Carbonic anhydrase inhibitors. Inhibition of transmembrane isozymes XII (cancer-associated) and XIV with anions

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 6, 2007, Pages 1532-1537

  Innocenti, Alessio ^a   Vullo, Daniela ^a   Pastorek, Jaromir ^b   Scozzafava, Andrea ^a   Pastorekova, Silvia ^b   Nishimori, Isao ^c   Supuran, Claudiu T ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b INSTITUTE OF VIROLOGY   (Slovakia)

^c KOCHI MEDICAL SCHOOL   (Japan)

Author keywords

Anion; Carbonic anhydrase; Enzyme inhibitor; Isoforms IX, XII, XIV; Tumor associated isozyme

Indexed keywords

ANION; ARSONIC ACID DERIVATIVE; BICARBONATE; BORONIC ACID DERIVATIVE; CARBONATE DEHYDRATASE I; CARBONATE DEHYDRATASE II; CARBONATE DEHYDRATASE INHIBITOR; CARBONATE DEHYDRATASE IX; CARBONIC ANHYDRASE XII; CARBONIC ANHYDRASE XIV; FLUORIDE; HALIDE; ISOENZYME; MEMBRANE ENZYME; METAL COMPLEX; NITRATE; NITRITE; PERCHLORATE; SULFATE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING SITE; CYTOSOL; ENZYME INHIBITION; ENZYME MECHANISM; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; ANIONS; CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASES; CELL MEMBRANE; CYTOSOL; HUMANS; HYDROGEN BONDING; ISOENZYMES; KINETICS; MOLECULAR SEQUENCE DATA; NEOPLASMS; RECOMBINANT PROTEINS;

EID: 33847155608     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.12.113     Document Type: Article

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