Comparative structural and functional analysis of photoreceptor neurons of Rho-/- mice reveal increased survival on C57BL/6J in comparison to 129Sv genetic background

Visual Neuroscience

Volumn 18, Issue 3, 2001, Pages 437-443

  Humphries, Marian M ^a   Kiang, Sophie ^a   McNally, Niamh ^a   Donovan, Mary Anne ^b   Sieving, Paul A ^c   Bush, Ronald A ^c   Machida, Shigeki ^c   Cotter, Thomas ^b   Hobson, Audrey ^a   Farrar, Jane ^a   Humphries, Pete ^a   Kenna, Paul ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b UNIVERSITY COLLEGE CORK   (Ireland)

^c UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Electroretinogram; Genetic backgrounds; Modifiers; Mouse rhodopsin knockout

Indexed keywords

DNA; RHODOPSIN;

AMPLITUDE MODULATION; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; DISEASE SEVERITY; ELECTRORETINOGRAM; MICROSCOPY; MOUSE; NERVE CELL; NICK END LABELING; NONHUMAN; PHENOTYPE; PHOTORECEPTOR; PRIORITY JOURNAL; RETINOPATHY; STRAIN DIFFERENCE; WAVEFORM;

AGING; ANIMALS; CELL NUCLEUS; CELL SURVIVAL; CONES (RETINA); ELECTRORETINOGRAPHY; MICE; MICE, INBRED C57BL; MICE, INBRED STRAINS; MICE, KNOCKOUT; NERVE DEGENERATION; PHENOTYPE; PHOTORECEPTORS, VERTEBRATE; RETINA; RHODOPSIN; SPECIES SPECIFICITY;

EID: 0034899355     PISSN: 09525238     EISSN: None     Source Type: Journal    
DOI: 10.1017/S0952523801183100     Document Type: Article

References (34)

1. Identification of a sixth locus for autosomal dominant retinitis pigmentosa on chromosome 19
2. Absence of P53 delays apoptotic photoreceptor cell death in the rds mouse
3. A novel mutation within the rhodopsin gene (Thr94Ile) causing autosomal dominant congenital night blindness
4. Bcl-2 over expression reduces apoptotic photoreceptor cell death in three different retinal degenerations
5. A QTL on distal Chromosome 3 that influences the severity of light-induced damage to mouse photoreceptors
6. Blocking apoptosis prevents blindness in Drosophila retinal degeneration mutants
7. Heterozygous missense mutation in the rhodopsin gene as a cause of congenital stationary night blindness
8. The absence of c-fos prevents light-induced apoptotic cell death of photoreceptors in retinal degeneration in vivo
9. On the molecular genetics of retinitis pigmentosa
10. Retinitis pigmentosa: Genetic mapping in X-linked and autosomal forms of the disease
11. Retinopathy induced in mice by targeted disruption of the rhodopsin gene
12. Severe ocular abnormalities in C57BL/6 but not in 129/Sv p53-deficient mice
13. Strain differences in sensitivity to light-induced photoreceptor degeneration in albino mice
14. Multiple growth factors, cytokines and neurotrophins rescue photoreceptors from the damaging effects of constant light
15. Morphological, physiological, and biochemical changes in rhodopsin knockout mice
16. Autosomal dominant retinitis pigmentosa caused by the threonine-17-methionine rhodopsin mutation: Retinal histopathology and immunocytochemistry
17. The rd gene defect triggers programmed rod cell death
18. Retinitis pigmentosa and progressive sensorineural hearing loss caused by a C12258A mutation in the mitochondrial MTTS2 gene
19. Stratagems in vitro for gene therapy directed to dominant mutations
20. Retinal damage by light in rats
21. Ribozyme-based therapeutic approaches for autosomal dominant retinitis pigmentosa
22. Retinal light damage: Practical and theoretical considerations
23. Retinitis pigmentosa
24. Cell death in the development of the human retina: Phagocytosis of pyknotic and apoptotic bodies by retinal cells
25. Apoptotic photoreceptor cell death in mouse models of retinitis pigmentosa
26. Influence of UV-A light stress on photoreceptor cell metabolism: Decreased rates of rhodopsin regeneration and opsin synthesis
27. The role of ocular pigmentation in protecting against retinal light damage
28. Dark-light: Model for nightblindness from the human rhodopsin Gly-90→Asp mutation
29. Unifactorial inheritance
30. Quantitative relationship of the scotopic and photopic ERG to photoreceptor cell loss in light damaged rat
31. The electroretinogram of the rhodopsin knockout mouse
32. Action spectrum of retinal light damage in albino rats
33. Cell death during differentiation of the retina in the mouse