Single channel analysis reveals different modes of Kv1.5 gating behavior regulated by changes of external pH

Biophysical Journal

Volumn 90, Issue 4, 2006, Pages 1212-1222

  Kwan, Daniel C H ^a   Fedida, David ^a   Kehl, Steven J ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

VOLTAGE GATED POTASSIUM CHANNEL; HISTIDINE; POTASSIUM CHANNEL KV1.5;

ACIDIFICATION; ANIMAL CELL; ARTICLE; CHANNEL GATING; CLUSTER ANALYSIS; CONTROLLED STUDY; DEPOLARIZATION; MOUSE; NONHUMAN; PH MEASUREMENT; REDUCTION; VOLTAGE CLAMP; ANIMAL; CELL LINE; CHEMISTRY; ELECTROPHYSIOLOGY; PATCH CLAMP; PH; PHYSIOLOGY;

ANIMALIA;

ANIMALS; CELL LINE; ELECTROPHYSIOLOGY; HISTIDINE; HYDROGEN-ION CONCENTRATION; ION CHANNEL GATING; KV1.5 POTASSIUM CHANNEL; MICE; PATCH-CLAMP TECHNIQUES;

EID: 33645778112     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1529/biophysj.105.068577     Document Type: Article

References (31)

1. + channel current. Circ. Res. 73:210-216.
2. + current in cultured adult human atrial myocytes. Circ. Res. 80:572-579.
3. 2+. J. Physiol. 541:9-24.
4. Lopez-Barneo, J., T. Hoshi, S. H. Heinemann, and R. W. Aldrich. 1993. Effects of external cations and mutations in the pore region on C-type inactivation of Shaker potassium channels. Receptors Channels. 1:61-71.
5. +-free external medium evokes a slowly rising phase of current. Biophys. J. 86:534a. (Abstr.).
6. Steidl, J. V., and A. J. Yool. 1999. Differential sensitivity of voltage-gated potassium channels Kv1.5 and Kv1.2 to acidic pH and molecular identification of pH sensor. Mol. Pharmacol. 55:812-820.
7. + current inhibition. J. Gen. Physiol. 121:215-225.
8. + channel Kv1.5. J. Physiol. 523:575-591.
9. Hoshi, T., W. N. Zagotta, and R. W. Aldrich. 1994. Shaker potassium channel gating. I: Transitions near the open state. J. Gen. Physiol. 103:249-278.
10. Saftenku, E., A. J. Williams, and R. Sitsapesan. 2001. Markovian models of low and high activity levels of cardiac ryanodine receptors. Biophys. J. 80:2727-2741.
11. Gibbons, J. D. 1985. Nonparametric Methods for Quantitative Analysis. American Sciences Press, Columbus, OH.
12. Horn, R., and C. A. Vandenberg. 1984. Statistical properties of single sodium channels. J. Gen. Physiol. 84:505-534.
13. Horn, R., C. A. Vandenberg, and K. Lange. 1984. Statistical analysis of single sodium channels. Effects of N-bromoacetamide. Biophys. J. 45:323-335.
14. Plummer, M. R., and P. Hess. 1991. Reversible uncoupling of inactivation in N-type calcium channels. Nature. 351:657-659.
15. Nilius, B. 1988. Modal gating behavior of cardiac sodium channels in cell-free membrane patches. Biophys. J. 53:857-862.
16. Zar, J. H. 1984. Biostatistical Analysis. Prentice-Hall, Englewood Cliffs, NJ.
17. Schoppa, N. E., and F. J. Sigworth. 1998. Activation of Shaker potassium channels. I. Characterization of voltage-dependent transitions. J. Gen. Physiol. 111:271-294.
18. 2+. Biophys. J. 86:2238-2250.
19. +. Biophys. J. 80:2704-2714.
20. Colquhoun, D., and F. J. Sigworth. 1995. Fitting and statistical analysis of single-channel records. In Single Channel Recording. B. Sakmann and E. Neher, editors. Plenum Press, New York. 483-587.
21. Starkus, J. G., Z. Varga, R. Schonherr, and S. H. Heinemann. 2003. Mechanisms of the inhibition of Shaker potassium channels by protons. Pflugers Arch. 447:44-54.
22. Trapani, J. G., and S. J. Korn. 2003. Effect of external pH on activation of the Kv1.5 potassium channel. Biophys. J. 84:195-204.
23. + channels. J. Gen. Physiol. 110:579-589.
24. Zagotta, W. N., T. Hoshi, J. Dittman, and R. W. Aldrich. 1994. Shaker potassium channel gating. II: Transitions in the activation pathway. J. Gen. Physiol. 103:279-319.
25. 2-terminal inactivation peptide binding to C-type-inactivated Kv channels. J. Gen. Physiol. 123:505-520.
26. Schoppa, N. E., and F. J. Sigworth. 1998. Activation of Shaker potassium channels. III. An activation gating model for wild-type and V2 mutant channels. J. Gen. Physiol. 111:313-342.
27. Zagotta, W. N., T. Hoshi, and R. W. Aldrich. 1994. Shaker potassium channel gating. III: Evaluation of kinetic models for activation. J. Gen. Physiol. 103:321-362.
28. + channel. Am. J. Physiol. Cell Physiol. 283:C1114-C1121.
29. + channel. Proc. Natl. Acad. Sci. USA. 89:2466-2470.
30. Eduljee, C., D. Chiang, D. Fedida, and S. J. Kehl. 2004. Inactivation and external potassium-dependent of the hKv1.5 channel can be modulated by altering the biophysical properties of the turret residue at position 463. Biophys. J. 86:534a. (Abstr.).
31. Yang, Y., Y. Yan, and F. J. Sigworth. 1997. How does the W434F mutation block current in Shaker potassium channels? J. Gen. Physiol. 109:779-789.