Permissive role of neurokinin NK3 receptors in NK1 receptor-mediated activation of the locus coeruleus revealed by SR 142801

Synapse

Volumn 43, Issue 1, 2002, Pages 62-69

  Bert, Lionel ^a   Rodier, Daniel ^a   Bougault, Isabelle ^a   Allouard, Nathalie ^a   Le Fur, Grard ^a   Soubri, Philippe ^a   Steinberg, Rgis ^a  

^a SANOFI   (France)

Author keywords

Dual probe microdialysis; Guinea pig; Norepinephrine; Prefrontal cortex; Tachykinin antagonists

Indexed keywords

3,4 DIHYDROXYPHENYLACETIC ACID; NEUROKININ 1 RECEPTOR; NEUROKININ 3 RECEPTOR; NORADRENALIN; OSANETANT; SENKTIDE; SEPTIDE; TACHYKININ RECEPTOR ANTAGONIST; VOFOPITANT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG EFFECT; DRUG RECEPTOR BINDING; GUINEA PIG; LOCUS CERULEUS; MALE; MICRODIALYSIS; NONHUMAN; NORADRENALIN BRAIN LEVEL; NORADRENERGIC SYSTEM; PREFRONTAL CORTEX; PRIORITY JOURNAL; REGULATORY MECHANISM;

3,4-DIHYDROXYPHENYLACETIC ACID; ANIMALS; ANTIEMETICS; DOSE-RESPONSE RELATIONSHIP, DRUG; GUINEA PIGS; LOCUS COERULEUS; MALE; NEURAL PATHWAYS; NEURONS; NOREPINEPHRINE; PEPTIDE FRAGMENTS; PIPERIDINES; PREFRONTAL CORTEX; PYRROLIDONECARBOXYLIC ACID; RECEPTORS, NEUROKININ-1; RECEPTORS, NEUROKININ-3; SUBSTANCE P; TETRAZOLES;

EID: 0036132430     PISSN: 08874476     EISSN: None     Source Type: Journal    
DOI: 10.1002/syn.10021     Document Type: Article

References (48)

1. Potency and selectivity of the tachykinin NK3 receptor antagonist SR 142801
2. Different subtypes of tachykinin NK(1) receptor binding sites are present in the rat brain
3. Presence of NK3-sensitive neurones in different proportions in the medial habenula of guinea-pig, rat and gerbil
4. Catecholamine metabolism in the rat locus coeruleus as studied by in vivo differential pulse voltammetry. I. Nature and origin of contributors to the oxidation current at +0.1 V
5. Substance P excitation of rat locus coeruleus neurones
6. Noradrenergic neurons expressing substance P receptor (NK1) in the locus coeruleus complex: A double immunofluorescence study in the rat
7. Point mutation increases a form of the NK1 receptor with high affinity for neurokinin A and B and septide
8. Pharmacological characterization and autoradiographic localization of substance P receptors in guinea pig brain
9. Visualization of neurokinin-3 receptor sites in rat brain using the highly selective ligand [3H]senktide
10. Localization of the neuromedin K receptor (NK3) in the central nervous system of the rat
11. SR 142801, the first potent non-peptide antagonist of the tachykinin NK3 receptor
12. Nucleus locus ceruleus: New evidence of anatomical and physiological specificity
13. GR205171: A novel antagonist with high affinity for the tachykinin NK1 receptor, and potent broad-spectrum anti-emetic activity
14. Pharmacological analysis of [3H]-senktide binding to NK3 tachykinin receptors in guinea-pig ileum longitudinal muscle-myenteric plexus and cerebral cortex membranes
15. Blockade of neurokinin3 receptors antagonizes drug-induced population response and depolarization block of midbrain dopamine neurons in guinea pigs
16. Excitation of neurons in the nucleus locus coeruleus by substance P and related peptides
17. Delayed iontophoretic ejection of substance P from glass micropipettes: Correlation with time-course of neuronal excitation in vivo
18. Effect of neurokinin-I receptor antagonists on the function of 5-HT and noradrenaline neurons
19. Stress-induced C-fos expression in the rat locus coeruleus is dependent on neurokinin 1 receptor activation
20. Characterization of neurokinin binding sites in rat brain membranes using highly selective ligands
21. Electrophysiological, behavioural and biochemical evidence for activation of brain noradrenergic systems following neurokinin NK3 receptor stimulation
22. Distinct mechanism for antidepressant activity by blockade of central substance P receptors
23. Activation of dopaminergic and cholinergic neurotransmission by tachykinin NK3 receptor stimulation: An in vivo microdialysis approach in guinea pig
24. Pharmacology of CP-99,994; a nonpeptide antagonist of the tachykinin neurokinin-1 receptor
25. Characterization of CP-122,721; a nonpeptide antagonist of the neurokinin NK1 receptor
26. Localization of neurokinin B in the central nervous system of the rat
27. Neurokinin-3 receptor distribution in rat and human brain: An immunohistochemical study
28. 1 receptors facilitates the activity of adrenergic pathways projecting to frontal cortex and dorsal hippocampus in rats
29. Tachykinin receptors: A radioligand binding perspective
30. In vivo microdialysis study of the extracellular 3,4-dihydroxyphenylacetic acid in the rat locus coeruleus: Topographical and pharmacological aspects
31. Electron microscopic localization of substance P and enkephalin in axon terminals related to dendrites of catecholaminergic neurons
32. The activity of GR205171, a potent non-peptide tachykinin NK1 receptor antagonist, in the trigeminovascular system
33. Localization of tachykinin binding sites (NK1, NK2, NK3 ligands) in the rat brain
34. Dopamine deficiency in the cerebral cortex in Parkinson disease
35. NK-3 receptors mediate enhancement of substance P release from capsaicin-sensitive spinal cord afferent terminals
36. Differences in the effects of tachykinin NK1 receptor antagonists: Neuronal versus smooth muscle tissues
37. Substance P opens cation channels and closes potassium channels in rat locus coeruleus neurons
38. In situ hybridization analysis of the distribution of neurokinin-3 mRNA in the rat central nervous system
39. A comparison of the anatomical distribution of substance P and substance P receptors in the rat central nervous system
40. Pharmacological characterization of tachykinin receptors controlling acetylcholine release from rat striatum: An in vivo microdialysis study
41. Facilitation of striatal acetylcholine release by dopamine D1 receptor stimulation: Involvement of enhanced nitric oxide production via neurokinin-2 receptor activation
42. Autoradiographic visualization of NK-3 tachykinin binding sites in the rat brain, utilizing [3H]senktide
43. In vitro study of the catecholaminergic metabolism of locus coeruleus neurones by differential normal pulse voltammetry
44. Opposing mechanisms of regulation of a G-protein-coupled inward rectifier K+ channel in rat brain neurons
45. Distribution of cells containing mRNAs encoding substance P and neurokinin B in the rat central nervous system
46. Quantitation, cellular localization and regulation of neurokinin receptor gene expression within the rat substantia nigra
47. Highly selective agonists for substance P receptor subtypes
48. Localization of Fos-like immunoreactivity induced by the NK3 tachykinin receptor agonist, senktide, in the guinea-pig brain