Suppression of growth hormone (GH) secretion by a selective GH-releasing hormone (GHRH) antagonist: Direct evidence for involvement of endogenous GHRH in the generation of GH pulses

Journal of Clinical Investigation

Volumn 92, Issue 2, 1993, Pages 695-701

  Jaffe, Craig A ^a   Friberg, Roberta DeMott ^a   Barkan, Ariel L ^a,b  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Human; Hypothalamus; Neuroendocrine; Pituitary; Pulsatility

Indexed keywords

GONADORELIN; GROWTH HORMONE; GROWTH HORMONE RELEASING FACTOR; HORMONE ANTAGONIST; HORMONE RECEPTOR;

ADULT; ARTICLE; CONTROLLED STUDY; GROWTH HORMONE RELEASE; HORMONAL REGULATION; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PRIORITY JOURNAL; PULSATILE HORMONE RELEASE;

ACTIVITY CYCLES; ADULT; GROWTH HORMONE; HUMAN; KINETICS; MALE; SERMORELIN; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S.; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0027222097     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI116639     Document Type: Article

References (61)

1. Plotsky, P. M., and W. Vale. 1985. Patterns of growth hormone-releasing factor and somatostatin secretion into the hypophysial-portal circulation of the rat. Science (Wash. DC). 230:461-463.
2. Wehrenberg, W. B., P. Brazeau, R. Luben, P. Bohlen, and R. Guillemin. 1982. Inhibition of the pulsatile secretion of growth hormone by monoclonal antibodies to the hypothalamic growth hormone releasing factor (GRF). Endocrinology. 111:2147-2148.
3. Tannenbaum, G. S., R. Eikelboom, and N. Ling. 1983. Human pancreas GH-releasing factor analog restores high-amplitude GH pulses in CNS lesion-induced GH deficiency. Endocrinology. 113:1173-1175.
4. Millard, W. J., S. B. Martin, Jr., J. Audet, S. M. Sagar, and J. B. Martin. 1982. Evidence that reduced growth hormone secretion observed in monosodium glutamate-treated rats is the result of a deficiency in growth hormone-releasing factor. Endocrinology. 110:540-550.
5. Ferland, L., F. Labrie, M. Jobin, A. Arimura, and A. V. Sehally. 1976. Physiological role of somatostatin in the control of growth hormone and thyrotropin secretion. Biochem. Biophys. Res. Commun. 68:149-156.
6. Frohman, L. A., T. R. Downs, I. J. Clarke, and G. B. Thomas. 1991. Measurement of growth hormone-releasing hormone and somatostatin in hypothalamic-portal plasma of unanesthetized sheep. J. Clin. Invest. 86:17-24.
7. Martha, P. M., Jr., A. D. Rogol, J. D. Veldhuis, J. R. Kerrigan, D. W. Goodman, and R. M. Blizzard. 1989. Alterations in the pulsatile properties of circulating growth hormone concentrations during puberty in boys. J. Clin. Endocrinol. & Metab. 69:563-570.
8. Ho, K. Y., W. S. Evans, R. M. Blizzard, J. D. Veldhuis, G. R. Merriam, E. Samojlik, R. Furlanetto, A. D. Rogol, D. L. Kaiser, and M. O. Thorner. 1987. Effects of sex and age on the 24-hour profile of growth hormone secretion in man: importance of endogenous estradiol concentrations. J. Clin. Endocrinol. & Metab. 64:51-58.
9. Hartman, M. L., J. D. Veldhuis, M. L. Johnson, M. M. Lee, K. G. M. M. Alberti, E. Samojlik, and M. O. Thorner. 1992. Augmented growth hormone (GH) secretory burst frequency and amplitude mediate enhanced GH secretion during a two-day fast in normal men. J. Clin. Endocrinol. & Metab. 74:757-765.
10. Faria, A. C. S., L. W. Bekenstein, R. A. Booth, Jr., V. A. Vaccaro, C. M. Asplin, J. D. Veldhuis, M. O. Thorner, and W. S. Evans. 1992. Pulsatile growth hormone release in normal women during the menstrual cycle. Clin. Endocrinol. 36:591-596.
11. Zadik, Z., S. A. Chalew, and A. Kowarski. 1992. The definition of a spontaneous growth hormone (GH) peak: studies in normally growing and GH-deficient children. J. Clin. Endocrinol. & Metab. 74:801-805.
12. Barkan, A. L., S. E. Stred, K. Reno, M. Markovs, N. J. Hopwood, R. P. Kelch, and I. Z. Beitins. 1989. Increased growth hormone pulse frequency in acromegaly. J Clin. Endocrinol. & Metab. 69:1225-1233.
13. Hartman, M. L., J. D. Veldhuis, M. L. Vance, A. C. Faria, R. W. Furlanetto, and M. O. Thorner. 1990. Somatotropin pulse frequency and basal concentrations are increased in acromegaly and are reduced by successful therapy. J Clin. Endocrinol. & Metab. 70:1375-1384.
14. Asplin, C. M., A. C. S. Faria, E. C. Carlsen, V. A. Vaccaro, R. E. Barr, A. Iranmanesh, M. M. Lee, J. D. Veldhuis, and W. S. Evans. 1989. Alterations in the pulsatile mode of growth hormone release in men and women with insulin-dependent diabetes mellitus. J. Clin. Endocrinol. & Metab. 69:239-245.
15. Veldhuis, J. D., A. Iranmanesh, K. K. Y. Ho, M. J. Waters, M. L. Johnson, and G. Lizarralde. 1991. Dual defects in pulsatile growth hormone secretion and clearance subserve the hyposomatotropism of obesity in man. J. Clin. Endocrinol. & Metab. 72:51-59.
16. Page, M. D., C. A. Edwards, C. Dieguez, and M. F. Scanlon. 1991. GHRH 1-44 and 1-40 secretion: effects of cholinergic blockade and somatostatin. J. Endocrinol. (Suppl.) 129:245. (Abstr.)
17. Patel, Y. C., and C. B. Srikant. 1986. Somatostatin modulation of adenohypophysial secretion. Annu. Rev. Physiol. 48:551-567.
18. Tannenbaum, G. S., J. B. Martin, and E. Colle. 1976. Ultradian growth hormone rhythm in the rat: effects of feeding, hyperglycemia, and insulin-induced hypoglycemia. Endocrinology. 99:720-727.
19. Roth, J., S. Glick, R. S. Yalow, and S. A. Berson. 1963. Hypoglycemia: a potent stimulus to secretion of growth hormone. Science (Wash. DC). 140:987-988.
20. Foster, D. L., F. J. P. Ebling, A. F. Micka, L. A. Vannerson, D. C. Bucholtz, R. I. Wood, J. M. Suttie, and D. E. Fenner. 1989. Metabolic interfaces between growth and reproduction. I. Nutritional modulation of gonadotropin, prolactin. and growth hormone secretion in the growth-limited female lamb. Endocrinology. 125:342-350.
21. Thomas, G. B., J. T. Cummins, H. Francis, A. W. Sudbury, P. I. McCloud, and I. J. Clarke. 1991. Effect of restricted feeding on the relationship between hypophysial portal concentrations of growth hormone (GH)-releasing factor and somatostatin, and jugular concentrations of GH in ovariectomized ewes. Endocrinology. 128:1151-1158.
22. Tannenbaum, G. S., O. Rorstad, and P. Brazeau. 1979. Effects of prolonged food deprivation on the ultradian growth hormone rhythm and immunoreactive somatostatin tissue levels in the rat. Endocrinology. 104:1733-1738.
23. Vance, M. L., D. L. Kaiser, W. S. Evans, R. Furlanetto, W. Vale, J. Rivier, and M. O. Thorner. 1985. Pulsatile growth hormone secretion in normal man during a continuous 24-hour infusion of human growth hormone releasing factor (1-40). J. Clin. Invest. 75:1584-1590.
24. Hizuka, N., K. Takano, K. Shizume, I, Tanaka, N. Honda, and N. C. Ling. 1985. Plasma growth hormone (GH) and somatomedin C response to continuous growth hormone-releasing factor (GRF) infusion in patients with GH deficiency. Acta Endocrinol. 110:17-23.
25. Rochiccioli, P. E., M.-T. Tauber, F. Uboldi, F.-X. Coude, and M. Morre. 1986. Effect of overnight constant infusion of human growth hormone (GH)-releasing hormone-(1-44) on 24-hour GH secretion in children with partial GH deficiency. J. Clin. Endocrinol. & Metab. 63:1100-1105.
26. Davies, R. R., S. J. Turner, H. Ørskov, and D. G. Johnston. 1985. The interaction of human pancreatic growth hormone releasing factor 1-44 with somatostatin in vivo in normal man. Clin. Endocrinol. 23:271-276.
27. Hindmarsh, P. C., C. E. Brain, I. C. A. F. Robinson, D. R. Mathews, and C. G. D. Brook. 1991. The interaction of growth hormone releasing hormone and somatostatin in the generation of a GH pulse in man. Clin. Endocrinol. 35:353-360.
28. 2 as a GRF antagonist on membranes. Endocrinology. 117:1759-1764.
29. Lumpkin, M. D., S. E. Mulroney, and A. Haramati. 1989. Inhibition of pulsatile growth hormone (GH) secretion and somatic growth in immature rats with a synthetic GH-releasing factor antagonist. Endocrinology. 124:1154-1159.
30. Gaylinn, B. D., J. K. Harrison, J. R. Zysk, C. E. Lyons, K. R. Lynch, and M. O. Thorner. 1993. Molecular cloning and expression of a human anterior pituitary receptor for growth hormone-releasing hormone. Mol. Endocrinol. 7:77-84.
31. Lumpkin, M. D., and J. K. McDonald. 1989. Blockade of growth hormone-releasing factor (GRF) activity in the pituitary and hypothalamus of the conscious rat with a peptidic GRF antagonist. Endocrinology. 124:1522-1531.
32. 2 on growth hormone (GH)-releasing factor-stimulated GH release and intracellular adenosine 3′,5′-monophosphate accumulation in rat primary pituitary cell culture. Endocrinology. 124:2791-2798.
33. Schlach, D. S., and M. L. Parker. 1964. A sensitive double antibody immunoassay for human growth hormone in plasma. Nature (Lond.). 203:1141-1142.
34. Veldhuis, J. D., and M. L. Johnson. 1986. Cluster analysis: a simple, versatile, and robust algorithm for endocrine pulse detection. Am. J. Physiol. 250:E486-493.
35. Veldhuis, J. D., R. J. Urban, J. P. Moorman, and M. L. Johnson. 1988. oOptimal Ouster parameters. Memorandum to users of Cluster analysis.
36. Vance, M. L., J. L. Borges, D. L. Kaiser, W. S. Evans, R. Furlanetto, J. L. Thominet, L. A. Frohman, A. D. Rogol, R. M. MacLeod, S. Bloom, J. Rivier, W. Vale, and M. O. Thorner. 1984. Human pancreatic tumor growth hormone-releasing factor: dose-response relationships in normal man. J. Clin. Endocrinol. & Metab. 58:838-844.
37. Gelato, M. C., O. H. Pescovitz, F. Cassorla, D. L. Loriaux, and G. R. Merriam. 1984. Dose-response relationships for the effects of growth hormone-releasing factor-(1-44)-NH2 in young adult men and women. J. Clin. Endocrinol. & Metab. 59:197-201.
38. Van Cauter, E., A. Caufriez, M. Kerkhofs, A. Van Onderbergen, M. O. Thorner, and G. Copinschi. 1992. Sleep, awakenings, and insulin-like growth-factor-I modulate the growth hormone (GH) secretion response to GH-releasing hormone. J. Clin Endocrinol. & Metab. 74:1451-1459.
39. Cronin, M. J., and M. O. Thorner. 1989. Basic studies with growth hormone-releasing factor. In Endocrinology. L. J. Degroot, G. M. Besser, G. F. Cahill, J. C. Marshall, D. H. Nelson, W. D. Odell, J. T. Potts, A. H. Rubenstein, and E. Steinberger, editors. W. B. Saunders Co., Philadelphia. 183-191.
40. Burrin, J. M., and G. R. Hart. 1991. A novel hypothalamic peptide, PACAP, causes release of pituitary GH, ACTH, LH and alpha subunit. 73rd Annual Meeting of the Endocrine Society, Washington, D.C. 618. (Abstr.)
41. Davis, T. M. E., J. M. Burrin, and S. R. Bloom. 1987. Growth hormone (GH) release in response to GH-releasing hormone in man is 3-fold enhanced by galanin. J. Clin. Endocrinol. & Metab. 65:1248-1252.
42. Sato, M., J. Takahara, M. Niimi, R. Tagawa, and S. Irino. 1991. Characterization of the stimulatory effect of galanin on growth hormone release from the rat anterior pituitary. Life Sci. 48:1639-1644.
43. Bowers, C. Y., F. A. Momany, G. A. Reynolds, and A. Hong. 1984. On the in vitro and in vivo activity of a new synthetic hexapeptide that acts on the pituitary to specifically release growth hormone. Endocrinology. 114:1537-1545.
44. Cowan, J. S., B. Moor, A. Chow, and J. Kraicer. 1983. Characteristics of the post-somatostatin rebound in growth hormone secretion from perifused somatotrophs. Endocrinology. 113:1056-1061.
45. Kraicer, J., J. S. Cowan, M. S. Sheppard, B. Lussier, and B. C. Moor. 1986. Effect of somatostatin withdrawal and growth hormone (GH)-releasing factor on GH release in vitro: amount available for release after disinhibition. Endocrinology. 119:2047-2051.
46. Weiss, J., M. J. Cronin, and M. O. Thorner. 1987. Periodic interactions of GH-releasing factor and somatostatin can augment GH release in vitro. Am. J. Physiol. 253:E508-E514.
47. Clark, R. G., and I. C. A. F. Robinson. 1988. Paradoxical growth-promoting effects induced by patterned infusions of somatostatin in female rats. Endocrinology. 122:2675-2682.
48. Clark, R. G., L. M. S. Carlsson, B. Rafferty, and I. C. A. F. Robinson. 1988. The rebound release of growth hormone (GH) following somatostatin infusion in rats involves hypothalamic GH-releasing factor release. J. Endocrinol. 119:397-404.
49. Fukata, J. D., J. Diamond, and J. B. Martin. 1985. Effects of rat growth hormone (rGH)-releasing factor and somatostatin on the release and synthesis of rGH in dispersed pituitary cells. Endocrinology. 117:457-467.
50. Vance, M. L., D. L. Kaiser, J. Rivier, W. Vale, and M. O. Thorner. 1986. Dual effects of growth hormone (GH)-releasing hormone infusion on normal men: somatotroph desensitization and increase in releasable GH. J. Clin. Endocrinol. & Metab. 62:591-594.
51. Ohtsuka, M., S. Hisano, and S. Daikoko. 1983. Electronmicroscopic study of somatostatin-containing neurons in rat arcuate nucleus with special reference to neuronal regulation. Brain Res. 263:191-199.
52. Loposits, Z. S., I. Merchenthaler, W. K. Paull, and B. Flerko. 1988. Synaptic communication between somatostatinergic axons and growth hormone-releasing factor (GRF) synthesizing neurons in the arcuate nucleus of the rat. Histochemistry. 89:247-252.
53. Willoughby, J. O., M. Brogan, and R. Kapoor. 1989. Hypothalamic interconnections of somatostatin and growth hormone releasing factor neurons. Neuroendocrinology. 50:584-591.
54. Tannenbaum, G. S., G. F. McCarthy, P. Zeitler, and A. Beaudet. 1990. Cysteamine-induced enhancement of growth hormone-releasing factor (GRF) immunoreactivity in arcuate neurons: morphological evidence for putative somatostatin/GRF interactions within hypothalamus. Endocrinology. 127:2551-2560.
55. Katakami, H., T. R. Downs, and L. A. Frohman. 1988. Inhibitory effect of hypothalamic medial preoptic area somatostatin on growth hormone-releasing factor in the rat. Endocrinology. 122:1103-1109.
56. Miki, N., M. Ono, and K. Shizume. 1988. Withdrawal of endogenous somatostatin induces secretion of growth hormone-releasing factor in rats. J. Endocrinol. 117:245-252.
57. Kraicer, J., M. S. Sheppard, J. Luke, B. Lussier, B. C. Moor, and J. S. Cowan. 1988. Effect of withdrawal of somatostatin and growth hormone (GH)-releasing factor on GH release in vitro. Endocrinology. 122:1810-1815.
58. Ono, M., N. Miki, and H. Demura. 1991. Effect of antiserum to rat growth hormone (GH)-releasing factor on physiological GH secretion in the female rat. Endocrinology. 129:1791-1796.
59. Painson, J. C., and G. S. Tannenbaum. 1991. Sexual dimorphism of somatostatin and growth hormone-releasing factor signaling in the control of pulsatile growth hormone secretion in the rat. Endocrinology. 128:2858-2866.
60. Maiter, D., L. E. Underwood, J. B. Martin, and J. I. Koenig. 1991. Neonatal treatment with monosodium glutamate: effects of prolonged growth hormone (GH)-releasing hormone deficiency on pulsatile GH secretion and growth in female rats. Endocrinology. 128:1100-1106.
61. Winer, L. M., M. A. Shaw, and G. Baumann. 1990. Basal plasma growth hormone levels in man: new evidence for rhythmicity of growth hormone secretion. J. Clin. Endocrinol. & Metab. 70:1678-1686.