Benzodiazepine Binding Sites in the Human Hypothalamus. Autoradiographic study

Journal of Brain Research

Volumn 39, Issue 4, 1999, Pages 493-502

  Najimi, Mohamed ^a   Bennis, M ^b   Chigr, F ^a,b   Kopp, N ^c   Moyse, E ^c   Miachon, S ^d  

^a SULTAN MOULAY SLIMANE UNIVERSITY   (Morocco)

^b FACULTÉ DES SCIENCES SEMLALIA   (Morocco)

^c UNIVERSITÉ LYON 1   (France)

^d INSERM   (France)

Author keywords

Benzodiazepines; Binding sites; Human; Hypothalamus

Indexed keywords

BENZODIAZEPINE DERIVATIVE; BENZODIAZEPINE RECEPTOR AFFECTING AGENT; FLUNITRAZEPAM; TRITIUM;

ADULT; AGED; ARTICLE; AUTORADIOGRAPHY; BINDING COMPETITION; BINDING SITE; CELL COUNT; CYTOLOGY; FEMALE; HUMAN; HYPOTHALAMUS; MALE; MAMMILLARY BODY; METABOLISM; MIDDLE AGED; PREOPTIC AREA; SEPTUM NUCLEUS;

ADULT; AGED; AGED, 80 AND OVER; AUTORADIOGRAPHY; BENZODIAZEPINES; BINDING SITES; BINDING, COMPETITIVE; CELL COUNT; FEMALE; FLUNITRAZEPAM; GABA MODULATORS; HUMANS; HYPOTHALAMUS; MALE; MAMILLARY BODIES; MIDDLE AGED; PREOPTIC AREA; SEPTAL NUCLEI; TRITIUM;

EID: 0345913410     PISSN: 09448160     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. BARNEA, E. R., FARES, F. and GAVISH, M.: Modulatory action of benzodiazepines in human term placental steroidogesis in vitro. Moll. Cell. Endocrinol. 64, 155-159 (1989).
2. BARRY, J.: Immunofluorescence study of LRF neurons in man. Cell. Tiss. Res. 181, 1-14 (1978).
3. BRAAK, H. and BRAAK, E.: The hypothalamus of the human adult: chiasmatic region. Anat. Embryol. 176, 315-330 (1987).
4. BRAESTRUP, C., ALBRECHTSEN, R. and SQUIRES, R. F.: High densities of benzodiazepine receptors in human cortical areas. Nature 269, 702-704 (1977).
5. CHUGANI, H. T. and OLSEN, R. W.: Benzodiazepine/GABA receptor binding in vitro and in vivo in analysis of clinical disorders, chapter 15 in: VENTER, J. C. and OLSEN, R. W. (Eds): Benzodiazepine/GABA receptors and chloride channels: structural and functional properties. Alan R. Liss, Inc., New York, 1986.
6. CORDA, M. G., GIORGI, O., UONGINI, B., ONGINI, E., BARNETT, A., MONTALDO, S. and BIGGIO, G.: Gamma aminobutyric acid and pentobarbital enhance 2-[3H] oxoquazepam binding to type I benzodiaezpine recognition sites in rat and human brain. J. Neurochem. 50, 681-687 (1988).
7. DE SOUZA, E. B.: Neuroendocrine effects of benzodiazepines. J. Psychiatr. Res. 24, 111-119 (1990).
8. DENNIS, T., DUBOIS, A., BENAVIDES, J. and SCATTON, B.: Distribution of central omega 1 (Benzodiazepine1) and omega 2 (Benzodiazepine2) receptors subtypes in the monkey and human brain. An autoradiographic study with [3H] flunitrazepam and the omega 1 selective ligand [3H] zolpidem. J. Pharmacol. Exp. Ther. 247, 309-322 (1988).
9. DIEPEN, D.: Der Hypothalamus. In: Handbuch der Microskopischen Anatomie des Menschen, Springer, Berlin, 1962.
10. DIERICKX, K. and VANDERSANDE, F.: Immunocytochemical localization of the vasopressinergic and the oxytocinergic neurons in the human hypthalamus. Cell. Tiss. Res. 184, 15-27 (1977).
11. EYMIN, C., KOPP, N., LAURENT, B., MARTIN, D., SIMON, L. and MIACHON, -S.: Central benzodiazepine binding sites in human cerebral structures associated with memory processes. Dementia 3, 232-238 (1992).
12. FAULL, R. L. M. and VILLIGER, J. W.: Benzodiazepine receptors in the human spinal cord: a detailed anatomical and pharmacological study. Neuroscience 17, 791-802 (1986a).
13. FAULL, R. L. M. and VILLIGER, J. W.: Heterogeneous distribution of benzodiazepine receptors in the human striatum: a quantitative autoradiographic study comparing the pattern of receptor labelling with the distribution of acetylcholinesterase staining. Brain Res. 381, 153-158 (1986b).
14. FAULL R. L. M., VILLIGER, J. W. and HOLFORD, N. H. G.: Benzodiazepine receptors in the human cerebellar cortex: a quantitative autoradiographic and pharmacological study demonstrating the predominance of type I receptors. Brain Res. 411, 379-385 (1987).
15. FAULL R. L. M. and VILLIGER, J. W.: Multiple benzadiazepine receptors in the human basal ganglia: a detailed pharmacological and anatomical study Neuroscience 24, 433-451 (1988).
16. GRANDISON, L.: Actions of benzodiazepines on the neuroendocrine system. Neuropharmacology 22, 1505-1510 (1983).
17. GRIFFITHS, P. D., PERRY, R. H. and CROSSMAN, A. R.: A detailed anatomical anlysis of neurotransmitter receptors in the putamen and caudate in Parkinson's disease and Alzheimer's disease. Neurosci Lett. 169, 68-72 (1994).
18. HEBEBRAND, J., FRIEDL, W., KESSLER, K., HEWING, M. and PROPPING, P.: Further characterization of the avian benzodiazepine receptor subunits including phylo-and ontogenetic aspects. J. Neurochem. 49, 1888-1893 (1987).
19. JANSEN, K. L., FAULL, R. L., DRAGUNOW, M. and SYNEK, B. L.: Alzheimer's disease: changes in hippocampal N-methyl-Daspartate, quisqualate, neurotensin, adenosine, benzodiazepine, serotonin and opioid receptors. An autoradiographic study. Neuroscience 39, 613-627 (1990).
20. JANSEN, K. L., FAULL, R. L., DRAGUNOW, M. and LESLIE, R. A.: Distribution of excitatory and inhibitory amino acid, sigma, monoamine, catecholamine, acetylcholine, opioid, neurotensin, substance P, adenosine and neuropeptide Y receptors in human motor and somatosensory cortex. Brain Res. 566, 225-238 (1991).
21. KORNEYEV, A. Y.: The role of the hypothalamic-pituitary-adrenocortical axis in memory-related effects of anxiolytics. Neurobiol. Learn. Mem. 67, 1-13 (1997).
22. LI, S. and PELLETIER, G.: Inhibitory effect of the endogenous benzodiazepine receptor ligand, octadecaneuropeptide (ODN), on gonadotropin-releasing hormone gene expression in the male rat brain. Neuroreport 6, 1354-1356 (1995).
23. LAKIC, L. N., PEICIC, D. and MANEV, H.: Mechanisms by which picrotoxin and a high dose of diazepam elevate plasma corticosterone level. Neuroendocrinol 43, 331-335 (1986).
24. LOWRY, O. H., ROSEBROWGH, N. J., PARR, A. L. and RANDALL, R. G.: Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193, 265-275 (1951).
25. MALOTEAUX, J. M., OCTAVE, J. N., VANISBERG, M. A., KOLLMANN, P., ACKERMANS, A. and LATERRE, C.: Benzodiazepine receptors in human brain: characterization, subcellular localization and solubilization. Prog. Neuropsychopharmacol Biol. Psychiatry 12, 773-782 (1988).
26. MANCHON, M., KOPP N, BOBILLIER, P, MIACHON, S.:- Autoradiography and quantitative study of benzodiazepine-binding sites in human hippocampus. Neurosci Lett. 62, 25-30 (1985).
27. MANNISTO, P. T., LAAKSO, M. L., JARVINEN, A. and RAGO, L.: Effects of central and peripheral type benzodiazepine ligands on growth hormone and gonadotropin secretion in male rats. Pharmacol. Toxicol. 71, 75-80 (1992).
28. MOHLER, H. and OKADA, T.: The benzodiazepine receptor in normal and pathological human brain. Br. J. Psychiat. 133, 261-268 (1978).
29. NAJIMI, M., CHIGR, F., JORDAN, D., LEDUQUE, P., BLOCH, B., TOMMASI, M., REBAUD, P. and KOPP, N.: Anatomical distribution of LH-RH immunoreactive neurons in the human infant hypothalamus and extrahypothalamic regions. Brain Res. 516, 280-291 (1990).
30. NAJIMI, M., JORDAN, D., CHIGR, F., CHAMPIER, J., KOPP, N., SLAMA, A., BERTHERAT, J., VIDEAU, C. and EPELBAUM, J.: Regional distribution of somatostatin binding sites in the human hypothalamus: a quantitative autoradiographic study. Neuroscience. 40, 321-335 (1991a).
31. NAJIMI, M., CHIGR, F., CHAMPIER, J., TABIB, A., KOPP, N. and JORDAN, D.: Autoradiographic distribution of TRH binding sites in the human hypothalamus. Brain Res. 563, 66-76 (1991b).
32. NIEHOFF, D. L. and WHITEHOUSE, P. J.: Multiple benzodiazepine receptors: autoradiographic localization in normal human amygdala. Brain Res. 276, 237-245 (1983).
33. RICHARDS, J. G., GLINZ, R., SCHOCH, P. and MÖHLER, H.: New trends in mapping benzodiazepine receptors. In: BIGGIO, B. and COSTA, E. (Eds.): Neurotransmitters and Drugs: Raven Press, New York, 1988.
34. SARRIEAU, A., NAJIMI, M., CHIGR, F., KOPP, N., JORDAN, D. and ROSTÈNE, W.: Localization and developmental pattern of vasoactive intestinal polypeptide binding sites in the human hypothalamus. Synapse 17, 129-140 (1994).
35. 3H] flunitrazepam. Life Sci. 22, 859-866 (1978).
36. UNNERSTALL, J. R., KUHAR, M. J., NIEHOFF, D. L. and PALACIOS, J. M.: Benzodiazepine receptors are coupled to a subpopulation of d-aminobutyric acid (GABA) receptors: evidence from a quantitative autoradiographic study. J. Pharmacol. Exp. Ther. 218-797 (1981).
37. WHITEHOUSE, P. J., LYNCH, D. and KUHAR, M. J.: Effects of postmortem delay and temperature on neurotransmitter receptor binding in rat model of human autopsy process. J. Neurochem. 43, 553-559 (1984).
38. YAGI, K. and ONAKA, T.: A benzodiazepine, chlordiazepoxide, blocks vasopressin and oxytocin release after foot shocks but not osmotic stimulus in the rat. Neurosci. Lett. 203, 49-52 (1996).
39. YOUNG, W. and KUHAR, M. J.: Autoradiographic localization of benzodiazepine receptors in the brains of humans and animals. Nature 280, 393-395 (1979).
40. ZEZULA, J., CORTES, R., PROBST, A. and PALACIOS, J. M.: Benzodiazepine receptor sites in the human brain: Autoradiographic mapping. Neuroscience 25, 771-795 (1988).