A2B Adenosine Receptor Agonists: Synthesis and Biological Evaluation of 2-Phenylhydroxypropynyl Adenosine and NECA Derivatives

Nucleosides, Nucleotides and Nucleic Acids

Volumn 23, Issue 1-2, 2004, Pages 471-481

  Vittori, S ^a   Costanzi, S ^a   Lambertucci, C ^a   Portino, F R ^a   Taffi, S ^a   Volpini, R ^a   Klotz, K N ^b   Cristalli, G ^a  

^a UNIVERSITY OF CAMERINO   (Italy)

^b UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

2 alkynyladenosine derivatives; 2 alkynylNECA derivatives; A2B adenosine receptor; Adenosine receptor

Indexed keywords

2 PHENYLHYDROXYPROPYNYL 5' N ETHYLCARBOXAMIDOADENOSINE; 2 PHENYLHYDROXYPROPYNYL 5' N METHYLCARBOXAMIDOADENOSINE; 2 PHENYLHYDROXYPROPYNYL 5' N PROPYLCARBOXAMIDOADENOSINE; 2 PHENYLHYDROXYPROPYNYLADENOSINE; ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE A1 RECEPTOR; ADENOSINE A2 RECEPTOR AGONIST; ADENOSINE A2A RECEPTOR; ADENOSINE A2B RECEPTOR; ADENOSINE A2B RECEPTOR AGONIST; ADENOSINE A3 RECEPTOR; ADENYLATE CYCLASE; N6 ETHYL 2 PHENYLHYDROXYPROPYNYL 5' N ETHYLCARBOXAMIDOADENOSINE; UNCLASSIFIED DRUG; 2-PHENYLHYDROXYPROPYNYLADENOSINE; ADENOSINE; DRUG DERIVATIVE; LIGAND;

ARTICLE; BINDING AFFINITY; DRUG BINDING; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ASSAY; LIGAND BINDING; RECEPTOR BINDING; ANIMAL; CHO CELL; DRUG POTENTIATION; HAMSTER; HUMAN; RADIOASSAY; SYNTHESIS;

ADENOSINE; ADENOSINE-5'-(N-ETHYLCARBOXAMIDE); ANIMALS; CHO CELLS; CRICETINAE; HUMANS; LIGANDS; RADIOLIGAND ASSAY; RECEPTOR, ADENOSINE A2B;

EID: 1542574031     PISSN: 15257770     EISSN: None     Source Type: Journal    
DOI: 10.1081/NCN-120028340     Document Type: Article

References (16)

1. Adenosine Receptors: Medicinal Chemistry, Pharmacology and Therapeutic Applications; Cristalli, G., Volpini, R., Eds.; Curr. Topics Med. Chem., 2003; Vol. 3.
2. Poulsen, S.-A.; Quinn, R.J. Adenosine receptors: new opportunity for future drugs. Bioorg. Med. Chem. 1998, 6, 619-641.
3. Williams, M.; Jarvis, M.F. Purinergic and pyrimidinergic receptors as potential drug targets. Biochem. Pharmacol. 2000, 59, 1173-1185.
4. Robeva, A.S.; Woodard, R.L.; Ji, X.D.; Gao, Z.; Bhattacharya, S.; Taylor, H.E.; Rosin, D.L.; Linden, J. Molecular characterization of recombinant human adenosine receptors. Drug Dev. Res. 1996, 39, 243-252.
5. Klotz, K.-N.; Hessling, J.; Hegler, J.; Owman, B.; Kull, B.; Fredholm, B.B.; Lohse, M.J. Comparative pharmacology of human adenosine subtypes-characterization of stably transfected receptors in CHO cells. Naunyn-Schmiedeberg's Arch. Pharmacol. 1998, 357, 1-9.
6. Fredholm, B.B.; IJzerman, A.P.; Jacobson, K.A.; Klotz, K.-N.; Linden, J. International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors. Pharmacol. Rev. 2001, 53, 527-552.
7. Klotz, K.-N. Adenosine receptors and their ligands. Naunyn-Schmiedeberg's Arch. Pharmacol. 2000, 362, 383-391.
8. Mueller, C.E. Adenosine receptor ligands-recent developments part I. Agonists. Curr. Med. Chem. 2000, 7, 1269-1288.
9. 2B ligands. J. Med. Chem. 2002, 45, 3271-3279.
10. 2B adenosine receptors. Curr. Top. Med. Chem. 2003, 3, 427-443.
11. 2 adenosine receptor agonists with potent inhibitory activity on platelet aggregation. J. Med. Chem. 1994, 37, 1720-1726.
12. Cristalli, G.; Camaioni, E.; Costanzi, S.; Vittori, S.; Volpini, R.; Klotz, K.-N. Characterization of potent ligands at human recombinant adenosine receptors. Drug Dev. Res. 1998, 45, 176-181.
13. 3 adenosine receptors. Naunyn-Schmiedeberg's Arch. Pharmacol. 1999, 360, 103-108.
14. 2 adenosine receptors. J. Med. Chem. 1992, 35, 2363-2368.
15. Volpini, R.; Camaioni, E.; Costanzi, S.; Vittori, S.; Klotz, K.-N.; Cristalli, G. Synthesis of di- and tri-substituted adenosine derivatives and their affinity at human adenosine receptor subtypes. Nucleosides Nucleotides 1999, 18, 2511-2520.
16. 2B receptor: a search for potent agonists. Nucleosides Nucleotides 1998, 17, 969-985.