Effects of RGH-237 [N-{4-[4-(3-aminocarbonyl-phenyl)-piperazin-1-yl]-butyl} -4-bromo-benzamide], an orally active, selective dopamine D3 receptor partial agonist in animal models of cocaine abuse

Journal of Pharmacology and Experimental Therapeutics

Volumn 320, Issue 3, 2007, Pages 1268-1278

  Gyertyán, István ^a   Kiss, Béla ^a   Gál, Krisztina ^a   Laszlovszky, István ^a   Horváth, Attila ^a   Gémesi, Larisza I ^a   Sághy, Katalin ^a   Pásztor, Gabriella ^a   Zájer, Mária ^a   Kapás, Margit ^a   Csongor, Éva Ágai ^a   Domány, György ^a   Tihanyi, Károly ^a   Szombathelyi, Zsolt ^a  

^a GEDEON RICHTER LTD   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

BP 897; COCAINE; DOPAMINE 3 RECEPTOR STIMULATING AGENT; N [4 [2 (6 CYANO 1,2,3,4 TETRAHYDRO 2 ISOQUINOLINYL)ETHYL]CYCLOHEXYL] 4 QUINOLINECARBOXAMIDE; N [4 [4 (3 AMINOCARBONYLPHENYL)PIPERAZIN 1 YL]BUTYL] 4 BROMOBENZAMIDE; OPIATE RECEPTOR; PIPERAZINE DERIVATIVE; RGH 237; SEROTONIN 1A RECEPTOR; SUCROSE; UNCLASSIFIED DRUG; WATER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COCAINE DEPENDENCE; CONTROLLED STUDY; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG DOSE COMPARISON; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELF ADMINISTRATION; LONG EVANS RAT; LOW DRUG DOSE; MALE; MOTOR ACTIVITY; NONHUMAN; PLACE PREFERENCE; PRIORITY JOURNAL; RAT; STATISTICAL SIGNIFICANCE;

ADMINISTRATION, ORAL; ANIMALS; BENZAMIDES; BINDING, COMPETITIVE; COCAINE-RELATED DISORDERS; CONDITIONING (PSYCHOLOGY); DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; MOTOR ACTIVITY; PIPERAZINES; RATS; RATS, WISTAR; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D3; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33847229437     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.106.107920     Document Type: Article

References (40)

1. 2 receptors. J Pharmacol Exp Ther 302:381-389.
2. 3 receptor test in vitro predicts decreased cocaine self-administration in rats. Neuroreport 8:2373-2377.
3. Caine SB, Negus SS, Mello NK, Patel S, Bristow L, Kulagowski J, Vallone D, Saiardi A, and Borrelli E (2002) Role of dopamine D2-like receptors in cocaine self-administration: studies with D2 receptor mutant mice and novel D2 receptor antagonists. J Neurosci 22:2977-2988.
4. Campiani G, Butini S, Trotta F, Fattorusso C, Catalanotti B, Aiello F, Gemma S, Nacci V, Novellino E, Stark JA, et al. (2003) Synthesis and pharmacological evaluation of potent and highly selective D3 receptor ligands: inhibition of cocaine-seeking behavior and the role of dopamine D3/D2 receptors. J Med Chem 46:3822-3839.
5. Cervo L, Carnovali F, Stark JA, and Mennini T (2003) Cocaine-seeking behavior in response to drug-associated stimuli in rats: involvement of D3 and D2 dopamine receptors. Neuropsychopharmacology 28:1150-1159.
6. Cervo L, Cocco A, Petrella C, and Heidbreder CA (2006) Selective antagonism at dopamine D3 receptors attenuates cocaine-seeking behaviour in the rat. Int J Neuropsychopharmacol 23:1-15.
7. 50) of an enzymatic reaction. Biochem Pharmacol 22:3099-3108.
8. Childress AR and O'Brien CP (2000) Dopamine receptor partial agonists could address the duality of cocaine craving. Trends Pharmacol Sci 21:6-9.
9. Corrigall WA and Coen KM (1991) Cocaine self-administration is increased by both D1 and D2 dopamine antagonists. Pharmacol Biochem Behav 39:799-802.
10. Crombag HS, Grimm JW, and Shaham Y (2002) Effect of dopamine receptor antagonists on renewal of cocaine seeking by reexposure to drug-associated contextual cues. Neuropsychopharmacology 27:1006-1015.
11. Cussac D, Newman-Tancredi A, Audinot V, Nicolas J-P, Boutin J, Gobert A, and Millan MJ (2000) The novel dopamine D3 receptor partial agonist, BP897, is a potent ligand at diverse adrenergic and serotonergic receptors. Soc Neurosci Abstr. Program no. 809.8, Society for Neuroscience, Washington, DC.
12. Di Ciano P, Underwood RJ, Hagan JJ, and Everitt BJ (2003) Attenuation of cue-controlled cocaine-seeking by a selective D3 dopamine receptor antagonist SB-277011-A. Neuropsychopharmacology 28:329-338.
13. Gál K and Gyertyán I (2003) Targeting the dopamine D3 receptor cannot influence continuous reinforcement cocaine self-administration in rats. Brain Res Bull 61:595-601.
14. Gál K and Gyertyán I (2006) Dopamine D3 as well as D2 receptor ligands attenuate the cue-induced cocaine-seeking in a relapse model in rats. Drug Alcohol Depend 81:63-70.
15. 3H-prazosin to rat brain α-adrenergic receptors. Eur J Pharmacol 55:323-326.
16. 3 receptor ligands show place conditioning effect but do not influence cocaine-induced place preference. Neuroreport 14:93-98.
17. Gyertyán I and Sághy K (2004) Effects of dopamine D3 receptor antagonists on spontaneous and agonist-reduced motor activity in NMRI mice and Wistar rats: comparative study with nafadotride, U 99194A and SB 277011. Behav Pharmacol 15:253-262.
18. 3H]8-Hydroxy-2-(di-n-propylamino)-tetraline binding to pre- and postsynaptic 5-hydroxytryptamine sites in various regions of the rat brain. J Neurochem 44:1685-1696.
19. Katz JL and Higgins ST (2003) The validity of the reinstatement model of craving and relapse to drug use. Psychopharmacology (Berl) 168:21-30.
20. Khroyan TV, Barrett-Larimore RL, Rowlett JK, and Spealman RD (2000) Dopamine D1- and D2-like receptor mechanisms in relapse to cocaine-seeking behavior: effects of selective antagonists and agonists. J Pharmacol Exp Ther 294:680-687.
21. 3 receptors: II. Functional and behavioral profile compared with GR218,231 and L741,626. J Pharmacol Exp Ther 293:1063-1073.
22. Morales L, Perez-Garcia C, and Alguacil LF (2001) Effects of yohimbine on the antinociceptive and place conditioning effects of opioid agonists in rodents. Br J Pharmacol 133:172-178.
23. 3 receptor stimulation enhances cocaine reinforcement. J Neurochem 67:1078-1089.
24. Pilla M, Perachon S, Sautel F, Garrido F, Manni A, Wermuth CG, Schwartz J-C, Everitt BJ, and Sokoloff P (1999) Selective inhibition of cocaine seeking behavior by partial dopamine D3 receptor agonist. Nature (Lond) 400:371-375.
25. Pulvirenti L and Koob GF (1994) Dopamine receptor agonists, partial agonists and psychostimulant addiction. Trends Pharmacol Sci 15:374-379.
26. Pulvirenti L, Balducci C, Piercy M, and Koob GF (1998) Characterization of the effects of the partial dopamine agonist terguride on cocaine self-administration in the rat. J Pharmacol Exp Ther 286:1231- 1238.
27. 3 receptor antagonist, SB-277011-A. J Pharmacol Exp Ther 294:1154-1165.
28. Sahraei H, Ghazzaghi H, Zarrindast MR, Ghoshooni H, Sepehri H, and Haeri-Rohan A (2004) The role of alpha-adrenoceptor mechanism(s) in morphine-induced conditioned place preference in female mice. Pharmacol Biochem Behav 78:135-141.
29. 3 receptor antagonist, activates locomotion in rodents. J Pharmacol Exp Ther 275:1239-1246.
30. 3H] ligands, in Methods in Biogenic Amine Research (Parvez S, Nagatsu T, Nagatsu I, and Parvez H eds) pp 591-622, Elsevier, Amsterdam.
31. Shapiro DA, Renock S, Arrington E, Sibley DR, Chiodo LA, Roth BL, and Mailman RB (2003) Aripiprazole, a novel atypical antipsychotic drug with a unique and robust pharmacology. Neuropsychopharmacology 28:1400-1411.
32. 3 agonists partially reproduce the discriminative stimulus effects of cocaine in squirrel monkeys. J Pharmacol Exp Ther 278:1128-1137.
33. Tzschenke TM (1998) Measuring reward with the conditioned place preference paradigm: A comprehensive review of drug effects, recent progress and new issues. Prog Neurobiol 56:613-672.
34. Urban JD, Clarke WP, von Zastrow M, Nichols DE, Kobilka B, Weinstein H, Javitch JA, Roth BL, Christopulos AC, Sexton PM, et al. (2007) Functional selectivity and classical concepts of quantitative pharmacology. J Pharmacol Exp Ther 320:1-13.
35. 3 receptor antagonism inhibits cocaine-seeking and cocaine-enhanced brain reward in rats. J Neurosci 22:9595-9603.
36. Weiss F, Martin-Fardon R, Ciccocioppo R, Kerr TM, Smith DL, and Ben-Shahar O (2001) Enduring resistance to extinction of cocaine-seeking behavior induced by drug-related cues. Neuropsychopharmacology 25:361-372.
37. 3 receptors. Eur J Pharmacol 424:85-90.
38. Wood MD, Boyfield I, Nash DJ, Jewitt FR, Avenell KY, and Riley GJ (2000) Evidence for antagonist activity of the dopamine D3 receptor partial agonist, BP 897, at human dopamine D3 receptor. Eur J Pharmacol 407:47-51.
39. Xi ZX, Gilbert J, Campos AC, Kline N, Ashby CR Jr, Hagan JJ, Heidbreder CA, and Gardner EL (2004) Blockade of mesolimbic dopamine D3 receptors inhibits stress-induced reinstatement of cocaine-seeking in rats. Psychopharmacology (Berl) 176:57-65.
40. Zhang XY and Kosten TA (2005) Prazosin, an alpha-1 adrenergic antagonist, reduces cocaine-induced reinstatement of drug-seeking. Biol Psychiatry 57:1202-1204.