Serotonin receptor activation inhibits sodium current and dendritic excitability in prefrontal cortex via a protein kinase C-dependent mechanism

Journal of Neuroscience

Volumn 22, Issue 16, 2002, Pages 6846-6855

  Carr, David B ^a   Cooper, Donald C ^a   Ulrich, Sasha L ^a   Spruston, Nelson ^a   Surmeier, D James ^a,b  

^a NORTHWESTERN UNIVERSITY   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Cerebral cortex; Neuromodulation; scRT PCR; Serotonin; Sodium channel; Voltage clamp

Indexed keywords

MESSENGER RNA; PROTEIN KINASE C; SEROTONIN 2A RECEPTOR; SEROTONIN 2C RECEPTOR; SEROTONIN RECEPTOR; SODIUM CHANNEL;

ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN SLICE; CONTROLLED STUDY; DENDRITE; ENZYME MECHANISM; MOUSE; NERVE CELL EXCITABILITY; NERVE CELL PLASTICITY; NERVE CONDUCTION; NEUROMODULATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PREFRONTAL CORTEX; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RECEPTOR UPREGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEROTONINERGIC NERVE; SIGNAL TRANSDUCTION; SODIUM CURRENT;

EID: 0037104778     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.22-16-06846.2002     Document Type: Article

References (48)

1. Aghajanian GK, Marek GJ (1997) Serotonin induces excitatory postsynaptic potentials in apical dendrites of neocortical pyramidal cells. Neuropharmacology 36:589-599.
2. q interface to inhibit in vivo pressure overload myocardial hypertrophy. Science 280:574-577.
3. Araneda R, Andrade R (1991) 5-Hydroxytryptamine 2 and 5-hydroxytryptamine 1A receptors mediate opposing responses on membrane excitability in rat association cortex. Neuroscience 40:399-412.
4. Ashby Jr CR, Edwards E, Harkins K, Wang RY (1989) Effects of (+/-)-DOI on medial prefrontal cortical cells: A microiontophoretic study. Brain Res 498:393-396.
5. + current in mouse neocortical slices. J Neurophysiol 80:1547-1551.
6. Bristow LJ, Kramer MS, Kulagowski J, Patel S, Ragan CI, Seabrook GR (1997) Schizophrenia and L-745, 870, a novel dopamine D4 receptor antagonist. Trends Pharmacol Sci 18:186-188.
7. + channels: An unexpected form of cellular plasticity. Nat Neurosci 2:397-407.
8. 2C receptor protein in the rat CNS. Neuropharmacology 39:123-132.
9. + current in hippocampal CA1 pyramidal neurons. J Neurophysiol 79:491-495.
10. 2A receptor in the central nervous system of adult rat. J Comp Neurol 409:187-209.
11. Crill WE (1996) Persistant sodium current in mammalian central neurons. Annu Rev Physiol 58:349-362.
12. + channel. Neuron 6:165-175.
13. 2a agonists on high voltage activated calcium currents in prefrontal pyramidal neurons. Soc Neuroscience Abstr 26:534.10.
14. 2+ channel currents via a PLCβ/IP3/calcineurin signaling cascade. J Neurophysiol, in press.
15. A receptor channels through activation of anchored protein kinase C in prefrontal cortical neurons. J Neurosci 21:6502-6511.
16. + currents increases the excitability of rat neocortical pyramidal neurones. J Physiol (Lond) 528:291-304.
17. Franklin KBJ, Paxinos G (1997) The Mouse Brain in Stereotaxic Coordinates. New York: Academic.
18. Glennon RA, Dukat M (1995) Serotonin receptor subtypes. In: Psychopharmacology: The Fourth Generation of Progress (Bloom FE, Kupfer DJ, eds), pp 415-429. New York: Raven.
19. Golding NL, Spruston N (1998) Dendritic sodium spikes are variable triggers of axonal action potentials in hippocampal CA1 pyramidal neurons. Neuron 21:1189-1200.
20. Golding NL, Jung HY, Mickus T, Spruston N (1999) Dendritic calcium spike initiation and repolarization are controlled by distinct potassium channel subtypes in CA1 pyramidal neurons. J Neurosci 19:8789-8798.
21. Gonzalez-Burgos GR, Barrionuevo G (2001) Voltage-gated sodium channels shape subthreshold EPSPs in layer 5 pyramidal neurons from rat prefrontal cortex. J Neurophysiol 86:1671-1684.
22. + currents in mouse neuroblastoma cells. J Membr Biol 140:101-110.
23. Hilborn MD, Vaillancourt RR, Rane SG (1998) Growth factor receptor tyrosine kinases acutely regulate neuronal sodium channels through the Src signaling pathway. J Neurosci 18:590-600.
24. Hille B (1992) Ionic Channels of Excitable Membranes, Ed 2. Sunderland, MA: Sinauer.
25. Hoffman DA, Johnston D (1998) Downregulation of transient K+ channels in dendrites of hippocampal CA1 pyramidal neurons by activation of PKA and PKC. J Neurosci 18:3521-3528.
26. 2A serotonin receptors in the primate cerebral cortex: Possible site of action of hallucinogenic and antipsychotic drugs in pyramidal cell apical dendrites. Proc Natl Acad Sci USA 95:735-740.
27. Larkum ME, Zhu JJ, Sakmann B (1999) A new cellular mechanism for coupling inputs arriving at different cortical layers. Nature 398:338-341.
28. + channels amplify EPSPs in hippocampal CA1 pyramidal cells. J Neurophysiol 76:2181-2191.
29. Liu WS, Heckman CA (1998) The sevenfold way of PKC regulation. Cell Signal 10:529-542.
30. Magee JC (1999) Voltage-gated ion channels in dendrites. In: Dendrites (Stuart G, Spruston N, Hausser M, eds), pp 139-160. New York: Oxford UP.
31. Magee JC, Johnston D (1997) A synaptically controlled associative signal for Hebbian plasticity in hippocampal neurons. Science 275:209-213.
32. Mantz J, Godbout R, Tassin J-P, Glowinski J, Thierry A-M (1990) Inhibition of spontaneous and evoked unit activity in the rat medial prefrontal cortex by mesencephalic raphe nuclei. Brain Res 524:22-30.
33. 5 dopamine receptor activation differentially modulates rapidly inactivating and persistent sodium currents in prefrontal cortex pyramidal neurons. J Neurosci 21:2268-2277.
34. Meltzer HY (1999) The role of serotonin in antipsychotic drug action. Neuropsychopharmacology 21:106S-115S.
35. + current in rat neocortical pyramidal neurons. J Neurophysiol 79:1579-1582.
36. Numan R, Catterall WA, Scheuer T (1991) Functional modulation of brain sodium channels by protein kinase C phosphorylation. Science 254:115-118.
37. Sanders-Bush E, Canton H (1995) Serotonin receptors: Signal transduction pathways. In: Psychopharmacology: The Fourth Generation of Progress (Bloom FE, Kupfer DJ, eds), pp 431-441. New York: Raven.
38. i changes in the apical dendrites of hippocampal CA1 pyramidal neurons. J Neuropyhysiol 81:216-274.
39. Schwindt PC, Crill WE (1995) Amplification of synaptic current by persistent sodium conductance in apical dendrite of neocortical neurons. J Neurophysiol 74:2220-2224.
40. 4. Neuropsychopharmacology 7:261-284.
41. Stuart G, Sakmann B (1994) Active propagation of somatic action potentials into neocortical pyramidal cell dendrites. Nature 367:69-72.
42. Stuart G, Sakmann B (1995) Amplification of EPSPs by axosomatic sodium channels in neocortical pyramidal neurons. Neuron 15:1065-1076.
43. Stuart G, Schiller J, Sakmann B (1997) Action potential initiation and propagation in rat neocortical pyramidal neurons. J Physiol (Lond) 505:617-632.
44. Stuart G, Spruston N, Hausser M (1999) Dendrites. New York: Oxford University Press.
45. Taddese A, Bean BP (2002) Subthreshold sodium current from rapidly inactivating sodium channels drives spontaneous firing of tuberomammillary neurons. Neuron 33:587-600.
46. 2+, ErbB3, and phosphoinositide 3-kinase in 1321N1 astrocytoma cells. J Biol Chem 277:338-344.
47. Vysokanov A, Flores-Hernandez J, Surmeier DJ (1998) mRNAs for clozapine sensitive receptors co-localize in rat prefrontal cortex neurons. Neurosci Lett 258:179-182.
48. Weinberger DR (1988) Schizophrenia and the frontal lobe. Trends Neurosci 11:367-370.