Postsynaptic 5-HT(1A) receptors mediate 5-hydroxytryptamine release in the amygdala through a feedback to the caudal linear raphe

European Journal of Pharmacology

Volumn 333, Issue 2-3, 1997, Pages 147-157

  Bosker, Fokko J ^a   Klompmakers, Andre ^a   Westenberg, Herman G M ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

5 HT (5 hydroxytryptamine, serotonin; 5 HT(1A) receptor; Feedback regulation; Flesinoxan; Microdialysis; Rat; WAY 100635

Indexed keywords

FLESINOXAN; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; SEROTONIN 1A RECEPTOR; PIPERAZINE DERIVATIVE; PYRIDINE DERIVATIVE; SEROTONIN; SEROTONIN 1 RECEPTOR; SEROTONIN AGONIST; SEROTONIN ANTAGONIST; SEROTONIN RECEPTOR;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DORSAL RAPHE NUCLEUS; FEEDBACK SYSTEM; INTRACEREBRAL DRUG ADMINISTRATION; MALE; MEDIAN RAPHE NUCLEUS; MICRODIALYSIS; NONHUMAN; PRIORITY JOURNAL; RAPHE NUCLEUS; RAT; SEROTONIN RELEASE; ANIMAL; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; NERVE CELL; SYNAPTIC TRANSMISSION; TRIGEMINAL NUCLEUS; WISTAR RAT;

AMYGDALA; ANIMALS; MALE; NEURONS; PIPERAZINES; PYRIDINES; RAPHE NUCLEI; RATS; RATS, WISTAR; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; SEROTONIN; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; SYNAPTIC TRANSMISSION; TRIGEMINAL CAUDAL NUCLEUS;

EID: 0030608865     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(97)01141-2     Document Type: Article

References (44)

1. Aghajanian G.K., Rosecrans J.A., Sheard M.H. Serotonin: Release in the forebrain by stimulation of midbrain raphe. Science. 156:1967;402-403.
2. 1A receptor agonists flesinoxan and 8-OH-DPAT in the rat. Eur. J. Pharmacol. 200:1991;259-266.
3. 3-like receptors. Synaps. 10:1992;7-15.
4. Azmitia E.C., Segal M. An autoradiographic analysis of the differential ascending projections of the dorsal and median raphe nuclei in the rat. J. Comp. Neurol. 179:1978;641-668.
5. 1A agonist gepirone: Electrophysiological studies in the rat brain. Synaps. 1:1987;470-480.
6. Bosker F.J., Klompmakers A.A., Westenberg H.G.M. Extracellular 5-hydroxytryptamine in median raphe nucleus of the conscious rat is decreased by nanomolar concentrations of 8-hydroxy-2-(di-n-propylamino)tetralin and is sensitive to tetrodotoxin. J. Neurochem. 63:1994;2165-2171.
7. 1A receptors. J. Neurochem. 66:1996;2546-2555.
8. 1A receptor agonist and antagonist on the 5-hydroxytryptamine release in the central nucleus of the amygdala: A microdialysis study with flesinoxan and WAY 100635. Naunyn-Schmiedeberg's Arch. Pharmacol. 355:1997;247-353.
9. Bunney B.S., Aghajanian G.K. D-amphetamine-induced inhibition of central dopaminergic neurons: Mediation by striato-nigral feedback pathway. Science. 192:1976;391-393.
10. Ceci A., Baschirotto A., Borsini F. The inhibitory effect of 8-OH-DPAT on the firing activity of dorsal raphe serotonergic neurons in rats is attenuated by lesion of the frontal cortex. Neuropharmacology. 33:1994;709-713.
11. 1A receptor antagonists. Neurosci. Lett. 188:1995;41-44.
12. 1A receptor agonists: Recent developments and controversial issues. Psychopharmacology. 121:1995;1-26.
13. Fernández-Guasti A., López-Rubalcava C., Pérez-Urizar J., Castañeda-Hernández G. Evidence for a postsynaptic action of the serotonergic anxiolytics: Ipsapirone, indorate and buspirone. Brain Res. Bull. 28:1992;497-501.
14. 1A-receptor ligands in the dorsal raphé and ventral hippocampus. Pharmacol. Biochem. Behav. 54:1996;123-128.
15. 1A receptor antagonist. Behav. Brain. Res. 73:1996;337-353.
16. Hillegaart V., Hjorth S., Ahlenius S. Effect of 5-HT and 8-OH-DPAT on forebrain monoamine synthesis after local application into the median and dorsal raphe nuclei of the rat. J. Neural. Transm. Gen. Sect. 81:1990;131-145.
17. Hodges H., Green S., Glenn B. Evidence that the amygdala is involved in benzodiazepine and serotonergic effects on punished responding but not in discrimination. Psychopharmacology. 92:1987;491-504.
18. Hogg S., Andrews N., File S.E. Contrasting behavioural effects of 8-OH DPAT in the dorsal raphé nucleus and ventral hippocampus. Neuropharmacology. 33:1994;343-348.
19. Imai H., Steindler D.A., Kitai S.T. The organization of divergent axonal projections from the midbrain raphe nuclei in the rat. J. Comp. Neurol. 243:1986;363-380.
20. Iqbal, N., Van Praag, H.M., 1995. The role of serotonin in schizophrenia. In: den Boer, J.A., Westenberg, H.G.M., van Praag, H.M. (Eds.), Advances in the Neurobiology of Schizophrenia. John Wiley & Sons, Chichester, pp. 221-244.
21. Iwatsubo K., Clouet D.H. Effects of morphine and haloperidol on the electrical activity of rat nigrostriatal neurons. J. Pharmacol. Exp. Ther. 202:1977;429-436.
22. Jacobs B.L., Azmitia E.C. Structure and function of the brain serotonin system. Physiol. Rev. 72:1992;165-229.
23. 1A receptor agonists and in their inhibitory effects on the firing of serotonergic neurons in the rat? J. Pharmacol. Exp. Ther. 272:1995;920-929.
24. Kahn A.S., Van Praag H.M., Wetzler S., Asnis G.M., Barr C. Serotonin and anxiety revisited. Biol. Psychiatry. 23:1988;189-208.
25. Kendrick K.M. Microdialysis measurement of in vivo neuropeptide release. J. Neurochem. Methods. 34:1990;35-46.
26. Kondo Y., Iwatsubo K. Diminished responses of nigral dopaminergic neurons to haloperidol and morphine following lesions in the striatum. Brain Res. 181:1980;237-240.
27. 1A autoreceptors of the dorsal and median raphe nuclei. J. Pharmacol. Exp. Ther. 269:1994;1268-1279.
28. Limberger N., Deicher R., Starke K. Species differences in presynaptic serotonin autoreceptors: mainly 5-HT1B but possibly in addition 5-HT1D in the rabbit and guinea-pig brain cortex. Naunyn-Schmiedeberg's Arch. Pharmacol. 343:1991;353-364.
29. Matsuzaki S., Takada M., Li Y.Q., Tokuno H., Mizuno N. Serotonergic projections from the dorsal raphe nucleus to the nucleus submedius in the rat and cat. Neuroscience. 55:1993;403-416.
30. Mehler W.R. Subcortical afferent connections of the amygdala in the monkey. J. Comp. Neurol. 190:1980;733-762.
31. Ohuoha D.C., Hyde T.M., Kleinman J.E. The role of serotonin in schizophrenia. An overview of the nomenclature, distribution and alterations of serotonin receptors in the central nervous system. Psychopharmacology. 112:1993;S5-S15.
32. 3H -hydroxytryptamine Neuroscience. 6:1981;115-138.
33. Pazos A., Palacios J.M. Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptors. Brain Res. 346:1985;205-230.
34. Paxinos, G., Watson, C., 1982. The Rat Brain in Stereotaxic Coordinates, Academic Press, Sydney.
35. o proteins in dorsal raphe nucleus. Eur. J. Pharmacol. 265:1994;103-106.
36. Schildkraut J.J. The catecholamine hypothesis of affective disorders: A review of supporting evidence. Am. J. Psychiatry. 122:1965;509-522.
37. 1A receptor agonists 8-OH-DPAT, ipsapirone and buspirone in the rat. Eur. J. Pharmacol. 249:1993;341-351.
38. 1A receptor agonists in the rat. J. Pharmacol. Exp. Ther. 265:1993;572-579.
39. Sharp T., Bramwell S.R., Hjorth S., Grahame-Smith D.G. Pharmacological characterization of 8-OH-DPAT-induced inhibition of rat hippocampal 5-HT release in vivo as measured by microdialysis. Br. J. Pharmacol. 98:1989;989-997.
40. 1A autoreceptors on serotoninergic neurons in the midbrain raphe nuclei. Eur. J. Neurosci. 12:1990;1144-1154.
41. 1B agonists. Synapse. 1:1987;3-9.
42. 1A autoreceptors modulate 5-HT release in the guinea-pig dorsal raphe nucleus. Neuropharmacology. 33:1994;393-402.
43. 1A receptor-related anxiolytics. Trends Pharmacol. Sci. 8:1987;432-437.
44. Westenberg, H.G.M., den Boer, J.A., 1994. The neuropharmacology of anxiety. In: den Boer, J.A., Sitsen, J.A.M., (Eds.), Handbook of Depression and Anxiety. Marcel Dekker, New York, pp. 405-447.