Age-related changes in the blood-brain barrier

Experimental Gerontology

Volumn 32, Issue 4-5, 1997, Pages 501-519

  Shah, Gul N ^a   Mooradian, Arshag D ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Carrier transport; Cerebral microvessels; Passive diffusion

Indexed keywords

AGING; BLOOD BRAIN BARRIER; BRAIN MICROCIRCULATION; CELL MEMBRANE PERMEABILITY; CELL MEMBRANE TRANSPORT; CONFERENCE PAPER; HUMAN; NONHUMAN; PRIORITY JOURNAL;

AGING; ANIMALS; ANTIGENS; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; CAPILLARIES; CARRIER PROTEINS; CEREBROVASCULAR CIRCULATION; ENDOTHELIUM, VASCULAR; ENZYMES; HUMANS;

ANIMALIA;

EID: 0030812065     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0531-5565(96)00158-1     Document Type: Conference Paper

References (190)

1. ABALAN, F. Alzheimer's disease and malnutrition. A new etiological hypothesis. Med. Hypotheses 15, 385-393, 1984.
2. ALBERGHINA, M., LUPO, G., ANFUSO, C.D., and MORO, F. Palmitate transport through the blood-retina and blood-brain barrier of rat visual system during aging. Neurosci. Lett. 150, 17-20, 1993.
3. ALBERT Z., ORLOWSKI, M., RUZUCIDLO, P., and ORLOWSKI, J. Studies on gamma-glutamyl transpeptidase activity and its histochemical localization in the central nervous system of man and different animal species. Acta Histochem. 25, 312-320, 1966.
4. BANKS, W.A. and KASTIN, A.J. Aluminum increases permeability of the blood-brain barrier to labeled DSIP and β-endorphin: Possible implications for senile and dialysis dementia. Lancet ii, 1227-1229, 1983.
5. BANKS, W.A. and KASTIN, A.J. Aging and the blood-brain barrier: Changes in the carrier-mediated transport of peptides in rats. Neurosci. Lett. 61, 171-175, 1985.
6. BARR, R.S., DEROSE, A., SANDRA, A., PEACOCK, M.L., and OWEN, W.G. Insulin binding to microvascular endothelium of insect heart: A kinetic and morphometric analysis. Am. J. Physiol. 244, E447-E452, 1983.
7. BARR, T. Morphological evolution of capillaries in different laminae of rat cerebral cortex by automatic image analysis: Changes during development and aging. Adv. Neurol. 20, 1-9, 1978.
8. BARTIFAI, T. Cyclic nucleotides in the central nervous system. Trends Biochem. Sci. 3, 121-124, 1978.
9. BECKER, R.A. and AIRD, R.B. Mechanisms influencing the permeability of the blood-brain barrier. J. Cell Comp. Physiol. 46, 127-141, 1955.
10. BEGLEY, D.J. and ZLOKOVIC, B.V. In: The Blood-Brain Barrier in Health and Disease, Suckling, A.J., Rumsby, M.G., and Bradbury, M.W.B. (Editors), pp. 98-108, Horwood, Chichester, England, 1986.
11. BERTLER, A., FALCK, B., and ROSENGRENN, E. The direct demonstration of a barrier mechanism in the brain capillaries. Acta Pharmacol. Toxicol. 20, 317-321, 1964.
12. BERTLER, A., FALCK B., OWMAN, C., and ROSENGRENN, E. The localization of monoaminergic blood-brain barrier mechanisms. Pharmacol. Rev. 18, 369-385, 1966.
13. BETZ, A.L. and GOLDSTEIN, G.W. Polarity of the blood-brain barrier: Neutral amino acid transport into isolated brain capillaries. Science 202, 225-227, 1978.
14. BETZ, A.L., FIRTH, J.A., and GOLDSTEIN, G.W. Polarity of the blood-brain barrier: Distribution of enzymes between the luminal and antiluminal membranes of brain capillary endothelial cells. Brain Res. 192, 17-28, 1980.
15. BJORKLUND, A., FALCK, B., HROMEK, F., and OWMAN, C. The enzymic barrier mechanism for monoamine precursors in the newly-forming brain capillaries following electrolytic or mechanical lesions. J. Neurochem. 16, 1605-1608, 1969.
16. BOADA, R.J. and PARDRIDGE, W.M. Differential expression of alpha-actin mRNA and immunoreactive protein in brain microvascular pericytes and smooth muscle cells. J. Neurosci. Res. 39, 430-435, 1994.
17. BRADBURY, M.W.B. The Concept of a Blood-Brain Barrier Wiley, Chichester, England, 1979.
18. BUBNA-LITTITZ, H. Age-related changes in blood-brain barrier in the rat with reference to methionine, lysine, glutamic acid and N-methyl-N-nitrosourea. Z. Gerontol. 21, 93-101, 1988.
19. BURNS, E.M., KRUCKEBERG, T.W., COMERFORD, L.E., and BUSCHMANN, M.B.T. Thinning of capillary walls and declining number of endothelial mitochondria in the cerebral cortex of the aging primate, Macaca nemestrina. J. Gerontol. 34, 642-650, 1979.
20. BURNS, E.M., KRUCKEBERG, T.W., and GAETANO, P.K. Changes with age in cerebral capillary morphology. Neurobiol. Aging 2, 285-291, 1981.
21. CALEY, D.W. and MAXWELL, D.S. Development of the blood vessels and extracellular spaces during postnatal maturation of rat cerebral cortex. J. Comp. Neurol. 138, 31-48, 1970.
22. CANCILLA, P.A. and DEBAULT, L.E. Neutral amino-acid transport properties of cerebral endothelial cells in vitro. Neuropathol. Exp. Neurol. 42, 191-199, 1983.
23. CHRISTENSEN, T.G. Developments in amino acid transport, illustrated for the blood-brain barrier. Biochem. Pharmacol. 28, 1989-1992, 1979.
24. CHRISTENSEN, T.G., DIEMER, N.H., LAURSEN, V., and GJEDDE, A. Starvation accelerates blood-brain transfer. Acta Physiol. Scand. 112, 221-223, 1981.
25. CONN, A.R., FELL, D.I., and STEELE, R.D. Characterization of α-keto acid transport across blood-brain barrier in rats. Am. J. Physiol. 245, E253-E260, 1983.
26. CORNFORD, E.M. and OLDENDORF, W.H. Independent blood-brain barrier transport systems for nucleic acid precursors. Biochim. Biophys. Acta 394, 211-219, 1975.
27. CORNFORD, E.M., BRAUN, L.D., and OLDENDORF, W.H. Carrier mediated blood-brain barrier transport of choline and certain choline analogs. J. Neurochem. 30, 299-308, 1978.
28. CORNFORD, E.M. and CORNFORD, M.E. Nutrient transport and the blood-brain barrier in developing animals. Fed. Proc. 45, 2065-2072, 1986.
29. CRAPPER, D.R., QUITTKAT, S., KRISHNAN, S.S., DALTON, A.J., and DEBONI, V. Intranuclear aluminum content in Alzheimer's disease, dialysis encephalopathy, and experimental aluminum encephalopathy. Acta Neuropathol. (Berl.) 50, 19-24, 1982.
30. CREMER, J.E., BRAUN, L.D., and OLDENDORF, W.H. Changes during development in transport processes. Biochem. Biophys. Acta 394, 211-219, 1976.
31. CREMER, J.E. Substrate utilization and brain development. J. Cereb. Blood Flow Metab. 2, 394-407, 1982.
32. CRONE, C. Facilitated transfer of glucose from blood into brain tissue. J. Physiol. (Lond.) 181, 103-113, 1965.
33. CRONE, G. and CHRISTENSEN, O. Electrical resistance of a capillary endothelium. J. Gen. Physiol. 77, 349-371, 1981.
34. CRONE, C. and OLESEN, S.P. Electrical resistance of brain microvascular endothelium. Brain Res. 24, 49-55, 1982.
35. DANON, D., LAVER-RUDICH, Z., and SKUTELSKY, E. Surface charge and flow properties of endothelial membranes in aging rats. Mech. Aging Dev. 14, 145-153, 1980.
36. DALLMAN, P.R. and SPIRITO, R.A. Brain response to proteins undernutrition. Mechanisms of preferential protein retention. J. Clin. Invest. 51, 2175-2180, 1972.
37. DANIEL, P.M., LOVE, E.R., and PRATT, O.E. The effect of age upon the influx of glucose into the brain. J. Physiol. 274, 141-148, 1978.
38. DE JONG, G.I., DE WEERD, H. SCHUURMAN, T., TRABER, and J. LUITEN, P.G. Microvascular changes in aged rat forebrain. Effects of chronic nimodipine treatment. Neurobiol. Aging 11, 381-389, 1990.
39. DELI, M.A., JOO, F., KRIZBAI, L, LENGYEL, I., NUNZI, M.G., and WOLFF, J.R. Calcium/calmodulin-stimulated protein kinase II is present in primary cultures of cerebral endothelial cells. Parmacol. Rev. 18, 369-385, 1993.
40. DERMIETZEL, R. and KRAUSE, D. Molecular anatomy of blood-brain barrier as defined by immunocytochemistry. Int. Rev. Cytol. 127, 57-109, 1991.
41. DONAHUE, S. and PAPPAS, G.D. The fine structure of capillaries in the cerebral cortex of the rat at various stages of development. Am. J. Anat. 108, 331-347, 1961.
42. DUFFY, K.R. and PARDRIDGE, W.M. Blood-brain barrier transcytosis of insulin in developing rabbits. Brain Res. 420, 32-38, 1987.
43. DURIEU-TRAUTMANN, O., POIGNANT, N., STROSBERG, A.D., and COURAUD, P.O. Coexpression of beta 1 and beta 2-adrenergic receptors on bovine brain capillary endothelial cells in culture. J. Neurochem. 56, 775-781, 1991.
44. EVANS, C.A.N., REYNOLDS, J.M., SOUNDERS, N.R., and SEGAL, M.B. The development of the blood-brain barrier mechanism in fetal sheep. J. Physiol. (Lond.) 238, 371-386, 1974.
45. FELSENFELD, O. and WOLF, R.H. Relationship of age and serum immunoglobulin to autoantibodies against brain constituents in primates I. A study in apparently healthy men, Maacaca mulata and Erythrocebus patas. J. Med. Primatol. 1, 287-296, 1972.
46. 14C sucrose into brain, cerebrospinal fluid and skeletal muscle of developing rats. Exp. Brain Res. 7, 181-194, 1969.
47. FIRTH, J.A. Cytochemical localization of K+ regulation interface between blood and brain. Experientia 33, 1093-1094, 1977.
48. FISHMAN, J.B., RUBIN, J.B., HANDRAHAN, J.V., CONNOR, J.R., and FINE, R.E. Receptor-mediated transcytosis of transferrin across the blood-brain barrier. J. Neurosci. Res. 18, 299-304, 1987.
49. FLUMERFELT, B. A., LEWIS, P.R., and GWYN, D.G. Cholinesterase activity of capillaries in the rat brain. A light and electron microscopic study. J. Histochem. 5, 67-77, 1973.
50. FRANK, H.J.L., PARDRIDGE, W.M., MORRIS, W.L. ROSENFELD, R.G., and CHOI, T.B. Binding and internalization of insulin and insulin-like growth factors by isolated brain microvessels. Diabetes 35, 654-661, 1986.
51. FREEDMAN, L.S. and SAMUELS, S. Sparing of the brain in neonatal undernutrition: Amino acid transport and incorporation into brain and muscle. Science 207, 902-907, 1980.
52. GJEDDE, A. and CRONE, C. Induction process in blood-brain transfer of ketone bodies during starvation. Am. J. Physiol. 229, 1165-1169, 1975.
53. GJEDDE, A. and CRONE, C. Blood-brain glucose transfer: Repression in chronic hyperglycemia. Science 814, 456-457, 1981.
54. GLENNER, G.G. Congophilic microangiopathy in the pathogenesis of Alzheimer's syndrome (presenile dementia). Med. Hypotheses 5, 1231-1236, 1979.
55. GLENNER, G.G. Alzheimer's disease: Multiple cerebral amyloidosis. In: Banbury Report 15: Biological Aspects of disease, New York: Cold Spring Harbor Laboratory, 1983a, pp 137-144.
56. GLENNER, G.G. Alzheimer's disease: The commonest form of amyloidosis. Arch. Pathol. Lab. Med. 107, 281-282, 1983b.
57. GLENNER, G.G. On causative theories in Alzheimer's disease. Hum. Pathol. 16, 433-435, 1985.
58. GOLDBERG, N.D. and HADDOX, M.K. Cyclic GMP metabolism and involvement in biological regulation. Annu. Rev. Biochem. 46, 823-896, 1977.
59. GOLDMAN, H., BERMAN, R.F., GERSHON, S., MOREHEAD, M. and ALTMAN, H.J. Cerebrovascular permeability and cognition in the aging rat. Neurobiol. Aging 13, 57-62, 1992.
60. GOLDSTEIN, G.W. and BETZ, L.A. Recent advances in understanding brain capillary function. Ann. Neurol. 14, 389-395, 1983.
61. GOODWIN, J.S., GOODWIN, J.M., and GARRY, P.J. Association between nutritional status and cognitive functioning in a healthy elderly population. JAMA 249, 2917-2921, 1983.
62. GORENSTEIN, B.C. and SNYDER, S.H. Enkephalinases. Proc. R. Soc. Lond. [Biol]. 210, 123-132, 1980.
63. GRACIA, M.J., MCNAMARA, P.M., GORDON, T., and KANNELL, U.B. Morbidity and morality in diabetics in the Framingham population: Sixteen year follow-up study. Diabetes 23, 105-111, 1974.
64. GREENE, D.A., LATTIMER, S.A., and SIMA, A.A.F. Sorbitol phosphoinositides and sodium potassium-ATPase in the pathogenesis of diabetic complications. N. Engl. J. Med. 316, 599-606, 1987.
65. GREENEGARD, P. Possible role for cyclic nucleotides and phosphorylated membrane proteins in postsynaptic actions of neurotransmitters. Nature 260, 101-108, 1976.
66. GREENWOOD, J., LOVE, E.R., and PRATT, O.E. Kinetic of thiamine transport across the blood-brain barrier in the rat. J. Physiol. (Lond.) 327, 95-103, 1982.
67. GREIG, M.E. and HOLLAND, W.C. Increased permeability of the hemoencephalic barrier produced by physostigmine and acetylcholine. Science 110, 237, 1949.
68. GREIG, M.E., HOLLAND, W.C., and MAYBERRY, T.C. The relationship between cholinesterase activity and the brain permeability. J. Pharmacol. Exp. Ther. 102, 1-4, 1951.
69. GRUBB, R.L., JR., RAICHLE, M.E., and EICHLING, J.O. Peripheral regulation of brain water permeability. Brain Res. 144, 204-207, 1978.
70. HARDEBO, I.E., and OWMAN, C. Barrier mechanisms for neurotransmitter monoamines and their precursors at the blood-brain interface. Ann. Neurol. 8, 1-31, 1980.
71. HARIK, S.I., MITCHELL, M.J., and KALARIA, R.N. Ouabain binding in the human brain. Effects of Alzheimer's disease and aging. Arch. Neurol. 46, 951-954, 1989.
72. HATZINIKOLAOU, P., BRECHER, P., and GAVRAS, H. Chronic hypertension increases tyrosine transport across the blood-brain barrier in the rat. Life Sci. 29, 1657-1660, 1981.
73. HAWKINS, R.A. and BIEBUYCK, J.F. Ketone bodies are selectively used by individual brain regions. Science 205, 325-327, 1979.
74. HICKEY, W.F. and KIMURA, H. Perivascular microglial cells of the CNS are bone-marrow derived and present antigen in vivo. Science 239, 290-292, 1987.
75. HICKS, P., ROLSTEN, C., BRIZZEE D., and SAMORAJSKI, T. Age-related changes in rat brain capillaries. Neurobiol. Aging 4, 69-75, 1983.
76. HOUGHTEN, R.A., SWANN, R.W., and LEE, C.H. Beta-Endorphin: Stability, clearance behavior, and entry into the central nervous system after intravenous injection of the tritiated peptides in rats and rabbits. Proc. Natl. Acad. Sci. USA 77, 4588-4591, 1980.
77. HUNZIKER, O., ABDEL'AL, S., SCHULTZ, U., and MEIER-RUGE, W. Steriological investigation in the cerebral cortex of aging subjects. Aktuelle Gerontol. 9, 503-508, 1978.
78. HUNZIKER, O., ABDEL'AL, S., and SCHULTZ, U. The aging human cerebral cortex: A steriological characterization of changes in the capillary net. J. Gerontol 34, 345-350, 1979.
79. INGRAM, C.R., PHEGAN, K.J., and BLUMENTHAL, H.T. Significance of an aging-linked neuron binding gamma globulin fraction of human sera. J. Gerontol. 29, 20-27, 1974.
80. JAMES, J.H., ESCOURROU, J., and FISCHER, J.E. Blood-brain neutral amino acid transport activity is increased after portacaval anastomosis. Science 200, 1395-1397, 1978.
81. JANZER, R.C. and RAFF, M.C. Astrocytes induce blood-brain barrier properties in endothelial cells. Nature 325, 253-257, 1987.
82. JANZER, R.C. The blood-brain barrier: Cellular basis. J. Inhert. Metabol. Dis. 16, 639-647, 1993.
83. JANZER, R.C., LOBRINUS, J.A., DAREKAR, P., and JUILLERAT, L. Astrocytes secrete a factor inducing the expression of HT7-protein and neurothelin in endothelial cells of chorioallantoic vessels. Adv. Exp. Med. Biol. 331, 217-221, 1993.
84. JEFFERIES, W.A., BRANDON, M.R., HUNT, S.W., WILLIAMS, A.F., GATTER, K.C., and MASON, D.Y. Transferrin receptor on endothelium of brain capillaries. Nature 312, 162-163, 1984.
85. JOO, F. and CSILLIK, B. Topographic correlation between the hepatoencephalic barrier and the cholinesterase activity of brain capillaries. Exp. Brain Res. 1, 147-151, 1966.
86. 2-dibutyryl cyclic 3′,5′-adenosine monophosphate on the pinocytosis of brain capillaries of mice. Experientia 28, 1470, 1972.
87. JOO, F., RAKONCZAY, Z., and WOLLEMANN, M. cAMP-mediated regulation of the permeability in the brain capillaries. Experientia 31, 582-583, 1975a.
88. JOO, F., TOTH, I., and JANCSO, G. Brain adenylate cyclase: Its common occurrence in the capillaries and astrocytes. Naturwissenschaften 8, 397, 1975b.
89. JOO, F. Significance of adenylate cyclase in the regulation of the permeability of brain capillaries. In: Pathophysiology of Energy Metabolism, Mrsulja, B.B., Taki, L.M., Klatzo, I., and Spatz, M. (Editors), pp. 211-220, Plenum, New York, 1979.
90. JUILLERAT-JEANNERET, L., DESSOUS L'EGLISE MANGE, P., ESKENASY-COTTIER, A.C., and JANZER, R.C. Direct and astrocyte-mediated effects of ethanol on brain-derived endothelial cells. Life Sci. 56, 1499-1509, 1995.
91. KALARIA, C.N. and HEDERA, P. Differential degeneration of the cerebral microvasculature in Alzheimer's disease. Neuroreport 6, 477-480, 1995.
92. KALARIA, C.N. and HARIK, S.I. Adenosine receptors and the nucleoside transporter in human brain vasculature. J. Cereb. Blood Flow Metab. 8, 32-39, 1988.
93. KARNUSHINA, I., TOTH, I., DUX, E., and JOO, F. Presence of the guanylate cyclase in brain capillaries: Histochemical and biochemical evidence. Brain Res. 189, 588-592, 1980.
94. KNOX, C. and OLIVERIA, A. Brain aging in normotensive and hypertensive strains of rats. A quantitative study of cerebrovasculature. Acta Neuropathol (Berl.) 52, 17-25, 1980.
95. KOELLE, G.B. The histochemical localization of cholinesterase in the central nervous system of the rat. J. Comp. Neurol. 100, 211-235, 1954.
96. KRISTENSSON, K. and OLSSON, Y. Accumulation of protein tracers in pericytes of the central nervous system: Following systemic injection in immature mice. Acta Neurol. Scand. 49, 189-194, 1973.
97. KUNZ, J., KRAUSE, D., KREMER, M., and DERMIETZEL, R. The 140-kDa protein of blood-brain barrier-associated pericytes is identical to aminopeptidase N. J. Neuroimmunol 62, 2375-2386, 1994.
98. KUNZ, J., KRAUSE, D., GEHRMANN, J., and DERMIETZEL, R. Changes in the expression pattern of blood-brain barrier-associated pericytic aminopeptidase N (pAP N) in the course of acute experimental autoimmune encephalomyelitis. J. Neuroimmunol. 59, 41-45, 1995.
99. LAJTHA, A. and TOTH, J. Stereospecificity of amino acid uptake exchange and efflux. J. Neurochem. 10, 909-920, 1963.
100. LANDERS, J.W., CHASON, J.L., GONZALEZ, J.E., and PALUTKE, W. Morphology and enzymatic activity of rat cerebral capillaries. Lab. Invest. 11, 1253-1259, 1962.
101. LAMPRECHT, F. and COYLE, J.T. DOPA decarboxylase in the developing rat brain. Brain Res. 41, 503-506, 1972.
102. LIDINSKY, W.A. and DREWES, L.R. Characterization of blood-brain barrier: Protein composition of the capillary endothelial cell membrane. J. Neurochem. 41, 1341-1348, 1983.
103. LOBRINUS, J.A., JUILLERAT-JEANNERET, L., DAREKAR, P., SCHLOSSHAUER, B., JANZER, R.C., and RAFF, M.C. Induction blood-brain barrier specific HT7 and neurothelin epitopes in endothelial cells of the chick cho-rioallantoic vessels by a soluble factor derived from the astrocytes. Brain Res. 70, 207-211, 1992.
104. LOSSINSKY, A.S., VORBRODT, A.W., and WISNIEWSKI, H.M. Transport related microdomains in endothelial cells in the developing, aging and injured mouse blood-brain barrier. Soc. Neurosci. Abstr. 12, 1072, 1986.
105. LUND-ANDERSON, H. Transport of glucose from blood to brain. Physiol. Rev. 59, 305-352, 1979.
106. MANS, A.M., BIEBUYCK, J.F., SAUNDERS, S.J., KIRSCH, R.E., and HAWKINS, R.A. Tryptophan transport across the blood-brain barrier during acute hepatic failure. J. Neurochem. 33, 409-418, 1979.
107. MANZ, H.J., ROBERTSON, D.M., HASS, R.A., and MEYERS, N. Cycloleucine uptake in the brainstem of thiamine-deficient rats. Acta Neuropathol (Berl.) 36, 47-56, 1976.
108. MAYHAN, W.G. Disruption of blood-brain barrier during acute hypertension in adult and aged rats. Am. J. Physiol. 285, H1735-H1738, 1990.
109. MCCALL, A.L., MILLINGTON, W.R., and WURTMAN, R.J. Metabolic fuel and amino acid transport into the brain in experimental diabetes mellitus. Proc. Natl. Acad. Sci. USA 78, 5406-5410, 1982.
110. MCCALL, A.L., FIXMAN, L.B., FLEMING, N., TORNHEIM, K., CHICK, W., and RUDERMAN, N.B. Chronic hypoglycemia increases brain glucose transport. Am. J. Physiol. 251, E442-E447, 1986.
111. MECOCCI, P., PARNETTI, L., ROMANO, G., SCARELLI, A., CHIONNE, F., CECCHETTI, R., POLIDORI, M.C., and PALUMBO, B. Serum anti-GFAP and anti-S100 autoantibodies in brain aging, Alzheimer's disease and vascular dementia. J. Neuroimmunol. 57, 165-170, 1995.
112. MICHAELSON, I. A. and BRADBURY, M. Effect of early inorganic lead exposure on rat blood brain barrier permeability to tyrosine of choline. Biochem. Pharmacol. 31, 1881-1885, 1982.
113. MILLER, D.T. and BLUMENTHAL, H.T. Neuron-thymic lymphocyte binding by serum IgG of 90- and 500-day-old female Wistar albino rats. J. Gerontol 33, 329-336, 1978.
114. MOLLGARD, K. and SAUNDERS, N.R. Complex tight junctions of epithelial and endothelial cells in early fetal brain. J. Neurocytol. (Berl.) 4, 453-568, 1975.
115. MONNIER, M., DUDLER, L., GACHTER, R., and SCHOENENBERGER, G.A. Transport of the synthetic peptide DSIP through the blood-brain barrier in rabbit. Experientia 33, 1609-1610, 1977.
116. MOORADIAN, A.D. The effect of ascorbate and dehydroascorbate on tissue uptake of glucose. Diabetes 36, 1001-1004, 1987.
117. MOORADIAN, A.D. Effect of aging on the blood-brain barrier. Neurobiol. Aging 9, 31-39, 1988a.
118. MOORADIAN, A.D. Blood-brain barrier transport of choline is reduced in aged rats. Brain Res. 440, 328-332, 1988b.
119. MOORADIAN, A.D. The hepatic transcellular transport of 3,5,3′ triiodothyronine is reduced in aged rats. Biochem. Biophys. Acta 1054, 1-7, 1990a.
120. MOORADIAN, A.D. Blood-brain transport of triiodothyronine is reduced in aged rats. Mech. Aging Dev. 52, 141-147, 1990b.
121. MOORADIAN, A.D. The blood-brain barrier transport of glucose and butyrate is reduced in aged rats. Clin. Res. 38, 81A, 1990c.
122. MOORADIAN, A.D. Metabolic fuel and amino acid transport into the brain in experimental hypothyroidism. Acta Endocrinol. 122, 152-162, 1990d.
123. MOORADIAN, A.D., MORIN, A.M., CLIP, L.J., and HASPEL, H.C. Glucose transport is reduced in the blood-brain barrier of aged rats. Brain Res. 551, 45-149, 1991.
124. MOORADIAN, A.D., and SCARPACE, P.J. β-adrenergic receptor activity of cerebral microvessels is reduced in aged rats. Neurochem. Res. 16, 447-451, 1991.
125. MOORADIAN, A.D. and MCCUSKEY, R.S. In vivo microscopic studies of age-related changes in the structure and reactivity of cerebral microvessels. Mech. Aging Dev. 64, 247-254, 1992.
126. MOORADIAN, A.D. and MERIDITH, K.E. The effect of age on protein composition of rat cerebral microvessels. Neurochem. Res. 17, 665-670, 1992.
127. MOORADIAN, A.D. and SMITH, T.L. The effect of age on lipid composition and order of rat cerebral microvessels. Neurochem. Res. 17, 233-237, 1992.
128. MOORADIAN, A.D., GRABAU, G., and UKO-ENINN, A. In situ quantitative estimates of the age-related and diabetes-related changes in cerebral endothelial barrier antigen. Brain Res. 609, 41-44, 1993.
129. MOORADIAN, A.D. and SMITH, T.L. Membrane disordering effects of ethanol on cerebral microvessels. Neurobiol. Aging 16, 229-232, 1993.
130. MOORDIAN, A.D. and BASTANI, B. Identification of proton-translocating adenosine triphosphatases in rat cerebral microvessels. Brain Res. 629, 128-132, 1993.
131. MOORADIAN, A.D. Potential mechanisms of age-related changes in the blood-brain barrier. Neurobiol. Aging 15, 751-755, 1994.
132. MOORADIAN, A.D. GRABAU, G., and BASTANI, B. Adenosine triphosphatases of rat cerebral microvessels. Effects of age and diabetes mellitus. Life Sci. 55, 1261-1265, 1994.
133. MOORADIAN, A.D. and UKO-ENINN, A. Age-related changes in antioxidant potential of cerebral microvessels. Brain Res. 671, 159-163, 1995.
134. NANDY, K. Significance of brain-reactive antibodies in serum of aged mice. J. Gerontol. 30, 412-416, 1975.
135. O'DONNELL, M.E., MARTINEA, A., and SUN, D. Cerebral microvascular endothelial cell Na-K-Cl cotransport: Regulation by astrocyte-conditioned medium. Am. J. Physiol. 268, C747-C754, 1995.
136. OLDENDORF, W.H. Brain uptake of amino acids, amines and hexoses after arterial injection. Am. J. Physiol. 221, 1629-1639, 1971.
137. OLDENDORF, W.H. Carrier-mediated blood-brain barrier transport of short-chain monocarboxylic organic acids. Am. J. Physiol. 224, 1450-1453, 1973.
138. OLDENDORF, W.H. Lipid solubility and drug penetration of the blood brain barrier. Proc. Soc. Exp. Biol. Med. 147, 813-816, 1974.
139. OLESEN, S.P. A calcium-dependent reversible permeability increase in microvessels in frog brain, induced by serotonin. J. Physiol. 361, 103-113, 1985.
140. O'NEILL, C., FOWLLER, C.J., and WINBLAD, B. Alpha 1-adrenergic receptor binding sites in post-mortal human cerebral microvessel preparations: Preservation in multi-infarct dementia and dementia of Alzheimer type. J. Neural. Transm. 1, 303-310, 1989.
141. ORLOWSKI, M. and MEISTER, A. The gamma-glutamyl cycle: A possible transport system for amino acids. Proc. Natl. Acad. Sci. USA 67, 1248-1255, 1970.
142. OZTAS, B., KAYA, M., and CAMURCU, S. Age-related changes in the effect of electroconvulsive shock on the blood-brain barrier permeability in rats. Mech. Aging Dev. 51, 149-155, 1990.
143. PARDRIDGE, W.M. and OLDENDORF, W.H. Kinetics of blood-brain transport of hexoses. Biochem. Biophys. Acta 382, 377-392, 1975a.
144. PARDRIDGE, W.M. and OLDENDORF, W.H. Kinetic analysis of blood-brain barrier transport of amino acids. Biochim. Biophys. Acta 401, 128-136, 1975b.
145. PARDRIDGE, W.M. Kinetics of competitive inhibition of neutral amino acid transport across the blood-brain barrier. J. Neurochem. 28, 103-108, 1977.
146. PARDRIDGE, W.M. Regulation of amino acid availability to brain: Selective control mechanisms for glutamate. In: Glutamic Acid: Advances in Biochemistry and Physiology, Filer, L.J., Jr., Garatini, S., Kare, M.R., Reynolds, W.A., and Wurtman, R.J. (Editors), pp. 125-137, Raven Press, New York, 1979.
147. PARDRIDGE, W.M. and MIETUS, L.J. Enkephalin and blood-brain barrier: Studies of binding and degradation in isolated brain microvessels. Endocrinology 109, 1138-1143, 1981.
148. PARDRIDGE, W.M., EISENBERG, J., and YANG, J. Human blood-brain barrier insulin receptor. J. Neurochem. 44, 1771-1778, 1985.
149. PARDRIDGE, W.M. Does the brain's gatekeeper falter in aging. Neurobiol. Aging 9, 44-46, 1988.
150. PETERSEN, D.R. Aldehyde dehydrogenase and aldehyde reductase in isolated bovine microvessels. Alcohol 2, 79-83, 1985.
151. PETROV, T., HOWARTH, A.G., KRUKOFF, T.L., and STEVENSON, B.R. Distribution of the tight junction-associated protein ZO-1 in circumventricular argans of the CNS. Mol. Brain Res. 21, 235-246, 1994.
152. PURKISS, J.R., WEST, D., WILKES, L.C., SCOTT, C., YARROW, P., WILKINSON, G.F., and BOARDER, M.R. Stimulation of phospholipase C in cultured microvascular endothelial cells from human frontal lobe by histamine, endothelin and purinoceptor agonist. Br. J. Pharmacol 111, 1041-1046, 1994.
153. RAICHLE, M.E., HARTMAN, B.K., EICHLING, J.O., and SHARPE, L.G. Central noradrenergic regulation of cerebral blood flow and vascular permeability. Proc. Natl. Acad. Sci. USA 72, 3726-3730, 1975.
154. RAPOPORT, S.J. Blood-Brain Barrier in Physiology and Medicine, Raven, New York, 1976.
155. RAPAPORT, S.I., OHNO, K., and PETTIGREW, K.D. Blood-brain barrier permeability in senescent rats. J. Gerontol. 34, 162-169, 1979.
156. RAVENS, J.R. Vascular changes in the human senile brain. Adv. Neurol. 20, 487-501, 1978.
157. RICHTER, J.J. and WAINER, A. Evidence for separate systems for the transport of neutral and basic amino acids across the blood-brain barrier. J. Neurochem. 18, 613-62, 1971.
158. RISAU, W., HALLMANN, R., and ALBRECHT, U. Differentiation-dependent expression of proteins in brain endothelium during development of the blood-brain barrier. Dev. Biol. 117, 537-545, 1986.
159. RISAU, W., DINGLER, A., ALBRECHT, U., DEHOUCK, M.P., and CECCHELLI, R. Blood-brain barrier pericytes are the main source of gamma-glutamyletranspeptidase activity in the brain capillaries. J. Neurochem. 58, 667-672, 1992.
160. RUDICK, R.A. and BUELL, S.J. Integrity of blood-brain barrier to peroxidase in senescent mice. Neurobiol. Aging 4, 283-287, 1983.
161. SAJA, A., PRINCI, P., D'AMICO, N., DE PASQUALE, R., and COSTA, G. Aging and sex influence the permeability of the blood-brain barrier in the rat. Life Sci. 47, 2261-2267, 1990.
162. SAJA, A., PRINCI, P., IMPERATORE, C., DE PASQUALE, R., and COSTA, G. Aging influences haloperidol-induced changes in the permeability of the blood-brain barrier in the rat. J. Pharm. Pharmacol. 44, 450-452, 1992.
163. SAMORAJSKI, T. and MCCLOUD, J. Alkaline phosphomonoesterase and blood-brain permeability. Soc. Lab. Invest. 10, 492-501, 1961.
164. SAMUELS, S., FISH, I., and SCHWARTZ, S.A. Age-related changes in blood-brain amino acid transport and incorporation into brain protein. Neurochem. Res. 8, 167-177, 1983.
165. SCHLOSSHAUER, B. and HERZOG, K.H. Neurothelin: An inducible cell surface glycoprotein of blood-brain barrier-specific endothelial cells and distinct neurons. J. Cell Biol. 110, 1261-1274, 1990.
166. SCHLOSSHAUER, B. Neurothelin: Molecular characteristics and developmental regulation in the chick CNS. Development 113, 129-140, 1991.
167. SEULBERGER, H., UNGER, C.M., and RISAU, W. HT7, Neurothelin, Basigin, gp42, and OX-47-many names for one developmentally regulated immuno-globulin-like surface glycoprotein on blood-brain barrier endothelium, epithelial tissue barriers and neurons. Neurosci. Lett. 140, 93-97, 1992.
168. SIMIONESCU, M., SIMIONESCU, N., SANTORO, F., and PALADE, G.E. Differentiated microdomains of the lumenal plasmalemma of murine muscle capillaries: Segmental variations in young and old animals. J. Cell Biol. 100, 1396-1407, 1985.
169. STANIMIROVIC, D.B., YAMAMOTO, T., UEMATSU, S. and SPATZ, M. Endothelin 1-receptor binding and cellular signal transduction in cultured human brain endothelial cells. J. Neurochem. 62, 592-601, 1994.
170. STERNBERGER, N.H. and STERNBERGER, L.A. Blood-brain barrier protein recognized by monoclonal antibody. Proc. Natl. Acad. Sci. USA 84, 8169-8173, 1987.
171. STEVENSON, B.R., SILICIANO, J.D., MOOSEKER, M.S., and GOODENOUGH, D.A. ZO-1 mRNA and protein expression during tight junction assembly in Caco-2 cells. J. Cell Biol. 103, 755-766, 1986.
172. STEWART, P.A. and WILEY, M.J. Developing nervous tissue induces formation of blood brain barrier characteristics in invading endothelial cells: A study using quail-chick transplantation chimera. Dev. Biol. 84: 183-192, 1981.
173. STEWART, P.A., MAGLIOCCO, M., HAYAKAWA, K., FARRELL, C.L., DEL MAESTRO, R.F., GIRVIN, J., KAUFMANN, J.C.E., VINTERS, H.V., and GILBERT, J. A quantitative analysis of blood-brain barrier ultrastructure in the aging human. Microvasc. Res. 33, 270-282, 1987.
174. SULLIVAN, S., AKIL, H., and BARCHAS, J.D. In vitro degradation of enkephalin: Evidence for cleavage at the gly-phe bond. Commun. Psychopharmacol. 2, 525-531, 1978.
175. TANG, J.P., XU, Z.Q., DOUGLAS, F.L., RAKHIT, A., and MELETHIL, S. Increased blood-brain barrier permeability of amino acids in chronic hypertension. Life Sci. 53, PL417-PL420, 1993.
176. TAYARANI, I., COLEZ, I., CLEMENT, M., and BOURRE, J.M. Antioxidant enzymes and related trace elements in aging brain capillaries and choroid plexus. J. Neurochem. 53, 817-824, 1989.
177. THREATT, J., NANDY, K., and FRITZ, R. Brain-reactive antibodies in serum of old mice demonstrated by immunoflorescence. J. Gerontol. 26, 316-323, 1971.
178. TIPPER, J., WOLLNY, E., FULLILOVE, S., KRAMER, G., and HARDESTY, B. Interaction of the 56,000 dalton phosphoprotein phophatase from reticulocytes with regulin and inhibitor 2. J. Biol. Chem. 261, 7144-7150, 1986.
179. TORACK, R.M. and BARRNETT, R.J. The fine structural localization of nucleotide phosphatase activity in the blood-brain barrier. J. Neuropathol. Exp. Neurol. 23, 46-59, 1964.
180. TOPPLE, A., FIFKOVA, E., and CULLEN-DOCKSTADER, K. Effect of age on blood vessels and neurovascular appositions in the rat dentate fascia. Neurobiol. Aging 11, 371-380, 1990.
181. TOPPLE, A., FIFKOVA, E., BAMUGARDNER, D., and CULLEN-DOCKSTADER, K. Effect of age on blood vessels and neurovascular appositions in the CA1 region of the rat hippocampus. Neurobiol. Aging 12, 211-217, 1991.
182. VARKONYI, T. and JOO, F. The effect of nickle chloride on the permeability of the blood-brain barrier. Experientia 24, 452-453, 1968.
183. VON GRAFFENRIED, B., DEL POZO, E., ROUBICEK, J., KREBS, E., POLDINGER, W., BURMEISTER, P., and KERP, L. Effects of the synthetic enkephalin analogue FK 33-824 in man. Nature 272, 729-730, 1978.
184. VON DEURS, B. Observations on the blood-brain barrier in hypertensive rats, with particular reference to phagocytic pericytes. J. Ultrastruct. Res. 56, 65-77, 1976.
185. WADHWANI, K.C., KOISTINAHO, J., BALBO, A., and RAPOPORT, S.I. Blood-nerve and blood-brain barrier permeabilities and nerve vascular space in Fisher-344 rats of different ages. Mech. Aging Dev. 58, 177-190, 1991.
186. WEBER, M., MEHLER, M., and WOLLNY, E. Isolation and partial characterization of 56,000-Dalton phosphoprotein phosphatase from the blood-brain barrier. J. Neurochem. 49, 1050-1056, 1987.
187. WHITTINGHAM, S., LENNON, V., MACKAY, I.R., DAVIES, G.V., and DAVIES, B. Absence of brain antibodies in senile dementia. Br. J. Psychiatry 116, 447-448, 1970.
188. WOLBURG, H., NEUHAUS, J., KNIESEL, U., KRAUSS, B., SCHMID, E.M., OCALAN, M., FARRELL, C., and RISAU, W. Modulation of tight junction structure in the blood-brain barrier endothelial cells. Effects of tissue culture, second messengers and cocultured astrocytes. J. Cell Sci. 107, 1347-1357, 1994.
189. WOLLNY, E., WATKINS, K., KRAMER, G., and HARDESTY, B. Purification to homogeneity and partial characterization of a 56,000 dalton protein phophatase from rabbit reticulocytes. J. Biol. Chem. 259, 2484-2492, 1984.
190. ZLOKOVIC, B.V., SHUNDRIC, D.S., SEGAL, M.B., LIPOVAC, M.V., MACKIC, J.B., and DAVSON, H.A saturable mechanism for transport of immunoglobulin G across the blood-brain barrier of the guinea pig. Exp. Neurol. 107, 263-290, 1990.