Concerted action of antiepileptic and antidepressant agents to depress spinal neurotransmission: Possible use in the therapy of spasticity and chronic pain

Neurochemistry International

Volumn 50, Issue 4, 2007, Pages 642-652

  Thán, Márta ^a   Kocsis, Pál ^a   Tihanyi, Károly ^a   Fodor, László ^a   Farkas, Bence ^a   Kovács, Gyula ^b   Kis Varga, Ágnes ^a   Szombathelyi, Zsolt ^a   Tarnawa, István ^a  

^a GEDEON RICHTER LTD   (Hungary)

^b BUDAPEST UNIVERSITY OF TECHNOLOGY AND ECONOMICS   (Hungary)

Author keywords

Chronic pain; Pharmacodynamic interaction; Serotonin reuptake inhibitors; Sodium channels; Spasticity; Spinal reflexes

Indexed keywords

CARBAMAZEPINE; CITALOPRAM; CROBENETINE; EPERISONE; FLUOXETINE; LAMOTRIGINE; PAROXETINE; RILUZOLE; SERTRALINE; TOLPERISONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHRONIC PAIN; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENTIATION; ELECTRIC SHOCK; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NEUROTRANSMISSION; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; SEIZURE; SODIUM CURRENT; SPASTICITY; SPINAL REFLEX;

AFFERENT PATHWAYS; ANIMALS; ANTICONVULSANTS; ANTIDEPRESSIVE AGENTS; CELLS, CULTURED; DRUG SYNERGISM; MALE; MICE; MUSCLE SPASTICITY; NEURAL INHIBITION; NOCICEPTORS; ORGAN CULTURE TECHNIQUES; PAIN, INTRACTABLE; POSTERIOR HORN CELLS; PROTEIN KINASE C; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; RECEPTOR, SEROTONIN, 5-HT2C; REFLEX, ABNORMAL; SEROTONIN UPTAKE INHIBITORS; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; SYNAPTIC TRANSMISSION; TRIAZINES;

EID: 33847363902     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuint.2006.12.008     Document Type: Article

References (60)

1. Applegate C.D., and Tecott L.H. Global increases in seizure susceptibility in mice lacking 5-HT2C receptors: a behavioral analysis. Exp. Neurol. 154 2 (1998) 522-530
2. Baker M.D., and Wood J.N. Involvement of Na+ channels in pain pathways. Trends Pharmacol. Sci. 22 1 (2001) 27-31
3. Barbosa L., Berk M., and Vorster M. A double-blind, randomized, placebo-controlled trial of augmentation with lamotrigine or placebo in patients concomitantly treated with fluoxetine for resistant major depressive episodes. J. Clin. Psychiatry 64 4 (2003) 403-407
4. Bardin L., Lavarenne J., and Eschalier A. Serotonin receptor subtypes involved in the spinal antinociceptive effect of 5-HT in rats. Pain 86 1-2 (2000) 11-18
5. Barnes N.M., and Sharp T. A review of central 5-HT receptors and their function. Neuropharmacology 38 8 (1999) 1083-1152
6. Bennett D.J., Sanelli L., Cooke C.L., Harvey P.J., and Gorassini M.A. Spastic long-lasting reflexes in the awake rat after sacral spinal cord injury. J. Neurophysiol. 91 5 (2004) 2247-2258
7. Bomholt S.F., Mikkelsen J.D., and Blackburn-Munro G. Antinociceptive effects of the antidepressants amitriptyline, duloxetine, mirtazapine and citalopram in animal models of acute, persistent and neuropathic pain. Neuropharmacology 48 2 (2005) 252-263
8. Budai D. A computer-controlled system for post-stimulus time histogram and wind-up studies. J. Neurosci. Meth. 51 2 (1994) 205-211
9. Cantrell A.R., and Catterall W.A. Neuromodulation of Na+ channels: an unexpected form of cellular plasticity. Nat. Rev. Neurosci. 2 6 (2001) 397-407
10. Cantrell A.R., Ma J.Y., Scheuer T., and Catterall W.A. Muscarinic modulation of sodium current by activation of protein kinase C in rat hippocampal neurons. Neuron 16 5 (1996) 1019-1026
11. Cantrell A.R., Tibbs V.C., Yu F.H., Murphy B.J., Sharp E.M., Qu Y., Catterall W.A., and Scheuer T. Molecular mechanism of convergent regulation of brain Na(+) channels by protein kinase C and protein kinase A anchored to AKAP-15. Mol. Cell Neurosci. 21 1 (2002) 63-80
12. Carr D.B., Cooper D.C., Ulrich S.L., Spruston N., and Surmeier D.J. Serotonin receptor activation inhibits sodium current and dendritic excitability in prefrontal cortex via a protein kinase C-dependent mechanism. J. Neurosci. 22 16 (2002) 6846-6855
13. Carr D.B., Day M., Cantrell A.R., Held J., Scheuer T., Catterall W.A., and Surmeier D.J. Transmitter modulation of slow, activity-dependent alterations in sodium channel availability endows neurons with a novel form of cellular plasticity. Neuron 39 5 (2003) 793-806
14. Chahine M., Ziane R., Vijayaragavan K., and Okamura Y. Regulation of Na v channels in sensory neurons. Trends Pharmacol. Sci. 26 10 (2005) 496-502
15. Chen Y., Cantrell A.R., Messing R.O., Scheuer T., and Catterall W.A. Specific modulation of Na+ channels in hippocampal neurons by protein kinase C epsilon. J. Neurosci. 25 2 (2005) 507-513
16. Chen Y., Yu F.H., Surmeier D.J., Scheuer T., and Catterall W.A. Neuromodulation of Na+ channel slow inactivation via cAMP-dependent protein kinase and protein kinase C. Neuron 49 3 (2006) 409-420
17. Clare J.J., Tate S.N., Nobbs M., and Romanos M.A. Voltage-gated sodium channels as therapeutic targets. Drug Discov. Today 5 11 (2000) 506-520
18. Dunham N.W., and Miya T.S. A note on a simple apparatus for detecting neurological deficit in rats and mice. J. Am. Pharm. Assoc. Am. Pharm. Assoc. (Baltim.) 46 3 (1957) 208-209
19. Farkas S., and Ono H. Participation of NMDA and non-NMDA excitatory amino acid receptors in the mediation of spinal reflex potentials in rats: an in vivo study. Br. J. Pharmacol. 114 6 (1995) 1193-1205
20. Fuxe K., Agnati L., Mascagni F., Kuga S., Helmer-Matyjek E., and Goldstein M. Central dopamine agonist activity on the 8-alpha-amino-ergoline CU 32-085. Brain Res. 328 2 (1985) 325-332
21. Goldin A.L. Mechanisms of sodium channel inactivation. Curr. Opin. Neurobiol. 13 3 (2003) 284-290
22. Hahn S.J., Choi J.S., Rhie D.J., Oh C.S., Jo Y.H., and Kim M.S. Inhibition by fluoxetine of voltage-activated ion channels in rat PC12 cells. Eur. J. Pharmacol. 367 1 (1999) 113-118
23. Herrero J.-F., Laird J.-M., and Lopez Garcia J.-A. Wind-up of spinal cord neurones and pain sensation: much ado about something?. Prog. Neurobiol. 61 2 (2000) 169-203
24. Isaac M. Serotonergic 5-HT2C receptors as a potential therapeutic target for the design antiepileptic drugs. Curr. Top. Med. Chem. 5 1 (2005) 59-67
25. Jakus R., Graf M., Juhasz G., Gerber K., Levay G., Halasz P., and Bagdy G. 5-HT2C receptors inhibit and 5-HT1A receptors activate the generation of spike-wave discharges in a genetic rat model of absence epilepsy. Exp. Neurol. 184 2 (2003) 964-972
26. Kaminski R.M., Van Rijn C.M., Turski W.A., Czuczwar S.J., and Van Luijtelaar G. AMPA and GABA(B) receptor antagonists and their interaction in rats with a genetic form of absence epilepsy. Eur. J. Pharmacol. 430 2-3 (2001) 251-259
27. Kocsis P., Farkas S., Fodor L., Bielik N., Than M., Kolok S., Gere A., Csejtei M., and Tarnawa I. Tolperisone-type drugs inhibit spinal reflexes via blockade of voltage-gated sodium and calcium channels. J. Pharmacol. Exp. Ther. 315 3 (2005) 1237-1246
28. Kocsis P., Tarnawa I., Szombathelyi Z., and Farkas S. Participation of AMPA- and NMDA-type excitatory amino acid receptors in the spinal reflex transmission, in rat. Brain Res. Bull. 60 1-2 (2003) 81-91
29. Kovacs G., Kocsis P., Tarnawa I., Horvath C., Szombathelyi Z., and Farkas S. NR2B containing NMDA receptor dependent windup of single spinal neurons. Neuropharmacology 46 1 (2004) 23-30
30. Kuo C.C., and Lu L. Characterization of lamotrigine inhibition of Na+ channels in rat hippocampal neurones. Br. J. Pharmacol. 121 6 (1997) 1231-1238
31. Lai J., Hunter J.C., and Porreca F. The role of voltage-gated sodium channels in neuropathic pain. Curr. Opin. Neurobiol. 13 3 (2003) 291-297
32. Leander J.D. Fluoxetine, a selective serotonin-uptake inhibitor, enhances the anticonvulsant effects of phenytoin, carbamazepine, and ameltolide (LY201116). Epilepsia 33 3 (1992) 573-576
33. Lenkey N., Karoly R., Kiss J.P., Szasz B.K., Vizi E.S., and Mike A. The mechanism of activity-dependent sodium channel inhibition by the antidepressants fluoxetine and desipramine. Mol. Pharmacol. 70 6 (2006) 2052-2063
34. Li Y., and Bennett D.J. Persistent sodium and calcium currents cause plateau potentials in motoneurons of chronic spinal rats. J. Neurophysiol. 90 2 (2003) 857-869
35. Mattia C., and Coluzzi F. Antidepressants in chronic neuropathic pain. Mini Rev. Med. Chem. 3 7 (2003) 773-784
36. McCleane G. Peripheral antinociceptive actions of desimipramine and fluoxetine in an inflammatory and neuropathic pain test in the rat. Pain 85 1-2 (2000) 311-312
37. Millan M.J. The induction of pain: an integrative review. Prog. Neurobiol. 57 1 (1999) 1-164
38. Mochizucki D. Serotonin and noradrenaline reuptake inhibitors in animal models of pain. Hum. Psychopharmacol. 19 Suppl. 1 (2004) S15-S19
39. Molnar M.J., and Karpati G. Efficacy and safety of combination of lamotrigine and sertraline in neuropathic pain management. American Academy of Neurology 57th Annual Meeting. Miami Beach, Florida, April 9-16, 2005 (2005)
40. Molnar M.J., and Karpati G. Spasticity management with lamotrigine augmented with sertraline: an open label clinical observation. American Academy of Neurology 57th Annual Meeting. Miami Beach, Florida, April 9-16, 2005 (2005)
41. Nicholson G.M., Blanche T., Mansfield K., and Tran Y. Differential blockade of neuronal voltage-gated Na(+) and K(+) channels by antidepressant drugs. Eur. J. Pharmacol. 452 1 (2002) 35-48
42. Normann C., Hummel B., Scharer L.O., Horn M., Grunze H., and Walden J. Lamotrigine as adjunct to paroxetine in acute depression: a placebo-controlled, double-blind study. J. Clin. Psychiatry 63 4 (2002) 337-344
43. Otsuka M., and Konishi S. Electrophysiology of mammalian spinal cord in vitro. Nature 252 5485 (1974) 733-734
44. Pancrazio J.J., Kamatchi G.L., Roscoe A.K., and Lynch III C. Inhibition of neuronal Na+ channels by antidepressant drugs. J. Pharmacol. Exp. Ther. 284 1 (1998) 208-214
45. Pratzel H.G., Alken R.G., and Ramm S. Efficacy and tolerance of repeated oral doses of tolperisone hydrochloride in the treatment of painful reflex muscle spasm: results of a prospective placebo-controlled double-blind trial. Pain 67 2-3 (1996) 417-425
46. Rekling J.C., Funk G.D., Bayliss D.A., Dong X.W., and Feldman J.L. Synaptic control of motoneuronal excitability. Physiol. Rev. 80 2 (2000) 767-852
47. Rowbotham M.C., Goli V., Kunz N.R., and Lei D. Venlafaxine extended release in the treatment of painful diabetic neuropathy: a double-blind, placebo-controlled study. Pain 110 3 (2004) 697-706
48. Schmidt B.J., and Jordan L.M. The role of serotonin in reflex modulation and locomotor rhythm production in the mammalian spinal cord. Brain Res. Bull. 53 5 (2000) 689-710
49. Schreibmayer W. Isoform diversity and modulation of sodium channels by protein kinases. Cell Physiol. Biochem. 9 4-5 (1999) 187-200
50. Schreibmayer W., Dascal N., Lotan I., Wallner M., and Weigl L. Molecular mechanism of protein kinase C modulation of sodium channel alpha-subunits expressed in Xenopus oocytes. FEBS Lett. 291 2 (1991) 341-344
51. Singh V.P., Jain N.K., and Kulkarni S.K. On the antinociceptive effect of fluoxetine, a selective serotonin reuptake inhibitor. Brain Res. 915 2 (2001) 218-226
52. Song J.H., Ham S.S., Shin Y.K., and Lee C.S. Amitriptyline modulation of Na(+) channels in rat dorsal root ganglion neurons. Eur. J. Pharmacol. 401 3 (2000) 297-305
53. Stahl S.M., Grady M.M., Moret C., and Briley M. SNRIs: their pharmacology, clinical efficacy, and tolerability in comparison with other classes of antidepressants. CNS Spectr. 10 9 (2005) 732-747
54. Stamenova P., Koytchev R., Kuhn K., Hansen C., Horvath F., Ramm S., and Pongratz D. A randomized, double-blind, placebo-controlled study of the efficacy and safety of tolperisone in spasticity following cerebral stroke. Eur. J. Neurol. 12 6 (2005) 453-461
55. Svendsen F., Tjolsen A., and Hole K. LTP of spinal A beta and C-fibre evoked responses after electrical sciatic nerve stimulation. Neuroreport 8 16 (1997) 3427-3430
56. Swinyard E.A., Brown W.C., and Goodman L.S. Comparative assays of antiepileptic drugs in mice and rats. J. Pharmacol. Exp. Ther. 106 3 (1952) 319-330
57. Vijayaragavan K., Boutjdir M., and Chahine M. Modulation of Nav1.7 and Nav1. 8 peripheral nerve sodium channels by protein kinase A and protein kinase C. J. Neurophysiol. 91 4 (2004) 1556-1569
58. + channels by amitriptyline via the local anesthetic receptor and its implication for neuropathic pain. Pain 110 1-2 (2004) 166-174
59. Watson C.P. Antidepressant drugs as adjuvant analgesics. J. Pain Symptom Manage. 9 6 (1994) 392-405
60. Yomono H.S., Suzuki H., and Yoshioka K. Serotonergic fibers induce a long-lasting inhibition of monosynaptic reflex in the neonatal rat spinal cord. Neuroscience 47 3 (1992) 521-531