메뉴 건너뛰기




Volumn 66, Issue 4, 2006, Pages 275-285

Hyperhomocysteinemia in developing age and nutritional aspects of folates: An early cardiovascular risk factor;Iperomocisteinemia in età evolutiva e aspetti nutrizionali dei folati: Un fattore di rischio cardiovascolare precoce

Author keywords

5 methyltetrahydrofolate; Arteriosclerotic vascular disease; Cardiovascular risk factors; Folic acid; Hyperhomocysteinemia

Indexed keywords

CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE; PYRIDOXINE;

EID: 33846952121     PISSN: 11220643     EISSN: None     Source Type: Journal    
DOI: 10.4081/monaldi.2006.519     Document Type: Review
Times cited : (4)

References (78)
  • 1
    • 33846986409 scopus 로고    scopus 로고
    • Rezvani I. Metionina, in Nelson: Trattato di Pediatria. Edizioni Minerva Medica. XVI Ed. 2002; X-82.3: 350-52.
    • Rezvani I. Metionina, in Nelson: Trattato di Pediatria. Edizioni Minerva Medica. XVI Ed. 2002; X-82.3: 350-52.
  • 3
    • 0000293534 scopus 로고
    • Vascular pathology of homocysteinemia: Implications for the pathogenesis of arteriosclerosis
    • McCully KS. Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis. Am J Pathol 1969; 561: 11-28.
    • (1969) Am J Pathol , vol.561 , pp. 11-28
    • McCully, K.S.1
  • 4
    • 0021894152 scopus 로고
    • The natural history of homocystinuria due to cystathionine-Beta-synthase deficiency
    • Mudd SH, Skovby R, Levy HL, et al. The natural history of homocystinuria due to cystathionine-Beta-synthase deficiency. Am J Hum Genet 1985; 37: 1-31.
    • (1985) Am J Hum Genet , vol.37 , pp. 1-31
    • Mudd, S.H.1    Skovby, R.2    Levy, H.L.3
  • 5
    • 0035806934 scopus 로고    scopus 로고
    • Oxidative Stress and Platelet Activation in Homozygous Homocystinuria
    • Davì G, Di Minno G, Coppola A, et al. Oxidative Stress and Platelet Activation in Homozygous Homocystinuria. Circulation 2001; 104: 1: 124.
    • (2001) Circulation , vol.104 , Issue.1 , pp. 124
    • Davì, G.1    Di Minno, G.2    Coppola, A.3
  • 6
    • 0029068922 scopus 로고
    • The molecular basis of homocystinuria due to cysthationine-Beta-synthase deficiency in Italian families and report of four novel mutations
    • Sebastio G, Sperandeo MT, Panico M, et al. The molecular basis of homocystinuria due to cysthationine-Beta-synthase deficiency in Italian families and report of four novel mutations. Am J Hum Genet 1995; 56: 1324-33.
    • (1995) Am J Hum Genet , vol.56 , pp. 1324-1333
    • Sebastio, G.1    Sperandeo, M.T.2    Panico, M.3
  • 7
    • 21644461697 scopus 로고    scopus 로고
    • Omocisteina, folati e patologia tromboembolica
    • Coppola A, De Simone C, Coppola D, et al. Omocisteina, folati e patologia tromboembolica. Riv I Ost Gin 2004; 1: 13-19.
    • (2004) Riv I Ost Gin , vol.1 , pp. 13-19
    • Coppola, A.1    De Simone, C.2    Coppola, D.3
  • 8
    • 0029049553 scopus 로고
    • A candidate genetic risk factor for vascular disease: A common mutation in methylenetetrahydrofolate reductase
    • Frosst P, Blom HJ, Milos R, et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 1995; 10: 111-3.
    • (1995) Nat Genet , vol.10 , pp. 111-113
    • Frosst, P.1    Blom, H.J.2    Milos, R.3
  • 9
    • 0029895024 scopus 로고    scopus 로고
    • Elevated total pasma homocysteine and 677→ T mutation of 5, 10-methylenetetrahydrofolate reductase gene in thrombotic vascular disease
    • de Franchis R, Mancini FR D Angelo A, et al. Elevated total pasma homocysteine and 677→ T mutation of 5, 10-methylenetetrahydrofolate reductase gene in thrombotic vascular disease. Am J Hum Genet 1996; 59: 262-4.
    • (1996) Am J Hum Genet , vol.59 , pp. 262-264
    • de Franchis, R.1    Mancini, F.D.2    Angelo, A.3
  • 10
    • 0034168107 scopus 로고    scopus 로고
    • D Angelo A, Coppola A, Madonna P, et al. The role of vitamin B12 in fasting hyperhomocysteinemia and its interaction with the homozygous C677T mutation of the methylenetetrahydrofolate reductase (MTHFR) gene. A case-control study of patients with early-onset thrombotic events. Thromb Haemost 2000; 83: 563-70.
    • D Angelo A, Coppola A, Madonna P, et al. The role of vitamin B12 in fasting hyperhomocysteinemia and its interaction with the homozygous C677T mutation of the methylenetetrahydrofolate reductase (MTHFR) gene. A case-control study of patients with early-onset thrombotic events. Thromb Haemost 2000; 83: 563-70.
  • 11
    • 0033782733 scopus 로고    scopus 로고
    • Contribution of the cystathionine beta-synthase gene (844ins68) polymorphism to the risk ofearly-onset venous and arterial occlusi ve disease and offasting hyperhomocysteinemia
    • De Franchis R, Fermo I, Mazzola G, et al. Contribution of the cystathionine beta-synthase gene (844ins68) polymorphism to the risk ofearly-onset venous and arterial occlusi ve disease and offasting hyperhomocysteinemia. Thromb Haemost 2000; 84: 576-82.
    • (2000) Thromb Haemost , vol.84 , pp. 576-582
    • De Franchis, R.1    Fermo, I.2    Mazzola, G.3
  • 12
    • 0742286981 scopus 로고    scopus 로고
    • High-level multiplex genotyping of polymorphisms involved in folate or homocysteine metabolism by matrix-assisted laser desorption/ionization mass spectrometry
    • Meyer K, Fredriksen A, Ueland PM. High-level multiplex genotyping of polymorphisms involved in folate or homocysteine metabolism by matrix-assisted laser desorption/ionization mass spectrometry. Clin Chem 2004; 50: 391-402.
    • (2004) Clin Chem , vol.50 , pp. 391-402
    • Meyer, K.1    Fredriksen, A.2    Ueland, P.M.3
  • 13
    • 0029655527 scopus 로고    scopus 로고
    • Nutritional ecogenetics: Homocysteine-related arteriosclerotic vascular disease, neural tube defects and folic acid
    • Motulsky A. Nutritional ecogenetics: homocysteine-related arteriosclerotic vascular disease, neural tube defects and folic acid. Am J Hum Genet 1996; 58: 17-20.
    • (1996) Am J Hum Genet , vol.58 , pp. 17-20
    • Motulsky, A.1
  • 14
    • 1842331509 scopus 로고    scopus 로고
    • Plasma homocysteine as a risk factor for vascular disease: The European Concerted Action Project
    • Graham IM, Daly LE, Refsum HM, et al. Plasma homocysteine as a risk factor for vascular disease: the European Concerted Action Project. JAMA 1997; 277: 1775-81.
    • (1997) JAMA , vol.277 , pp. 1775-1781
    • Graham, I.M.1    Daly, L.E.2    Refsum, H.M.3
  • 15
    • 0029066299 scopus 로고
    • A quantitative assessment of plasma homocysteine as a risk factor for vascular disease: Probable benefits of increasing folic acid intakes
    • Boushey CJ, Beresford SAA, Omenn GS, et al. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease: probable benefits of increasing folic acid intakes. JAMA 1995; 274: 1049-57.
    • (1995) JAMA , vol.274 , pp. 1049-1057
    • Boushey, C.J.1    Beresford, S.A.A.2    Omenn, G.S.3
  • 16
    • 0031733260 scopus 로고    scopus 로고
    • Hyperhomocysteinemia and venous thrombosis: A meta-analysis
    • den Heijer M, Rosendaal FR, Blom HJ et al. Hyperhomocysteinemia and venous thrombosis: a meta-analysis. Thromb Haemost 1998; 80: 874-7.
    • (1998) Thromb Haemost , vol.80 , pp. 874-877
    • den Heijer, M.1    Rosendaal, F.R.2    Blom, H.J.3
  • 17
    • 0029974036 scopus 로고    scopus 로고
    • Determinants and vitamin responsiveness of intermediate hyperhomocysteinemia
    • Guttormsen AB, Ueland PM, Nesthus I, et al. Determinants and vitamin responsiveness of intermediate hyperhomocysteinemia. J Clin Jnvest 1996; 98: 2174-83.
    • (1996) J Clin Jnvest , vol.98 , pp. 2174-2183
    • Guttormsen, A.B.1    Ueland, P.M.2    Nesthus, I.3
  • 18
    • 0038446637 scopus 로고    scopus 로고
    • Genetic and nutritional factors contributing to hyperhomocysteinemia in young adults
    • Kluijtmans LA, Young IS, Boreham CA, et al. Genetic and nutritional factors contributing to hyperhomocysteinemia in young adults. Blood 2003; 101: 2483-8.
    • (2003) Blood , vol.101 , pp. 2483-2488
    • Kluijtmans, L.A.1    Young, I.S.2    Boreham, C.A.3
  • 19
    • 0004905797 scopus 로고
    • Studies in "pernicias anaemia" of pregnancy, I preliminary report
    • Willis L, Mehta MM. Studies in "pernicias anaemia" of pregnancy, I preliminary report. Indian Journal of Medical Research 1930; 17: 777-15.
    • (1930) Indian Journal of Medical Research , vol.17 , pp. 777-715
    • Willis, L.1    Mehta, M.M.2
  • 20
    • 84965244622 scopus 로고
    • Treatment of "pernicias anaemia of pregnancy" and "tropical anaemia" with special reference to yeast extract as curative agent
    • Willis L. Treatment of "pernicias anaemia of pregnancy" and "tropical anaemia" with special reference to yeast extract as curative agent. Br Med J 1931; 1: 1059-63.
    • (1931) Br Med J , vol.1 , pp. 1059-1063
    • Willis, L.1
  • 21
    • 0001448013 scopus 로고
    • Synthesis of a compound identical with the L. casei factor isolated from liver
    • Angier RB, Boothe JH, Hutchings BL, et al. Synthesis of a compound identical with the L. casei factor isolated from liver. Science 1945; 102: 227-30.
    • (1945) Science , vol.102 , pp. 227-230
    • Angier, R.B.1    Boothe, J.H.2    Hutchings, B.L.3
  • 22
    • 0036391542 scopus 로고    scopus 로고
    • Decreasing prevalence of neural tube defects in Utah, 1985-2000
    • 66 S
    • Feldkamp M, Friedrichs M, Carey JC. Decreasing prevalence of neural tube defects in Utah, 1985-2000. Teratology 2002; 66 S.1: S23-8.
    • (2002) Teratology
    • Feldkamp, M.1    Friedrichs, M.2    Carey, J.C.3
  • 23
    • 85133630086 scopus 로고    scopus 로고
    • Persad VL, Van den Ho/MC, Dubé IM, et al. Incidence of open neural tube defects in Nova Scotia after folic acid fortification. CMAI 2002; 167: 241-6
    • Persad VL, Van den Ho/MC, Dubé IM, et al. Incidence of open neural tube defects in Nova Scotia after folic acid fortification. CMAI 2002; 167: 241-6
  • 24
    • 0037153743 scopus 로고    scopus 로고
    • Association of neural tube defects and folic acid food fortification in Canada
    • Ray JG, Meier C, Vermeulen MJ, Boss S, et al. Association of neural tube defects and folic acid food fortification in Canada. Lancet 2002; 360: 2047-8.
    • (2002) Lancet , vol.360 , pp. 2047-2048
    • Ray, J.G.1    Meier, C.2    Vermeulen, M.J.3    Boss, S.4
  • 25
    • 0037072702 scopus 로고    scopus 로고
    • Folic acid and prevention of spina bifida and anencephaly. 10 years after the U.S. Public Health Service recommendation
    • Erickson JD. Folic acid and prevention of spina bifida and anencephaly. 10 years after the U.S. Public Health Service recommendation. MMWR Recomm Rep 2002; 51: 1-3.
    • (2002) MMWR Recomm Rep , vol.51 , pp. 1-3
    • Erickson, J.D.1
  • 26
    • 1542652343 scopus 로고    scopus 로고
    • The use of folic acid for the prevention of neural tube defects and other congenital anomalies. Genetics Committee and Executive and Council of the Society of Obstetricians and Gynaecologists of Canada
    • Wilson RD, Davies G, Desilets V, et al. The use of folic acid for the prevention of neural tube defects and other congenital anomalies. Genetics Committee and Executive and Council of the Society of Obstetricians and Gynaecologists of Canada. J Obstet Gynaecol Can 2003; 25: 959-73.
    • (2003) J Obstet Gynaecol Can , vol.25 , pp. 959-973
    • Wilson, R.D.1    Davies, G.2    Desilets, V.3
  • 27
    • 33846944758 scopus 로고    scopus 로고
    • MMWR Morb Mortal Wkly Rep. Knowledge and use of folic acid among women of reproductive age - Michigan, 1998. 2001 Mar 16; 50: 185-9.
    • MMWR Morb Mortal Wkly Rep. Knowledge and use of folic acid among women of reproductive age - Michigan, 1998. 2001 Mar 16; 50: 185-9.
  • 28
    • 0033620779 scopus 로고    scopus 로고
    • Homocysteine and vascular disease
    • Hankey CI, Eikelboom JW. Homocysteine and vascular disease. Lancet 1999; 354: 407-15.
    • (1999) Lancet , vol.354 , pp. 407-415
    • Hankey, C.I.1    Eikelboom, J.W.2
  • 32
    • 0032937408 scopus 로고    scopus 로고
    • Folate deficiency beyond megaloblastic anemia: Hyperhomocysteinemia and other manifestations of dysfunctional folate status
    • Green R, Miller JW. Folate deficiency beyond megaloblastic anemia: hyperhomocysteinemia and other manifestations of dysfunctional folate status. Seminars in Hematology 1999; 36: 47-51.
    • (1999) Seminars in Hematology , vol.36 , pp. 47-51
    • Green, R.1    Miller, J.W.2
  • 33
    • 0036324027 scopus 로고    scopus 로고
    • Epidemiologic studies of folate and colorectal neoplasia. A review
    • Giovannucci E.: Epidemiologic studies of folate and colorectal neoplasia. A review. J Nutr 2002; 132: 2350-5.
    • (2002) J Nutr , vol.132 , pp. 2350-2355
    • Giovannucci, E.1
  • 34
    • 21644439942 scopus 로고    scopus 로고
    • L'uso farmacologico dei folati: Prospettive attuali
    • Coppola A, Di Mimmo G. L'uso farmacologico dei folati: prospettive attuali. Riv It Ost Gin 2004; 1: 21-25.
    • (2004) Riv It Ost Gin , vol.1 , pp. 21-25
    • Coppola, A.1    Di Mimmo, G.2
  • 35
    • 0035806934 scopus 로고    scopus 로고
    • Oxidative stress and platelet activation in homozygous homocystinuria
    • Davì G, Di Minno G, Coppola A, et al. Oxidative stress and platelet activation in homozygous homocystinuria. Circulation 2001; 104: 1124-28.
    • (2001) Circulation , vol.104 , pp. 1124-1128
    • Davì, G.1    Di Minno, G.2    Coppola, A.3
  • 36
    • 0033822421 scopus 로고    scopus 로고
    • Coppola A, Davì G, De Stefano V, et al. Homocysteine, coagulation, platelet fiinction and thrombosis. Semin Thromb Hemost 2000; 26.243-54.
    • Coppola A, Davì G, De Stefano V, et al. Homocysteine, coagulation, platelet fiinction and thrombosis. Semin Thromb Hemost 2000; 26.243-54.
  • 37
    • 0032499024 scopus 로고    scopus 로고
    • Homocysteine and atherothrombosis
    • Welch CN, Loscalzo J. Homocysteine and atherothrombosis. N Engl J Med 1998; 338: 1042-50.
    • (1998) N Engl J Med , vol.338 , pp. 1042-1050
    • Welch, C.N.1    Loscalzo, J.2
  • 39
    • 0345169177 scopus 로고    scopus 로고
    • Influence of hyperhomocysteinemia on the cellular redox state-impact on homocysteine-induced endothelial dysfunction
    • Weiss N, Heydrick SJ, Postea O, et al. Influence of hyperhomocysteinemia on the cellular redox state-impact on homocysteine-induced endothelial dysfunction. Clin Chem Lab Med 2003; 41: 1455-61.
    • (2003) Clin Chem Lab Med , vol.41 , pp. 1455-1461
    • Weiss, N.1    Heydrick, S.J.2    Postea, O.3
  • 40
    • 0042882190 scopus 로고    scopus 로고
    • Homocysteine altered ROS generation and NO accumulation in endothelial cells
    • Tsen CM, Hsieh CC, Yen CH, Lau YT. Homocysteine altered ROS generation and NO accumulation in endothelial cells. Chin J Physiol 2003; 46: 129-36.
    • (2003) Chin J Physiol , vol.46 , pp. 129-136
    • Tsen, C.M.1    Hsieh, C.C.2    Yen, C.H.3    Lau, Y.T.4
  • 41
    • 0035018871 scopus 로고    scopus 로고
    • Cellular regulation of endothelial nitric oxide synthase
    • Covers R, Rabelink TJ. Cellular regulation of endothelial nitric oxide synthase. Am J Physiol Renal Physiol 2001; 280: 193-6.
    • (2001) Am J Physiol Renal Physiol , vol.280 , pp. 193-196
    • Covers, R.1    Rabelink, T.J.2
  • 43
    • 0037304124 scopus 로고    scopus 로고
    • Effect of homocysteinylation on human high-density lipoproteins: A correlation with paraoxonase activity
    • Ferretti G, Bacchetti T, Marotti E, Curatola G. Effect of homocysteinylation on human high-density lipoproteins: a correlation with paraoxonase activity. Metabolism 2003; 52: 146-51.
    • (2003) Metabolism , vol.52 , pp. 146-151
    • Ferretti, G.1    Bacchetti, T.2    Marotti, E.3    Curatola, G.4
  • 44
    • 4544308769 scopus 로고    scopus 로고
    • Effect of homocysteinylation of low density lipoproteins on lipid peroxidation of human endothelial cells
    • Ferretti G, Bacchetti T, Moroni C, et al. Effect of homocysteinylation of low density lipoproteins on lipid peroxidation of human endothelial cells. J Cell Biochem 2004; 92: 51-60.
    • (2004) J Cell Biochem , vol.92 , pp. 51-60
    • Ferretti, G.1    Bacchetti, T.2    Moroni, C.3
  • 45
    • 33846991008 scopus 로고    scopus 로고
    • Effects of 5-MTHF therapy on hyperhomocysteinemia in dialysis patients
    • Cianciolo C, Manna C, Isola E, et al. Effects of 5-MTHF therapy on hyperhomocysteinemia in dialysis patients. Nephrol Dial Transplant 2000; 15: 9-13.
    • (2000) Nephrol Dial Transplant , vol.15 , pp. 9-13
    • Cianciolo, C.1    Manna, C.2    Isola, E.3
  • 46
    • 0036095165 scopus 로고    scopus 로고
    • 5- methyltetrahydrofolate restores endothelial function in uraemic patients on convective haemodialysis
    • Buccianti C, Raselli S, Baragetti I, et al. 5- methyltetrahydrofolate restores endothelial function in uraemic patients on convective haemodialysis. Nephrol Dial Transplant 2002; 17: 857-61.
    • (2002) Nephrol Dial Transplant , vol.17 , pp. 857-861
    • Buccianti, C.1    Raselli, S.2    Baragetti, I.3
  • 47
    • 0142184375 scopus 로고    scopus 로고
    • Folic acid and Vitamin E supplementation effects on homocysteinemia, endothelial function and plasma antioxidant capacity in young myocardial infarction patients
    • Assanelli D, Bonanome A, Pezzini A, et al. Folic acid and Vitamin E supplementation effects on homocysteinemia, endothelial function and plasma antioxidant capacity in young myocardial infarction patients. Pharmacol Res 2004; 49: 79-84.
    • (2004) Pharmacol Res , vol.49 , pp. 79-84
    • Assanelli, D.1    Bonanome, A.2    Pezzini, A.3
  • 48
    • 0034625532 scopus 로고    scopus 로고
    • Folic acid reverts dysfunction of endothelial nitric oxide synthase
    • Stroes ESG, van Faassen EE, Yo M, et al. Folic acid reverts dysfunction of endothelial nitric oxide synthase. Circ Res 2000; 86: 1129-34.
    • (2000) Circ Res , vol.86 , pp. 1129-1134
    • Stroes, E.S.G.1    van Faassen, E.E.2    Yo, M.3
  • 49
    • 0032570254 scopus 로고    scopus 로고
    • 5- methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolemia
    • Verhaar MC, Wevwr RMR Kastelein JJP, et al. 5- methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolemia. Circulation 1998; 97: 237-41.
    • (1998) Circulation , vol.97 , pp. 237-241
    • Verhaar, M.C.1    Wevwr, R.M.R.2    Kastelein, J.J.P.3
  • 50
    • 0036140785 scopus 로고    scopus 로고
    • Folic acid improves endothelial function in coronary artery disease via mechanisms largely independent of homocysteine lowering
    • Doshi SN, McDowell FW, Moat SJ, et al. Folic acid improves endothelial function in coronary artery disease via mechanisms largely independent of homocysteine lowering. Circulation 2002; 105: 22-6.
    • (2002) Circulation , vol.105 , pp. 22-26
    • Doshi, S.N.1    McDowell, F.W.2    Moat, S.J.3
  • 51
    • 0037707568 scopus 로고    scopus 로고
    • Folic acid says No to vascular diseases
    • Das UN. Folic acid says No to vascular diseases. Nutrition 2003; 19: 686-90.
    • (2003) Nutrition , vol.19 , pp. 686-690
    • Das, U.N.1
  • 52
    • 0036083567 scopus 로고    scopus 로고
    • Interaction of 5-methytertahydrofolate and tetrahydrobiopterin on endothelial function
    • Hyndman ME, Verma S, Rosenfeld RJ. Interaction of 5-methytertahydrofolate and tetrahydrobiopterin on endothelial function. Am J Physiol Heart Circ Physiol 2002; 282: 2167-72.
    • (2002) Am J Physiol Heart Circ Physiol , vol.282 , pp. 2167-2172
    • Hyndman, M.E.1    Verma, S.2    Rosenfeld, R.J.3
  • 53
    • 0347627540 scopus 로고    scopus 로고
    • Tetrahydrofolate and 5-methyltetrahydrofolate are folates with high antioxidant activity. Identification of the antioxidant pharmacophore
    • Reazk BM, Haenen CR, van der Vijgh WJ, Bast A. Tetrahydrofolate and 5-methyltetrahydrofolate are folates with high antioxidant activity. Identification of the antioxidant pharmacophore. FEBS Lett 2003; 555: 601-5.
    • (2003) FEBS Lett , vol.555 , pp. 601-605
    • Reazk, B.M.1    Haenen, C.R.2    van der Vijgh, W.J.3    Bast, A.4
  • 54
    • 33846989064 scopus 로고    scopus 로고
    • Homocysteine-lowering effects and reduction of oxidative stress by 5-methyltetrahydrofolate (Prefolic) in subjects with 677TT methylenetetrahydrofolate reductase (MTHFR) genotype
    • Coppola A, Mazzola C, Fermo I, et al. Homocysteine-lowering effects and reduction of oxidative stress by 5-methyltetrahydrofolate (Prefolic) in subjects with 677TT methylenetetrahydrofolate reductase (MTHFR) genotype. J Inherit Metab Dis 2003; 26 (S1): 123-7.
    • (2003) J Inherit Metab Dis , vol.26 , Issue.S1 , pp. 123-127
    • Coppola, A.1    Mazzola, C.2    Fermo, I.3
  • 55
    • 2142695679 scopus 로고    scopus 로고
    • Homocysteine plasma levels after suspension of vitamin treatment
    • Santi R, Demicheli M, Contino L, et al. Homocysteine plasma levels after suspension of vitamin treatment. J Thromb Haemost 2003; 1: 1330-4.
    • (2003) J Thromb Haemost , vol.1 , pp. 1330-1334
    • Santi, R.1    Demicheli, M.2    Contino, L.3
  • 56
    • 33846990195 scopus 로고    scopus 로고
    • Is it possible to manage hyperhomocysteinemia with an intermittent therapy? Preliminaiy results
    • Saban-Ruiz J, Bajo-Martinez A, Bernai Morell E, et al. Is it possible to manage hyperhomocysteinemia with an intermittent therapy? Preliminaiy results. J Inherit Metab Dis 2003; 26 (S1): 118-22.
    • (2003) J Inherit Metab Dis , vol.26 , Issue.S1 , pp. 118-122
    • Saban-Ruiz, J.1    Bajo-Martinez, A.2    Bernai Morell, E.3
  • 57
    • 0742304414 scopus 로고    scopus 로고
    • Is folic acid the ultimate functional food component for disease prevention?
    • Lucock M. Is folic acid the ultimate functional food component for disease prevention? BMJ 2004; 328: 211-214.
    • (2004) BMJ , vol.328 , pp. 211-214
    • Lucock, M.1
  • 58
    • 1842331509 scopus 로고    scopus 로고
    • Plasma homocysteine as a risk factor for vascular disease: The European Concerted Action Project
    • Graham IM, Daly LE, Refsum HM, et al. Plasma homocysteine as a risk factor for vascular disease: the European Concerted Action Project. JAMA 1997; 277: 1775-81.
    • (1997) JAMA , vol.277 , pp. 1775-1781
    • Graham, I.M.1    Daly, L.E.2    Refsum, H.M.3
  • 59
    • 1842370239 scopus 로고    scopus 로고
    • Plasma homocysteine levels and mortality in patients with coronary artery disease
    • Nygard O, Nordrehaug JE, Refsum H, et al. Plasma homocysteine levels and mortality in patients with coronary artery disease. N Engl J Med 1997; 337: 230-6.
    • (1997) N Engl J Med , vol.337 , pp. 230-236
    • Nygard, O.1    Nordrehaug, J.E.2    Refsum, H.3
  • 60
    • 0025756673 scopus 로고
    • Hyperhomocysteinemia: An independent risk factor for vascular disease
    • Clarke R, Daly L, Robinson K, et al. Hyperhomocysteinemia: an independent risk factor for vascular disease. N Engl J Med 1991; 324: 1149-55.
    • (1991) N Engl J Med , vol.324 , pp. 1149-1155
    • Clarke, R.1    Daly, L.2    Robinson, K.3
  • 63
    • 0033537653 scopus 로고    scopus 로고
    • Demonstration of rapid onset vascular endothelial dysfunction after hyperhomocysteinemia: An effect reversible with vitamin C therapy
    • Chambers JC, McGregor A, Jean-Marie J, Obeid OA, Kooner JS. Demonstration of rapid onset vascular endothelial dysfunction after hyperhomocysteinemia: an effect reversible with vitamin C therapy. Circulation 1999; 99: 1156-60.
    • (1999) Circulation , vol.99 , pp. 1156-1160
    • Chambers, J.C.1    McGregor, A.2    Jean-Marie, J.3    Obeid, O.A.4    Kooner, J.S.5
  • 64
    • 0027250615 scopus 로고
    • Homocysteine, a risk factor for premature vascular disease and thrombosis, induces tissue factor activity in endothelial cells
    • Fryer R, Wilson B, Gubler D, Fitzgerald L, Rodgers G. Homocysteine, a risk factor for premature vascular disease and thrombosis, induces tissue factor activity in endothelial cells. Arterioscler Thromb Vasc Biol 1993; 13: 1327-33.
    • (1993) Arterioscler Thromb Vasc Biol , vol.13 , pp. 1327-1333
    • Fryer, R.1    Wilson, B.2    Gubler, D.3    Fitzgerald, L.4    Rodgers, G.5
  • 65
    • 0038706687 scopus 로고    scopus 로고
    • Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) Final Report
    • Third Report of the National Cholesterol Education Program NCEP
    • Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) Final Report. Circulation 2002; 17/24: 3144-3421.
    • (2002) Circulation , vol.17-24 , pp. 3144-3421
  • 66
    • 0034530033 scopus 로고    scopus 로고
    • Multivitamin/mineral supplementation improves plasma B-vitamin status and homocysteine concentration in healthy older adults consuming a folate-fortified diet
    • McKay DL, Perrone G, Rasmussen H, Dallal G, Blumberg JB. Multivitamin/mineral supplementation improves plasma B-vitamin status and homocysteine concentration in healthy older adults consuming a folate-fortified diet. J Nutr 2000; 130: 3090-6.
    • (2000) J Nutr , vol.130 , pp. 3090-3096
    • McKay, D.L.1    Perrone, G.2    Rasmussen, H.3    Dallal, G.4    Blumberg, J.B.5
  • 67
    • 2242477014 scopus 로고    scopus 로고
    • Lowering blood homocysteine with folic acid based supplements: Meta-analysis of randomised trials
    • Homocysteine Lowering Trialists' Collaboration
    • Homocysteine Lowering Trialists' Collaboration. Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomised trials. BMJ 1998; 316: 894-8.
    • (1998) BMJ , vol.316 , pp. 894-898
  • 68
    • 0029066299 scopus 로고
    • A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes
    • Boushey CJ, Beresford SA, Omen GS, Motulsky AG. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes. JAMA 1995; 274: 1049-57.
    • (1995) JAMA , vol.274 , pp. 1049-1057
    • Boushey, C.J.1    Beresford, S.A.2    Omen, G.S.3    Motulsky, A.G.4
  • 69
    • 0037132839 scopus 로고    scopus 로고
    • Importance of both folic acid and vitamin B12 in reduction of risk of vascular disease
    • Quinlivan EP, McPartlin J, McNulty H, et al. Importance of both folic acid and vitamin B12 in reduction of risk of vascular disease. Lancet 2002; 359: 227-8.
    • (2002) Lancet , vol.359 , pp. 227-228
    • Quinlivan, E.P.1    McPartlin, J.2    McNulty, H.3
  • 70
    • 0036305521 scopus 로고    scopus 로고
    • Vitamin B12 status is inversely associated with plasma homocysteine in young women with C677T and/or A1298C methylenetetrahydrofolate reductase polymorphisms
    • Bailey LB, Duhaney RL, Maneval DR, et al. Vitamin B12 status is inversely associated with plasma homocysteine in young women with C677T and/or A1298C methylenetetrahydrofolate reductase polymorphisms. J Nutr 2002; 132: 1872-8.
    • (2002) J Nutr , vol.132 , pp. 1872-1878
    • Bailey, L.B.1    Duhaney, R.L.2    Maneval, D.R.3
  • 71
    • 0037216404 scopus 로고    scopus 로고
    • Effect of food fortification on folic acid intake in the United States
    • Quinlivan EP, Gregory JF.: Effect of food fortification on folic acid intake in the United States. AJCN 2003; 77: 221-225.
    • (2003) AJCN , vol.77 , pp. 221-225
    • Quinlivan, E.P.1    Gregory, J.F.2
  • 73
    • 0038387939 scopus 로고    scopus 로고
    • Homocysteine and Alzheimer's disease
    • Morris MS. Homocysteine and Alzheimer's disease. Lancet Neurol 2003; 2: 425-8.
    • (2003) Lancet Neurol , vol.2 , pp. 425-428
    • Morris, M.S.1
  • 74
    • 1842529053 scopus 로고    scopus 로고
    • Homocysteine and neuropsychiatric disorders
    • Sachdev P. Homocysteine and neuropsychiatric disorders. Rev Bras Psiquiatr 2004; 26: 50-6.
    • (2004) Rev Bras Psiquiatr , vol.26 , pp. 50-56
    • Sachdev, P.1
  • 75
    • 0242610822 scopus 로고    scopus 로고
    • Bailey LB. Folate, Methyl-Related Nutrients, Alcohol, and the MTHFR 677CT Polymorphism Affect Cancer Risk: Intake Recommendations. Supplement: International Research Conference on Food, Nutrition and Cancer. J Nutr 2003; 133: 3748S-53S
    • Bailey LB. Folate, Methyl-Related Nutrients, Alcohol, and the MTHFR 677CT Polymorphism Affect Cancer Risk: Intake Recommendations. Supplement: International Research Conference on Food, Nutrition and Cancer. J Nutr 2003; 133: 3748S-53S
  • 76
    • 0033533527 scopus 로고    scopus 로고
    • Homocysteine and cardiovascular disease: A critical review of the epidemiologic evidence
    • Eikelboom JW, Lonn E, Genest J Jr, et al. Homocysteine and cardiovascular disease: a critical review of the epidemiologic evidence. Ann Intern Med 1999; 131: 363-75.
    • (1999) Ann Intern Med , vol.131 , pp. 363-375
    • Eikelboom, J.W.1    Lonn, E.2    Genest Jr, J.3
  • 77
    • 0033878934 scopus 로고    scopus 로고
    • The controversy over homocysteine and cardiovascular risk
    • Ueland PM, Refsum H, Beresford SAA, et al. The controversy over homocysteine and cardiovascular risk. Am J Clin Nutr 2000; 72: 324-8.
    • (2000) Am J Clin Nutr , vol.72 , pp. 324-328
    • Ueland, P.M.1    Refsum, H.2    Beresford, S.A.A.3
  • 78
    • 0035569991 scopus 로고    scopus 로고
    • Long term homocysteine-lowering treatment with folic acid plus pyridoxine is associated with a decreased blood pressure but not with improved brachial artery endothelium-dependent vasodilatation or carotid artery stiffness
    • Van Dijk, RAJM, Rauwerda JA, Steyn M, et al. Long term homocysteine-lowering treatment with folic acid plus pyridoxine is associated with a decreased blood pressure but not with improved brachial artery endothelium-dependent vasodilatation or carotid artery stiffness. Arterioscler Thromb Vasc Biol 2001; 21: 2072-8.
    • (2001) Arterioscler Thromb Vasc Biol , vol.21 , pp. 2072-2078
    • Van Dijk, R.A.J.M.1    Rauwerda, J.A.2    Steyn, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.