Factors Regulating Growth Hormone Secretion in Humans

Endocrinology and Metabolism Clinics of North America

Volumn 36, Issue 1, 2007, Pages 37-55

  Goldenberg, Naila ^a   Barkan, Ariel ^a  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROSTANOLONE; ARGININE; CLONIDINE; FATTY ACID; GHRELIN; GROWTH HORMONE; GROWTH HORMONE RELEASING FACTOR; GROWTH HORMONE RELEASING FACTOR RECEPTOR; HISTIDYL DEXTRO TRYPTOPHYLALANYLTRYPTOPHYL DEXTRO PHENYLALANYLLYSINAMIDE; HUMAN GROWTH HORMONE; INSULIN; LEVODOPA; MESSENGER RNA; NEOSTIGMINE; OCTREOTIDE; OXANDROLONE; PYRIDOSTIGMINE; SERMORELIN; SOMATOSTATIN; TESTOSTERONE;

AGING; CONTINUOUS INFUSION; DRUG MEGADOSE; GROWTH HORMONE DEFICIENCY; GROWTH HORMONE RELEASE; HORMONE DEFICIENCY; HORMONE RELEASE; HUMAN; NEGATIVE FEEDBACK; NONHUMAN; NUTRITION; PRIORITY JOURNAL; PUBERTY; PULSATILE HORMONE RELEASE; REVIEW; SLEEP;

ANIMALS; FEEDBACK, BIOCHEMICAL; FOOD; GENE EXPRESSION REGULATION; GONADAL STEROID HORMONES; GONADOTROPIN-RELEASING HORMONE; GROWTH HORMONE; HUMANS; MODELS, BIOLOGICAL; PEPTIDE HORMONES; SLEEP; SOMATOSTATIN;

EID: 33847329661     PISSN: 08898529     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ecl.2006.11.003     Document Type: Review

References (105)

1. Isgaard J., Carlsson L., Isaksson O.G., et al. Pulsatile intravenous growth hormone (GH) infusion to hypophysectomized rats increases insulin-like growth factor 1 messenger ribonucleic acid in skeletal tissues more effectively than continuous GH infusion. Endocrinology 123 (1988) 2605-2610
2. Cheung C., Yu A.M., Chen C.S., et al. Growth hormone determines sexual dimorphism of hepatic cytochrome P450 3A4 expression in transgenic mice. J Pharmacol Exp Ther 316 (2006) 1328-1334
3. Reichlin S. Growth and the hypothalamus. Endocrinology 67 (1960) 760-763
4. Frohman L.A., Bernardis L.L., and Kant K.J. Hypothalamic stimulation of growth hormone secretion. Science 162 (1968) 580-582
5. Frohman L.A., and Bernardis L.L. Growth hormone and insulin levels in weanling rats with ventromedial hypothalamic lesions. Endocrinology 82 (1968) 1125-1132
6. Thorner M.O., Perryman R.L., Cronin M.J., et al. Somatotroph hyperplasia: successful treatment of acromegaly by removal of a pancreatic islet tumor secreting growth hormone-releasing factor. J Clin Invest 70 (1982) 967-977
7. Sassolas G., Chayvialle J.A., Partensky C., et al. Acromegaly, clinical expression of the production of growth hormone releasing factor in pancreatic tumors. Ann Endocrinol (Paris) 44 (1983) 347-354
8. Ling N., Esch F., Bohlen P., et al. Isolation, primary structure, and synthesis of human hypothalamic somatocrine: growth hormone-releasing factor. Proc Natl Acad Sci U S A 81 (1984) 4302-4306
9. Plotsky P.M., and Vale W. Patterns of growth hormone-releasing factor and somatostatin secretion into the hypophysial-portal circulation of the rat. Science 230 (1985) 461-463
10. Ono M., Miki N., and Demura H. Effect of antiserum to rat growth hormone (GH)-releasing factor on physiological GH secretion in the female rat. Endocrinology 129 (1991) 1791-1796
11. Nakamura S., Mizuno M., Katakami H., et al. Aging-related changes in in vivo release of growth hormone-releasing hormone and somatostatin from the stalk-median eminence in female rhesus monkeys (Macaca mulatta). J Clin Endocrinol Metab 88 (2003) 827-833
12. Cataldi M., Magnan E., Guillaume V., et al. Relationship between hypophyseal portal GH-RH and somatostatin and peripheral GH levels in the conscious sheep. J Endocrinol Invest 17 (1994) 717-722
13. Clark R.G., and Robinson I.C. Growth induced by pulsatile infusion of an amidated fragment of human growth hormone releasing factor in normal and GHRF-deficient rats. Nature 314 (1985) 281-283
14. Borski R.J., Tsai W., Demott-Friberg R., et al. Induction of growth hormone (GH) mRNA by pulsatile GH-releasing hormone in rats is pattern specific. Am J Physiol Endocrinol Metab 278 (2000) 885-891
15. Vance M.L., Kaiser D.L., Martha Jr. P.M., et al. Lack of in vivo somatotroph desensitization or depletion after 14 days of continuous growth hormone (GH)-releasing hormone administration in normal men and a GH-deficient boy. J Clin Endocrinol Metab 68 (1989) 22-28
16. Russell-Aulet M., Dimaraki E.V., Jaffe C.A., et al. Aging-related growth hormone (GH) decrease is a selective hypothalamic GH-releasing hormone pulse amplitude mediated phenomenon. J Gerontol A Biol Sci Med Sci 56 (2001) 124-129
17. Jaffe CA, Friberg RD, Barkan AL. Suppression of growth hormone (GH) secretion by a selective GH-releasing hormone (GH-RH) antagonist: direct evidence for involvement of endogenous GH-RH in the generation of GH pulses. J Clin Invest 1993;92:695-701.
18. Jessup S.K., Dimaraki E.V., Symons K.V., et al. Sexual dimorphism of growth hormone (GH) regulation in humans: endogenous GH-releasing hormone maintains basal GH in women but not in men. J Clin Endocrinol Metab 88 (2003) 4776-4780
19. Maheshwari H.G., Pezzoli S.S., Rahim A., et al. Pulsatile growth hormone secretion persists in genetic growth hormone-releasing hormone resistance. Am J Physiol Endocrinol Metab 282 (2002) 943-951
20. Magnan E., Cataldi M., Guillaume V., et al. Neostigmine stimulates growth hormone-releasing hormone release into hypophysial portal blood of conscious sheep. Endocrinology 132 (1993) 1247-1251
21. Jaffe C.A., DeMott-Friberg R., and Barkan A.L. Endogenous growth hormone (GH)-releasing hormone is required for GH responses to pharmacological stimuli. J Clin Invest 97 (1996) 934-940
22. Pandya N., DeMott-Friberg R., Bowers C.Y., et al. Growth hormone (GH)-releasing peptide-6 requires endogenous hypothalamic GH-releasing hormone for maximal GH stimulation. J Clin Endocrinol Metab 83 (1998) 1186-1189
23. Jaffe C.A., Ocampo-Lin B., Guo W., et al. Regulatory mechanisms of growth hormone secretion are sexually dimorphic. J Clin Invest 102 (1998) 153-164
24. Billestrup N., Swanson L.W., and Vale W. Growth hormone-releasing factor stimulates proliferation of somatotrophs in vitro. Proc Natl Acad Sci U S A 83 (1986) 6854-6857
25. Dimaraki E.V., Jaffe C.A., DeMott-Friberg R., et al. Generation of growth hormone pulsatility in women: evidence against somatostatin withdrawal as pulse initiator. Am J Physiol Endocrinol Metab 280 (2001) 489-495
26. Dimaraki E.V., Jaffe C.A., Bowers C.Y., et al. Pulsatile and nocturnal growth hormone secretions in men do not require periodic declines of somatostatin. Am J Physiol Endocrinol Metab 285 (2003) 163-170
27. Zheng H., Bailey A., Jiang M.H., et al. Somatostatin receptor subtype 2 knockout mice are refractory to growth hormone-negative feedback on arcuate neurons. Mol Endocrinol 11 (1997) 1709-1717
28. Low M.J., Hammer R.E., Goodman R.H., et al. Tissue-specific posttranslational processing of pre-prosomatostatin encoded by a metallothionein-somatostatin fusion gene in transgenic mice. Cell 41 (1985) 211-219
29. Bass J.J., Gluckman P.D., Fairclough R.J., et al. Effect of nutrition and immunization against somatostatin on growth and insulin-like growth factors in sheep. J Endocrinol 112 (1987) 27-31
30. Maccario M., Grottoli S., Procopio M., et al. The GH/IGF-1 axis in obesity: influence of neuro-endocrine and metabolic factors. Int J Obes Relate Metab Disord 24 Suppl 2 (2000) S96-S99
31. Mozid A.M., Tringali G., Forsling M.L., et al. Ghrelin is released from rat hypothalamic explants and stimulates corticotrophin-releasing hormone and arginine-vasopressin. Horm Metab Res 35 (2003) 455-459
32. Smith R.G., Jiang H., and Sun Y. Developments in ghrelin biology and potential clinical relevance. Trends Endocrinol Metab 16 (2005) 436-442
33. Bowers C.Y., Sartor A.O., Reynolds G.A., et al. On the actions of the growth hormone-releasing hexapeptide, GHRP. Endocrinology 128 (1991) 2027-2035
34. Herrington J., and Hille B. Growth hormone-releasing hexapeptide elevates intracellular calcium in rat somatotropes by two mechanisms. Endocrinology 135 (1994) 1100-1108
35. Robinson B.M., Friberg R.D., Bowers C.Y., et al. Acute growth hormone (GH) response to GH-releasing hexapeptide in humans is independent of endogenous GH-releasing hormone. J Clin Endocrinol Metab 75 (1992) 1121-1124
36. Jaffe C.A., Ho P.J., DeMott-Friberg R., et al. Effects of a prolonged growth hormone (GH)-releasing peptide infusion on pulsatile GH secretion in normal men. J Clin Endocrinol Metab 77 (1993) 1631-1637
37. Avram A.M., Jaffe C., Symons K.V., et al. Endogenous circulating ghrelin does not mediate growth hormone rhythmicity or response to fasting. J Clin Endocrinol Metab 90 (2005) 2982-2987
38. Corbetta S., Peracchi M., Cappiello V., et al. Circulating ghrelin levels in patients with pancreatic and gastrointestinal neuroendocrine tumors: identification of one pancreatic ghrelinoma. J Clin Endocrinol Metab 88 (2003) 3117-3120
39. Tsolakis A.V., Portela-Gomes G.M., Stridsberg M., et al. Malignant gastric ghrelinoma with hyperghrelinemia. J Clin Endocrinol Metab 89 (2004) 3739-3744
40. Sun Y., Ahmed S., and Smith R.G. Deletion of ghrelin impairs neither growth nor appetite. Mol Cell Biol 23 (2003) 7973-7981
41. Wortley K.E., Anderson K.D., Garcia K., et al. Genetic deletion of ghrelin does not decrease food intake but influences metabolic fuel preference. Proc Natl Acad Sci U S A 101 (2004) 8227-8232
42. Wortley K.E., del Rincon J.P., Murray J.D., et al. Absence of ghrelin protects against early-onset obesity. J Clin Invest 115 (2005) 3393-3397
43. Zigman J.M., Nakano Y., Coppari R., et al. Mice lacking ghrelin receptors resist the development of diet-induced obesity. J Clin Invest 115 (2005) 3564-3572
44. Lumpkin M.D., and McDonald J.K. Blockade of growth hormone-releasing factor (GRF) activity in the pituitary and hypothalamus of the conscious rat with a peptidic GRF antagonist. Endocrinology 124 (1989) 1522-1531
45. Lumpkin M.D., Mulroney S.E., and Haramati A. Inhibition of pulsatile growth hormone (GH) secretion and somatic growth in immature rats with a synthetic GH-releasing factor antagonist. Endocrinology 124 (1989) 1154-1159
46. Peterfreund R.A., and Vale W.W. Somatostatin analogs inhibit somatostatin secretion from cultured hypothalamus cells. Neuroendocrinology 39 (1984) 397-402
47. Mitsugi N., Arita J., and Kimura F. Effects of intracerebroventricular administration of growth hormone-releasing factor and corticotrophin-releasing factor on somatostatin secretion into rat hypophysial portal blood. Neuroendocrinology 51 (1990) 9306
48. Yamauchi N., Shibasaki T., Ling N., et al. In vitro release of growth hormone-releasing factor (GRF) from the hypothalamus: somatostatin inhibits GRF release. Regul Pept 33 (1991) 71-78
49. Frohman M.A., Downs T.R., Chomczynski P., et al. Cloning and characterization of mouse growth hormone-releasing hormone (GRH) complementary DNA: increased GRH messenger RNA levels in the growth hormone-deficient lit/lit mouse. Mol Endocrinol 3 (1989) 1529-1536
50. Chomczynski P., Downs T.R., and Frohman L.A. Feedback regulation of growth hormone (GH)-releasing hormone gene expression by GH in rat hypothalamus. Mol Endocrinol 2 (1988) 236-241
51. Chihara K., Minamitani N., Kaji H., et al. Intraventricularly injected growth hormone stimulates somatostatin release into rat hypophysial portal blood. Endocrinology 109 (1981) 2279-2281
52. Berelowitz M., Firestone S.L., and Frohman L.A. Effects of growth hormone excess and deficiency on hypothalamic somatostatin content and release and on tissue somatostatin distribution. Endocrinology 109 (1981) 714-719
53. Laron Z., Pertzelan A., and Karp M. Pituitary dwarfism with high serum levels of growth hormone. Isr J Med Sci 4 (1968) 883-894
54. Rosenfeld R.G., and Buckway C.K. Growth hormone insensitivity syndromes: lessons learned and opportunities missed. Horm Res 55 (2001) 36-39
55. Rosenfeld R.G., and Hwa V. New molecular mechanisms of GH resistance. Eur J Endocrinol 151 (2004) 11-15
56. Bermann M., Jaffe C.A., Tsai W., et al. Negative feedback regulation of pulsatile growth hormone secretion by insulin-like growth factor I. Involvement of hypothalamic somatostatin. J Clin Invest 94 (1994) 138-145
57. Chapman I.M., Hartman M.L., Pieper K.S., et al. Recovery of growth hormone release from suppression by exogenous insulin-like growth factor I (IGF-I): evidence for a suppressive action of free rather than bound IGF-I. J Clin Endocrinol Metab 83 (1998) 2836-2842
58. Ho P.J., Friberg R.D., and Barkan A.L. Regulation of pulsatile growth hormone secretion by fasting in normal subjects and patients with acromegaly. J Clin Endocrinol Metab 75 (1992) 812-819
59. Darzy K.H., Murray R.D., Gleeson H.K., et al. The impact of short-term fasting on the dynamics of 24-hour growth hormone (GH) secretion in patients with severe radiation-induced GH deficiency. J Clin Endocrinol Metab 91 (2005) 987-994
60. Hashimoto Y., Kamioka T., Hosaka M., et al. Exogenous 20K growth hormone (GH) suppresses endogenous 22K GH secretion in normal men. J Clin Endocrinol Metab 85 (2000) 601-606
61. Beckers A., Stevenaert A., Foidart J.M., et al. Placental and pituitary growth hormone secretion during pregnancy in acromegalic women. J Clin Endocrinol Metab 71 (1990) 725-731
62. Obal Jr. F., and Krueger J.M. GH-RH and sleep. Sleep Med Rev 8 (2004) 367-377
63. Van Cauter E., Plat L., and Copinschi G. Interrelations between sleep and the somatotropic axis. Sleep 21 (1998) 553-566
64. Holl R.W., Hartman M.L., Veldhuis J.D., et al. Thirty-second sampling of plasma growth hormone in man: correlation with sleep stages. J Clin Endocrinol Metab 72 (1991) 854-861
65. Van Cauter E., Plat L., Scharf M.B., et al. Simultaneous stimulation of slow-wave sleep and growth hormone secretion by gamma-hydroxybutyrate in normal young men. J Clin Invest 100 (1997) 745-753
66. Hochberg Z. Mechanisms of steroid impairment of growth. Horm Res 58 (2002) 33-38
67. Samuels M.H. Effects of variations in physiological cortisol levels on thyrotropin secretion in subjects with adrenal insufficiency: a clinical research center study. J Clin Endocrinol Metab 85 (2000) 1388-1393
68. Barkan A.L., DeMott-Friberg R., and Samuels M.H. Growth hormone (GH) secretion in primary adrenal insufficiency: effects of cortisol withdrawal and patterned replacement of GH pulsatility and circadian rhythmicity. Pituitary 3 (2000) 175-179
69. Jaffe C.A., Turgeon D.K., Friberg R.D., et al. Nocturnal augmentation of growth hormone (GH) secretion is preserved during repetitive bolus administration of GH-releasing hormone: potential involvement of endogenous somatostatin-a clinical research center study. J Clin Endocrinol Metab 80 (1995) 3321-3326
70. Maheshwari H.G., Silverman B.L., Dupuis J., et al. Phenotype and genetic analysis of a syndrome caused by an inactivating mutation in the growth hormone-releasing hormone receptor: dwarfism of Sindh. J Clin Endocrinol Metab 83 (1998) 4065-4074
71. Jessup S.K., Malow B.A., Symons K.V., et al. Blockade of endogenous growth hormone-releasing hormone receptors dissociates nocturnal growth hormone secretion and slow-wave sleep. Eur J Endocrinol 151 (2004) 561-566
72. Veldhuis J.D., Roemmich J.N., Richmond E.J., et al. Somatotropic and gonadotropic axes linkages in infancy, childhood, and the puberty-adult transition. Endocr Rev 27 (2006) 101-140
73. Giordano R., Lanfranco F., Bo M., et al. Somatopause reflects age-related changes in the neural control of GH/IGF-I axis. J Endocrinol Invest 28 (2005) 94-98
74. Wehrenberg W.B., and Giustina A. Feedback regulation of growth hormone secretion. In: Kostyo J.L., and Goodman H.M. (Eds). Handbook of physiology, vol. 5. Hormonal control of growth (1999), Oxford University Press, Oxford 299-327
75. Metzger D.L., and Kerrigan J.R. Estrogen receptor blockade with tamoxifen diminishes growth hormone secretion in boys: evidence for stimulatory role of endogenous estrogens during male adolescence. J Clin Endocrinol Metab 79 (1994) 513-518
76. Metzger D.L., and Kerrigan J.R. Androgen receptor blockade with flutamide enhances growth hormone secretion in late pubertal males: evidence for independent actions of estrogen and androgen. J Clin Endocrinol Metab 76 (1993) 1147-1152
77. Veldhuis J.D., Metzger D.L., Martha Jr. P.M., et al. Estrogen and testosterone, but not a nonaromatizable androgen, direct network integration of the hypothalamosomatotrope (growth hormone)-insulin-like growth factor I axis in the human: evidence from pubertal pathophysiology and sex-steroid hormone replacement. J Clin Endocrinol Metab 82 (1997) 3414-3420
78. Racine M.S., Symons K.V., Foster C.M., et al. Augmentation of growth hormone secretion after testosterone treatment in boys with constitutional delay of growth and adolescence: evidence against an increase in hypothalamic secretion of growth hormone-releasing hormone. J Clin Endocrinol Metab 89 (2004) 3326-3331
79. Orrego J.J., Dimaraki E., Symons K., et al. Physiological testosterone replenishment in healthy elderly men does not normalize pituitary growth hormone output: evidence against the connection between senile hypogonadism and somatopause. J Clin Endocrinol Metab 89 (2004) 3255-3260
80. Borski R.J., Tsai W., DeMott-Friberg R., et al. Regulation of somatic growth and the somatotropic axis by gonadal steroids: primary effect of insulin-like growth factor I gene expression and secretion. Endocrinology 137 (1996) 3253-3259
81. Dimaraki E.V., Symons K.V., and Barkan A.L. Raloxifene decreases serum IGF-1 in male patients with active acromegaly. Eur J Endocrinol 150 (2004) 481-487
82. Cozzi R., Barausse M., Lodrini S., et al. Estroprogestinic pill normalizes IGF-1 levels in acromegalic women. J Endocrinol Invest 26 (2003) 347-352
83. Leung K.C., Johannsson G., Leong G.M., et al. Estrogen regulation of growth hormone action. Endocr Rev 25 (2004) 693-721
84. Leung K.C., Doyle N., Ballesteros M., et al. Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2. Proc Natl Acad Sci U S A 100 (2003) 1016-1021
85. Roth A., Cligg S.M., Yallow C.P., et al. Secretion of human growth hormone: physiological and experimental modification. Metabolism 12 (1963) 557-559
86. Yalow R.S., Goldsmith S.J., and Berson S.A. Influence of physiologic fluctuations in plasma growth hormone on glucose tolerance. Diabetes 18 (1969) 402-408
87. Masuda A., Shibasaki T., Nakahara M., et al. The effect of glucose on growth hormone (GH)-releasing hormone-mediated GH secretion in man. J Clin Endocrinol Metab 60 (1985) 523-526
88. Broglio F., Benso A., Gottero C., et al. Effects of glucose, free fatty acids or arginine load on the GH-releasing activity of ghrelin in humans. Clin Endocrinol (Oxf) 57 (2002) 265-271
89. Valcavi R., Zini M., Davoli S., et al. The late growth hormone rise induced by oral glucose is enhanced by cholinergic stimulation with pyridostigmine in normal subjects. Clin Endocrinol (Oxf) 37 (1992) 360-364
90. Gharib H., Cook D.M., Saenger P.H., et al. American Association of Clinical Endocrinologists medical guidelines for clinical practice for growth hormone use in adults and children: 2003 update. Endocr Pract 9 (2003) 64-76
91. Imaki T., Shibasaki T., Shizume K., et al. The effect of free fatty acids on growth hormone (GH)-releasing hormone-mediated GH secretion in man. J Clin Endocrinol Metab 60 (1985) 290-293
92. Fuccella L., Golaniga G., and Lovisolo P. Inhibition of lipolysis by nicotinic acid and acipimox. Clin Pharmacol Ther 28 (1980) 790-795
93. Cordido F., Peino R., Penalva A., et al. Impaired growth hormone secretion in obese subjects is partially reversed by acipimox-mediated plasma free fatty acid depression. J Clin Endocrinol Metab 81 (1996) 914-918
94. Pontiroli A.E., Lanzi R., Monti L.D., et al. Effect of acipimox, a lipid lowering drug, on growth hormone (GH) response to GH-releasing hormone in normal subjects. J Endocrinol Invest 13 (1990) 539-542
95. Maccario M., Grottoli S., Procopio M., et al. The GH/IGF-I axis in obesity: influence of neuro-endocrine and metabolic factors. Int J Obes Relat Metab Disord 24 Suppl 2 (2000) S96-S99
96. Clasey J.L., Weltman A., Patrie J., et al. Abdominal visceral fat and fasting insulin are important predictors of 24-hour GH release independent of age, gender, and other physiological factors. J Clin Endocrinol Metab 86 (2001) 3845-3852
97. Kok P., Buijs M.M., Kok S.W., et al. Acipimox enhances spontaneous growth hormone secretion in obese women. Am J Physiol Regul Integr Comp Physiol 286 (2004) R693-R698
98. Douyon L., and Schteingart D.E. Effect of obesity and starvation on thyroid hormone, growth hormone, and cortisol secretion. Endocrinol Metab Clin North Am 31 (2002) 173-189
99. Sandhu M.S., Gibson J.M., Heald A.H., et al. Association between insulin-like growth factor-I: insulin-like growth factor-binding protein-1 ratio and metabolic and anthropometric factors in men and women. Cancer Epidemiol Biomarkers Prev 13 (2004) 166-170
100. Fletcher T.P., Thomas G.B., Dunshea F.R., et al. IGF feedback effects on growth hormone secretion in ewes: evidence for action at the pituitary but not the hypothalamic level. J Endocrinol 144 (1995) 323-331
101. Hartman M.L., Clayton P.E., Johnson M.L., et al. A low dose euglycemic infusion of recombinant human insulin-like growth factor I rapidly suppresses fasting-enhanced pulsatile growth hormone secretion in humans. J Clin Invest 91 (1993) 2453-2462
102. Ghigo E., Procopio M., Boffano G.M., et al. Arginine potentiates but does not restore the blunted growth hormone response to growth hormone-releasing hormone in obesity. Metabolism 41 (1992) 560-563
103. Alvarez-Castro P., Isidro M.L., Garcia-Buela J., et al. Marked GH secretion after ghrelin alone or combined with GH-.releasing hormone (GH-RH) in obese patients. Clin Endocrinol (Oxf) 61 (2004) 250-255
104. Koutkia P., Schurgin S., Berry J., et al. Reciprocal changes in endogenous ghrelin and growth hormone during fasting in healthy women. Am J Physiol Endocrinol Metab 289 (2005) E814-E822
105. Katz L.E., DeLeon D.D., Zhao H., et al. Free and total insulin-like growth factor (IGF)-I levels decline during fasting: relationships with insulin and IGF-binding protein-1. J Clin Endocrinol Metab 87 (2002) 2978-2983