Antioxidant vitamins and Alzheimer's disease: A review of the epidemiological literature

Aging Health

Volumn 3, Issue 1, 2007, Pages 23-32

  Harrington, Meredith ^a   Grodstein, Francine ^a,b  

^a CHANNING LABORATORY   (United States)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

carotene; Alzheimer's disease; Antioxidants; Cognitive decline; Dementia; Vitamin C; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL; AMYLOID BETA PROTEIN; ANTIOXIDANT; ASCORBIC ACID; BETA CAROTENE; C REACTIVE PROTEIN; FREE RADICAL; GAMMA TOCOPHEROL; INTERLEUKIN 6; PLACEBO; SELEGILINE; VITAMIN;

AGING; ALPHA TOCOPHEROL DEFICIENCY; ALZHEIMER DISEASE; ANTIOXIDANT ACTIVITY; CLINICAL TRIAL; COGNITIVE DEFECT; COMBINATION CHEMOTHERAPY; CONTROLLED CLINICAL TRIAL; DAILY LIFE ACTIVITY; DEMENTIA; DIET SUPPLEMENTATION; DIETARY INTAKE; DISEASE COURSE; DISEASE SEVERITY; DRUG MEGADOSE; HIPPOCAMPUS; HUMAN; INCIDENTAL FINDING; INFLAMMATION; LIPID PEROXIDATION; LONG TERM CARE; MONOTHERAPY; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; RANDOMIZED CONTROLLED TRIAL; REVIEW; VITAMIN INTAKE;

EID: 33847332001     PISSN: 1745509X     EISSN: 17455103     Source Type: Journal    
DOI: 10.2217/1745509X.3.1.23     Document Type: Review

References (41)

1. Ferri CP, Prince M, Brayne C et al: Global prevalence of dementia: a Delphi consensus study. Lancet 366(9503), 2112-2117 (2005).
2. Kim KY, Wood BE, Wilson MI: Risk factors for Alzheimer's disease: an overview for clinical practitioners. Consult. Pharm. 20(3), 224-230 (2005).
3. Brookmeyer R, Grays S, Kawas C: Projections of Alzheimer's disease in the United States and the publich health impact of delaying disease onset. Am. J. Public Health 88(9), 1337-1342 (1998).
4. Institute of Medicine: Food and Nutrition board. Dietary Reference Intakes: Vitamin C, Vitamin E, Selenium and Carotenoids. National Academy Press. WA, USA (2000).
5. Harman, D: Aging: a theory based on free radical and radiation chemistry. J. Gerontol. 11(3), 298-300 (1956).
6. Lecanu L, Greeson J, Papadopoulos B: β-amyloid and oxidative stress jointly induce neuronal death, amyloid deposits, gliosis, and memory impairment in the rat brain. Pharmacology 76(1), 19-33 (2006).
7. Morris MC: Diet and Alzheimer's disease: what the evidence shows. MedGenMed. 6(1), 48 (2004).
8. Gilgun-Sherki Y, Melamed E, Offen D: Antioxidant treatment in Alzheimer's disease: current state. J. Mol. Neurosci. 21(1), 1-11 (2003).
9. Retz W, Gsell W, Munch G, Rosler M, Riederer P: Free radicals in Alzheimer's disease. J. Neural Transm. Suppl. 54, 221-236 (1998) (Abstract).
10. Rota C, Rimbach G, Minihane AM, Stoecklin E, Barella L: Dietary vitamin E modulates differential gene expression in the rat hippocampus: potential implications for its neuroprotective properties. Nutr. Neurosri. 8(1), 21-29 (2005).
11. Goodman Y, Mattson MP: Secreted forms of β-amyloid precursor protein protect hippocampal neurons against amyloid β-peptid-induced oxidative injury. Exp. Neurol. 128, 1-12 (1994).
12. Behi C. Davis J, Cole GM, Schubert D: Vitamin E protects nerve cells from amyloid β-protein toxicity. Biochem. Biophys. Res. Commun. 186, 944-950 (1992).
13. Sung S, Yao Y, Uryu K et al.: Early vitamin E supplementation in young but not aged mice reduces Aβ levels and amylold deposition in a transgenic model of Alzheimer's disease. FASEB J. 18(2), 323-325 (2004).
14. Montiel T, Quiroz-Baez R, Massieu L, Arias C: Role of oxidative stress on β-amyloid neurotoxicity elicited during impairment of energy metabolism in the hippocampus: protection by antioxidants. Exp. Neurol. 200(2), 496-508 (2006).
15. Yamada K, Tanaka T, Han D. Senzaki K, Kameyama T, Nabeshimia T: Protective effects of idebenone and α-tocopherol on β-amyloid- (1-42)-induced learning and memory deficits in rats: implication of oxidative stress in β-amyloid-induced neurotoxicity in vivo. Eur. J. Neurosci. 11(1), 83-90 (1999).
16. Biegon A, Alvarado M, Budinger TF et al.: Region-selective effects of neuroinflammation and antioxidant treatment an peripheral benzodiazepine receptors and NMDA receptors in the rat brain. J. Neurochem. 82(4), 924-934 (2002).
17. Devaraj D, Jialal I: α-tocopherol supplementation decreases serum C-reactive protein and monocyte interleukin-6 levels in normal volunteers and Type 2 diabetic patients. Free Radic. Biol. Med. 29(8), 790-792 (2000).
18. Jiang Q, Ames BN: γ-tocopherol, but not α-tocopherol, decrease proinflammatory eicosanoids and inflammation damage in rats. FASEB J. 17(8), 816-822 (2003).
19. Lambelet P, Saucy F, Loliger J: Chemical evidence for interactions between vitamins E and C. Experientia 41(11), 1384-1388 (1985).
20. Arzi A, Hemmati AA, Razian A: Effect of vitamin C and E on cognitive function in mice. Pharmacol. Res. 49(3), 249-252 (2004).
21. Joseph JA, Shukitt-Hale B, Denisova NA et al.: Long-term strawberry, spinach, or vitamin E supplementation retards the onset of age-related neuronal signal-transduction and cognitive behavioral deficits. J. Neurosci. 18(19), 8047-8055 (1998).
22. Socci DJ, Crandall BM, Arendash GW: Chronic antioxidant treatment improves the cognitive performance of aged rats. Brain Res. 693(1-2), 88-94 (1995).
23. Zandi PP, Anthony JC, Khachaturian AS et al.: Reduced risk of Alzheimer disease in users of antioxidant vitamin supplements. Arch. Neurol, 61, 82-88 (2004).
24. Maxwell CJ, Hicks MS, Hogan DB. Basran J. Ebly EM: Supplemental use of antioxidant vitamins and subsequent risk of cognitive decline and dementia. Dement. Geriatr: Cogn. Disord. 20, 45-51 (2005).
25. Fillenbaum GC, Kuchibhatla MN, Hanlon JT et al: Dementia and Alzheimer's disease in community-dwelling elders taking vitamin C and/or vitamin E. Ann. Pharmacother. 39(12), 2009-2014 (2005). 30.
26. Grodstein F, Chen J, Willet WC: High-dose antioxidant supplements and cognitive function in community-dwelling elderly women. Am. J. Clin. Nutr. 77, 975-984 (2003).
27. Masaki KH, Losonczy KG, Izmirlian G et al.: Association of vitamin E and C supplement use with cognitive function and dementia in elderly men. Neurology 54, 1265-1272 (2000).
28. Morris MC, Tangney CC, Bienias JL et al.: Validity and reproducibility of a food frequency questionnaire by cognition in an older biracial sample. Am. J. Epidemiol. 158(12), 1213-1217 (2003).
29. Engelhart MJ, Geerlings MI, Ruitenberg A et al.: Dietary intake of antioxidants and risk of Alzheimer disease. JAMA 287(24), 3223-3229 (2002).
30. Morris MC, Evans DA, Bienias JL, Tagney CC, Wilson RS: Vitamin E and cognitive decline in older persons. Arch. Neurol. 59, 1125-1132 (2002).
31. Morris MC, Evans DA, Bienias JL et al.: Dietary intake of antioxidant nutrients and the risk of incident Alzheimer's disease in a biracial community study. JAMA 287(24), 3230-3237 (2002).
32. Commenges D, Scotet V, Renaud S, Jaqmin-Gadda H, Barberger-Gateau P, Dartigues JF: Intake of flavonoids and risk of dementia. Eur. J. Epidemiol. 16, 357-363 (2000).
33. Luchsinger JA, Tang MX, Shea S, Mayeux R: Antioxidant vitamin intake and risk of Alzheimer's disease. Arch. Neurol. 60, 203-208 (2003).
34. Laurin D, Masaki KM, Foley DJ et al.: Midlife dietary intake of antioxidants and risk of late-life incident dementia: the Honolulu-Asia aging study. Am. J. Epidemiol. 159(10), 959-967 (2004).
35. Morris MC, Evans DE, Tangney CC etal.: Relation of the tocopherol forms to incident Alzheimer disease and to cognitive change. Am. J. Clin. Nutr. 81, 508-514 (2005).
36. Petersen RC, Thomas RG, Grundman M et al.: Vitamin E and donepezil for the treatment of mild cognitive impairment. N. Engl. J. Med. 352(23), 2379-2388 (2005).
37. Sano M, Ernesto C, Thomas RG et al.: A controlled trial of selegiline α-tocopherol, or both as treatment for Alzheimer's disease. N. Engl. J. Med. 336(17), 1216-1222 (1997).
38. Age-Reiated Eye Disease Study Research Group: Impact of antioxidants, zinc, and copper in the elderly: a randomized, controlled trial. Neurology 63, 1705-1707 (2004).
39. Heart Protection Study Collaborative Group: MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20536 high-risk individuals: a randomised placebo-controlled trial. Lancet 360, 23-33 (2002).
40. Kang JH, Cook N, Manson J, Buring JE, Grodstein F: A large randomized trial of vitamin E supplements in women. Arch. Intern. Med. (2006) (In Press).
41. Grodstein F, Kang JH, Glynn RJ, Cook NR, Gaziano JM: A randomized trial of β-carotene supplements and cognitive function in healthy men. Neurobiol. Aging 25(Suppl. 2) (2004).