Role of hypothalamic neuropeptide Y neurons in the defective thermogenic response to acute cold exposure in fatty Zucker rats

Neuroscience

Volumn 80, Issue 1, 1997, Pages 277-284

  Bing, C ^a   Pickavance, L ^a   Wang, Q ^a   Frankish, H ^a   Trayhurn, P ^b   Williams, G ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b ROWETT RESEARCH INSTITUTE   (United Kingdom)

Author keywords

Brown adipose tissue; Hypothalamus; NPY; Obesity; Paraventricular nucleus; Uncoupling protein

Indexed keywords

INSULIN; MESSENGER RNA; NEUROPEPTIDE Y;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BROWN ADIPOSE TISSUE; COLD EXPOSURE; CONTROLLED STUDY; HYPOTHALAMUS; MALE; NONHUMAN; NORTHERN BLOTTING; OBESITY; PRIORITY JOURNAL; RADIOIMMUNOASSAY; RAT; THALAMUS MIDLINE NUCLEUS; THALAMUS VENTRAL NUCLEUS; THERMOGENESIS;

EID: 0030820084     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(97)00121-8     Document Type: Article

References (56)

1. Abe M., Salto M. and Shimazu T. (1989) Neuropeptide Y and norepinephrine injected into the paraventricular nucleus of the hypothalamus activate endocrine pancreas. Biomed. Res. 10, 431-436.
2. Arase K., York D. A., Shimizu H., Shargill N. and Bray G. A. (1988) Effects of corticotropin-releasing factor on food intake and brown adipose tissue thermogenesis in rats. Am. J. Physiol. 255, E255-E259.
3. Ahima R. S., Prabakaran D., Mantzoros C., Qu D., Lowell B., Maratos-Flier E. and Flier J. S. (1996) Role of leptin in the neuroendocrine response to fasting. Nature 382, 250-252.
4. Bai F. L., Yamano M., Shiotani Y., Emson P. C., Smith A. D., Powell J. F. and Tohyama M. (1985) An arcuate-paraventricular and -dorsomedial hypothalamic neuropeptide Y containing system which lacks noradrenaline in the rat. Brain Res. 331, 172-175.
5. Bchini-Hooft-van-Huijsduijnen O. B., Rohner-Jeanrenaud F. and Jeanrenaud B. (1993) Hypothalamic neuropeptide Y messenger ribonucleic acid levels in pre-obese and genetically obese (fa/fa) rats; potential regulation thereof by corticotropin-releasing factor. J. Neuroendocrinol. 5, 381-386.
6. Beck B., Burlet A., Nicolas J. and Burlet C. (1990) Hypothalamic neuropeptide Y in obese Zucker rats: implications in feeding and sexual behaviors. Physiol. Behav. 47, 449-453.
7. Billington C. J., Briggs J. E., Grace H. M. and Levine A. S. (1994) Neuropeptide Y in hypothalamic paraventricular nucleus: a center coordinating energy metabolism. Am. J. Physiol. 266, R1765-R1770.
8. Billington C. J., Briggs J. E., Grace M. and Levine A. S. (1991) Effects of intracerebroventricular injection of neuropeptide Y on energy metabolism. Am. J. Physiol. 260, R321-R327.
9. Bing C., Frankish H. M., Wang Q., Pickavance L., Mitchell L., Keith J., Trayhurn P. and Williams G. (1996) Cold exposure increases uncoupling protein mRNA expression without affecting hypothalamic neuropeptide Y synthesis in wistar rats (Abstract). J. Endocrinol. 148 Suppl., P9.
10. Brander F., Keith J. S. and Trayhurn P. (1993) A 27-mer oligonucleotide probe for the detection and measurement of the mRNA for uncoupling protein in brown adipose tissue of different species. Comp. Biochem. Physiol. B104, 125-131.
11. Bray G. A. (1977) The Zucker-fatty rat: a review. Fedn Proc. 36, 148-153.
12. Bray G. A. (1989) Genetic and hypothalamic mechanisms for obesity - finding the needle in the haystack. Am. J. clin. Nutr. 50, 891-902.
13. Carlisle H. J., Dubuc P. and Stock M. J. (1993) Effects of β-adrenoceptor agonists and antagonists on thermoregulation in the cold in lean and obese Zucker rats. Pharmac. Biochem. Behav. 46, 953-958.
14. Castonguay T. W., Hartman W. J., Fitzpatrick E. A. and Stern J. S. (1982) Dietary self-selection and the Zucker rat. J. Nutr. 112, 796-800.
15. Chua S. C. Jr., White D. W., Wu-Peng S., Liu S. M., Okada N., Kershaw E. E., Chung W. K., Power-Kehoe L., Chua M., Tartaglia L. and Leibel R. L. (1996) Phenotypes of fatty due to Gln269 Pro mutation in the leptin receptor (Lepr). Diabetes 45, 1141-1143.
16. Cleary M. P., Vasselli J. R. and Greenwood M. R. C. (1980) Development of obesity in the Zucker obese (fa/fa) rat in absence of hyperphagia. Am. J. Physiol. 238, E284-E292.
17. Dryden S., Pickavance L., Frankish H. M. and Williams G. (1995) Increased neuropeptide Y secretion in the hypothalamic paraventricular nucleus of obese (fa/fa) Zucker rats. Brain Res. 690, 185-188.
18. Egawa M., Yoshimatsu H. and Bray G. A. (1991) Neuropeptide Y suppresses sympathetic activity to intrascapular brown adipose tissue in rats. Am. J. Physiol. 260, R328-R334.
19. Esteban J., Chova A. J., Sanchez P. A., Mico J. A. and Gilbert-Ranola J. (1989) Central administration of neuropeptide Y induces hypothermia in mice: possible interactions with central noradrenergic systems. Life Sci. 45, 2395-2398.
20. Frankish H. M., Dryden S., Hopkins D., Wang Q. and Williams G. (1995) Neuropeptide Y, the hypothalamus and diabetes: insights into the central control of metabolism. Peptides 16, 757-771.
21. Foster D. O. and Frydman M. L. (1978) Non-shivering thermogenesis in the rat. 2: Measurement of blood flow with microspheres point to brown adipose tissue as the dominant site of the calorigenesis induced by noradrenaline. Can. J. Physiol. 56, 110-112.
22. Giraudo S. Q., Kotz C.M., Grace M. K., Levine A. S. and Billington C. J. (1994) Rat hypothalamic NPY mRNA and brown fat uncoupling protein mRNA after high-carbohydrate or high-fat diets. Am. J. Physiol. 266, R1578-R1583.
23. Godbole V. Y., York D. A. and Bloxham D. P. (1978) Developmental changes in the fatty (fa/fa) rat: evidence for defective thermogenesis preceding the hyperlipogenesis and hyperinsulinaemia. Diabetologia 15, 41-44.
24. Himms-Hagen J. (1984) Non-shivering thermogenesis. Brain Res. Bull. 12, 151-160.
25. Himms-Hagen J. (1989) Brown adipose tissue thermogenesis and obesity. Prog. Lipid Res. 28, 67-115.
26. Holt S. J., Wheal H. V. and York D. A. (1987) Hypothalamic control of brown adipose tissue thermogenesis in Zucker lean and obese rats. Effects of electrical stimulation of the ventromedial nucleus and other hypothalamic centres. Brain Res. 405, 227-233.
27. Holt S., York A. and Fitzsimons T. R. (1983) The effects of corticosterone, cold exposure and overfeeding with sucrose on brown adipose tissue of obese Zucker rats (fa/fa). Biochem. J. 214, 215-223.
28. Iida M., Murakami T., Ishida K., Mizuno A., Kuwajima M. and Shima K. (1996) Phenotype-linked amino acid alteration in leptin receptor cDNA from Zucker fatty (fa/fa) rat. Biochem. biophys. Res. Commun. 222, 19-21.
29. Ikeda H., West D. B. and Pustek J. J. (1986) Intraventricular insulin reduces food intake and body weight of lean but not obese Zucker rats. Appetite 1, 381-386.
30. Jones P. M., Pierson A. M., Williams G., Ghatei M. A. and Bloom S. R. (1992) Increased hypothalamic neuropeptide Y messenger RNA in two rat models of diabetes. Diabetic Med. 9, 76-80.
31. Lee H. C., Curry D. L. and Stern J. S. (1989) Direct effect of CNS on insulin hypersecretion in obese Zucker rats: involvement of vagus nerve. Am. J. Physiol. 256, E439-E444.
32. Levin B. E., Triscari J. and Sullivan A. C. (1980) Abnormal sympathoadrenal function and plasma catecholamines in obese Zucker rats. Pharmac. Biochem. Behav. 13, 107-113.
33. Levin B. E., Triscari J. and Sullivan A. C. (1982) Sympathetic activity in thyroid-treated Zucker rats. Am. J. Physiol. 243, R170-R178.
34. McCarthy H. D., Kilpatrick A. P., Trayhurn P. and Williams G. (1993) Widespread increases in regional hypothalamic neuropeptide Y levels in acute cold-exposed rats. Neuroscience 54, 127-132.
35. McCarthy H. D., McKibbin P. E., Holloway B., Mayers R. and Williams G. (1991) Hypothalamic neuropeptide Y receptor characteristics and NPY-induced feeding responses in lean and obese Zucker rats. Life Sci. 49, 1491-1497.
36. McKibbin P. E., Cotton S. J., McMillan S., Holloway B., Mayers R., McCarthy H. D. and Williams G. (1991) Altered neuropeptide Y concentrations in specific hypothalamic regions of obese (fa/fa) Zucker rats. Diabetes 40, 1423-1429.
37. Morioka H., Inui A., Ooya K., Suenaga M., Mizuro N. and Baba S. (1984) Effects of intracerebroventricular injection of neuropeptide Y (NPY), peptide Y (PYY) and pancreatic polypeptide (PP) on thermoregulation in conscious canine (Abstract). Dig. Dis. Sci. 29, 555.
38. Nicholls D. G., Cunningham S. A. and Eduardo R. (1986) The bioenergetic mechanisms of brown adipose tissue mitochondria. In Brown Adipose Tissue (eds Trayhurn P. and Nicholls D. G.), pp. 52-85. Edward Arnold, London.
39. Onai T., Kilroy G., York D. A. and Bray G. A. (1995) Regulation of beta 3-adrenergic receptor mRNA by sympathetic nerves and glucocorticoids in BAT of Zucker obese rats. Am. J. Physiol. 269, R519-R526.
40. Penicaud L., Fere P., Terretaz J., Kinebanyan M. F., Leturque A., Dore E., Girard J., Jeanrenaud B. and Picon L. (1987) Development of obesity in Zucker rats: early insulin resistance in muscles but normal sensitivity in white adipose tissue. Diabetes 36, 626-631.
41. Rohner-Jeanrenaud F. and Jeanrenaud B. (1985) Involvement of the cholinergic system in insulin and glucagon oversecretion of genetic pre-obesity. Endocrinology 116, 830-834.
42. Rohner-Jeanrenaud F., Greco Perotta R. and Jeanrenaud B. (1989) Central CRF administration prevents excess body weight gain in genetic obese rats. Endocrinology 124, 733-739.
43. Rothwell N. J. and Stock M. J. (1982) Effects of feeding a palatable "cafeteria" diet on energy balance in young and adult lean (+/?) Zucker rats. Br. J. Nutr. 47, 461-472.
44. Sanacora G., Kershaw M., Finkelstein J. A. and White J. D. (1990) Increased hypothalamic content of preproneuropeptide Y messenger ribonucleic acid in genetically obese Zucker rats and its regulation by food deprivation. Endocrinology 127, 730-737.
45. Schwartz M. W., Marks J. L., Sipols A. J., Baskin D. G., Woods S. C., Kahn S. E. and Porte D. (1991) Central insulin administration reduces NPY mRNA expression in the arcuate nucleus of food deprived lean (Fa/Fa) but not obese (fa/fa) Zucker rats. Endocrinology 128, 2645-2647.
46. Schwartz M. W., Seeley R. J., Campfield L. A., Burn P. and Baskin D. G. (1996) Identification of targets of leptin action in rat hypothalamus. J. clin. Invest. 98, 1101-1106.
47. Schwartz M. W., Figlewicz D. P., Baskin D. G., Woods S. C. and Porte D. (1992) Insulin in the brain: a hormonal regulator of energy balance. Endocrin. Rev. 13, 387-414.
48. Stanley B. G., Kyrkouli S. E., Lampert S. and Leibowitz S. F. (1986) Neuropeptide Y chronically injected into the hypothalamus: a powerful neurochemical inducer of hyperphagia and obesity. Peptides 7, 1189-1192.
49. Stephens T. W., Basinski M., Bristow P. K., Bue-Valleskey J. M., Burgett S. G., Craft L., Hale J., Hoffmann J., Hsing N. H., Kriaciunas A., MaKellar W., Rosteck P. R., Schoner B., Smith D., Tinsley F. C., Zhang X. Y. and Heiman M. (1995) The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature 377, 530-532.
50. Trayhurn P. and Duncan J. S. (1994) Rapid chemiluminescent detection of the mRNA for uncoupling protein in brown adipose tissue by Northern hybridization with a 32-mer oligonucleotide end-labelled with digoxigenin. Int. J. Obesity 18, 449-452.
51. Trayhurn P., Duncan J. S. and Rayner D. V. (1995) Acute cold-induced suppression of ob (obese) gene expression in white adipose tissue of mice: mediation by the sympathetic system. Biochem. J. 311, 729-733.
52. Trayhurn P., Turlby P. L. and James W. P. T. (1976) A defective response to cold in the obese (ob/ob) mouse and the obese Zucker (fa/fa) rat. Proc. Nutr. Soc. 35, 133A.
53. Triandafillou J. and Himms-Hagen J. (1983) Normal cold-but defective diet-induced activation on brown adipose tissue mitochondria in genetically obese (fa/fa) rats. Am. J. Physiol. 244, E145-E150.
54. Wang Q., Bing C., Al-Barazanji K., Mossakowaska D. E., Wang X., McBay D. L., Neville W. A., Pickavance L., Dryden S., Thomas M. E. A., Wilson S., Buckingham R., Arch J. R. S., Trayhurn P. and Williams G. (1996) Interactions between the ob gene product leptin and hypothalamic neuropeptide Y neurons in the control of food intake and energy homeostasis. Diabetes (in press).
55. Williams G., Gill J. S., Lee Y. C., Cardoso H. M., Okpere B. E. and Bloom S. R. (1989) Increased neuropeptide Y concentrations in specific hypothalamic regions of streptozocin-induced diabetic rats. Diabetes 38, 3321-3327.
56. Williams G., Steel J. H., Cardoso M. A., Ghatei M. A., Lee Y. C., Gill J. S., Burrin J. M., Polak J. M. and Bloom S. R. (1988) Increased hypothalamic neuropeptide Y concentrations in diabetic rat. Diabetes 37, 763-772.