Inhibition by fluoxetine of voltage-activated ion channels in rat PC12 cells

European Journal of Pharmacology

Volumn 367, Issue 1, 1999, Pages 113-118

  Hahn, Sang June ^a   Choi, Jin Sung ^a   Rhie, Duck Joo ^a   Oh, Chan Seok ^a   Jo, Yang Hyeok ^a   Kim, Myung Suk ^a  

^a The Catholic University of Korea   (South Korea)

Author keywords

Fluoxetine; Ion channel, voltage activated; PC12 cell

Indexed keywords

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; CALCIUM CHANNEL; CALCIUM ION; CYCLIC AMP DEPENDENT PROTEIN KINASE; FLUOXETINE; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE DIPHOSPHATE; ION CHANNEL; PERTUSSIS TOXIN; POTASSIUM CHANNEL; POTASSIUM ION; PROTEIN KINASE C; SODIUM CHANNEL; SODIUM ION; STAUROSPORINE;

ANIMAL CELL; ARTICLE; CALCIUM CURRENT; CONCENTRATION RESPONSE; CONTROLLED STUDY; NONHUMAN; PATCH CLAMP; PHEOCHROMOCYTOMA; POTASSIUM CURRENT; PRIORITY JOURNAL; RAT; SODIUM CURRENT;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; ANIMALS; BARIUM; CALCIUM CHANNELS; CYCLIC AMP; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; ENZYME INHIBITORS; FLUOXETINE; GUANOSINE DIPHOSPHATE; ION CHANNELS; MEMBRANE POTENTIALS; PATCH-CLAMP TECHNIQUES; PC12 CELLS; PERTUSSIS TOXIN; POTASSIUM CHANNELS; PROTEIN KINASE C; PROTEIN KINASE INHIBITORS; RATS; SEROTONIN UPTAKE INHIBITORS; SODIUM CHANNELS; THIONUCLEOTIDES; VIRULENCE FACTORS, BORDETELLA;

EID: 0033006199     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(98)00955-8     Document Type: Article

References (19)

1. Altamura A.C., Moro A.R., Percudani M. Clinical pharmacokinetics of fluoxetine. Clin. Pharmacokinet. 26:1994;201-214.
2. Farrugia G. Modulation of ionic currents in isolated canine and human jejunal circular smooth muscle cells by fluoxetine. Gastroenterology. 110:1996;1438-1445.
3. Fuller R.W., Wong D.T. Serotonin uptake and serotonin uptake inhibition. Ann. New York Acad. Sci. 600:1990;68-78.
4. Garber S.S., Hoshi T., Aldrich R.W. Regulation of ionic currents in pheochromocytoma cells by nerve growth factor and dexamethasone. J. Neurosci. 9:1989;3976-3987.
5. García-Colunga J., Awad J.N., Miledi R. Blockage of muscle and neuronal nicotinic acetylcholine receptors by fluoxetine (Prozac). Proc. Natl. Acad. Sci. U.S.A. 94:1997;2041-2044.
6. Hamill O.P., Marty A., Neher E., Sakmann B., Sigworth F.J. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflüg. Arch. 391:1981;85-100.
7. + channels in pheochromocytoma cells. J. Gen. Physiol. 91:1988;73-106.
8. Hoshi T., Zagotta W.N., Aldrich R.W. Shaker potassium channel gating: I. Transitions near the open state. J. Gen. Physiol. 103:1994;249-278.
9. Jonas E.A., Kaczmarek L.K. Regulation of potassium channels by protein kinase. Curr. Opin. Neurobiol. 6:1996;318-323.
10. Karson C.N., Newton J.E.O., Livingston R., Jolly J.B., Cooper T.B., Sprigg J., Komoroski R.A. Human brain fluoxetine concentrations. J. Neuropsychiatry Clin. Neurosci. 5:1993;322-329.
11. Levitan I.B. Modulation of ion channels by protein phosphorylation and dephosphorylation. Annu. Rev. Physiol. 56:1994;193-212.
12. + current in rat phaeochromocytoma cells. Br. J. Pharmacol. 116:1995;2603-2610.
13. + channels by antidepressant drugs. J. Pharmacol. Exp. Ther. 284:1998;208-214.
14. Rae J.L., Rich A., Zamudio A.C., Candia O.A. Effect of prozac on whole cell ionic currents in lens and corneal epithelia. Am. J. Physiol. 269:1995;C250-C256.
15. Reuter H., Sigel E. Ionic channels: modulation by G proteins and by phosphorylation. Curr. Opin. Neurobiol. 1:1991;27-31.
16. Stark P., Fuller R.W., Wong D.T. The pharmacologic profile of fluoxetine. J. Clin. Psychiatry. 46:1985;7-13.
17. Tsuneizumi T., Babb S.M., Cohen B.M. Drug distribution between blood and brain as a determinant of antipsychotic drug effects. Biol. Psychiatry. 32:1992;817-824.
18. Tytgat J., Maertens Ch., Daenens P. Effect of fluoxetine on a neuronal, voltage-dependent potassium channel (Kv1.1). Br. J. Pharmacol. 122:1997;1417-1424.
19. Wong D.T., Bymaster F.P., Engleman E.A. Prozac (fluoxetine, Lilly 110140), the first selective serotonin uptake inhibitor and an antidepressant drug: twenty years since its first publication. Life Sci. 57:1995;411-441.