Specific regulation of Fos family transcription factors in thymocytes at two developmental checkpoints

International Immunology

Volumn 11, Issue 5, 1999, Pages 677-688

  Chen, Fei ^a   Chen, Dan ^b   Rothenberg, Ellen V ^a  

^a CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

AP 1; Positive selection; T cell development; selection

Indexed keywords

MESSENGER RNA; TRANSCRIPTION FACTOR AP 1;

ANIMAL CELL; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; GENE INDUCTION; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; ONCOGENE C FOS; PRIORITY JOURNAL; PROTEIN DNA BINDING; T LYMPHOCYTE; THYMOCYTE; TRANSCRIPTION REGULATION;

EID: 0032913701     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/11.5.677     Document Type: Article

References (62)

1. Rothenberg, E. V., Diamond, R. A. and Chen, D. 1994. Programming for recognition and programming for response: separate developmental subroutines in the murine thymus. Thymus 22:215.
2. Chen, D. and Rothenberg, E. V. 1993. Molecular basis for developmental changes in interleukin-2 gene inducibility. Mol. Cell. Biol. 13:228.
3. Rincon, M. and Flavell, R. A. 1996. Regulation of AP-1 and NFAT transcription factors during thymic selection of T cells. Mol. Cell. Biol. 16:1074.
4. Jain, J., Valge-Archer, V. E. and Rao, A. 1992. Analysis of the AP-1 sites in the IL-2 promoter. J. Immunol. 148:1240.
5. Masuda, E. S., Tokumitsu, H., Tsuboi, A., Shlomai, J., Hung, P., Arai, K.-I. and Arai, N. 1993. The granulocyte-macrophage colony-stimulating factor promoter cis-acting element CLEO mediates induction signals in T cells and is recognized by factors related to AP1 and NFAT. Mol. Cell. Biol. 13:7399.
6. Cippitelli, M., Sica, A., Viggiano, V., Ye, J. P., Ghosh, P., Birrer, M. J. and Young, H. A. 1995. Negative transcriptional regulation of the interferon-gamma promoter by glucocorticoids and dominant-negative mutants of c-Jun. J. Biol. Chem. 270:12548.
7. Rooney, J. W., Sun, Y.-L., Glimcher, L. H. and Hoey, T. 1995. Novel NFAT sites that mediate activation of the interleukin-2 promoter in response to T cell receptor stimulation. Mol. Cell. Biol. 15:6299.
8. Mondino, A., Whaley, C. D., DeSilva, D. R., Li, W., Jenkins, M. K. and Mueller, D. L. 1996. Defective transcription of the IL-2 gene is associated with impaired expression of c-Fos, FosB, and JunB in anergic T helper 1 cells. J. Immunol. 157:2048.
9. Chen, J., Stewart, V., Spyrou, G., Hilberg, F., Wagner, E. F. and Alt, F. W. 1994. Generation of normal T and B lymphocytes by c-jun deficient embryonic stem cells. Immunity 1:65.
10. Barton, K., Muthusamy, N., Chanyangam, M., Fischer, C., Clendenin, C. and Leiden, J. M. 1996. Defective thymocyte proliferation and IL-2 production in transgenic mice expressing a dominant-negative form of CREB. Nature 379:81.
11. + thymocytes. A protective role of c-Fos. J. Biol. Chem. 272:8558.
12. Karin, M., Liu, Z.-G. and Zandi, E. 1997. AP-1 function and regulation. Curr Opin. Cell. Biol. 9:240.
13. Foletta, V. C. 1996. Transcription factor AP-1, and the role of Fra-2. Immunol. Cell Biol. 74:121.
14. Halazonetis, T. D., Georgopoulos, K., Greenberg, M. E. and Leder, P. 1988. c-Jun dimerizes with itself and with c-Fos, forming complexes of different DNA-binding affinities. Cell 55:917.
15. Ryseck, R. and Bravo, R. 1991. c-JUN, JUN B, and JUN D differ in their binding affinities to AP-1 and CRE consensus sequences: effect of FOS proteins. Oncogene 6:533.
16. Kim, J. and Struhl, K. 1995. Determinants of half-site spacing preferences that distinguish AP-1 and ATF/CREB bZIP domains. Nucleic Acids Res. 23:2531.
17. Davis, R. J. 1995. Transcriptional regulation by MAP kinases. Mol. Rep. Dev. 42:459.
18. Hunter, T. and Karin, M. 1992. The regulation of transcription by phosphorylation. Cell 70:375.
19. Jain, J., Nalefski, E. A., McCaffrey, G., Johnson, R. S., Spiegelman, B. M., Papaioannou, V. and Rao, A. 1994. Normal peripheral T cell function in c-Fos-deficient mice. Mol. Cell. Biol. 14:1566.
20. Scherer, L. J., Diamond, R. A. and Rothenberg, E. V. 1995. Developmental regulation of cAMP signaling pathways in thymocyte development. Thymus 23:231.
21. Novak, T. J., Yoshimura, F. K. and Rothenberg, E. V. 1992. In vitro transfection of fresh thymocytes and T cells shows subset-specific expression of viral promoters. Mol. Cell. Biol. 12:1515.
22. Wang, H., Diamond, R. A., Yang-Snyder, J. A. and Rothenberg, E. V. 1998. Precocious expression of T cell functional response genes in vivo in primitive thymocytes before T-lineage commitment. Int. Immunol. 10:1623.
23. + thymocytes to the CD4 lineage without TCR engagement. Int. Immunol. 8:297.
24. + thymocytes in suspension culture. Eur. J. Immunol. 26:2081.
25. Wang, H., Diamond, R. A. and Rothenberg, E. V. 1998. Cross-lineage expression of Ig-β (B29) in thymocytes: positive and negative gene regulation to establish T cell identity. Proc. Natl Acad. Sci. USA 95:6831.
26. -/- and scid thymocytes on two genetic backgrounds: developmental choices and cell death mechanisms before TCR gene rearrangement. J. Immunol. 158:4052.
27. Chomczynski, P. and Sacchi, N. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156.
28. Rothenberg, E. V., Chen, D. and Diamond, R. A. 1993. Functional and phenotypic analysis of thymocytes in SCID mice: evidence for functional response transitions before and after the SCID arrest point. J. Immunol. 151:3530.
29. Rothenberg, E. V. and Diamond, R. A. 1994. Costimulation by interleukin-1 of multiple activation responses in a developmentally restricted subset of immature thymocytes. Eur. J. Immunol. 24:24.
30. -) thymocytes - identification of 4 major phenotypically distinct subsets differing in cell-cycle status and in vitro activation requirements. J. Immunol. 140:1047.
31. Rothenberg, E. V., Diamond, R. A., Pepper, K. A. and Yang, J. A. 1990. Interleukin-2 gene inducibility in T cells prior to T cell receptor expression: changes in signaling pathways and gene expression requirements during intrathymic maturation. J. Immunol. 144:1614.
32. Fischer, M., MacNeil, I., Suda, T., Cupp, J. E., Shortman, K. and Zlotnik, A. 1991. Cytokine production by mature and immature thymocytes. J. Immunol. 146:3452.
33. Chen, D. 1994. Molecular mechanisms of interleukin-2 gene inducibility: developmental control and combinatorial action of transcription factors. PhD thesis, California Institute of Technology.
34. Lazo, P. S., Dorfman, K., Noguchi, T., Mattei, M. G. and Bravo, R. 1992. Structure and mapping of the FosB gene - FosB down-regulates the activity of the FosB promoter. Nucleic Acids Res. 20:343.
35. Janknecht, R. 1995. Regulation of the c-fos promoter. Immunobiology 193:137.
36. Price, M. A., Rogers, A. E. and Treisman, R. 1995. Comparative analysis of the ternary complex factors Elk-1, SAP-1a and SAP-2 (ERP/NET). EMBO J. 14:2589.
37. Maira, S. M., Wurtz, J. M. and Wasylyk, B. 1996. Net (ERP/SAP2), one of the Ras-inducible TCFs, has a novel inhibitory domain with resemblance to the helix-loop-helix motif. EMBO J. 15:5849.
38. Giovane, A., Pintzas, A., Maira, S. M., Sobieszcuk, P. and Wasylyk, B. 1994. Net, a new ets transcription factor that is activated by Ras. Genes Dev. 8:1502.
39. Vasquez, N.J., Kane, L. P. and Hedrick, S. M. 1994. Intracellular signals that mediate thymic negative selection. Immunity 1:45.
40. Ashton-Rickardt, P. G., Bandeira, A., Delaney, J. R., Van Kaer, L., Pircher, H.-P., Zinkernagel, R. M. and Tonegawa, S. 1994. Evidence for a differential avidity model of T cell selection in the thymus. Cell 76:651.
41. Sebzda, E., Wallace, V. A., Mayer, J., Yeung, R. S. M., Mak, T. W. and Ohashi, P. S. 1994. Positive and negative thymocyte selection induced by different concentrations of a single peptide. Science 263:1615.
42. Alam, S. M., Travers, P. J., Wung, J. L., Nasholds, W., Redpath, S., Jameson, S. C. and Gascoigne, N. R. 1996. T cell receptor affinity and thymocyte positive selection. Nature 381:616.
43. Ohoka, Y., Kuwata, T., Asada, A., Zhao, Y., Mukai, M. and Iwata, M. 1997. Regulation of thymocyte lineage commitment by the level of classical protein kinase C activity. J. Immunol. 158:5707.
44. de Groot, R. P., Auwerx, J., Bourois, M. and Sassone-Corsi, P. 1993. Negative regulation of Jun/AP-1: conserved function of glycogen synthase kinase 3 and the Drosophila kinase shaggy. Oncogene 8:841.
45. Lin, A. N., Frost, J., Deng, T. L., Smeal, T., Alalawi, N., Kikkawa, U., Hunter, T., Brenner, D. and Karin, M. 1992. Casein kinase-II is a negative regulator of c-jun DNA-binding and AP-1 activity. Cell 70:777.
46. Boyle, W. J., Smeal, T., Defize, L. H. K., Angel, P., Woodgett, J. R., Karin, M. and Hunter, T. 1991. Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity. Cell 64:573.
47. Ochi, Y., Koizumi, T., Kobayashi, S., Phuchareon, J., Hatano, M., Takada, M., Tomita, Y. and Tokuhisa, T. 1994. Analysis of IL-2 gene regulation in c-fos transgenic mice. Evidence for an enhancement of IL-2 expression in splenic T cells stimulated via TCR/CD3 complex. J. Immunol. 153:3485.
48. Northrop, J. P., Ullman, K. S. and Crabtree, G. R. 1993. Characterization of the nuclear and cytoplasmic components of the lymphoid-specific nuclear factor of activated T cells (NF-AT) complex. J. Biol. Chem. 268:2917.
49. De Cesare, D., Vallone, D., Caracciolo, A., Sassone-Corsi, P., Nerlov, C. and Verde, P. 1995. Heterodimerization of c-Jun with ATF-2 and c-Fos is required for positive and negative regulation of the human urokinase enhancer. Oncogene 11:365.
50. Sen, J., Shinkai, Y., Alt, F. W., Sen, R. and Burakoff, S. J. 1994. Nuclear factors that mediate intrathymic signals are developmentally regulated. J. Exp. Med. 180:2321.
51. Simon, A. K., Auphan, N. and Schmitt-Verhulst, A. M. 1996. Developmental control of antigen-induced thymic transcription factors. Int. Immunol. 8:1421.
52. Suzuki, T., Okuno, H., Yoshida, T., Endo, T., Nishina, H. and Iba, H. 1991. Difference in transcriptional regulatory function between c-Fos and Fra-2. Nucleic Acids Res. 19:5537.
53. Yoshioka, K., Deng, T., Cavigelli, M. and Karin, M. 1995. Antitumor promotion by phenolic antioxidants: inhibition of AP-1 activity through induction of Fra expression. Proc. Natl Acad. Sci. USA 92:4972.
54. Robertson, L. M., Kerppola, T. K., Vendrell, M., Luk, D., Smeyne, R. J., Bocchiaro, C., Morgan, J. I. and Curran, T. 1995. Regulation of c-fos expression in transgenic mice requires multiple interdependent transcription control elements. Neuron 14:241.
55. Zinck, R., Hipskind, R. A., Pingoud, V. and Nordheim, A. 1993. c-fos transcriptional activation and repression correlate temporally with the phosphorylation status of TCF. EMBO J. 12:2377.
56. Sen, J., Kapeller, R., Fragoso, R., Sen, R., Zon, L. I. and Burakoff, S. J. 1996. Intrathymic signals in thymocytes are mediated by p38 mitogen-activated protein kinase. J. Immunol. 156:4535.
57. Alberola-Ila, J., Forbush, K. A., Seger, R., Krebs, E. G. and Perlmutter, R. M. 1995. Selective requirement for MAP kinase activation in thymocyte differentiation. Nature 373:620.
58. Alberola-Ila, J., Hogquist, K. A., Swan, K. A., Bevan, M. J. and Perlmutter, R. M. 1996. Positive and negative selection invoke distinct signaling pathways. J. Exp. Med. 184:9.
59. Okada, S., Wang, Z. Q., Grigoriadis, A. E., Wagner, E. F. and von Ruden, T. 1994. Mice lacking c-fos have normal hematopoietic stem cells but exhibit altered B-cell differentiation due to an impaired bone marrow environment. Mol. Cell. Biol. 14:382.
60. Wang, Z.-Q., Ovitt, C., Grigoriadis, A. E., Möhle-Steinlein, U., Rüther, U. and Wagner, E. F. 1992. Bone and haematopoietic defects in mice lacking c-fos. Nature 360:741.
61. Rüther, R., Müller, W., Sumida, T., Tokuhisa, T., Rajewsky, K. and Wagner, E. F. 1988. c-fos expression interferes with thymus development in transgenic mice. Cell 53:847.
62. Carrozza, M. L., Jacobs, H., Acton, D., Verma, I. and Berns, A. 1997. Overexpression of the FosB2 gene in thymocytes causes aberrant development of T cells and thymic epithelial cells. Oncogene 14:1083.