Endogenous growth hormone (GH)-releasing hormone is required for GH responses to pharmacological stimuli

Journal of Clinical Investigation

Volumn 97, Issue 4, 1996, Pages 934-940

  Jaffe, Craig A ^a,b   DeMott Friberg, Roberta ^a   Barkan, Ariel L ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

arginine; clonidine; dopamine; hypoglycemia; pyridostigmine

Indexed keywords

ARGININE; CLONIDINE; GROWTH HORMONE; GROWTH HORMONE RELEASING FACTOR; INSULIN; LEVODOPA; PYRIDOSTIGMINE; SOMATOSTATIN;

ADULT; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG MECHANISM; GROWTH HORMONE RELEASE; HORMONAL REGULATION; HORMONE RESPONSE; HUMAN; HUMAN EXPERIMENT; HYPOTHALAMUS; INTRAVENOUS DRUG ADMINISTRATION; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL;

EID: 0030039638     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118516     Document Type: Article

References (45)

1. Strobl, J.S., and M J. Thomas. 1994. Human growth hormone. Pharmacol Rev 46.1-32.
2. Delitala, G., P. Tomasi, and R. Virdis. 1988. Neuroendocrine regulation of human growth hormone secretion. Diagnostic and clinical applications. J. Endocrinol. Invest. 11:441-462.
3. Muller, E.E., V. Locatelli, E. Ghigo, S.G. Cella, S. Loche, C. Pintor, and F. Camanni. 1991. Involvement of brain catecholamines and acetylcholine in growth hormone deficiency states: pathophysiological, diagnostic and therapeutic implications. Drugs. 41:161-177.
4. Plotsky, P.M. and W. Vale. 1985. Patterns of growth hormone-releasing factor and somatostatin secretion into the hypophysial-portal circulation of the rat. Science (Wash. DC). 230:461-463.
5. Frohman, L.A., T.R. Downs, I.J. Clarke, and G.B. Thomas. 1991. Measurement of growth hormone-releasing hormone and somatostatin in hypothalamic-portal plasma of unanesthetized sheep. J. Clin Invest. 86:17-24.
6. Thomas, G.B , J.T Cummins, H. Francis, A.W. Sudbury, P.I. McCloud, and I.J. Clarke. 1991. Effect of restricted feeding on the relationship between hypophysial portal concentrations of growth hormone (GH)-releasing factor and somatostatin, and jugular concentrations of GH m ovariectomized ewes. Endocrinology. 128:1151-1158.
7. Cataldi, M., E. Magnan, V. Guillaume, A Dutour, B. Conte-Devolx, G Lombardi, and C. Oliver, 1994. Relationship between hypophyseal portal GHRH and somatostatin and peripheral GH levels in the conscious sheep. J. Endocrinol. Invest. 17:717-722.
8. Vance, M.L., D.L. Kaiser, W.S. Evans, R. Furlanetto, W. Vale, J. Rivier, and M.O. Thorner. 1985. Pulsatile growth hormone secretion in normal man during a continuous 24-hour infusion of human growth hormone releasing factor (1-40). J. Clin. Invest. 75:1584-1590
9. Hindmarsh, P C., C.E. Brain, I.C.A.F. Robinson, D.R. Mathews, and C.G. Brook. 1991. The interaction of growth hormone releasing hormone and somatostatin m the generation of a GH pulse in man. Clin. Endocrinol. 35:353-360.
10. Clark, R G., L.M.S. Carlsson, B. Rafferty, and I.C.A.F. Robinson. 1988. The rebound release of growth hormone (GH) following somatostatin infusion in rats involves hypothalamic GH-releasing factor release. J. Endocrinol. 119: 397-404.
11. Miki, N., M. Ono, and K. Shizume. 1988. Withdrawal of endogenous somatostatin induces secretion of growth hormone-releasing factor in rats. J Endocrinol. 117:245-252.
12. Jaffe, C.A , R. DeMott-Friberg, and A L. Barkan. 1993. Suppression of growth hormone (GH) secretion by a selective GH-releasing hormone (GHRH) antagonist. Direct evidence for involvement of endogenous GHRH in the generation of GH pulses. J. Clin. Invest. 92:695-701.
13. Jaffe, C.A., P.J. Ho, R DeMott-Friberg, C.Y. Bowers, and A.L Barkan. 1993 Effects of a prolonged growth hormone (GH)-releasing peptide infusion on pulsatile GH secretion in normal men. J. Clin. Endocrinol & Metab 77: 1641-1647
14. Vinik, A.I., N.S. Levitt, B.L Pimstone, and L. Wagner. 1981. Peripheral plasma somatostatin-like immunoreactive responses to insulin hypoglycemia and a mixed meal in healthy subjects and in noninsulin-dependent maturityonset diabetics. J. Clin. Endocrinol. & Metab 52:330-337.
15. Zar, J.H. 1984. Biostatistical Analysis Prentice-Hall. Inc., Englewood Cliffs, NJ. 194-195
16. Conway, S., L. Richardson, S. Speciale, R Moherek, H. Mauceri, and L. Krulich. 1990. Interaction between norepinephrine and serotonin in the neuroendocrine control of growth hormone release in the rat. Endocrinology 126: 102.2-1030.
17. Chihara, K., Y. Kashio, T. Kita, Y. Okimura, H. Kaji, H Abe, and T. Fujita. 1986. L-dopa stimulates release of hypothalamic growth hormone-releasing hormone in humans. J. Clin Endocrinol. & Metab. 62.466-473.
18. Kraicer, J 1979. Acetylcholine does not stimulate the release of growth hormone from perfused rat adenohypophyses Can J Physiol Pharmacol. 57: 748-750.
19. Richardson, S.B., C.S. Mollander, R D'Elleto, P.W. Greenleaf, and C. Thaw. 1980. Acetylcholine inhibits the release of somatostatin from rat hypothalamus in vitro. Endocrinology. 107:122-129
20. Magnan, E., M Cataldi, V Guillaume, L Mazzocchi, A. Dutour, B. Conte-Devolx, P Giraud, and C. Oliver. 1993. Neostigmine stimulates growth hormone-releasing hormone release into hypophysial portal blood of conscious sheep. Endocrinology. 132:1247-1251
21. Magnan, E., M. Cataldi, V. Guillaume, L. Mazzocchi, A. Dutour, H Razafindraibe, N. Sauze, M Renard, and C Oliver. 1994. Role of growth hormone (GH)-releasing hormone and somatostatin m the mediation of clonidineinduced GH release in sheep. Endocrinology 134.562-567.
22. Rosskamp, R , G Schmid, J. Klumpp, and A Tegeler 1987 Insulinhypoglycemia but not arginine infusion stimulates circulating plasma growth hormone-releasing hormone (GHRH) concentrations in children. Horm Metab. Res 19:434-436.
23. Page, M.D., C. Dieguez, R Valcavi, H.P.F. Koppeschaar, and M.F. Scanlon. 1994. Growth hormone releasing hormone 1-44 NH2 and 1-40 OH levels in normal subjects during growth hormone stimulation tests Clin. Endocrinol 40.97-102.
24. Donnadieu, M., D. Evain-Brion, M.C. Tonon, H. Vaudry, and J.C. Job. 1985. Variations of plasma growth hormone (GH)-releasing factor levels during GH stimulation tests in children J. Clin. Endocrinol. & Metab 60:1132-1134
25. Loche, S , S. Balzano, M Bozzola, A. Moretta, S. Pintus, A. Faedda, A Muntoni, D. Carta, and C. Pintor. 1992 Secretion of growth hormone releasing hormone in obese children. J. Endocrinol. Invest. 15:453-457.
26. Tapanainen, P , M. Knip, P Lautala, and J. Leppäluoto. 1988. Variable plasma growth hormone (GH)-releasing hormone and GH responses to clonidine, L-dopa, and insulin in normal men. J. Clin. Endocrinol & Metab. 67:845-849.
27. Gil-Ad, I., N. Leibowitch, Z. Josefsberg, M. Wasserman, and Z. Laron. 1990. Effect of oral clonidine, insulin-induced hypoglycemia and exercise on plasma GHRH levels in short-stature children. Acta Endocrinol. 122:89-95.
28. Kashio, Y., K. Chihara, T. Kita, Y. Okimura, M. Sato, S Kadowaki, and T. Fujita. 1987. Effect of oral glucose administration on plasma growth hormone-releasing hormone (GHRH)-like immunoreactivity in normal subjects and patients with idiopathic GH deficiency: evidence that GHRH is released not only from the hypothalamus but also from extrahypothalmic tissue. J. Clin. Endocrinol. & Metab. 64:92-97.
29. Sopwith, A.M., E.S. Penny, G.M Besser, and L.H. Rees 1985. Stimulation by food of peripheral plasma immunoreactive growth hormone releasing factor, Clin. Endocrinol. 22:337-340.
30. Patel, Y.C., and C.B. Srikant 1986. Somatostatin modulation of adenohypophysial secretion Annu. Rev Physiol. 48:551-567.
31. Alba-Roth, J., C. von Creytz, G. Mehltretter, J. Schopohl, O.A. Muller, and K. von Werder. 1989. Interaction of L-dopa and GHRH on GH secretion in normal men. J. Endocrinol. Invest. 12:783-787.
32. Alba-Roth, J., M. Losa, Y. Spiess, J. Schopohl, O.A. Muller, and K. von Werder. 1989. Interaction of clonidine and GHRH on GH secretion in vivo and in vitro. Clin Endocrinol. 30:485-491.
33. Devesa, J., M.J. Diaz, J.A. Tresguerres, V. Arce, and L. Lima. 1991. Evidence that alpha 2-adrenergic pathways play a major role in growth hormone (GH) neuroregulation: alpha 2-adrenergic agonism counteracts the inhibitory effect of muscarinic cholinergic receptor blockade on the GH response to GH-releasing hormone, while alpha 2-adrenergic blockade diminishes the potentiating effect of increased cholinergic tone on such stimulation in normal men. J Clin. Endocrinol. & Metab. 73:251-256.
34. Alba-Roth, J., O.A. Muller, J. Schopohl, and K. von Werder. 1988. Arginine stimulates growth hormone secretion by suppressing endogenous somatostatin secretion. J. Clin. Endocrinol. & Metab. 67:1186-1189.
35. Massara, F., E. Ghigo, P Molinatti, E Mazza, V. Locatelli, E.E. Müller, and F. Camanni. 1986. Potentiation of cholinergic tone by pyridostigmine bromide reinstates and potentiates the growth hormone responsiveness to intermittent administration of growth hormone-releasing factor in man. Acta Endocrinol. 113:12-16.
36. Page, M.D., H.P. Koppeschaar, C.A. Edwards, C. Dieguez, and M.F. Scanlon. 1987. Additive effects of growth hormone releasing factor and insulin hypoglycaemia on growth hormone release in man. Clin. Endocrinol. 26.589-595.
37. Kehjman, M., and L.A. Frohman. 1988. Discordant effects of insulinhypoglycemia on growth hormone (GH)-releasing hormone-stimulated GH and thyrotropin (TSH)-releasing hormone-stimulated TSH secretion. J. Clin Endocrinol. & Metab. 66:872-875
38. Masuda, A., T. Shibasaki, M. Hotta, N. Yamauchi, N. Ling, H Demura, and K. Shizume. 1990. Insulin-induced hypoglycemia, L-dopa and arginine stimulate GH secretion through different mechanisms in man. Regul. Pept. 31 53-64
39. Cowan, J.S., B. Moor, A. Chow, and J. Kraicer. 1983 Characteristics of the post-somatostatin rebound in growth hormone secretion from perfused somatotrophs. Endocrinology. 113:1056-1061.
40. Liposits, Z.S., I. Merchenthaler, W.K. Paull, and B. Flerko. 1988. Synaptic communication between somatostatinergic axons and growth hormonereleasing factor (GRF) synthesizing neurons in the arcuate nucleus of the rat. Histochemistry. 89:247-252.
41. Willoughby, J.O., M. Brogan, and R. Kapoor. 1989. Hypothalamic interconnections of somatostatin and growth hormone releasing factor neurons Neuroendocrinology 50:584-591.
42. Magnan, E., M. Catsldi, V. Guillaume , B. Conte-Devolx, N. Graziani. J.C. Figaroli, F. Thomas, K Chihara, and C. Oliver. 1992. Acute changes in growth hormone-releasing hormone secretion after injection of BIM 23014, a long acting somatostatin analog, in rams. Life Sci. 51:831-838.
43. Ho. P.J., G.B. Kletter, N.J. Hopwood, R DeMott Friberg, and A.L. Barkan. 1993. Somatostatin withdrawal alone is an ineffective generator of pulsatile growth hormone release in man. Acta Endocrinol. 129:414-418.
44. Vance, M.L., D.L. Kaiser, J. Rivier, W. Vale, and M.O Thorner. 1986 Dual effects of growth hormone (GH)-releasing hormone infusion in normal men: somatotroph desensitization and increase in releasable GH. J. Clin. Endocrinol. & Metabol. 62:591-594.
45. Robinson, B.M., R. DeMott-Friberg, C Y. Bowers, and A.L. Barkan. 1992. Acute growth hormone (GH) response to GH-releasing hexapeptide in humans is independent of endogenous GH-releasing hormone. J. Clin. Endocrinol. & Metabol 75:1121-1124.