Metabolic complications of obesity: inflated or inflamed?

Journal of Diabetes and its Complications

Volumn 21, Issue 2, 2007, Pages 128-136

  Chandalia, Manisha ^a,b   Abate, Nicola ^a,b  

^a Div of Repro Endocrinol/Infertil   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Adipose tissue; Inflammation; Insulin resistance; South Asians; Type 2 diabetes

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; GLITAZONE DERIVATIVE; RIMONABANT;

ADIPOSE TISSUE; ARTICLE; CARDIOVASCULAR DISEASE; DRUG MECHANISM; DYSLIPIDEMIA; ETHNICITY; HIGH RISK POPULATION; HUMAN; INFLAMMATION; INSULIN RESISTANCE; MORBIDITY; MORTALITY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL;

ABDOMINAL FAT; CYTOKINES; DIABETES MELLITUS, TYPE 2; HUMANS; INFLAMMATION; METABOLIC SYNDROME X; MODELS, BIOLOGICAL; OBESITY;

EID: 33847199385     PISSN: 10568727     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jdiacomp.2006.10.004     Document Type: Article

References (71)

1. Abate N., Carulli L., Cabo-Chan A.V., Chandalia M., Snell P.G., and Grundy S.M. Genetic polymorphism PC-1 K121Q and ethnic susceptibility to insulin resistance. Journal of Clinical Endocrinology and Metabolism 88 12 (2003) 5927-5934
2. Abate N., and Chandalia M. Ethnicity and Type 2 diabetes: focus on Asian Indians. Journal of Diabetes and its Complications 15 6 (2001) 320-327
3. Abate N., Chandalia M., Satija P., Adams-Huet B., Grundy S., Sandeep M., Radha S., Deepa V., and Mohan R. E-NPP1/PC-1 K121Q polymorphism and genetic susceptibility to Type 2 diabetes. Diabetes 54 4 (2005) 1207-1213
4. Abate N., Chandalia M., Snell P.G., and Grundy S.M. Adipose tissue metabolites and insulin resistance in nondiabetic Asian Indian men. Journal of Clinical Endocrinology and Metabolism 89 6 (2004) 2750-2755
5. Abate N., Garg A., Peshock R.M., Stray-Gundersen J., and Grundy S.M. Relationships of generalized and regional adiposity to insulin sensitivity in men. Journal of Clinical Investigation 96 1 (1995) 88-98
6. Arita Y., Kihara S., Ouchi N., et al. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochemical and Biophysical Research Communications 257 1 (1999) 79-83
7. Bensaid M., Gary-Bobo M., and Esclangon A. The cannabinoid CB1 receptor antagonist SR141716 increases Acrp30 mRNA expression in adipose tissue of obese fa/fa rats and in cultured adipocyte cells. Molecular Pharmacology 63 4 (2003) 908-914
8. Bermudez E.A., Rifai N., Buring J., et al. Interrelationships among circulating interleukin-6, C-reactive protein, and traditional cardiovascular risk factors in women. Arteriosclerosis, Thrombosis, and Vascular Biology 22 10 (2002) 1668-1673
9. Chandalia M., Abate N., Garg A., Stray-Gundersen J., and Grundy S.M. Relationship between generalized and upper body obesity to insulin resistance in Asian Indian men. Journal of Clinical Endocrinology and Metabolism 84 7 (1999) 2329-2335
10. Chandalia M., and Deedwania P.C. Coronary heart disease and risk factors in Asian Indians. Advances in Experimental Medicine and Biology 498 (2001) 27-34
11. Charriere G., Cousin B., Arnaud E., Andre M., Bacou F., Penicaud L., and Casteilla L. Preadipocyte conversion to macrophage. Evidence of plasticity. Journal of Biological Chemistry 278 11 (2003) 9850-9855
12. Cinti S., Mitchell G., Barbatelli G., Murano I., Ceresi E., Faloia E., Wang S., Fortier M., Greenberg A.S., and Obin M.S. Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. Journal of Lipid Research 46 11 (2005, Nov) 2347-2355
13. Clement K., Viguerie N., Poitou C., Carette C., Pelloux V., Curat C.A., Sicard A., Rome S., Benis A., Zucker J.D., Vidal H., Laville M., Barsh G.S., Basdevant A., Stich V., Cancello R., and Langin D. Weight loss regulates inflammation-related genes in white adipose tissue of obese subjects. FASEB Journal 18 14 (2004) 1657-1669
14. Despres J.P., Golay A., Sjostrom L., and Rimonabant in Obesity-Lipids Study Group. Effects of timonabant on metabolic risk factors in overweight patients with dyslipidemia. New England Journal of Medicine 353 20 (2005) 2121-2134
15. Di Gregorio G.B., Yao-Borengasser A., Rasouli N., Varma V., Lu T., Miles L.M., Ranganathan G., Peterson C.A., McGehee R.E., and Kern P.A. Expression of CD68 and macrophage chemoattractant protein-1 genes in human adipose and muscle tissues: Association with cytokine expression, insulin resistance, and reduction by pioglitazone. Diabetes 54 8 (2005) 2305-2313
16. Engeli S., Feldpausch M., Gorzelniak K., Hartwig F., Heintze U., Janke J., Mohlig M., Pfeiffer A.F., Luft F.C., and Sharma A.M. Association between adiponectin and mediators of inflammation in obese women. Diabetes 52 4 (2003) 942-947
17. Festa A., D'Agostino R., and Howard G. Chronic subclinical inflammation as part of the insulin resistance syndrome - the Insulin Resistance Atherosclerosis Study (IRAS). Circulation 102 (2000) 42-47
18. Folsom A.R., Aleksic N., Catellier D., et al. C-reactive protein and incident coronary heart disease in the Atherosclerosis Risk In Communities (ARIC) study. American Heart Journal 144 2 (2002) 233-238
19. Ford E.S. The metabolic syndrome and C-reactive protein, fibrinogen, and leukocyte count: findings from the Third National Health and Nutrition Examination Survey. Atherosclerosis 168 2 (2003) 351-358
20. Freeman D.J., Norrie J., Caslake M.J., et al. West of Scotland Coronary Prevention Study. C-reactive protein is an independent predictor of risk for the development of diabetes in the West of Scotland Coronary Prevention Study. Diabetes 51 5 (2002) 1596-1600
21. Halle M., Korsten-Reck U., Wolfarth B., and Berg A. Low-grade systemic inflammation in overweight children: impact of physical fitness. Exercise Immunology Review 10 (2004) 66-74
22. Hamaguchi K., Terao H., Kusuda Y., Yamashita T., Hazoury Bahles J.A., Cruz L.L.M., Brugal V.L.I., Jongchong W.B., Yoshimatsu H., and Sakata T. The PC-1 Q121 allele is exceptionally prevalent in the Dominican Republic and is associated with Type 2 diabetes. Journal of Clinical Endocrinology and Metabolism 89 3 (2004) 1359-1364
23. Hanley A.J., and Festa A. Metabolic and inflammation variable clusters and prediction of Type 2 diabetes: factor analysis using directly measured insulin sensitivity. Diabetes 53 7 (2004) 1773-1781
24. Hotamisligil G.S., Shargill N.S., and Spiegelman B.M. Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance. Science 259 5091 (1993) 87-91
25. Hotta K., Funahashi T., Arita Y., et al. Plasma concentrations of a novel, adipose-specific protein, adiponectin, in Type 2 diabetic patients. Arteriosclerosis, Thrombosis, and Vascular Biology 20 6 (2000) 1595-1599
26. Hu F.B., Willett W.C., Li T., Stampfer M.L., Colditz G.A., and Manson J.E. Adiposity as compared with physical activity in predicting mortality among women. New England Journal of Medicine 351 (2004) 2694-2703
27. International diabetes foundation web site: www.idf.org.
28. Jager A., van Hinsbergh V.W., Kostense P.J., et al. von Willebrand factor, C-reactive protein, and 5-year mortality in diabetic and nondiabetic subjects: The Hoorn Study. Arteriosclerosis, Thrombosis, and Vascular Biology 19 12 (1999) 3071-3078
29. Jeffery R.W. Does weight cycling present a health risk?. American Journal of Clinical Nutrition (1996) 452S-455S
30. Jialal I., and Devaraj S. Inflammation and atherosclerosis: the value of the high-sensitivity C-reactive protein assay as a risk marker. American Journal of Clinical Pathology 116 Suppl (2001) S108-S115
31. Klein S. The case of visceral fat: Argument for the defense. Journal of Clinical Investigation 113 11 (2004) 1530-1532
32. Klein S., Fontana L., Young V.L., Coggan A.R., Kilo C., Patterson B.W., and Mohammed B.S. Absence of an effect of liposuction on insulin action and risk factors for coronary heart disease. New England Journal of Medicine 350 25 (2004) 2549-2557
33. Kubaszek A., Markkanen A., Eriksson J.G., Forsen T., Osmond C., Barker D.J., and Laakso M. The association of the K121Q polymorphism of the plasma cell glycoprotein-1 gene with Type 2 diabetes and hypertension depends on size at birth. Journal of Clinical Endocrinology and Metabolism 89 5 (2004) 2044-2047
34. Kumada M., Kihara S., Sumitsuji S., and Osaka CAD Study Group. Coronary artery disease. Association of hypoadiponectinemia with coronary artery disease in men. Arteriosclerosis, Thrombosis, and Vascular Biology 23 1 (2003) 85-89
35. Lee W.Y., Park J.S., Noh S.Y., Rhee E.J., Kim S.W., and Zimmet P.Z. Prevalence of the metabolic syndrome among 40,698 Korean metropolitan subjects. Diabetes Research and Clinical Practice 65 2 (2004) 143-149
36. Lindsay R.S., Krakoff J., Hanson R.L., et al. Gamma globulin levels predict Type 2 diabetes in the Pima Indian population. Diabetes 50 7 (2001) 1598-1603
37. Lyon C.J., Law R.E., and Hsueh W.A. Minireview: adiposity, inflammation, and atherogenesis. Endocrinology 144 6 (2003, Jun) 2195-2200
38. Mokdad A.H., Marks J.S., Stroup D.F., and Gerberding J.L. Actual causes of death in the United States, 2000. Journal of the American Medical Association 291 10 (2004) 1238-1245
39. Mokdad A.H., Marks J.S., Stroup D.F., and Gerberding J.L. Correction: actual causes of death in the United States, 2000. Journal of the American Medical Association 293 3 (2005) 293-294
40. Muntner P., He J., and Chen J. Prevalence of non-traditional cardiovascular disease risk factors among persons with impaired fasting glucose, impaired glucose tolerance, diabetes, and the metabolic syndrome: analysis of the Third National Health and Nutrition Examination Survey (NHANES III). Annals of Epidemiology 14 9 (2004) 686-695
41. Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation 106 (2002) 3143-3421
42. National Institute of Diabetes and Digestive and Kidney Diseases. Prevalence statistics related to overweight and obesity. http://www.niddk.nih.gov/stastistics/index.htm November, 2004
43. Nesto R. C-reactive protein, its role in inflammation, Type 2 diabetes and cardiovascular disease, and the effects of insulin-sensitizing treatment with thiazolidinediones. Diabetic Medicine 21 8 (2004) 810-817
44. NHANES (1999-2000). www.cdc.gov
45. Pickup J.C., Mattock M.B., Chusney G.D., et al. NIDDM as a disease of the innate immune system - association of acute-phase reactants and interleukin-6 with metabolic syndrome. Diabetologia 40 (1997) 1286-1292
46. Pietilainen K.H., Kannisto K., Korsheninnikova E., Rissanen A., Kaprio J., Ehrenborg E., Hamsten A., and Yki-Jarvinen H. Acquired obesity increases CD68 and tumor necrosis factor-alpha and decreases adiponectin gene expression in adipose tissue: a study in monozygotic twins. Journal of Clinical Endocrinology and Metabolism 91 7 (2006, Jul) 2776-2781
47. Pi-Sunyer F.K., Aronne L.J., Heshmati H.M., Devin J., Rosenstock J., and RIO-North America Study Group. Effect of rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients: RIO-North America: a randomized controlled trial. JAMA 295 7 (2006) 761-775
48. Pradhan A.D., Manson J.E., and Rifai N. C-reactive protein, interleukin 6, and risk of developing Type 2 diabetes mellitus. Journal of the American Medical Association 286 3 (2001) 327-334
49. Rajala M.W., and Scherer P.E. The adipocyte - at the crossroads of energy homeostasis, inflammation, and atherosclerosis. Endocrinology 144 9 (2003, Sep) 3765-3773
50. Reaven G.M. Role of insulin resistance in human disease. Diabetes 37 (1988) 1595-1697
51. Rifai N., and Ridker O.M. HsCRP - a novel and promising marker of CHD. Clinical Chemistry 47 (2001) 403-411
52. Roche R., Hoareau L., Bes-Houtmann S., Gonthier M.P., Laborde C., Baron J.F., Haffaf Y., Cesari M., and Festy F. Presence of the cannabinoid receptors, CB1 and CB2, in human omental and subcutaneous adipocytes. Histochemistry and Cell Biology 126 2 (2006) 177-187
53. Rosen B.S., Cook K.S., Yaglom J., Groves D.L., Volanakis J.E., Damm D., White T., and Spiegelman B.M. Adipsin and complement factor D activity: An immune-related defect in obesity. Science 244 4911 (1989) 1483-1487
54. Ruderman N., Chisholm D., Pi-Sunyer X., and Schneider S. The metabolically obese, normal-weight individual revisited. Diabetes 47 5 (1998) 699-713
55. Shoelson S.E., Lee J., and Goldfine A.B. Inflammation and insulin resistance. Journal of Clinical Investigation 116 7 (2006) 1793-1801
56. Sims E.A. Are there persons who are obese, but metabolically healthy?. Metabolism 50 12 (2001) 1499-1504
57. Stevens J., Cai J., Pamuk E.R., Williamson D.F., Thun M.J., and Wood J.L. The effect of age on the association between body-mass index and mortality. New England Journal of Medicine 338 1 (1998) 1-7
58. Tan C.E., Ma S., Wai D., Chew S.K., and Tai E.S. Can we apply the National Cholesterol Education Program Adult Treatment Panel definition of the metabolic syndrome to Asians?. Diabetes Care 27 5 (2004) 1182-1186
59. Thorand B., Lowel H., Schneider A., et al. C-reactive protein as a predictor for incident diabetes mellitus among middle-aged men: results from the MONICA Augsburg cohort study, 1984-1998. Archives of Internal Medicine 163 1 (2003) 93-99
60. Tracy R.P., Lemaitre R.N., Psaty B.M., et al. Relationship of C-reactive protein to risk of cardiovascular disease in the elderly. Results from the Cardiovascular Health Study and the Rural Health Promotion Project. Arteriosclerosis, Thrombosis, and Vascular Biology 17 6 (1997) 1121-1127
61. Ukkola O., and Santaniemi M. Adiponectin: A link between excess adiposity and associated comorbidities?. Journal of Molecular Medicine 80 11 (2002) 696-702
62. Vazquez L.A., Pazos F., Berrazueta J.R., Fernandez-Escalante C., Garcia-Unzueta M.T., Freijanes J., and Amado J.A. Effects of changes in body weight and insulin resistance on inflammation and endothelial function in morbid obesity after bariatric surgery. Journal of Clinical Endocrinology and Metabolism 90 1 (2005) 316-322
63. Wei M., Kampert J.B., Barlow C.E., Nichaman M.Z., Gibbons L.W., PaffenbargerJr R.S., and Blair S.N. Relationship between low cardiorespiratory fitness and mortality in normal-weight, overweight, and obese men. Journal of the American Medical Association 282 16 (1999) 1547-1553
64. Weisberg S.P., McCann D., Desai M., et al. Obesity is associated with macrophage accumulation in adipose tissue. Journal of Clinical Investigation 112 12 (2003) 1796-1808
65. Weyer C., Funahashi T., and Tanaka S. Hypoadiponectinemia in obesity and Type 2 diabetes: close association with insulin resistance and hyperinsulinemia. Journal of Clinical Endocrinology and Metabolism 86 5 (2000) 1930-1935
66. WHO website: www.who.int/en/.
67. Wise B.E. The inflammatory syndrome: the role of adipose tissue cytokines in metabolic disorders linked to obesity. Journal of the American Society of Nephrology 15 11 (2004, Nov) 2792-2800
68. Xu H., Barnes G.T., Yang Q., Tan G., et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. Journal of Clinical Investigation 112 12 (2003) 1821-1830
69. Xydakis A.M., Case C.C., Jones P.H., Hoogeveen R.C., Liu M.Y., Smith E.O., Nelson K.W., and Ballantyne C.M. Adiponectin, inflammation, and the expression of the metabolic syndrome in obese individuals: the impact of rapid weight loss through caloric restriction. Journal of Clinical Endocrinology and Metabolism 89 6 (2004) 2697-2703
70. Yang W.S., and Lee W.J. Weight reduction increases plasma levels of an adipose-derived anti-inflammatory protein, adiponectin. Journal of Clinical Endocrinology and Metabolism 86 8 (2001) 3815-3819
71. Yokota T., Oritani K., Takahashi I., Ishikawa J., Matsuyama A., Ouchi N., Kihara S., Funahashi T., Tenner A.J., Tomiyama Y., and Matsuzawa Y. Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages. Blood 96 5 (2000) 1723-1732