Short-term cold exposure may cause a local decrease of neuropeptide Y in the rat hypothalamus

Molecules and Cells

Volumn 23, Issue 1, 2007, Pages 88-93

  Park, Joong Jean ^a   Lee, Heung Kyung ^a   Shin, Min Woo ^a   Kim, Sung Jin ^a   Noh, Seung Yeon ^a   Shin, Jin ^a   Yu, Woo Sung ^a  

^a Korea University College of Medicine   (South Korea)

Author keywords

Arcuate nucleus; C Fos; Hypothalamus; Hypothermia; Neuropeptide Y

Indexed keywords

MESSENGER RNA; NEUROPEPTIDE Y; PROTEIN C FOS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTERIOR HYPOTHALAMUS; ARCUATE NUCLEUS; ARTICLE; BRAIN NERVE CELL; CELL COUNT; COLD EXPOSURE; CONTROLLED STUDY; FEEDING BEHAVIOR; GENE EXPRESSION; HORMONE ACTION; HORMONE SYNTHESIS; HYPOTHALAMUS NUCLEUS; HYPOTHERMIA; MALE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; THERMOGENESIS;

ANIMALS; ARCUATE NUCLEUS; BODY TEMPERATURE REGULATION; DORSOMEDIAL HYPOTHALAMIC NUCLEUS; GENE EXPRESSION REGULATION; HEART RATE; HYPOTHALAMUS; HYPOTHERMIA, INDUCED; MALE; MOTOR ACTIVITY; NEUROPEPTIDE Y; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS;

RATTUS;

EID: 33947394826     PISSN: 10168478     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Baulmann, J., Spitznagel, H., Herdegen, T., Unger, T., and Culman, J. (2000) Tachykinin receptor inhibition and c-Fos expression in the rat brain following formalin-induced pain. Neuroscience 95, 813-820.
2. Bernardis, L. L. and Bellinger, L. L. (1998) The dorsomedial hypothalamic nucleus revisited: 1998 update. Proc. Soc. Exp. Biol. Med. 218, 284-306.
3. Bing, C., Pickavance, L., Wang, Q., Frankish, H., Trayhurn, P., et al. (1997) Role of hypothalamic neuropeptide Y neurons in the defective thermogenic response to acute cold exposure in fatty Zucker rats. Neuroscience 80, 277-284.
4. Bing, C., Frankish, H. M., Pickavance, L., Wang, Q., Hopkins, D. F., et al. (1998) Hyperphagia in cold-exposed rats is accompanied by decreased plasma leptin but unchanged hypothalamic NPY. Am. J. Physiol. 274, R62-68.
5. Cao, W. H., Fan, W., and Morrison, S. F. (2004) Medullary pathways mediating specific sympathetic responses to activation of dorsomedial hypothalamus. Neuroscience 126, 229-240.
6. Egawa, M., Yoshimatsu, H., and Bray, G. A. (1991) Neuropeptide Y suppresses sympathetic activity to interscapular brown adipose tissue in rats. Am. J. Physiol. 260, R328-334.
7. Elias, C. F., Aschkenasi, C., Lee, C., Kelly, J., Ahima, R. S., et al. (1999) Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area. Neuron 23, 775-786.
8. Grove, K. L. and Smith, M. S. (2003) Ontogeny of the hypothalamic neuropeptide Y system. Physiol. Behav. 79, 47-63.
9. Kollack-Walker, S., Don, C., Watson, S. J., and Akil, H. (1999) Differential expression of c-fos mRNA within neurocircuits of male hamsters exposed to acute or chronic defeat. J Neuroendocrinol. 11, 547-559.
10. Kotz, C. M., Briggs, J. E., Grace, M. K., Levine, A. S., and Billington, C. J. (1998) Divergence of the feeding and thermogenic pathways influenced by NPY in the hypothalamic PVN of the rat. Am. J. Physiol. 275, R471-477.
11. B2 receptor mRNAs in the rat brain. Mol. Cells 16, 40-47.
12. Lowell, B. B. and Flier, J. S. (1997) Brown adipose tissue, beta 3-adrenergic receptors, and obesity. Annu. Rev. Med. 48, 307-316.
13. McCarthy, H. D., Kilpatrick, A. P., Trayhurn, P., and Williams, G. (1993) Widespread increases in regional hypothalamic neuropeptide Y levels in acute cold-exposed rats. Neuroscience 54, 127-132.
14. Merchenthaler, I., Lopez, F. J., and Negro-Vilar, A. (1993) Anatomy and physiology of central galanin-containing pathways. Prog. Neurobiol. 40, 711-769.
15. Nagashima, K., Nakai, S., Tanaka, M., and Kanosue, K. (2000) Neuronal circuitries involved in thermoregulation. Auton. Neurosci. 85, 18-25.
16. Najimi, M., Bennis, M., Chigr, F., Kopp, N., Moyse, E., et al. (1999) Benzodiazepine binding sites in the human hypothalamus. Autoradiographic study. J. fur Hirnforschung. 39, 493-502.
17. Nakamura, K., Matsumura, K., Hubschle, T., Nakamura, Y., Hioki, H., et al. (2004) Identification of sympathetic premotor neurons in medullary raphe regions mediating fever and other thermoregulatory functions. J. Neurosci. 24, 5370-5380.
18. Park, J. J., Baum, M. J., and Tobet, S. A. (1997) Sex difference and steroidal stimulation of galanin immunoreactivity in the ferret's dorsal preoptic area/anterior hypothalamus. J. Comp. Neurol. 389, 277-288.
19. Petervari, E., Balasko, M., Uzsoki, B., and Szekely, M. (2006) Effects of neuropeptide Y antagonists on food intake in rats: differences with cold-adaptation. Peptides 27, 150-156.
20. Skofitsch, G. and Jacobowitz, D. M. (1985) Immunohistochemical mapping of galanin-like neurons in the rat central nervous system. Peptides 6, 509-546.
21. Szekely, M., Petervari, E., Pakai, E., Hummel, Z., and Szelenyi, Z. (2005) Acute, subacute and chronic effects of central neuropeptide Y on energy balance in rats. Neuropeptides 39, 103-115.
22. Wouterlood, F. G., Gaykema, R. P., Steinbusch, H. W., Watanabe, T., and Wada, H. (1988) The connections between the septum-diagonal band complex and histaminergic neurons in the posterior hypothalamus of the rat. Anterograde tracing with Phaseolus vulgaris-leucoagglutinin combined with immunocytochemistry of histidine decarboxylase. Neuroscience 26, 827-845.