic homolog of serotonin. Biol Psychiatry 15:349-352.
18. Krootila K, Palkama A, and Uusitalo H (1987) Effect of serotonin and its antagonist (ketanserin) on intraocular pressure in the rabbit. J Ocul Pharmacol 3:279-290.
19. Maeda I, Ueda T, Koide R, Inatomi M, Fukado Y, Uchida E, Oguchi K, and Yasuhara H (1988) Ocular hypotensive effects of monoamine oxidase-A inhibitors in rabbit. Jpn J Ophthalmol 32:211-218.
20. Martin XD, Malina HZ, Brennan MC, Hendrickson PH, and Lichter PR (1992) The ciliary body - the third organ found to synthesize indoleamines in humans. Eur J Ophthalmol 2:67-72.
21. Mastropasqua L, Costagliola C, Ciancaglini M, Carpineto P, and Gallenga PE (1997) Ocular hypotensive effect of ketanserin in patients with primary open angle glaucoma. Acta Ophthalmol Scand Suppl 224:24-25.
22. McBride MC (2000) Bufotenine: toward an understanding of possible psychoactive mechanisms. J Psychoact Drugs 32:321-331.
23. Mehra KS, Roy PN, and Singh R (1974) Pargyline drops in glaucoma. Arch Ophthalmol 92:453-454.
24. 1-agonist 5-CT intraocular pressure in rabbits. Investig Ophthalmol Vis Sci 34:3035-3042.
25. 2 receptor agonist in Suncus murinus. Br J Pharmacol 114:931-934.
26. Osborne NN, Wood JP, Melena J, Chao HM, Nash MS, Bron AJ, and Chidlow G (2000) 5-Hydroxytryptamine1A agonists: potential use in glaucoma. Evidence from animal studies. Eye 14:454-463.
27. Podos SM, Wang RF, Lee PY, and Mittag TW (1999) Effect of WB-4101 on aqueous humor dynamics in monkeys. Investig Ophthalmol Vis Sci 40:S826.
28. 2C receptors in CHO-K1 cells. Br J Pharmacol 128:13-20.
29. Sharif NA, Xu SX, Crider JY, McLaughlin M, and Davis TL (2001) Levobetaxolol (Betaxon™) and other beta-adrenergic antagonists: preclinical pharmacology, IOP-lowering activity and sites of action in human eyes. J Ocul Pharmacol Ther 17:305-317.
30. Shulgin A and Shulgin A (1991) PIHKAL - A Chemical Love Story. Transform Press, Berkeley, CA.
31. Shulgin AT (1973) Stereospecific requirements for hallucinogenesis. J Pharm Pharmacol 25:271-272.
32. Tadano T, Neda M, Hozumi M, Yonezawa A, Arai Y, Fujita T, Kinemuchi H, and Kisara K (1995) Alpha-methylated tryptamine derivatives induce a 5-HT receptormediated head-twitch response in mice. Neuropharmacology 34:229-234.
33. 2 antagonist on intraocular pressure in glaucoma patients. Investig Ophthalmol Vis Sci 36:S734.
34. Tipton KF, McCrodden JM, Kalir AS, and Youdim MBH (1982) Inhibition of rat liver monoamine oxidase by α-methyl- and N-propargyl-amine derivatives. Biochem Pharmacol 31:1251-1255.
35. 11C]labeled PET ligands. Bioorg Med Chem 8:2427-2432.
36. Veglio F, De Sanctis U, Schiavone D, Cavallone S, Mulatero P, Grignolo FM, and Chiandussi L (1998) Evaluation of serotonin levels in human aqueous humor. Ophthalmologica 212:160-163.
37. 2C receptor agonists. Pharmacol Biochem Behav 69:643-652.
38. Wang RF, Lee PY, Mittag TW, Podos SM, and Serle JB (1997) Effect of 5-methyhurapidil, an alpha 1A-adrenergic antagonist and 5-hydroxytryptamine1A agonist, on aqueous humor dynamics in monkeys and rabbits. Curr Eye Res 16:769-775.
39. Weil AT and Davis W (1994) Bufo alvarius: potent hallucinogen of animal origin. J Ethnopharmacol 41:1-8.
40. Weinkam RJ, Gal J, Callery P, and Castagnoli N Jr (1976) Application of chemical ionization mass spectrometry to the study of stereoselective in vitro metabolism of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane. Anal Chem 48:203-209.