Modification of norepinephrine and serotonin, but not dopamine, neuron firing by sustained bupropion treatment

Psychopharmacology

Volumn 155, Issue 1, 2001, Pages 52-57

  Dong, J ^a   Blier, P ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

Antidepressant; Dorsal raphe; Locus coeruleus; Ventral tegmental area; 2 Adrenoceptors and autoreceptors

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; AMFEBUTAMONE; AUTORECEPTOR; DOPAMINE; IDAZOXAN; NORADRENALIN; NORADRENALIN UPTAKE INHIBITOR; SEROTONIN; SEROTONIN UPTAKE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN NERVE CELL; CHEMICAL MODIFICATION; CONTROLLED STUDY; DORSAL RAPHE NUCLEUS; DOSE RESPONSE; LOCUS CERULEUS; MALE; MESOLIMBIC DOPAMINERGIC SYSTEM; NONHUMAN; OSMOTIC MINIPUMP; PRIORITY JOURNAL; RAT; SMOKING CESSATION; VENTRAL TEGMENTUM;

ACTION POTENTIALS; ANIMALS; BUPROPION; DOPAMINE; DOPAMINE UPTAKE INHIBITORS; LOCUS COERULEUS; MALE; NEURONS; NOREPINEPHRINE; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN;

EID: 0035068099     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002130000665     Document Type: Article

References (29)

1. Suppression of serotonergic neuronal firing by alpha-adrenoceptor antagonists: Evidence against GABA mediation
2. Effects of the co-administration of mirtazapine and paroxetine on serotonergic neurotransmission in the rat brain
3. Electrophysiological investigations on the effect of repeated zimelidine administration on serotonergic neurotransmission in the rat
4. Serotonergic but not noradrenergic neurons in rat central nervous system adapt to long-term treatment with monoamine oxidase inhibitors
5. Dopaminergic neurons: Effect of antipsychotic drugs and amphetamine on single cell activity
6. 3H]noradrenaline uptake and effect of DSP-4 lesioning and antidepressant treatment
7. Evidence that the acute behavioral and electrophysiological effects of bupropion (Wellbutrin) are mediated by a noradrenergic mechanism
8. Binding of antidepressants to human brain receptors: Focus on newer generation compounds
9. Electrophysiological effects of cocaine in the mesoaccumbens dopamine system: Studies in the ventral tegmental area
10. Some neurochemical properties of a new antidepressant, bupropion hydrochloride (Wellbutrin)
11. Idazoxan (RX 781094) selectively antagonizes alpha 2-adrenoceptors on rat central neurons
12. Selective effects of DSP-4 on locus coeruleus axons: Are there pharmacologically different types of noradrenergic axons in the central nervous system?
13. Effects of bupropion on norepinephrine and serotonin reuptake in healthy human subjects
14. Intracellular and extracellular electrophysiology of nigral dopaminergic neurons-1. Identification and characterization
15. 2-adrenoceptor antagonist mirtazapine on the 5-hydroxytryptamine system in the rat brain
16. Organization of medullary adrenergic and noradrenergic projections to the periaqueductal gray matter in the rat
17. A partial noradrenergic lesion induced by DSP-4 increases extracellular noradrenaline concentration in rat frontal cortex: A microdialysis study in vivo
18. A comparison of sustained-release bupropion and placebo for smoking
19. 1A receptors
20. Relative potencies of alpha-1 and alpha-1 antagonists in the locus ceruleus, dorsal raphe and dorsal lateral geniculate nuclei: An electrophysiological study
21. Minacipran. Effect of acute, short-term and long-term administration on rat locus coeruleus noradrenergic and dorsal raphe serotonergic neurons
22. Acute effects of bupropion on extracellular dopamine concentrations in rat striatum and nucleus accumbens studied by in vivo microdialysis
23. Down regulation of beta-receptors by bupropion and its major metabolite in mouse brain
24. The disposition of bupropion and its metabolites in healthy male volunteers after single and multiple doses
25. A multicenter evaluation of the efficacy and safety of 150 and 300 mg/d sustained release bupropion tablets versus placebo in depressed outpatients
26. Afferent connections of the nucleus raphe dorsalis in the cat as visualized by the peroxidase technique
27. Inhibition of both noradrenergic and serotonergic neurons in brain by the alpha-adrenergic agonist clonidine
28. Effect of acute and sustained administration of reboxetine on locus coeruleus noradrenergic and dorsal raphe 5-HT neurons
29. Progressive attenuation of the firing activity of locus coerueleus noradrenergic neurons by sustained administration of selective serotonin reuptake inhibitors