The impact of short-term fasting on the dynamics of 24-hour growth hormone (GH) secretion in patients with severe radiation-induced GH deficiency

Journal of Clinical Endocrinology and Metabolism

Volumn 91, Issue 3, 2006, Pages 987-994

  Darzy, Ken H ^a   Murray, Robert D ^a   Gleeson, Helena K ^a   Pezzoli, Suzan S ^b   Thorner, Michael O ^b   Shalet, Stephen M ^a  

^a CHRISTIE HOSPITAL   (United Kingdom)

^b UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH HORMONE;

ADULT; ARTICLE; BRAIN TUMOR; CANCER RADIOTHERAPY; CANCER SURVIVAL; CHEMOLUMINESCENCE; CIRCADIAN RHYTHM; CLINICAL ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; FEMALE; GROWTH HORMONE BLOOD LEVEL; GROWTH HORMONE DEFICIENCY; GROWTH HORMONE RELEASE; HUMAN; HYPOTHALAMUS HYPOPHYSIS SYSTEM; MALE; NEUROTRANSMISSION; PRIORITY JOURNAL; PULSATILE HORMONE RELEASE; RADIATION INDUCED GROWTH HORMONE DEFICIENCY; RADIATION INJURY; SKULL IRRADIATION;

3-HYDROXYBUTYRIC ACID; ADULT; AREA UNDER CURVE; BILIRUBIN; BLOOD GLUCOSE; CLUSTER ANALYSIS; EATING; FASTING; FATTY ACIDS, NONESTERIFIED; FEMALE; HUMAN GROWTH HORMONE; HUMANS; NEOPLASMS; RADIOTHERAPY;

EID: 33644828674     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2005-2145     Document Type: Article

References (25)

1. Darzy K, Pezzoli S, Thorner M, Shalet SM 2005 The dynamics of GH secretion in adult cancer survivors with severe GH deficiency acquired following brain irradiation in childhood for non-pituitary brain tumors: evidence for preserved pulsatility and diurnal variation with increased secretory disorderliness. J Clin Endocrinol Metab 90:2794-2803
2. Ho KY, Veldhuis JD, Johnson ML, Furlanetto R, Evans WS, Alberti KG, Thorner MO 1988 Fasting enhances growth hormone secretion and amplifies the complex rhythms of growth hormone secretion in man. J Clin Invest 81:968-975
3. Bergendahl M, Vance ML, Iranmanesh A, Thorner MO, Veldhuis JD 1996 Fasting as a metabolic stress paradigm selectively amplifies cortisol secretory burst mass and delays the time of maximal nyctohemeral cortisol concentrations in healthy men. J Clin Endocrinol Metab 81:692-699
4. Bergendahl M, Iranmanesh A, Mulligan T, Veldhuis JD 2000 Impact of age on cortisol secretory dynamics basally and as driven by nutrient-withdrawal stress. J Clin Endocrinol Metab 85:2203-2214
5. Bergendahl M, Evans WS, Pastor C, Patel A, Iranmanesh A, Veldhuis JD 1999 Short-term fasting suppresses leptin and (conversely) activates disorderly growth hormone secretion in midluteal phase women - a clinical research center study. J Clin Endocrinol Metab 84:883-894
6. Hartman ML, Veldhuis JD, Johnson ML, Lee MM, Alberti KG, Samojlik E, Thorner MO 1992 Augmented growth hormone (GH) secretory burst frequency and amplitude mediate enhanced GH secretion during a two-day fast in normal men. J Clin Endocrinol Metab 74:757-765
7. Aimaretti G, Colao A, Corneli G, Pivonello R, MacCario M, Morrison K, Pflaum CD, Strasburger CJ, Lombardi G, Ghigo E 1999 The study of spontaneous GH secretion after 36-h fasting distinguishes between GH-deficient and normal adults. Clin Endocrinol (Oxf) 51:771-777
8. Maccario M, Aimaretti G, Grottoli S, Gauna C, Tassone F, Corneli G, Rossetto R, Wu Z, Strasburger CJ, Ghigo E 2001 Effects of 36 hour fasting on GH/IGF-I axis and metabolic parameters in patients with simple obesity. Comparison with normal subjects and hypopituitary patients with severe GH deficiency. Int J Obes Relat Metab Disord 25:1233-1239
9. Jeevanandam M, Hsu YC, Ramias L, Schiller WR 1989 A rapid, automated micromethod for measuring free fatty acids in plasma/serum. Clin Chem 35:2228-2231
10. McMurray CH, Blanchflower WJ, Rice DA 1984 Automated kinetic method for D-3-hydroxybutyrate in plasma or serum. Clin Chem 30:421-425
11. Veldhuis JD, Johnson ML 1986 Cluster analysis: a simple, versatile, and robust algorithm for endocrine pulse detection. Am J Physiol 250:E486-E493
12. Nelson W, Tong YL, Lee JK, Halberg F 1979 Methods for cosinor-rhythmometry. Chronobiologia 6:305-323
13. Pincus SM, Gladstone IM, Ehrenkranz RA 1991 A regularity statistic for medical data analysis. J Clin Monit 7:335-345
14. Iranmanesh A, Grisso B, Veldhuis JD 1994 Low basal and persistent pulsatile growth hormone secretion are revealed in normal and hyposomatotropic men studied with a new ultrasensitive chemiluminescence assay. J Clin Endocrinol Metab 78:526-535
15. Veldhuis JD, Carlson ML, Johnson ML 1987 The pituitary gland secretes in bursts: appraising the nature of glandular secretory impulses by simultaneous multiple-parameter deconvolution of plasma hormone concentrations. Proc Natl Acad Sci USA 84:7686-7690
16. Hartman ML, Pezzoli SS, Hellmann PJ, Suratt PM, Thorner MO 1996 Pulsatile growth hormone secretion in older persons is enhanced by fasting without relationship to sleep stages. J Clin Endocrinol Metab 81:2694-2701
17. Veldhuis JD, Johnson ML 1992 Deconvolution analysis of hormone data. Methods Enzymol 210:539-575
18. Riedel M, Hoeft B, Blum WF, von zur Muhlen A, Brabant G 1995 Pulsatile growth hormone secretion in normal-weight and obese men: differential metabolic regulation during energy restriction. Metabolism 44:605-610
19. Procopio M, Maccario M, Grottoli S, Oleandri SE, Boffano GM, Camanni F, Ghigo E 1995 Short-term fasting in obesity fails to restore the blunted GH responsiveness to GH-releasing hormone alone or combined with arginine. Clin Endocrinol (Oxf) 43:665-669
20. Maccario M, Aimaretti G, Corneli G, Gauna C, Grottoli S, Bidlingmaier M, Strasburger CJ, Dieguez C, Casanueva FF, Ghigo E 2000 Short-term fasting abolishes the sex-related difference inGHand leptin secretion in humans. Am J Physiol Endocrinol Metab 279:E411-E416
21. Hoffman DM, O'Sullivan AJ, Baxter RC, Ho KK 1994 Diagnosis of growth-hormone deficiency in adults. Lancet 343:1064-1068
22. Toogood AA, Nass RM, Pezzoli SS, PA ON, Thorner MO, Shalet SM 1997 Preservation of growth hormone pulsatility despite pituitary pathology, surgery, and irradiation. J Clin Endocrinol Metab 82:2215-2221
23. Reutens AT, Hoffman DM, Leung KC, Ho KK 1995 Evaluation and application of a highly sensitive assay for serum growth hormone (GH) in the study of adult GH deficiency. J Clin Endocrinol Metab 80:480-485
24. Baum HB, Biller BM, Katznelson L, Oppenheim DS, Clemmons DR, Cannistraro KB, Schoenfeld DA, Best SA, Klibanski A 1996 Assessment of growth hormone (GH) secretion in men with adult-onset GH deficiency compared with that in normal men - a clinical research center study. J Clin Endocrinol Metab 81:84-92
25. Darzy KH, Aimaretti G, Wieringa G, Gattamaneni HR, Ghigo E, Shalet SM 2003 The usefulness of the combined growth hormone (GH)-releasing hormone and arginine stimulation test in the diagnosis of radiation-induced GH deficiency is dependent on the post-irradiation time interval. J Clin Endocrinol Metab 88:95-102