Cloning and expression of murine IFNβ and a TNF antagonist for gene therapy of experimental allergic encephalomyelitis

Gene Therapy

Volumn 5, Issue 2, 1998, Pages 253-263

  Triantaphyllopoulos, K A ^a   Croxford, J L ^b   Baker, D ^b   Chernajovsky, Y ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Cytokine receptors; Cytokines; Gene expression; IFN ; Multiple sclerosis model; TNF antagonists

Indexed keywords

BETA INTERFERON; CHIMERIC PROTEIN; CYTOKINE; IMMUNOGLOBULIN; LIPOSOME; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR; VIRUS VECTOR;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL ACTIVITY; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; DRUG ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FIBROBLAST; GENE EXPRESSION; GENE THERAPY; IMMUNOBLOTTING; IMMUNOMODULATION; MOLECULAR CLONING; MOUSE; MULTIPLE SCLEROSIS; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; RETROVIRUS; TISSUE SPECIFICITY;

ANIMALIA; MURINAE; UNIDENTIFIED RETROVIRUS;

EID: 0031934634     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3300570     Document Type: Article

References (44)

1. Naldini L, et al. In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science 1996; 272: 263-267.
2. Russ AP, Friedel C, Grez M, von Melchner H. Self-deleting retrovirus vectors for gene therapy. J Virol 1996; 70: 4927-4932
3. Wohlgemuth JG et al Long-term gene expression from autonomously replicating vectors in mammalian cells. Gene Therapy 1996; 3: 503-512.
4. Chernajovsky Y et al. Inhibition of transfer of collagen-induced arthritis into SCID mice by ex vivo infection of spleen cells with retroviruses expressing soluble tumor necrosis factor receptor. Gene Therapy 1995; 2: 731-735.
5. Chernajovsky Y et al. Pathogenic lymphoid cells engineered to express TGFβ1 ameliorate disease in a collagen-induced arthritis model. Gene Therapy 1997; 4: 553-559.
6. Croxford JL et al. Cytokine gene therapy in experimental allergic encephalomyelitis by injection of plasmid DNA - cationic liposome complexes into the central nervous system (submitted)
7. Triantaphyllopoulos KA et al. Expression of cytokines and cytokine inhibitors in retroviral vectors for use in gene therapy of chronic relapsing experimental allergic encephalomyelitis. Mul Sclerosis 1995; 2: 23 Abstr.
8. Dorr RT. Interferon-α in malignant and viral diseases. A review. Drugs 1993; 45: 177-211.
9. Paty DW, Li DK. Interferon β-1b is effective in relapsmg-remitting multiple sclerosis. II. MR1 analysis results of a multicenter, randomized, double-blind, placebo-controlled trial. UBC MS/MRI Study Group and the IFNβ Multiple Sclerosis Study Group. Neurology 1993; 43: 662-667.
10. Porrini AM, Reder AT. IFN-γ, IFN-β, and PGE1 affect monokine secretion: relevance to monocyte activation in multiple sclerosis. Cell Immunol 1994; 157, 428-438.
11. Panitch HS, Bever C Jr. Clinical trials of interferons in multiple sclerosis. What have we learned? J Neuroimmunol 1993; 46: 155-164.
12. Abreu SL Interferon in experimental autoimmune encephalomyelitis (EAE). effects of exogeneous Interferon on the antigen-enhanced adoptive transfer of EAE. Int Arch Allergy Appl Immunol 1985; 76: 302-307.
13. Ruuls SR et al. The length of treatment determines whether IFN-β prevents or aggravates experimental autoimmune encephalomyelitis in Lewis rats. J Immunol 1996; 157: 5721-5731.
14. Brod SA, Khan M. Oral administration of IFNα is superior to subcutaneous administration of IFNα in the suppression of chronic relapsing experimental autoimmune encephalomyelitis. J Autoimmun 1996; 9: 11-20.
15. Baker D et al. Control of established experimental allergic encephalomyelitis by inhibition of tumor necrosis factor (TNF) activity within the central nervous system using monoclonal antibodies and TNF receptor-immunoglobulin fusion proteins Eur J Immunol 1994; 24: 2040-2048.
16. Baker D, Gibjels K, Steinman LS. Cytokines in multiple sclerosis In: Brennan FM and Feldmann M (eds). The Role of Cytokines in Autoimmunity. RG Landes Company: New York, 1996, pp 77-99.
17. Elliot M et al. Treatment of rheumatoid arthritis with chimeric antibodies to TNFα. Arthritis Rheum 1993; 36: 1681-1689.
18. Van Dulleman HM et al. Treatment of Crohn's disease with antitumor necrosis factor chimeric monoclonal antibody (cA2). Gastroenterology 1995; 109: 129-135.
19. Kolls J, Peppel K, Silva M, Beutler B. Prolonged and effective blockade of tumor necrosis factor activity through adenovirus-mediated gene transfer. Proc Natl Acad Sci USA 1994; 91: 215-219.
20. Morgenstern JP, Land H. Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line. Nucleic Acids Res 1990; 18: 3587-3596.
21. Forss-Petter S et al. Transgenic mice expressing beta-galactosidase in mature neurons under neuron-specific enolase promoter control. Neuron 1990; 5: 187-197.
22. Andersson S et al. Cloning, structure, and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme. J Biol Chem 1989; 264: 8222-8229.
23. Arnason BGW, Reder AT. Interferons and multiple sclerosis. Clin Neuropharmacol 1994; 17: 495-502.
24. Higashi Y et al. Structure and expression of a cloned cDNA for mouse interferon-β. J Biol Chem 1983; 258: 9522-9529.
25. Belardelli F, Gresser I The neglected role of type I interferon in the T-cell response: implications for its clinical use. Immunol Today 1996; 17: 369-372.
26. Chabot S, Williams G, Wee Yong V. Microglial production of TNFα is induced by activated T lymphocytes involvement of VLA-4 inhibition by interferonβ-1b. J Clin Invest 1997; 100: 604-612.
27. Baker D et al. Induction of CREAE in Biozzi mice. J Neuroimmunol 1990; 28: 261-270.
28. Allen SJ et al. Kinetics of cellular infiltration of the CNS during CREAE in the Biozzi AB/H mouse. Cell Immunol 1993; 146: 335-350.
29. Butter C, Baker D, O'Neill JK, Turk JL. Mononuclear cell traffic and plasma protein extravasation into the CNS during CREAE in the Biozzi AB/H mice. J Neurol Sci 1991; 104: 9-12.
30. Sambrook J, Fritsch EF, Maniatis T. Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory: NY, 1989, vol. 1-3.
31. Yanisch-Perron C, Vieira J, Messing J. Improved M13 phage cloning vectors and hosts strains-nucleotide sequences of the M13MP18 and PUC19 vectors. Gene 1985; 33: 103-199.
32. Davis J, Jacob F. Genetic mapping of the regulator and operator genes of the lac operon. J Mol Biol 1968; 36: 413-118.
33. Sanger F, Coulson AW. A rapid method for determining sequences in DNA by primer synthesis with DNA polymerase. J Mol Biol 1975; 94: 441-448.
34. Hattman S, Brooks JE, Masurekar M. Sequence specificity of the P1 modification methylase (M.Eco P1) and the DNA methylase (M.Eco dam) controlled by the Escherichia coli dam gene. J Mol Biol 1978; 126: 367-380
35. Neve R et al. Expression of an efficient small molecular weight tumour necrosis factor/lymphotoxin antagonist. Cytokine 1996; 8: 365-370.
36. Almazan G, McKay R. An oligodendrocyte precursor cell line from rat optic nerve Brain Res 1992; 579: 234-245.
37. Mellon P, Parker V, Gluzman Y, Maniatis T. Identification of DNA sequences required for transcription of the human alpha 1-globin gene in a new SV40 host-vector system. Cell 1981; 27: 279-288.
38. Chernajovsky Y, Brown A, Clark J. Human kinesin light (beta) chain gene: DNA sequence and functional characterization of its promoter and first exon. DNA Cell Biol 1996; 15: 965-974.
39. Pear WS, Nolan GP, Scott ML, Baltimore D. Production of high-titer helper-free retroviruses by transient transfection. Proc Natl Acad Sci USA 1993; 90: 8392-8396.
40. Markowitz D, Goff S, Bank A. Construction and use of a safe and efficient amphotropic packaging cell line. Virology 1988; 167: 400-406.
41. Chernajovsky Y, Kirby-Sanders HM. A cis-acting sequence, located at -450 in the promoter of the human interferon-inducible gene 6-16, binds constitutively to a nuclear protein and decreases the expression of a reporter interferon-inducible promoter. Lymphokine Res 1990; 9: 199-212.
42. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (Lond.) 1970; 227: 680-685.
43. Butler D et al. TNF receptor fusion proteins are effective inhibitors of TNF-mediated cytotoxicity on human KYM-ID4 rhabdomyosarcoma cells. Cytokine 1994; 6: 616-623.
44. Chernajovsky Y et al. Efficient constitutive production of human fibroblast interferon by hamster cells transformed with the IFN-β1 gene fused to an SV40 early promoter. DNA 1984; 3: 297-308.