Genome-wide identification of novel genes involved in early Th1 and Th2 cell differentiation

Journal of Immunology

Volumn 178, Issue 6, 2007, Pages 3648-3660

  Lund, Riikka J ^a   Löytömäki, Maritta ^a   Naumanen, Tiina ^a   Dixon, Craig ^a   Chen, Zhi ^a   Ahlfors, Helena ^a,b   Tuomela, Soile ^a   Tahvanainen, Johanna ^a   Scheinin, Joonas ^a   Henttinen, Tiina ^a   Rasool, Omid ^a   Lahesmaa, Riitta ^a  

^a UNIVERSITY OF TURKU   (Finland)

^b ÅBO AKADEMI UNIVERSITY   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

G PROTEIN COUPLED RECEPTOR; GAMMA INTERFERON; INTERLEUKIN 4; SMALL INTERFERING RNA; STAT6 PROTEIN; TRANSCRIPTOME;

ARTICLE; ASTHMA; CELL DIFFERENTIATION; CELL POLARITY; DISEASE COURSE; EXPRESSED SEQUENCE TAG; GENE; GENE IDENTIFICATION; GENETIC TRANSCRIPTION; GENOME ANALYSIS; HUMAN; HUMAN CELL; HUMAN GENOME; IMMUNOMODULATION; IMMUNOREGULATION; INSULIN DEPENDENT DIABETES MELLITUS; MULTIGENE FAMILY; NDFIP2 GENE; NUCLEOTIDE SEQUENCE; ONCOGENE RAS; PATHOGENESIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TH1 CELL; TH2 CELL; UNINDEXED SEQUENCE;

EID: 33947207887     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.178.6.3648     Document Type: Article

References (43)

1. Romagnani, S. 1996. Th1 and Th2 in human diseases. Clin. Immunol. Immunopathol. 80: 225-235.
2. Glimcher, L. H., and K. M. Murphy. 2000. Lineage commitment in the immune system: the T helper lymphocyte grows up. Genes Dev. 14: 1693-1711.
3. Szabo, S. J., S. T. Kim, G. L. Costa, X. Zhang, C. G. Fathman, and L. H. Glimcher. 2000. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 100: 655-669.
4. Szabo, S. J., B. M. Sullivan, C. Stemmann, A. R. Satoskar, B. P. Sleckman, and L. H. Glimcher. 2002. Distinct effects of T-bet in TH1 lineage commitment and IFN-γ production in CD4 and CD8 T cells. Science 295: 338-342.
5. Zhang, D. H., L. Cohn, P. Ray, K. Bottomly, and A. Ray. 1997. Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 gene. J. Biol. Chem. 272: 21597-21603.
6. Zheng, W., and R. A. Flavell. 1997. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell 89: 587-596.
7. Hamalainen, H., H. Zhou, W. Chou, H. Hashizume, R. Heller, and R. Lahesmaa. 2001. Distinct gene expression profiles of human type 1 and type 2 T helper cells. Genome Biol. 2: RESEARCH0022.1-RESEARCH0022.11.
8. Rogge, L., E. Bianchi, M. Biffi, E. Bono, S. Y. Chang, H. Alexander, C. Santini, G. Ferrari, L. Sinigaglia, M. Seiler, et al. 2000. Transcript imaging of the development of human T helper cells using oligonucleotide arrays. Nat. Genet. 25: 96-101.
9. Lu, B., P. Zagouras, J. E. Fischer, J. Lu, B. Li, and R. A. Flavell. 2004. Kinetic analysis of genomewide gene expression reveals molecule circuitries that control T cell activation and Th1/2 differentiation. Proc. Natl. Acad. Sci. USA 101: 3023-3028.
10. + lymphocytes. J. Immunol. 171: 5328-5336.
11. Lund, R. J., E. K. Ylikoski, T. Aittokallio, O. Nevalainen, and R. Lahesmaa. 2003. Kinetics and STAT4- or STAT6-mediated regulation of genes involved in lymphocyte polarization to Th1 and Th2 cells. Eur. J. Immunol. 33: 1105-1116.
12. Chen, Z., R. Lund, T. Aittokallio, M. Kosonen, O. Nevalainen, and R. Lahesmaa. 2003. Identification of novel IL-4/Stat6-regulated genes in T lymphocytes. J. Immunol. 171: 3627-3623.
13. + type 1 and type 2 T cells. J. Immunol. 167: 3057-3063.
14. Hoey, T., S. Zhang, N. Schmidt, Q. Yu, S. Ramchandani, X. Xu, L. K. Naeger, Y. L. Sun, and M. H. Kaplan. 2003. Distinct requirements for the naturally occurring splice forms Stat4α and Stat4β in IL-12 responses. EMBO J. 22: 4237-4248.
15. Lund, R., H. Ahlfors, E. Kainonen, A. M. Lahesmaa, C. Dixon, and R. Lahesmaa. 2005. Identification of genes involved in the initiation of human Th1 or Th2 cell commitment. Eur. J. Immunol. 35: 3307-3319.
16. Hamalainen, H. K., J. C. Tubman, S. Vikman, T. Kyrola, E. Ylikoski, J. A. Warrington, and R. Lahesmaa. 2001. Validation of endogenous reference genes for profiling of lymphocyte differentiation by quantitative real-time RT-PCR. Anal. Biochem. 299: 63-70.
17. Liu, G., A. E. Loraine, R. Shigeta, M. Cline, J. Cheng, V. Valmeekam, S. Sun, D. Kulp, and M. A. Siani-Rose. 2003. NetAffx: Affymetrix probe sets and annotations. Nucleic Acids Res. 31: 82-86.
18. + T cells: a novel and efficient method for studying gene function and role in human primary T helper cell differentiation. J. Immunol. Methods 310: 30-39.
19. Seki, Y., H. Inoue, N. Nagata, K. Hayashi, S. Fukuyama, K. Matsumoto, O. Komine, S. Hamano, K. Himeno, K. Inagaki-Ohara, et al. 2003. SOCS-3 regulates onset and maintenance of Th2-mediated allergic responses. Nat. Med. 9: 1047-1054.
20. Li-Weber, M., O. Laur, I. Davydov, C. Hu, P. Salgame, and P. H. Krammer. 1997. What controls tissue-specific expression of the IL-4 gene? Immunobiology 198: 170-178.
21. Avice, M. N., M. Rubio, M. Sergerie, G. Delespesse, and M. Sarfati. 2000. CD47 ligation selectively inhibits the development of human naive T cells into Th1 effectors. J. Immunol. 165: 4624-4631.
22. + T cells into effector Th1 and Th2 cells. Microbes Infect. 1: 43-50.
23. Nagai, S., S. Hashimoto, T. Yamashita, N. Toyoda, T. Satoh, T. Suzuki, and K. Matsushima. 2001. Comprehensive gene expression profile of human activated Th1- and Th2-polarized cells. Int. Immunol. 13: 367-376.
24. + T cells, analyzed at the single-cell level. J. Exp. Med. 184: 473-483.
25. Cousins, D. J., T. H. Lee, and D. Z. Staynov. 2002. Cytokine coexpression during human Th1/Th2 cell differentiation: direct evidence for coordinated expression of Th2 cytokines. J. Immunol. 169: 2498-2506.
26. Bradley, L. M., D. K. Dalton, and M. Croft. 1996. A direct role for IFN-γ in regulation of Th1 cell development. J. Immunol. 157: 1350-1358.
27. Wenner, C. A., M. L. Guler, S. E. Macatonia, A. O'Garra, and K. M. Murphy. 1996. Roles of IFN-γ and IFN-α in IL-12-induced T helper cell-1 development. J. Immunol. 156: 1442-1447.
28. + T cells. Nat. Immunol. 3: 549-557.
29. Grogan, J. L., M. Mohrs, B. Harmon, D. A. Lacy, J. W. Sedat, and R. M. Locksley. 2001. Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets. Immunity 14: 205-215.
30. Mullen, A. C., F. A. High, A. S. Hutchins, H. W. Lee, A. V. Villarino, D. M. Livingston, A. L. Kung, N. Cereb, T. P. Yao, S. Y. Yang, and S. L. Reiner. 2001. Role of T-bet in commitment of TH1 cells before IL-12-dependent selection. Science 292: 1907-1910.
31. Lighvani, A. A., D. M. Frucht, D. Jankovic, H. Yamane, J. Aliberti, B. D. Hissong, B. V. Nguyen, M. Gadina, A. Sher, W. E. Paul, and J. J. O'Shea. 2001. T-bet is rapidly induced by interferon-γ in lymphoid and myeloid cells. Proc. Natl. Acad. Sci. USA 98: 15137-15142.
32. Tau, G. Z., T. von der Weid, B. Lu, S. Cowan, M. Kvatyuk, A. Pernis, G. Cattoretti, N. S. Braunstein, R. L. Coffman, and P. B. Rothman. 2000. Interferon γ signaling alters the function of T helper type 1 cells. J. Exp. Med. 192: 977-986.
33. Gollob, J. A., H. Kawasaki, and J. Ritz. 1997. Interferon-γ and interleukin-4 regulate T cell interleukin-12 responsiveness through the differential modulation of high-affinity interleukin-12 receptor expression. Eur. J. Immunol. 27: 647-652.
34. Yamashita, M., M. Kimura, M. Kubo, C. Shimizu, T. Tada, R. M. Perlmutter, and T. Nakayama. 1999. T cell antigen receptor-mediated activation of the Ras/mitogen-activated protein kinase pathway controls interleukin 4 receptor function and type-2 helper T cell differentiation. Proc. Natl. Acad. Sci. USA 96: 1024-1029.
35. Yamashita, M., M. Katsumata, M. Iwashima, M. Kimura, C. Shimizu, T. Kamata, T. Shin, N. Seki, S. Suzuki, M. Taniguchi, and T. Nakayama. 2000. T cell receptor-induced calcineurin activation regulates T helper type 2 cell development by modifying the interleukin 4 receptor signaling complex. J. Exp. Med. 191: 1869-1879.
36. Shibata, Y., T. Kamata, M. Kimura, M. Yamashita, C. R. Wang, K. Murata, M. Miyazaki, M. Taniguchi, N. Watanabe, and T. Nakayama. 2002. Ras activation in T cells determines the development of antigen-induced airway hyperresponsiveness and eosinophilic inflammation. J. Immunol. 169: 2134-2140.
37. Johnson, E. N., and K. M. Druey. 2002. Heterotrimeric G protein signaling: role in asthma and allergic inflammation. J. Allergy Clin. Immunol. 109: 592-602.
38. Cristillo, A. D., L. Nie, M. J. Macri, and B. E. Bierer. 2003. Cloning and characterization of N4WBP5A, an inducible, cyclosporine-sensitive, Nedd4-binding protein in human T lymphocytes. J. Biol. Chem. 278: 34587-34597.
39. Shearwin-Whyatt, L. M., D. L. Brown, F. G. Wylie, J. L. Stow, and S. Kumar. 2004. N4WBP5A (Ndfip2), a Nedd4-interacting protein, localizes to multivesicular bodies and the Golgi, and has a potential role in protein trafficking. J. Cell Sci. 117: 3679-3689.
40. Matsuda, A., Y. Suzuki, G. Honda, S. Muramatsu, O. Matsuzaki, Y. Nagano, T. Doi, K. Shimotohno, T. Harada, E. Nishida, et al. 2003. Large-scale identification and characterization of human genes that activate NF-κB and MAPK signaling pathways. Oncogene 22: 3307-3318.
41. Nishina, H., H. Sato, T. Suzuki, M. Sato, and H. Iba. 1990. Isolation and characterization of fra-2, an additional member of the fos gene family. Proc. Natl. Acad. Sci. USA 87: 3619-3623.
42. Chen, F., D. Chen, and E. V. Rothenberg. 1999. Specific regulation of fos family transcription factors in thymocytes at two developmental checkpoints. Int. Immunol. 11: 677-688.
43. + T-cells into effector Th1 and Th2 cells. Genes Fund. 1: 51-68.