Protease-activated receptors differentially regulate human platelet activation through a phosphatidic acid-dependent pathway

Molecular Pharmacology

Volumn 71, Issue 3, 2007, Pages 686-694

  Holinstat, Michael ^a   Voss, Bryan ^a   Bilodeau, Matthew L ^a,b   Hamm, Heidi E ^a,b  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; BUTANOL; LIPID PHOSPHATE PHOSPHATASE 1; NADOLOL; PHOSPHATASE; PHOSPHATIDIC ACID; PHOSPHATIDYLCHOLINE; PHOSPHOLIPASE D; PROPRANOLOL; PROTEINASE ACTIVATED RECEPTOR; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 4; THROMBIN; THROMBIN RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STATISTICAL SIGNIFICANCE; THROMBOCYTE ACTIVATION;

CYTOPLASMIC GRANULES; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; NADOLOL; PHOSPHATIDATE PHOSPHATASE; PHOSPHATIDIC ACIDS; PHOSPHOLIPASE D; PLATELET ACTIVATION; PLATELET AGGREGATION; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PROPRANOLOL; PROTEIN KINASE C; RAP1 GTP-BINDING PROTEINS; RECEPTOR, PAR-1; RECEPTORS, THROMBIN;

EID: 33847116251     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.106.029371     Document Type: Article

References (46)

1. Bernardi B, Guidetti GF, Campus F, Crittenden JR, Graybiel AM, Balduini C, and Torti M (2006) The small GTPase Rap1b regulates the cross talk between platelet integrin alpha2beta1 and integrin alphaIIbbeta3. Blood 107:2728-2735.
2. Bos JL (2005) Linking Rap to cell adhesion. Curr Opin Cell Biol 17:123-128.
3. Brass LF (2003) Thrombin and platelet activation. Chest 124:18S-25S.
4. 2+ transport ATPase in muscle and blood platelets by diacylglycerol analogues and cyclosporin A antagonism. Biochem J 327:795-801.
5. Chen JS and Exton JH (2004) Regulation of phospholipase D2 activity by protein kinase C. J Biol Chem 279:22076-22083.
6. Chrzanowska-Wodnicka M, Smyth SS, Schoenwaelder SM, Fischer TH, and White GC 2nd (2005) Rap1b is required for normal platelet function and hemostasis in mice. J Clin Investig 115:680-687.
7. Coughlin SR (2005) Protease-activated receptors in hemostasis, thrombosis and vascular biology. J Thromb Haemost 3:1800-1814.
8. Crittenden JR, Bergmeier W, Zhang Y, Piffath CL, Liang Y, Wagner DD, Housman DE, and Graybiel AM (2004) CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation. Nat Med 10:982-986.
9. Davey MG and Luscher EF (1967) Actions of thrombin and other coagulant and proteolytic enzymes on blood platelets. Nature (Lond) 216:857-858.
10. Dupuy AJ, Morgan K, von Lintig FC, Shen H, Acar H, Hasz DE, Jenkins NA, Copeland NG, Boss GR, and Largaespada DA (2001) Activation of the Rap1 guanine nucleotide exchange gene, CalDAG-GEF I, in BXH-2 murine myeloid leukemia. J Biol Chem 276:11804-11811.
11. Exton JH (2002) Regulation of phospholipase D. FEBS Lett 531:58-61.
12. Falker K, Lange D, and Presek P (2004) ADP secretion and subsequent P2Y12 receptor signalling play a crucial role in thrombin-induced ERK2 activation in human platelets. Thromb Haemost 92:114-123.
13. Franke B, van Triest M, de Bruijn KM, van Willigen G, Nieuwenhuis HK, Negrier C, Akkerman JW, and Bos JL (2000) Sequential regulation of the small GTPase Rap1 in human platelets. Mol Cell Biol 20:779-785.
14. Fukami K and Takenawa T (1992) Phosphatidic acid that accumulates in platelet-derived growth factor-stimulated Balb/c 3T3 cells is a potential mitogenic signal. J Biol Chem 267:10988-10993.
15. Ha KS and Exton JH (1993a) Activation of actin polymerization by phosphatidic acid derived from phosphatidylcholine in IIC9 fibroblasts. J Cell Biol 123:1789-1796.
16. Ha KS and Exton JH (1993b) Differential translocation of protein kinase C isozymes by thrombin and platelet-derived growth factor. A possible function for phosphatidylcholine-derived diacylglycerol. J Biol Chem 268:10534-10539.
17. Haslam RJ and Coorssen JR (1993) Evidence that activation of phospholipase D can mediate secretion from permeabilized platelets. Adv Exp Med Biol 344:149-164.
18. Hechler B, Cattaneo M, and Gachet C (2005) The P2 receptors in platelet function. Semin Thromb Hemostasis 31:150-161.
19. Henage LG, Exton JH, and Brown HA (2006) Kinetic analysis of a mammalian phospholipase D: allosteric modulation by monomeric GTPases, protein kinase C, and polyphosphoinositides. J Biol Chem 281:3408-3417.
20. 2+ mobilization and synergistic P2Y12 receptor activation. J Biol Chem 281:26665-26674.
21. Hu T and Exton JH (2003) Mechanisms of regulation of phospholipase D1 by protein kinase Cα. J Biol Chem 278:2348-2355.
22. Jamieson GA (1997) Pathophysiology of platelet thrombin receptors. Thromb Haemostasis 78:242-246.
23. Kahn ML, Zheng YW, Huang W, Bigornia V, Zeng D, Moff S, Farese RV Jr, Tam C, and Coughlin SR (1998) A dual thrombin receptor system for platelet activation. Nature (Lond) 394:690-694.
24. Kanaho Y, Kanoh H, Saitoh K, and Nozawa Y (1991) Phospholipase D activation by platelet-activating factor, leukotriene B4, and formyl-methionyl-leucylphenylalanine in rabbit neutrophils. Phospholipase D activation is involved in enzyme release. J Immunol 146:3536-3541.
25. Kawasaki H, Springett GM, Toki S, Canales JJ, Harlan P, Blumenstiel JP, Chen EJ, Bany IA, Mochizuki N, Ashbacher A, et al. (1998) A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia. Proc Natl Acad Sci USA 95:13278-13283.
26. Kim SY, Ahn BH, Min KJ, Lee YH, Joe EH, and Min do S (2004) Phospholipase D isozymes mediate epigallocatechin gallate-induced cyclooxygenase-2 expression in astrocyte cells. J Biol Chem 279:38125-38133.
27. Kiss Z (1996) Regulation of phospholipase D by protein kinase C. Chem Phys Lipids 80:81-102.
28. Ma L, Perini R, McKnight W, Dicay M, Klein A, Hollenberg MD, and Wallace JL (2005) Proteinase-activated receptors 1 and 4 counter-regulate endostatin and VEGF release from human platelets. Proc Natl Acad Sci USA 102:216-220.
29. Macfarlane SR, Seatter MJ, Kanke T, Hunter GD, and Plevin R (2001) Proteinase-activated receptors. Pharmacol Rev 53:245-282.
30. Martinson EA, Scheible S, Greinacher A, and Presek P (1995) Platelet phospholipase D is activated by protein kinase C via an integrin alpha IIb beta 3-independent mechanism. Biochem J 310 (Pt 2):623-628.
31. McKenzie FR, Seuwen K, and Pouyssegur J (1992) Stimulation of phosphatidylcholine breakdown by thrombin and carbachol but not by tyrosine kinase receptor ligands in cells transfected with M1 muscarinic receptors. Rapid desensitization of phosphocholine-specific (PC) phospholipase D but sustained activity of PC-phospholipase C. J Biol Chem 267:22759-22769.
32. Natarajan V and Garcia JG (1993) Agonist-induced activation of phospholipase D in bovine pulmonary artery endothelial cells: regulation by protein kinase C and calcium. J Lab Clin Med 121:337-347.
33. Offermanns S (2000) The role of heterotrimeric G proteins in platelet activation. Biol Chem 381:389-396.
34. Ossovskaya VS and Bunnett NW (2004) Protease-activated receptors: contribution to physiology and disease. Physiol Rev 84:579-621.
35. Pappu AS and Hauser G (1983) Propranolol-induced inhibition of rat brain cytoplasmic phosphatidate phosphohydrolase. Neurochem Res 8:1565-1575.
36. Preininger AM, Henage LG, Oldham WM, Yoon EJ, Hamm HE, and Brown HA (2006) Direct modulation of phospholipase D activity by Gbetagamma. Mol Pharmacol 70:311-318.
37. Reed GL, Houng AK, and Fitzgerald ML (1999) Human platelets contain SNARE proteins and a Sec1p homologue that interacts with syntaxin 4 and is phosphorylated after thrombin activation: implications for platelet secretion. Blood 93:2617-2626.
38. Rendu F and Brohard-Bohn B (2001) The platelet release reaction: granules' constituents, secretion and functions. Platelets 12:261-273.
39. Rubin R (1988) Phosphatidylethanol formation in human platelets: evidence for thrombin-induced activation of phospholipase D. Biochem Biophys Res Commun 156:1090-1096.
40. Shattil SJ, Cunningham M, and Hoxie JA (1987) Detection of activated platelets in whole blood using activation-dependent monoclonal antibodies and flow cytometry. Blood 70:307-315.
41. Siess W (1989) Molecular mechanisms of platelet activation. Physiol Rev 69:58-178.
42. Steinhoff M, Buddenkotte J, Shpacovitch V, Rattenholl A, Moormann C, Vergnolle N, Luger TA, and Hollenberg MD (2005) Proteinase-activated receptors: transducers of proteinase-mediated signaling in inflammation and immune response. Endocr Rev 26:1-43.
43. van Triest M, de Rooij J, and Bos JL (2001) Measurement of GTP-bound Ras-like GTPases by activation-specific probes. Methods Enzymol 333:343-348.
44. Walter M, Reinecke H, Gerdes U, Nofer JR, Hobbel G, Seedorf U, and Assmann G (1996) Defective regulation of phosphatidylcholine-specific phospholipases C and D in a kindred with Tangier disease. Evidence for the involvement of phosphatidylcholine breakdown in HDL-mediated cholesterol efflux mechanisms. J Clin Investig 98:2315-2323.
45. Werner MH and Hannun YA (1991) Delayed accumulation of diacylglycerol in platelets as a mechanism for regulation of onset of aggregation and secretion. Blood 78:435-444.
46. i family members in platelets. J Biol Chem 277:23382-23390.