SCAM analysis reveals a discrete region of the pore turret that modulates slow inactivation in Kv1.5

American Journal of Physiology - Cell Physiology

Volumn 292, Issue 3, 2007, Pages

  Eduljee, Cyrus ^a   Claydon, Thomas W ^a   Viswanathan, Vijay ^a   Fedida, David ^a   Kehl, Steven J ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Electrophysiology; Substituted cysteine accessibility method; Voltage gated potassium channels

Indexed keywords

[2 (TRIMETHYLAMMONIUM)ETHYL]METHANETHIOSULFONATE BROMIDE; BROMINE DERIVATIVE; CYSTEINE; POTASSIUM; POTASSIUM CHANNEL KV1.5; SODIUM (2 SULFONATOETHYL)METHANETHIOSULFONATE; SULFONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; DEPOLARIZATION; ELECTRICITY; ELECTROPHYSIOLOGY; HUMAN; HUMAN CELL; MUTANT; NUCLEOTIDE SEQUENCE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTON TRANSPORT;

AMINO ACID SUBSTITUTION; CELL LINE; CYSTEINE; HUMANS; ION CHANNEL GATING; KIDNEY; KV1.5 POTASSIUM CHANNEL; MEMBRANE POTENTIALS; MUTAGENESIS, SITE-DIRECTED; POROSITY; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33947324979     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00274.2006     Document Type: Article

References (53)

1. + channel revealed by the NMR-derived structures of scorpion toxins. Neuron 15: 1181, 1995.
2. Akabas MH, Stauffer DA, Xu M, Karlin A. Acetylcholine receptor channel structure probed in cysteine-substitution mutants. Science 258: 307-310, 1992.
3. Andalib P, Consiglio JF, Trapani JG, Korn SJ. The external TEA binding site and C-type inactivation in voltage-gated potassium channels. Biophys J 87: 3148-3161, 2004.
4. +]: a tale of two inactivation mechanisms. Neuron 15: 951-960, 1995.
5. + channel. Science 271: 653-656, 1996.
6. + channel. Nat Struct Biol 7: 309-311, 2000.
7. Choi WS, Khurana A, Mathur R, Viswanathan V, Steele DF, Fedida D. Kv1.5 surface expression is modulated by retrograde trafficking of newly endocytosed channels by the dynein motor. Circ Res 97: 363-371, 2005.
8. + channel Kv1.4 by acidosis: protonaton of an extracellular histidine slows the recovery from N-type inactivation. J Physiol 526: 253-264, 2000.
9. Cordero-Morales JF, Cuello LG, Perozo E. Voltage-dependent gating at the KcsA selectivity filter. Nat Struct Mol Biol 13: 319-322, 2006.
10. Cordero-Morales JF, Cuello LG, Zhao Y, Jogini V, Cortes DM, Roux B, Perozo E. Molecular determinants of gating at the potassium-channel selectivity filter. Nat Struct Mol Biol 13: 311-318, 2006.
11. Coulter KL, Perier F, Radeke CM, Vandenberg CA. Identification and molecular localization of a pH-sensing domain for the inward rectifier potassium channel HIR. Neuron 15: 1157-1168, 1995.
12. Dodier Y, Banderali U, Klein H, Topalak O, Dafi O, Simoes M, Bernatchez G, Sauve R, Parent L. Outer pore topology of the ECaC-TRPV5 channel by cysteine scan mutagenesis. J Biol Chem 279: 6853-6862, 2004.
13. + conduction and selectivity. Science 280: 69-77, 1998.
14. Ebeling W, Hennrich N, Klockow M, Metz H, Orth HD, Lang H. Proteinase K from Tritirachium album Limber. Eur J Biochem 47: 91-97, 1974.
15. + (Abstract). Biophys J 84: 221a, 2003.
16. Elinder F, Arhem P. Role of individual surface charges of voltage-gated K channels. Biophys J 77: 1358-1362, 1999.
17. Fedida D, Bouchard R, Chen FS. Slow gating charge immobilization in the human potassium channel Kv1.5 and its prevention by 4-aminopyridine. J Physiol 494: 377-387, 1996.
18. Fedida D, Maruoka ND, Lin S. Modulation of slow inactivation in human cardiac Kv1.5 channels by extra- and intracellular permeant cations. J Physiol 515: 315-329, 1999.
19. Heinemann SH, Rettig J, Graack HR, Pongs O. Functional characterization of Kv channel beta-subunits from rat brain. J Physiol 493: 625-633, 1996.
20. Holmgren M, Liu Y, Xu Y, Yellen G. On the use of thiol-modifying agents to determine channel topology. Neuropharmacology 35: 797-804, 1996.
21. Hoshi T, Zagotta WN, Aldrich RW. Biophysical and molecular mechanisms of Shaker potassium channel inactivation. Science 250: 533-538, 1990.
22. + channels: effects of alterations in the carboxy-terminal region. Neuron 7: 547-556, 1991.
23. Jäger H, Grissmer S. Regulation of a mammalian Shaker-related potassium channel, hKv1.5, by extracellular potassium and pH. FEBS Lett 488: 45-50, 2001.
24. Jurman ME, Boland LM, Liu Y, Yellen G. Visual identification of individual transfected cells for electrophysiology using antibody-coated beads. Biotechniques 17: 876-881, 1994.
25. 2+. J Physiol 541: 9-24, 2002.
26. Kitaguchi T, Sukhareva M, Swartz KJ. Stabilizing the closed S6 gate in the Shaker Kv channel through modification of a hydrophobic seal. J Gen Physiol 124: 319-332, 2004.
27. + channel probed by sulfhydryl-specific reagents after cysteine-scanning mutagenesis. Biophys J 68: 900-905, 1995.
28. Kwan DC, Fedida D, Kehl SJ. Single channel analysis reveals different modes of Kv1.5 gating behaviour regulated by changes of external pH. Biophys J 90: 1212-1222, 2006.
29. Laine M, Lin MC, Bannister JP, Silverman WR, Mock AF, Roux B, Papazian DM. Atomic proximity between S4 segment and pore domain in Shaker potassium channels. Neuron 39: 467-481, 2003.
30. + channels. Neuron 27: 573-583, 2000.
31. Leicher T, Bahring R, Isbrandt D, Pongs O. Coexpression of the KCNA3B gene product with Kv1.5 leads to a novel A-type potassium channel. J Biol Chem 273: 35095-35101, 1998.
32. + channel. Science 309: 897-903, 2005.
33. Long SB, Campbell EB, MacKinnon R. Voltage sensor of Kv1.2: structural basis of electromechanical coupling. Science 309: 903-908, 2005.
34. + channel. J Gen Physiol 112: 377-389, 1998.
35. López-Barneo J, Hoshi T, Heinemann SH, Aldrich RW. Effects of external cations and mutations in the pore region on C-type inactivation of Shaker potassium channels. Receptors Channels 1: 61-71, 1993.
36. Ogielska EM, Zagotta WN, Hoshi T, Heinemann SH, Haab J, Aldrich RW. Cooperative subunit interactions in C-type inactivation of K channels. Biophys J 69: 2449-2457, 1995.
37. + channels. J Gen Physiol 110: 579-589, 1997.
38. + channels. J Gen Physiol 116: 181-190, 2000.
39. + channel. Proc Natl Acad Sci USA 89: 2466-2470, 1992.
40. + channels. Pflügers Arch 437: 865-870, 1999.
41. + channels. Neuron 11: 353-358, 1993.
42. Schlief T, Schönherr R, Heinemann SH. Modification of C-type inactivating Shaker potassium channels by chloramine-T. Pflügers Arch 431: 483-493, 1996.
43. Trapani JG, Korn SJ. Effect of external pH on activation of the Kv1.5 potassium channel. Biophys J 84: 195-204, 2003.
44. + channels. Biophys J 82: 234e, 2002.
45. Yang Y, Yan Y, Sigworth FJ. How does the W434F mutation block current in Shaker potassium channels? J Gen Physiol 109: 779-789, 1997.
46. Yeh BI, Sun TJ, Lee JZ, Chen HH, Huang CL. Mechanism and molecular determinant for regulation of rabbit transient receptor potential type 5 (TRPV5) channel by extracellular pH. J Biol Chem 278: 51044-51052, 2003.
47. + channel allows inactivation to be modulated by metal binding. Biophys J 66: 1068-1075, 1994.
48. + channel. Cell 111: 231-239, 2002.
49. Zagotta WN, Hoshi T, Aldrich RW. Restoration of inactivation in mutants of Shaker potassium channels by a peptide derived from ShB. Science 250: 568-571, 1990.
50. Zagotta WN, Hoshi T, Dittman J, Aldrich RW. Shaker potassium channel gating. II. Transitions in the activation pathway. J Gen Physiol 103: 279-319, 1994.
51. +-free solutions at physiological pH. Cell Biochem Biophys 43: 221-230, 2005.
52. 2+ in human Kv1.5 potassium channels. J Physiol 532: 349-358, 2001.
53. Zhou M, Morais-Cabral JH, Mann S, MacKinnon R. Potassium channel receptor site for the inactivation gate and quaternary amine inhibitors. Nature 411: 657-661, 2001.