Involvement of cGMP-dependent protein kinase in the relaxation of ovine pulmonary arteries to cGMP and cAMP

Journal of Applied Physiology

Volumn 88, Issue 5, 2000, Pages 1637-1642

  Dhanakoti, Srinivas N ^a   Gao, Yuansheng ^a   Nguyen, Minh Q ^a   Raj, J Usha ^a  

^a HARBOR UCLA MEDICAL CENTER   (United States)

Author keywords

Lambs; Lung; Protein kinase A; Protein kinase G; Smooth muscle

Indexed keywords

8 BROMO CYCLIC AMP; 8 BROMO CYCLIC GMP; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE; ENDOTHELIN 1; KT 5720;

ANIMAL TISSUE; ARTERY DILATATION; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME SPECIFICITY; FEMALE; MALE; NONHUMAN; PRIORITY JOURNAL; PULMONARY ARTERY;

EID: 0034036218     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.2000.88.5.1637     Document Type: Article

References (32)

1. Archer SL, Huang JM, Hampl V, Nelson DP, Shultz PJ, and Weir EK. Nitric oxide and cGMP cause vasorelaxation by activation of a charybdotoxin-sensitive K channel by cGMP-dependent protein kinase. Proc Natl Acad Sci USA 91: 7583-7587, 1994.
2. Barnes PJ. Cyclic nucleotides and phosphodiesterases and airway function. Eur Respir J 8: 457-462, 1995.
3. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254, 1976.
4. Butt E, Pohler D, Genieser H-G, Huggins JP, and Bucher B. Inhibition of cyclic GMP-dependent protein kinase-mediated effects by (Rp)-8-bromo-PET-cyclic GMPS. Br J Pharmacol 116: 3110-3116, 1995.
5. i responses are negatively modulated via a cGMP-dependent protein kinase I pathway. J Biol Chem 270: 22277-22282, 1995.
6. Colbran JL, Francis SH, Leach AB, Thomas MK, Jiang H, McAllister LM, and Corbin JD. A phenylalanine in peptide substrates provides for selectivity between cGMP- and cAMP-dependent protein kinases. J Biol Chem 267: 9589-9594, 1992.
7. Cornfield DN, Reeve HL, Tolarova S, Weir EK, and Archer S. Oxygen causes fetal pulmonary vasodilation through activation of a calcium-dependent potassium channel. Proc Natl Acad Sci USA 93: 8089-8094, 1996.
8. Cornwell TL, Arnold E, Boerth NJ, and Lincoln TM. Inhibition of smooth muscle cell growth by nitric oxide and activation of cAMP-dependent protein kinase by cGMP. Am J Physiol Cell Physiol 267: C1405-C1413, 1994.
9. 2+ by atriopeptin and 8-bromo-cyclic GMP is mediated by cyclic GMP-dependent protein kinase. J Biol Chem 264: 1146-1155, 1989.
10. Felbel J, Trockur B, Ecker T, Landgraf W, and Hofmann F. Regulation of cytosolic calcium by cAMP and cGMP in freshly isolated smooth muscle cells from bovine trachea. J Biol Chem 263: 16764-16771, 1988.
11. Fineman JR, Soifer SJ, and Heymann MA. Regulation of pulmonary vascular tone in the perinatal period. Annu Rev Physiol 57: 115-134, 1995.
12. Fouty B, Komalavilas P, Muramatsu M, Cohen A, McMurtry IF, Lincoln TM, and Rodman DM. Protein kinase G is not essential to NO-cGMP modulation of basal tone in rat pulmonary circulation. Am J Physiol Heart Circ Physiol 274: H672-H677, 1998.
13. Francis SH and Corbin JD. Progress in understanding the mechanism and function of cyclic GMP-dependent protein kinase. Adv Pharmacol 26: 115-170, 1994.
14. Francis SH, Lincoln TM, and Corbin JD. Characterization of a novel cGMP binding protein from rat lung. J Biol Chem 255: 620-626, 1980.
15. Francis SH, Noblett BD, Todd BW, Wells JN, and Corbin JD. Relaxation of vascular and tracheal smooth muscle by cyclic nucleotide analogs that preferentially activate purified cGMP-dependent protein kinase. Mol Pharmacol 34: 506-517, 1988.
16. Gamm DM, Francis SH, Angelotti TP, Corbin JD, and Uhler MD. The type II isoform of cGMP-dependent protein kinase is dimeric and possesses regulatory and catalytic properties distinct from the type I isoform. J Biol Chem 270: 27380-27383, 1995.
17. Gao Y, Tolsa J-F, and Raj JU. Heterogeneity in endothelium-derived nitric oxide-mediated relaxation of different sized pulmonary arteries of newborn lambs. Pediatr Res 44: 723-729, 1998.
18. 2. J Appl Physiol 84: 13-18, 1998.
19. 2 cause greater relaxations in pulmonary veins than in arteries of newborn lambs. J Appl Physiol 81: 2534-2539, 1996.
20. Gao Y, Zhou H, and Raj JU. Heterogeneity in role of endothelium-derived NO in pulmonary arteries and veins of full-term fetal lambs. Am J Physiol Heart Circ Physiol 268: H1586-H1592, 1995.
21. Gao Y, Zhou H, and Raj JU. Endothelium-derived nitric oxide plays a larger role in pulmonary veins than in arteries of newborn lambs. Circ Res 76: 559-565, 1995.
22. Ignarro LJ and Kadowitz PJ. The pharmacological and physiological role of cGMP in vascular smooth muscle relaxation. Annu Rev Pharmacol Toxicol 25: 171-191, 1985.
23. Jiang H, Colbran JL, Francis SH, and Corbin JD. Direct evidence for cross-activation of cGMP-dependent protein kinase by cAMP in pig coronary arteries. J Biol Chem 267: 1015-1019, 1992.
24. Kase H, Iwahashi K, Nakanishi K, Matsuda Y, Yamada K, Takahashi M, Murakata L, Sato A, and Kaneko M. K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases. Biochem Biophys Res Commun 142: 436-440, 1987.
25. Komalavilas P and Lincoln TM. Phosphorylation of the inositol 1,4,5-triphosphate receptor. Cyclic GMP-dependent protein kinase mediates cAMP and cGMP-dependent phosphorylation in the intact rat aorta. J Biol Chem 271: 21933-21938, 1996.
26. Lincoln TM and Cornwell TL. Intracellular cyclic GMP receptor proteins. FASEB J 7: 328-338, 1993.
27. 2+ by cAMP in vascular smooth muscle cells. Am J Physiol Cell Physiol 258: C399-C407, 1990.
28. Lohmann SM, Vaandrager AB, Smolenski A, Walter U, and De Jonge HR. Distinct and specific functions of cGMP-dependent protein kinases. Trends Biochem Sci 22: 307-312, 1997.
29. Pfeifer A, Klatt P, Massberg S, Ny L, Sausbier M, Hirneiss C, Wang GX, Korth M, Aszodi A, Andersson KE, Krombach F, Mayerhofer A, Ruth P, Fassler R, and Hofmann F. Defective smooth muscle regulation in cGMP-kinase I-deficient mice. EMBO J 17: 3045-3051, 1998.
30. 2+-ATPase by cGMP-dependent protein kinase. Proc Natl Acad Sci USA 84: 5685-5689, 1987.
31. Roskoski R Jr. Assays of protein kinase. Methods Enzymol 99: 3-6, 1983.
32. 2+ channels by cyclic nucleotide cross activation of opposing protein kinases in rabbit portal vein. Circ Res 82: 557-565, 1998.